Experiment set34IT083 for Escherichia coli BW25113

Compare to:

Utah_phage 15 MOI

200 most important genes:

  gene name fitness t score description  
b2620 smpB -4.1 -2.8 SsrA-binding protein (NCBI) compare
b0683 fur -3.7 -3.7 ferric uptake regulator (NCBI) compare
b0142 folK -3.6 -1.3 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) compare
b3863 polA -3.4 -2.3 DNA polymerase I (NCBI) compare
b4172 hfq -2.7 -1.9 RNA-binding protein Hfq (NCBI) compare
b1865 nudB -2.5 -2.9 dATP pyrophosphohydrolase (NCBI) compare
b4202 rpsR -2.5 -3.2 30S ribosomal protein S18 (NCBI) compare
b2699 recA -2.4 -2.2 recombinase A (NCBI) compare
b3341 rpsG -2.4 -2.1 30S ribosomal protein S7 (NCBI) compare
b2935 tktA -2.3 -3.8 transketolase 1, thiamin-binding (NCBI) compare
b2820 recB -2.3 -2.2 exonuclease V (RecBCD complex), beta subunit (NCBI) compare
b2330 yfcB -2.3 -3.3 putative adenine-specific methylase (VIMSS) compare
b1607 ydgC -1.9 -2.5 conserved inner membrane protein associated with alginate biosynthesis (NCBI) compare
b3706 trmE -1.8 -7.0 tRNA modification GTPase (NCBI) compare
b0730 mngR -1.8 -2.7 DNA-binding transcriptional dual regulator, fatty-acyl-binding (NCBI) compare
b3164 pnp -1.7 -3.1 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b0990 cspG -1.7 -1.2 DNA-binding transcriptional regulator (NCBI) compare
b3741 gidA -1.7 -7.6 glucose-inhibited division protein A (NCBI) compare
b3979 thrT -1.7 -0.6 tRNA-Thr (NCBI) compare
b1951 rcsA -1.7 -1.1 DNA-binding transcriptional activator, co-regulator with RcsB (NCBI) compare
b1863 ruvC -1.6 -3.1 Holliday junction resolvase (NCBI) compare
b1129 phoQ -1.5 -1.1 sensory histidine kinase in two-compoent regulatory system with PhoP (NCBI) compare
b4402 yjjY -1.5 -1.8 hypothetical protein (NCBI) compare
b2822 recC -1.4 -6.5 exonuclease V (RecBCD complex), gamma chain (NCBI) compare
b4375 prfC -1.4 -5.3 peptide chain release factor 3 (NCBI) compare
b0232 yafN -1.3 -0.7 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b2830 nudH -1.3 -1.9 dinucleoside polyphosphate hydrolase (NCBI) compare
b0114 aceE -1.3 -0.9 pyruvate dehydrogenase subunit E1 (NCBI) compare
b4647 mokA -1.3 -1.3 no description compare
b1536 ydeI -1.3 -1.2 hypothetical protein (NCBI) compare
b1257 yciE -1.3 -0.8 hypothetical protein (NCBI) compare
b2912 ygfA -1.3 -2.5 putative ligase (VIMSS) compare
b1861 ruvA -1.2 -1.4 Holliday junction DNA helicase motor protein (NCBI) compare
b2426 ucpA -1.2 -1.4 putative oxidoreductase (VIMSS) compare
b1293 sapB -1.2 -1.6 predicted antimicrobial peptide transporter subunit (NCBI) compare
b0630 lipB -1.1 -1.6 protein of lipoate biosynthesis (VIMSS) compare
b0782 moaB -1.1 -1.9 molybdopterin biosynthesis protein B (NCBI) compare
b2431 b2431 -1.1 -6.0 orf, hypothetical protein (VIMSS) compare
b2567 rnc -1.1 -1.2 ribonuclease III (NCBI) compare
b4155 yjeA -1.1 -0.7 putative lysyl-tRNA synthetase (VIMSS) compare
