| | gene | name | fitness | t score | description | |
|---|
| b2476 | purC | -5.5 | -4.0 | phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI) | compare |
| b3642 | pyrE | -5.4 | -8.1 | orotate phosphoribosyltransferase (NCBI) | compare |
| b0523 | purE | -5.4 | -5.5 | phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI) | compare |
| b1062 | pyrC | -5.3 | -12.7 | dihydroorotase (NCBI) | compare |
| b4006 | purH | -4.8 | -16.6 | bifunctionalphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI) | compare |
| b2499 | purM | -4.7 | -8.0 | phosphoribosylaminoimidazole synthetase (NCBI) | compare |
| b2557 | purL | -4.4 | -17.2 | phosphoribosylformylglycinamidine synthase (NCBI) | compare |
| b2312 | purF | -4.3 | -9.6 | amidophosphoribosyltransferase (NCBI) | compare |
| b1281 | pyrF | -4.3 | -5.1 | orotidine 5'-phosphate decarboxylase (NCBI) | compare |
| b4005 | purD | -4.2 | -11.1 | phosphoribosylamine--glycine ligase (NCBI) | compare |
| b4388 | serB | -4.1 | -7.3 | 3-phosphoserine phosphatase (NCBI) | compare |
| b0907 | serC | -4.1 | -9.2 | phosphoserine aminotransferase (NCBI) | compare |
| b0945 | pyrD | -4.1 | -13.5 | dihydroorotate dehydrogenase (NCBI) | compare |
| b0049 | apaH | -4.0 | -2.8 | diadenosinetetraphosphatase (NCBI) | compare |
| b2913 | serA | -4.0 | -11.5 | D-3-phosphoglycerate dehydrogenase (NCBI) | compare |
| b0033 | carB | -3.6 | -18.7 | carbamoyl-phosphate synthase large subunit (NCBI) | compare |
| b4245 | pyrB | -3.6 | -14.7 | aspartate carbamoyltransferase catalytic subunit (NCBI) | compare |
| b1865 | nudB | -3.3 | -2.7 | dATP pyrophosphohydrolase (NCBI) | compare |
| b0032 | carA | -3.2 | -7.5 | carbamoyl-phosphate synthase small subunit (NCBI) | compare |
| b2318 | truA | -3.1 | -5.7 | tRNA pseudouridine synthase A (NCBI) | compare |
| b2168 | fruK | -3.1 | -2.2 | 1-phosphofructokinase (NCBI) | compare |
| b1863 | ruvC | -3.0 | -2.9 | Holliday junction resolvase (NCBI) | compare |
| b0564 | appY | -3.0 | -1.1 | DLP12 prophage; DNA-binding transcriptional activator (NCBI) | compare |
| b0222 | lpcA | -2.9 | -4.3 | phosphoheptose isomerase (NCBI) | compare |
| b4647 | mokA | -2.6 | -1.4 | no description | compare |
| b0438 | clpX | -2.6 | -7.9 | ATP-dependent protease ATP-binding subunit (NCBI) | compare |
| b3619 | rfaD | -2.4 | -6.0 | ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) | compare |
| b3621 | rfaC | -2.4 | -8.1 | ADP-heptose:LPS heptosyl transferase I (NCBI) | compare |
| b3390 | aroK | -2.3 | -3.1 | shikimate kinase I (NCBI) | compare |
| b0990 | cspG | -2.3 | -1.6 | DNA-binding transcriptional regulator (NCBI) | compare |
| b4042 | dgkA | -2.3 | -2.7 | diacylglycerol kinase (NCBI) | compare |
| b1236 | galU | -2.3 | -6.3 | glucose-1-phosphate uridylyltransferase (NCBI) | compare |
| b0437 | clpP | -2.3 | -7.4 | ATP-dependent Clp protease proteolytic subunit (NCBI) | compare |
| b3052 | rfaE | -2.3 | -7.7 | fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) | compare |
| b0522 | purK | -2.2 | -9.7 | phosphoribosylaminoimidazole carboxylase (NCBI) | compare |
| b0889 | lrp | -2.2 | -3.7 | DNA-binding transcriptional dual regulator, leucine-binding (NCBI) | compare |
| b0053 | surA | -2.2 | -6.5 | peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) | compare |
| b0688 | pgm | -2.2 | -5.2 | phosphoglucomutase (NCBI) | compare |
| b0019 | nhaA | -2.1 | -10.8 | pH-dependent sodium/proton antiporter (NCBI) | compare |
