Experiment set2S751 for Escherichia coli ECRC62

Compare to:

Sodium-DL-Lactate

200 most important genes:

  gene name fitness t score description  
BNILDI_18870 ldcA -6.9 -6.5 muramoyltetrapeptide carboxypeptidase compare
BNILDI_16505 aroD -6.8 -3.7 3-dehydroquinate dehydratase compare
BNILDI_11985 glyA -6.3 -2.8 serine hydroxymethyltransferase compare
BNILDI_14720 hisA -6.1 -2.8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)me thylideneamino]imidazole-4-carboxamide isomerase compare
BNILDI_21310 sucA -6.1 -4.1 2-oxoglutarate dehydrogenase E1 component compare
BNILDI_08580 cra -6.0 -8.2 catabolite repressor/activator compare
BNILDI_08980 dksA -6.0 -8.4 RNA polymerase-binding protein DksA compare
BNILDI_21485 pgm -5.6 -3.7 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) compare
BNILDI_01645 argG -5.6 -18.8 argininosuccinate synthase compare
BNILDI_08540 leuC1 -5.6 -17.4 3-isopropylmalate dehydratase large subunit 1 compare
BNILDI_08545 leuA -5.4 -10.5 2-isopropylmalate synthase compare
BNILDI_20305 serC -5.3 -12.3 3-phosphoserine/phosphohydroxythreonine transaminase compare
BNILDI_22950 proC -5.3 -12.4 pyrroline-5-carboxylate reductase compare
BNILDI_22670 lon_P403L -5.3 -6.2 Lon protease compare
BNILDI_12210 guaB -5.3 -5.1 IMP dehydrogenase compare
BNILDI_05805 argH -5.2 -8.9 argininosuccinate lyase compare
BNILDI_14715 hisF -5.2 -8.1 Imidazole glycerol phosphate synthase subunit HisF compare
BNILDI_20300 aroA -5.2 -13.2 3-phosphoshikimate 1-carboxyvinyltransferase compare
BNILDI_14735 hisC -5.1 -7.7 histidinol-phosphate transaminase compare
BNILDI_22255 purE -5.1 -4.5 N5-carboxyaminoimidazole ribonucleotide mutase compare
BNILDI_21775 lipB -4.9 -1.1 lipoyl(octanoyl) transferase LipB compare
BNILDI_12215 guaA -4.9 -6.8 glutamine-hydrolyzing GMP synthase compare
BNILDI_07225 cysQ -4.8 -9.8 3'(2'),5'-bisphosphate nucleotidase CysQ compare
BNILDI_05725 metF -4.7 -10.2 methylenetetrahydrofolate reductase compare
BNILDI_07310 fbp -4.6 -9.4 class 1 fructose-bisphosphatase compare
BNILDI_11705 pheA -4.6 -12.2 bifunctional chorismate mutase/prephenate dehydratase compare
BNILDI_02615 aroB -4.5 -9.3 3-dehydroquinate synthase compare
BNILDI_05785 ppc -4.5 -12.6 phosphoenolpyruvate carboxylase compare
BNILDI_16455 ppsA -4.4 -9.9 phosphoenolpyruvate synthase compare
BNILDI_14730 hisB -4.4 -4.3 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB compare
BNILDI_13170 aroC -4.3 -5.0 chorismate synthase compare
BNILDI_08070 serB -4.3 -9.8 phosphoserine phosphatase compare
BNILDI_00240 proA -4.3 -9.8 glutamate-5-semialdehyde dehydrogenase compare
BNILDI_00245 proB -4.3 -10.1 Glutamate 5-kinase compare
BNILDI_18465 -4.2 -15.6 hypothetical protein compare
BNILDI_20015 pyrD -4.2 -10.2 quinone-dependent dihydroorotate dehydrogenase compare
BNILDI_05075 metE -4.2 -17.0 5-methyltetrahydropteroyltriglutamate--homocystei ne S-methyltransferase compare
BNILDI_18480 trpA -4.2 -9.6 tryptophan synthase subunit alpha compare
BNILDI_03980 rfaG -4.2 -4.1 Lipopolysaccharide core biosynthesis protein RfaG compare
BNILDI_14725 hisH -4.2 -6.2 imidazole glycerol phosphate synthase subunit HisH compare
BNILDI_10310 lysA -4.1 -9.3 diaminopimelate decarboxylase compare