b1279 yciS -1.1 -1.1 conserved inner membrane protein (NCBI) compare
b1749 xthA -1.1 -3.4 exonuclease III (NCBI) compare
b4239 treC -1.0 -2.4 trehalose-6-P hydrolase (NCBI) compare
b4546 ypeB -1.0 -1.4 hypothetical protein (NCBI) compare
b3198 kdsC -1.0 -4.7 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (NCBI) compare
b4451 ryhB -1.0 -1.4 Regulatory sRNA mediating positive Fur regulon response; requires Hfq for function; global iron regulator; degraded by RNase E when bound to target (RefSeq) compare
b0051 ksgA -1.0 -3.2 dimethyladenosine transferase (NCBI) compare
b0812 dps -1.0 -4.4 DNA protection during starvation conditions (NCBI) compare
b1108 ycfP -1.0 -1.2 orf, hypothetical protein (VIMSS) compare
b4702 mgtL -1.0 -2.0 regulatory leader peptide for mgtA (NCBI) compare
b1506 yneL -1.0 -0.9 predicted transcriptional regulator (NCBI) compare
b2846 yqeH -1.0 -0.5 orf, hypothetical protein (VIMSS) compare
b3043 ygiL -1.0 -4.6 predicted fimbrial-like adhesin protein (NCBI) compare
b3652 recG -1.0 -5.9 ATP-dependent DNA helicase (NCBI) compare
b1862 yebB -1.0 -3.4 orf, hypothetical protein (VIMSS) compare
b1712 ihfA -0.9 -1.9 integration host factor subunit alpha (NCBI) compare
b0890 ftsK -0.9 -4.0 DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) compare
b4242 mgtA -0.9 -6.3 magnesium transporter (NCBI) compare
b0912 ihfB -0.9 -2.2 integration host factor subunit beta (NCBI) compare
b3916 pfkA -0.9 -2.6 6-phosphofructokinase (NCBI) compare
b1130 phoP -0.9 -1.5 DNA-binding response regulator in two-component regulatory system with PhoQ (NCBI) compare
b3026 qseC -0.8 -3.3 sensory histidine kinase in two-component regulatory system with QseB (NCBI) compare
b3229 sspA -0.8 -2.0 stringent starvation protein A (NCBI) compare
b0658 ybeX -0.8 -0.6 predicteed ion transport (NCBI) compare
b1527 yneK -0.8 -2.2 hypothetical protein (NCBI) compare
b3649 rpoZ -0.8 -1.9 DNA-directed RNA polymerase subunit omega (NCBI) compare
b0989 cspH -0.8 -2.1 stress protein, member of the CspA-family (NCBI) compare
b0059 hepA -0.8 -6.3 ATP-dependent helicase HepA (NCBI) compare
b1968 yedV -0.8 -2.6 predicted sensory kinase in two-component regulatory system with YedW (NCBI) compare
b0101 yacG -0.8 -1.7 zinc-binding protein (NCBI) compare
b2518 ndk -0.8 -1.8 nucleoside diphosphate kinase (NCBI) compare
b2289 lrhA -0.8 -4.5 DNA-binding transcriptional repressor of flagellar, motility and chemotaxis genes (NCBI) compare
b4426 isrA -0.8 -1.5 unknown RNA (NCBI) compare
b2652 ileY -0.8 -0.5 tRNA-Ile (NCBI) compare
b3624 rfaZ -0.8 -2.2 lipopolysaccharide core biosynthesis protein (NCBI) compare
b2565 recO -0.8 -2.6 DNA repair protein RecO (NCBI) compare
b1196 ycgY -0.7 -2.2 hypothetical protein (NCBI) compare
b2297 pta -0.7 -0.7 phosphate acetyltransferase (NCBI) compare
b4184 yjfL -0.7 -2.6 conserved inner membrane protein (NCBI) compare