| b0142 | folK | -2.1 | -0.8 | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) | compare |
| b4651 | yibW | -2.1 | -1.3 | no description | compare |
| b0145 | dksA | -2.1 | -5.1 | DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) | compare |
| b0738 | tolR | -2.1 | -3.9 | membrane spanning protein in TolA-TolQ-TolR complex (NCBI) | compare |
| b1235 | rssB | -2.0 | -7.6 | response regulator of RpoS (NCBI) | compare |
| b0589 | fepG | -2.0 | -9.9 | iron-enterobactin transporter subunit (NCBI) | compare |
| b3842 | rfaH | -1.9 | -8.6 | transcriptional activator RfaH (NCBI) | compare |
| b3387 | dam | -1.9 | -13.8 | DNA adenine methylase (NCBI) | compare |
| b3237 | argR | -1.9 | -6.0 | arginine repressor (NCBI) | compare |
| b3620 | rfaF | -1.9 | -6.0 | ADP-heptose:LPS heptosyltransferase II (NCBI) | compare |
| b3026 | qseC | -1.9 | -5.6 | sensory histidine kinase in two-component regulatory system with QseB (NCBI) | compare |
| b2479 | gcvR | -1.8 | -7.6 | transcriptional regulation of gcv operon (VIMSS) | compare |
| b0741 | pal | -1.8 | -4.7 | peptidoglycan-associated outer membrane lipoprotein (NCBI) | compare |
| b0584 | fepA | -1.8 | -10.4 | iron-enterobactin outer membrane transporter (NCBI) | compare |
| b3631 | rfaG | -1.8 | -13.3 | glucosyltransferase I (NCBI) | compare |
| b0590 | fepD | -1.8 | -9.6 | iron-enterobactin transporter subunit (NCBI) | compare |
| b0592 | fepB | -1.7 | -8.5 | iron-enterobactin transporter subunit (NCBI) | compare |
| b2567 | rnc | -1.7 | -1.0 | ribonuclease III (NCBI) | compare |
| b0588 | fepC | -1.7 | -6.0 | iron-enterobactin transporter subunit (NCBI) | compare |
| b2504 | yfgG | -1.7 | -2.1 | Negative regulator of nickel and cobalt uptake (YfgG) (from data) | compare |
| b0585 | fes | -1.7 | -5.3 | enterobactin/ferric enterobactin esterase (NCBI) | compare |
| b0740 | tolB | -1.7 | -4.9 | translocation protein TolB precursor (NCBI) | compare |
| b2528 | iscA | -1.7 | -2.0 | iron-sulfur cluster assembly protein (NCBI) | compare |
| b2784 | relA | -1.7 | -9.7 | (p)ppGpp synthetase I/GTP pyrophosphokinase (NCBI) | compare |
| b0912 | ihfB | -1.6 | -4.4 | integration host factor subunit beta (NCBI) | compare |
| b0739 | tolA | -1.6 | -3.6 | cell envelope integrity inner membrane protein TolA (NCBI) | compare |
| b3792 | wzxE | -1.6 | -7.5 | O-antigen translocase (NCBI) | compare |
| b1712 | ihfA | -1.6 | -1.8 | integration host factor subunit alpha (NCBI) | compare |
| b0677 | nagA | -1.6 | -5.8 | N-acetylglucosamine-6-phosphate deacetylase (NCBI) | compare |
| b2313 | cvpA | -1.6 | -3.4 | membrane protein required for colicin V production (NCBI) | compare |
| b3389 | aroB | -1.6 | -9.0 | 3-dehydroquinate synthase (NCBI) | compare |
| b3977 | tyrU | -1.6 | -0.9 | tRNA-Tyr (NCBI) | compare |
| b2329 | aroC | -1.6 | -5.6 | chorismate synthase (NCBI) | compare |
| b3807 | cyaY | -1.5 | -7.0 | frataxin-like protein (NCBI) | compare |
| b3613 | yibP | -1.5 | -3.9 | putative membrane protein (VIMSS) | compare |
| b0002 | thrA | -1.5 | -11.3 | bifunctional aspartokinase I/homeserine dehydrogenase I (NCBI) | compare |
| b0004 | thrC | -1.5 | -7.8 | threonine synthase (NCBI) | compare |
| b1730 | ydjO | -1.4 | -1.5 | predicted protein (RefSeq) | compare |
| b0890 | ftsK | -1.4 | -3.4 | DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) | compare |
| b0003 | thrB | -1.4 | -7.7 | homoserine kinase (NCBI) | compare |
| b1252 | tonB | -1.4 | -3.2 | membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) | compare |