b1134 ymfB -0.7 -2.1 bifunctional thiamin pyrimidine pyrophosphate hydrolase/ thiamin pyrophosphate hydrolase (NCBI) compare
b1523 yneG -0.7 -1.6 hypothetical protein (NCBI) compare
b3870 glnA -0.7 -1.7 glutamine synthetase (NCBI) compare
b1028 ymdE -0.7 -3.1 orf, hypothetical protein (VIMSS) compare
b1165 ymgA -0.7 -0.5 hypothetical protein (NCBI) compare
b0310 ykgH -0.7 -0.9 predicted inner membrane protein (NCBI) compare
b0145 dksA -0.7 -2.0 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b4201 priB -0.7 -1.4 primosomal replication protein N (NCBI) compare
b2376 ypdI -0.7 -2.8 predicted lipoprotein involved in colanic acid biosynthesis (NCBI) compare
b2369 evgA -0.7 -2.9 DNA-binding response regulator in two-component regulatory system with EvgS (NCBI) compare
b1758 b1758 -0.7 -1.0 putative cytochrome oxidase (VIMSS) compare
b2498 upp -0.7 -1.8 uracil phosphoribosyltransferase (VIMSS) compare
b4177 purA -0.7 -1.2 adenylosuccinate synthetase (NCBI) compare
b3764 yifE -0.7 -2.8 hypothetical protein (NCBI) compare
b1684 sufA -0.7 -2.3 iron-sulfur cluster assembly scaffold protein (NCBI) compare
b0580 ybdJ -0.7 -1.0 predicted inner membrane protein (NCBI) compare
b3210 arcB -0.7 -3.4 hybrid sensory histidine kinase in two-component regulatory system with ArcA (NCBI) compare
b2111 yehD -0.7 -2.1 predicted fimbrial-like adhesin protein (NCBI) compare
b1400 paaY -0.7 -1.4 predicted hexapeptide repeat acetyltransferase (NCBI) compare
b0953 rmf -0.7 -1.4 ribosome modulation factor (NCBI) compare
b1269 rluB -0.7 -2.4 23S rRNA pseudouridylate synthase (NCBI) compare
b2061 wzb -0.7 -1.5 protein-tyrosine phosphatase (NCBI) compare
b4048 yjbM -0.7 -1.5 hypothetical protein (NCBI) compare
b0550 rusA -0.7 -1.3 DLP12 prophage; endonuclease RUS (NCBI) compare
b1642 slyA -0.7 -1.1 transcriptional regulator for cryptic hemolysin (VIMSS) compare
b1409 ynbB -0.7 -0.4 predicted CDP-diglyceride synthase (NCBI) compare
b0386 proC -0.7 -2.4 pyrroline-5-carboxylate reductase (NCBI) compare
b1330 ynaI -0.6 -2.7 conserved inner membrane protein (NCBI) compare
b3806 cyaA -0.6 -3.0 adenylate cyclase (NCBI) compare
b0439 lon -0.6 -2.3 DNA-binding ATP-dependent protease La (NCBI) compare
b1600 mdtJ -0.6 -1.3 multidrug efflux system transporter (NCBI) compare
b4480 hdfR -0.6 -2.7 transcriptional regulator HdfR (NCBI) compare
b1346 ydaQ -0.6 -0.9 orf, hypothetical protein (VIMSS) compare
b3700 recF -0.6 -4.5 recombination protein F (NCBI) compare
b4436 ryeC -0.6 -1.1 Novel sRNA, function unknown; paralogous to the other QUAD sRNA genes unknown (RefSeq) compare
b1164 ycgZ -0.6 -1.3 hypothetical protein (NCBI) compare
b1505 ydeT -0.6 -0.8 hypothetical protein (RefSeq) compare
b1291 sapD -0.6 -0.9 predicted antimicrobial peptide transporter subunit (NCBI) compare
b2808 gcvA -0.6 -2.0 DNA-binding transcriptional dual regulator (NCBI) compare