| b0737 | tolQ | -1.4 | -2.8 | membrane spanning protein in TolA-TolQ-TolR complex (NCBI) | compare |
| b1984 | asnW | -1.4 | -1.2 | tRNA-Asn (NCBI) | compare |
| b3630 | rfaP | -1.4 | -9.3 | kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) | compare |
| b4481 | rffT | -1.4 | -6.1 | 4-alpha-L-fucosyltransferase (NCBI) | compare |
| b3082 | ygjM | -1.4 | -2.1 | predicted DNA-binding transcriptional regulator (NCBI) | compare |
| b4317 | fimD | -1.4 | -12.8 | outer membrane usher protein, type 1 fimbrial synthesis (NCBI) | compare |
| b3791 | rffA | -1.4 | -8.2 | TDP-4-oxo-6-deoxy-D-glucose transaminase (NCBI) | compare |
| b4314 | fimA | -1.4 | -9.7 | major type 1 subunit fimbrin (pilin) (NCBI) | compare |
| b4316 | fimC | -1.4 | -8.2 | periplasmic chaperone, required for type 1 fimbriae (VIMSS) | compare |
| b4312 | fimB | -1.4 | -9.5 | tyrosine recombinase/inversion of on/off regulator of fimA (NCBI) | compare |
| b0676 | nagC | -1.4 | -7.0 | DNA-binding transcriptional dual regulator, repressor of N-acetylglucosamine (NCBI) | compare |
| b3005 | exbD | -1.4 | -5.6 | membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) | compare |
| b3911 | cpxA | -1.3 | -9.3 | two-component sensor protein (NCBI) | compare |
| b1257 | yciE | -1.3 | -0.7 | hypothetical protein (NCBI) | compare |
| b4178 | yjeB | -1.3 | -4.2 | predicted DNA-binding transcriptional regulator (NCBI) | compare |
| b3006 | exbB | -1.3 | -8.2 | membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) | compare |
| b2683 | ygaH | -1.3 | -4.1 | predicted inner membrane protein (NCBI) | compare |
| b2699 | recA | -1.3 | -1.5 | recombinase A (NCBI) | compare |
| b3961 | oxyR | -1.3 | -8.0 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b2501 | ppk | -1.3 | -7.3 | polyphosphate kinase (NCBI) | compare |
| b3790 | rffC | -1.3 | -4.9 | TDP-fucosamine acetyltransferase (RefSeq) | compare |
| b2830 | nudH | -1.3 | -1.3 | dinucleoside polyphosphate hydrolase (NCBI) | compare |
| b1434 | ydcN | -1.3 | -2.2 | predicted DNA-binding transcriptional regulator (NCBI) | compare |
| b3281 | aroE | -1.2 | -9.5 | dehydroshikimate reductase, NAD(P)-binding (NCBI) | compare |
| b0722 | sdhD | -1.2 | -4.4 | succinate dehydrogenase cytochrome b556 small membrane subunit (NCBI) | compare |
| b4435 | isrC | -1.2 | -1.9 | unknown RNA (NCBI) | compare |
| b3609 | secB | -1.2 | -5.4 | export protein SecB (NCBI) | compare |
| b3787 | rffD | -1.2 | -8.8 | UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase (NCBI) | compare |
| b2894 | xerD | -1.2 | -1.0 | site-specific tyrosine recombinase XerD (NCBI) | compare |
| b3838 | tatB | -1.2 | -5.3 | sec-independent translocase (NCBI) | compare |
| b2285 | nuoE | -1.2 | -2.0 | NADH dehydrogenase subunit E (NCBI) | compare |
| b2279 | nuoK | -1.2 | -1.0 | NADH dehydrogenase subunit K (NCBI) | compare |
| b2188 | yejM | -1.2 | -8.6 | predicted hydrolase, inner membrane (NCBI) | compare |
| b2350 | yfdG | -1.1 | -5.1 | CPS-53 (KpLE1) prophage; bactoprenol-linked glucose translocase (flippase) (NCBI) | compare |
| b3916 | pfkA | -1.1 | -2.9 | 6-phosphofructokinase (NCBI) | compare |
| b1144 | ymfJ | -1.1 | -2.8 | orf, hypothetical protein (VIMSS) | compare |
| b1545 | pinQ | -1.1 | -0.3 | Qin prophage; predicted site-specific recombinase (NCBI) | compare |
| b3786 | rffE | -1.1 | -8.4 | UDP-N-acetyl glucosamine-2-epimerase (NCBI) | compare |
| b3839 | tatC | -1.1 | -4.9 | TatABCE protein translocation system subunit (NCBI) | compare |
| b4246 | pyrL | -1.1 | -1.9 | pyrBI operon leader peptide (NCBI) | compare |
| b3500 | gor | -1.1 | -1.4 | glutathione reductase (NCBI) | compare |
| b3761 | trpT | -1.1 | -1.4 | tRNA-Trp (NCBI) | compare |
| b0481 | ybaK | -1.1 | -2.2 | hypothetical protein (NCBI) | compare |
| b2198 | ccmD | -1.1 | -1.1 | cytochrome c biogenesis protein (NCBI) | compare |
| b0908 | aroA | -1.1 | -5.5 | 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) | compare |
| b3794 | rffM | -1.1 | -6.2 | putative UDP-N-acetyl-D-mannosaminuronic acid transferase (NCBI) | compare |
| b0726 | sucA | -1.1 | -3.3 | alpha-ketoglutarate decarboxylase (NCBI) | compare |
| b0755 | gpmA | -1.0 | -4.2 | phosphoglyceromutase (NCBI) | compare |
| b3226 | yhcK | -1.0 | -4.3 | putative FADA-type transcriptional regulator (VIMSS) | compare |
| b1058 | yceO | -1.0 | -0.4 | hypothetical protein (NCBI) | compare |
| b2071 | yegJ | -1.0 | -1.9 | hypothetical protein (NCBI) | compare |
| b0560 | nohB | -1.0 | -2.2 | DLP12 prophage; DNA packaging protein (NCBI) | compare |
| b0937 | ssuE | -1.0 | -2.4 | NAD(P)H-dependent FMN reductase (NCBI) | compare |
| b2175 | spr | -1.0 | -3.2 | predicted peptidase, outer membrane lipoprotein (NCBI) | compare |
| b0439 | lon | -1.0 | -4.0 | DNA-binding ATP-dependent protease La (NCBI) | compare |
| b3774 | ilvC | -1.0 | -7.4 | ketol-acid reductoisomerase (NCBI) | compare |
| b0101 | yacG | -1.0 | -2.6 | zinc-binding protein (NCBI) | compare |
| b2808 | gcvA | -1.0 | -2.9 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b2082 | ogrK | -1.0 | -3.2 | DNA-binding transcriptional regulator prophage P2 remnant (NCBI) | compare |
| b1642 | slyA | -1.0 | -1.5 | transcriptional regulator for cryptic hemolysin (VIMSS) | compare |
| b1273 | yciN | -1.0 | -1.4 | hypothetical protein (NCBI) | compare |
| b1361 | ydaW | -0.9 | -0.4 | orf, hypothetical protein (VIMSS) | compare |
| b0097 | yacA | -0.9 | -2.2 | orf, hypothetical protein (VIMSS) | compare |
| b2104 | thiM | -0.9 | -2.6 | hydroxyethylthiazole kinase (NCBI) | compare |
| b0390 | aroM | -0.9 | -4.9 | hypothetical protein (NCBI) | compare |
| b2456 | cchB | -0.9 | -3.8 | predicted carboxysome structural protein, ethanolamine utilization protein (NCBI) | compare |
| b3778 | rep | -0.9 | -5.2 | DNA helicase and single-stranded DNA-dependent ATPase (NCBI) | compare |
| b3405 | ompR | -0.9 | -3.2 | osmolarity response regulator (NCBI) | compare |
| b0928 | aspC | -0.9 | -4.1 | aspartate aminotransferase, PLP-dependent (NCBI) | compare |
| b0721 | sdhC | -0.9 | -2.8 | succinate dehydrogenase cytochrome b556 large membrane subunit (NCBI) | compare |
| b3771 | ilvD | -0.9 | -6.7 | dihydroxy-acid dehydratase (NCBI) | compare |
| b2572 | rseA | -0.9 | -3.8 | anti-sigma factor (NCBI) | compare |
| b1850 | eda | -0.9 | -2.1 | keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) | compare |
| b1192 | ldcA | -0.9 | -2.8 | L,D-carboxypeptidase A (NCBI) | compare |
| b4025 | pgi | -0.9 | -5.6 | glucose-6-phosphate isomerase (NCBI) | compare |
| b0632 | dacA | -0.9 | -5.7 | D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5) (NCBI) | compare |
| b1999 | yeeP | -0.9 | -3.5 | putative histone (VIMSS) | compare |
| b3860 | dsbA | -0.9 | -5.1 | periplasmic protein disulfide isomerase I (NCBI) | compare |
| b2689 | yqaA | -0.9 | -3.0 | conserved inner membrane protein (NCBI) | compare |
| b1921 | fliZ | -0.9 | -1.9 | orf, hypothetical protein (VIMSS) | compare |