b0974 hyaC -0.6 -2.0 hydrogenase 1, b-type cytochrome subunit (NCBI) compare
b4685 yrbN -0.6 -1.6 expressed protein (RefSeq) compare
b0472 recR -0.6 -4.1 recombination protein RecR (NCBI) compare
b4503 yafF -0.6 -0.5 no description compare
b3462 ftsX -0.6 -3.4 predicted transporter subunit: membrane component of ABC superfamily (NCBI) compare
b1677 lpp -0.6 -1.1 murein lipoprotein (NCBI) compare
b0949 uup -0.6 -3.5 fused predicted transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b1195 ymgE -0.6 -1.5 predicted inner membrane protein (NCBI) compare
b2195 ccmG -0.6 -1.0 periplasmic thioredoxin of cytochrome c-type biogenesis (NCBI) compare
b1553 ydfP -0.6 -1.1 Qin prophage; conserved protein (NCBI) compare
b1125 potB -0.6 -1.4 spermidine/putrescine ABC transporter membrane protein (NCBI) compare
b3493 pitA -0.6 -3.4 phosphate transporter, low-affinity (NCBI) compare
b1524 yneH -0.6 -0.6 predicted glutaminase (NCBI) compare
b4603 rseX -0.6 -0.5 sRNA regulating ompA and ompC translation, with Hfq (RefSeq) compare
b3726 pstA -0.6 -1.9 phosphate transporter subunit (NCBI) compare
b3728 pstS -0.6 -2.0 phosphate transporter subunit (NCBI) compare
b0143 pcnB -0.6 -2.6 poly(A) polymerase I (VIMSS) compare
b2047 wcaJ -0.5 -2.9 predicted UDP-glucose lipid carrier transferase (NCBI) compare
b0888 trxB -0.5 -2.1 thioredoxin reductase, FAD/NAD(P)-binding (NCBI) compare
b0767 ybhE -0.5 -1.8 6-phosphogluconolactonase (NCBI) compare
b3162 deaD -0.5 -2.2 inducible ATP-independent RNA helicase (VIMSS) compare
b2617 smpA -0.5 -1.4 small membrane protein A (VIMSS) compare
b4416 rybA -0.5 -0.9 unknown RNA (NCBI) compare
b4522 yciX_1 -0.5 -1.0 hypothetical protein (NCBI) compare
b2252 ais -0.5 -2.7 hypothetical protein (NCBI) compare
b1950 fliR -0.5 -1.5 flagellar biosynthesis protein R (NCBI) compare
b4094 phnN -0.5 -1.9 ribose 1,5-bisphosphokinase (NCBI) compare
b0791 ybhQ -0.5 -2.1 predicted inner membrane protein (NCBI) compare
b4093 phnO -0.5 -2.3 predicted acyltransferase with acyl-CoA N-acyltransferase domain (NCBI) compare
b3181 greA -0.5 -2.6 transcription elongation factor: cleaves 3' nucleotide of paused mRNA (VIMSS) compare
b0456 ybaA -0.5 -2.2 hypothetical protein (NCBI) compare
b1359 ydaU -0.5 -1.4 Rac prophage; conserved protein (NCBI) compare
b1295 ymjA -0.5 -1.1 hypothetical protein (NCBI) compare
b3545 proK -0.5 -1.1 tRNA-Pro (NCBI) compare
b4179 vacB -0.5 -2.6 putative enzyme (VIMSS) compare
b0746 valZ -0.5 -1.6 tRNA-Val (NCBI) compare
b2741 rpoS -0.5 -2.4 RNA polymerase sigma factor (NCBI) compare
b1711 btuC -0.5 -1.9 vtamin B12-transporter permease (NCBI) compare
b2659 b2659 -0.5 -1.9 orf, hypothetical protein (VIMSS) compare
b4513 kdpF -0.5 -0.8 potassium ion accessory transporter subunit (NCBI) compare
b4431 rprA -0.5 -1.2 Positive regulatory sRNA for RpoS translation; non-essential gene (RefSeq) compare