| b1677 | lpp | -0.9 | -1.2 | murein lipoprotein (NCBI) | compare |
| b1530 | marR | -0.9 | -2.6 | multiple antibiotic resistance protein; repressor of mar operon (VIMSS) | compare |
| b2500 | purN | -0.9 | -3.9 | phosphoribosylglycinamide formyltransferase (NCBI) | compare |
| b2912 | ygfA | -0.9 | -2.2 | putative ligase (VIMSS) | compare |
| b4232 | fbp | -0.9 | -5.5 | fructose-1,6-bisphosphatase (NCBI) | compare |
| b0178 | hlpA | -0.9 | -2.6 | periplasmic chaperone (NCBI) | compare |
| b4202 | rpsR | -0.9 | -1.1 | 30S ribosomal protein S18 (NCBI) | compare |
| b1693 | aroD | -0.9 | -5.4 | 3-dehydroquinate dehydratase (NCBI) | compare |
| b4503 | yafF | -0.8 | -0.5 | no description | compare |
| b4066 | yjcF | -0.8 | -0.5 | hypothetical protein (NCBI) | compare |
| b4451 | ryhB | -0.8 | -1.6 | Regulatory sRNA mediating positive Fur regulon response; requires Hfq for function; global iron regulator; degraded by RNase E when bound to target (RefSeq) | compare |
| b0251 | yafY | -0.8 | -3.2 | CP4-6 prophage; predicted DNA-binding transcriptional regulator (RefSeq) | compare |
| b2064 | asmA | -0.8 | -4.9 | predicted assembly protein (NCBI) | compare |
| b3210 | arcB | -0.8 | -4.4 | hybrid sensory histidine kinase in two-component regulatory system with ArcA (NCBI) | compare |
| b0724 | sdhB | -0.8 | -3.8 | succinate dehydrogenase, FeS subunit (NCBI) | compare |
| b1363 | trkG | -0.8 | -0.5 | Rac prophage; potassium transporter subunit (NCBI) | compare |
| b3035 | tolC | -0.8 | -4.1 | outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) | compare |
| b2156 | lysP | -0.8 | -5.0 | lysine transporter (NCBI) | compare |
| b0763 | modA | -0.8 | -3.8 | molybdate transporter subunit (NCBI) | compare |
| b1977 | asnT | -0.8 | -1.0 | tRNA-Asn (NCBI) | compare |
| b0723 | sdhA | -0.8 | -5.2 | succinate dehydrogenase flavoprotein subunit (NCBI) | compare |
| b1151 | ymfO | -0.8 | -1.8 | e14 prophage; conserved protein (RefSeq) | compare |
| b1497 | b1497 | -0.8 | -0.5 | putative enzyme (VIMSS) | compare |
| b1438 | ydcQ | -0.8 | -1.5 | predicted DNA-binding transcriptional regulator (RefSeq) | compare |
| b0920 | ycbC | -0.8 | -2.8 | conserved inner membrane protein (NCBI) | compare |
| b1951 | rcsA | -0.8 | -1.3 | DNA-binding transcriptional activator, co-regulator with RcsB (NCBI) | compare |
| b3869 | glnL | -0.8 | -4.0 | sensory histidine kinase in two-component regulatory system with GlnG (NCBI) | compare |
| b0436 | tig | -0.8 | -4.6 | trigger factor (NCBI) | compare |
| b1594 | dgsA | -0.8 | -2.3 | DNA-binding transcriptional repressor (NCBI) | compare |
| b1260 | trpA | -0.8 | -3.9 | tryptophan synthase subunit alpha (NCBI) | compare |
| b0247 | ykfG | -0.8 | -1.2 | CP4-6 prophage; predicted DNA repair protein (NCBI) | compare |
| b0200 | gmhB | -0.8 | -0.9 | hypothetical protein (NCBI) | compare |
| b1383 | ydbL | -0.8 | -2.0 | orf, hypothetical protein (VIMSS) | compare |
| b1839 | yebY | -0.8 | -1.8 | hypothetical protein (NCBI) | compare |
| b1963 | b1963 | -0.8 | -2.9 | orf, hypothetical protein (VIMSS) | compare |
| b1347 | ydaC | -0.8 | -0.3 | Rac prophage; predicted protein (NCBI) | compare |
| b1090 | plsX | -0.7 | -2.8 | glycerolphosphate auxotrophy in plsB background (VIMSS) | compare |
| b1196 | ycgY | -0.7 | -2.2 | hypothetical protein (NCBI) | compare |
| b2553 | glnB | -0.7 | -2.6 | regulatory protein P-II for glutamine synthetase (NCBI) | compare |
| b2481 | hyfA | -0.7 | -2.5 | hydrogenase 4 Fe-S subunit (VIMSS) | compare |