b0212 gloB -0.5 -0.9 predicted hydroxyacylglutathione hydrolase (NCBI) compare
b4541 yehK -0.5 -1.8 hypothetical protein (NCBI) compare
b2301 yfcF -0.5 -2.4 predicted enzyme (NCBI) compare
b3813 uvrD -0.5 -4.1 DNA-dependent ATPase I and helicase II (NCBI) compare
b1383 ydbL -0.5 -2.1 orf, hypothetical protein (VIMSS) compare
b3623 rfaK -0.5 -1.4 lipopolysaccharide core biosynthesis (NCBI) compare
b0018 mokC -0.5 -0.8 regulatory protein for HokC, overlaps CDS of hokC (NCBI) compare
b1831 proQ -0.5 -1.5 putative solute/DNA competence effector (NCBI) compare
b1643 ydhI -0.5 -1.6 predicted inner membrane protein (NCBI) compare
b0991 ymcE -0.5 -2.1 cold shock gene (NCBI) compare
b0279 yagM -0.5 -0.3 CP4-6 prophage; predicted protein (NCBI) compare
b2317 dedA -0.5 -2.0 conserved inner membrane protein (NCBI) compare
b4462 ygaQ -0.5 -0.7 hypothetical protein (RefSeq) compare
b1058 yceO -0.5 -0.2 hypothetical protein (NCBI) compare
b3875 ompL -0.5 -1.7 predicted outer membrane porin L (NCBI) compare
b1143 ymfI -0.5 -1.2 orf, hypothetical protein (VIMSS) compare
b0840 deoR -0.5 -2.2 DNA-binding transcriptional repressor (NCBI) compare
b2236 yfaE -0.5 -1.7 predicted 2Fe-2S cluster-containing protein (NCBI) compare
b1558 cspF -0.5 -1.3 Qin prophage; cold shock protein (NCBI) compare
b3161 mtr -0.5 -3.0 tryptophan transporter of high affinity (NCBI) compare
b4640 yoeG -0.5 -1.7 no description compare
b2814 metZ -0.5 -0.9 tRNA-Met (NCBI) compare
b0864 artP -0.5 -2.1 arginine transporter subunit (NCBI) compare
b1499 ydeO -0.5 -0.3 predicted DNA-binding transcriptional acfivator (NCBI) compare
b1144 ymfJ -0.5 -1.4 orf, hypothetical protein (VIMSS) compare
b4441 glmY -0.5 -0.9 sRNA activator of glmS mRNA (RefSeq) compare
b1282 yciH -0.5 -2.4 orf, hypothetical protein (VIMSS) compare
b0001 thrL -0.5 -1.5 thr operon leader peptide (NCBI) compare
b0099 mutT -0.5 -1.5 nucleoside triphosphate pyrophosphohydrolase, marked preference for dGTP (NCBI) compare
b4536 yobH -0.4 -1.0 hypothetical protein (NCBI) compare
b4413 sokC -0.4 -0.8 regulatory antisense RNA (NCBI) compare
b4215 ytfI -0.4 -1.0 hypothetical protein (NCBI) compare
b2476 purC -0.4 -1.2 phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI) compare
b3871 bipA -0.4 -3.3 GTP-binding protein (NCBI) compare
b0880 cspD -0.4 -1.1 cold shock protein homolog (NCBI) compare
b0080 fruR -0.4 -2.0 DNA-binding transcriptional dual regulator (NCBI) compare
b3629 rfaS -0.4 -1.7 lipopolysaccharide core biosynthesis protein (NCBI) compare
b1824 yobF -0.4 -1.0 hypothetical protein (NCBI) compare
b4042 dgkA -0.4 -1.1 diacylglycerol kinase (NCBI) compare
b3794 rffM -0.4 -2.6 putative UDP-N-acetyl-D-mannosaminuronic acid transferase (NCBI) compare
b2058 wcaB -0.4 -0.6 predicted acyl transferase (NCBI) compare


Specific Phenotypes

For 1 genes in this experiment

For phage Utah_phage in Escherichia coli BW25113

For phage Utah_phage across organisms