BNILDI_14745 hisG -4.1 -8.9 ATP phosphoribosyltransferase compare
BNILDI_08550 -4.1 -9.9 2-isopropylmalate synthase compare
BNILDI_11700 tyrA -4.1 -12.6 bifunctional chorismate mutase/prephenate dehydrogenase compare
BNILDI_08325 carA -4.1 -5.6 carbamoyl phosphate synthase small subunit compare
BNILDI_10305 lysR -4.1 -11.7 DNA-binding transcriptional regulator LysR compare
BNILDI_06065 purH -4.0 -11.5 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase compare
BNILDI_02165 aroE -4.0 -6.7 shikimate dehydrogenase compare
BNILDI_19420 pyrC -4.0 -9.1 dihydroorotase compare
BNILDI_06995 purA -3.9 -4.0 adenylosuccinate synthase compare
BNILDI_09905 serA -3.9 -9.8 phosphoglycerate dehydrogenase compare
BNILDI_18475 trpB -3.9 -10.3 tryptophan synthase subunit beta compare
BNILDI_07425 argF -3.9 -12.8 ornithine carbamoyltransferase compare
BNILDI_08330 carB -3.9 -11.8 carbamoyl-phosphate synthase large subunit compare
BNILDI_18470 trpD -3.9 -11.5 bifunctional anthranilate synthase glutamate amidotransferase component TrpG/anthranilate phosphoribosyltransferase TrpD compare
BNILDI_10745 cysH -3.8 -5.6 phosphoadenosine phosphosulfate reductase compare
BNILDI_08535 leuD -3.8 -5.6 3-isopropylmalate dehydratase small subunit compare
BNILDI_05795 argC -3.8 -11.1 N-acetyl-gamma-glutamyl-phosphate reductase compare
BNILDI_11945 purL -3.8 -16.1 phosphoribosylformylglycinamidine synthase compare
BNILDI_10425 argA -3.8 -9.7 amino-acid N-acetyltransferase compare
BNILDI_22685 clpP -3.8 -5.8 ATP-dependent Clp endopeptidase proteolytic subunit ClpP compare
BNILDI_14740 hisD -3.7 -5.5 Histidinol dehydrogenase compare
BNILDI_05800 -3.6 -12.6 acetylglutamate kinase compare
BNILDI_11900 pdxJ -3.6 -1.6 pyridoxine 5'-phosphate synthase compare
BNILDI_08165 thrB -3.5 -8.0 homoserine kinase compare
BNILDI_05790 argE -3.5 -12.8 acetylornithine deacetylase compare
BNILDI_18365 pyrF -3.5 -5.8 orotidine-5'-phosphate decarboxylase compare
BNILDI_04745 ilvE -3.5 -10.3 branched-chain-amino-acid transaminase compare
BNILDI_04765 ilvC -3.5 -13.1 ketol-acid reductoisomerase compare
BNILDI_05070 metR -3.4 -8.9 HTH-type transcriptional regulator MetR compare
BNILDI_21250 tolQ -3.3 -3.4 Tol-Pal system protein TolQ compare
BNILDI_13255 purF -3.3 -13.0 amidophosphoribosyltransferase compare
BNILDI_07385 pyrB -3.3 -11.5 aspartate carbamoyltransferase compare
BNILDI_20400 lrp -3.3 -8.2 leucine-responsive transcriptional regulator Lrp compare
BNILDI_03855 lldP -3.3 -13.5 L-lactate permease compare
BNILDI_08555 leuL -3.2 -1.5 leu operon leader peptide compare
BNILDI_06060 purD -3.2 -9.4 Phosphoribosylamine--glycine ligase compare
BNILDI_12105 hscB -3.2 -1.4 co-chaperone HscB compare
BNILDI_10815 cysC -3.2 -11.4 Adenylyl-sulfate kinase compare
BNILDI_21240 tolA -3.1 -7.1 cell envelope integrity protein TolA compare
BNILDI_08160 thrA -3.1 -14.6 bifunctional aspartate kinase/homoserine dehydrogenase I compare
BNILDI_04035 pyrE -3.1 -8.6 Orotate phosphoribosyltransferase compare
BNILDI_21340 gltA -3.0 -5.2 citrate synthase compare
BNILDI_18610 hns -3.0 -1.2 DNA-binding transcriptional regulator H-NS compare
BNILDI_22260 purK -3.0 -14.0 5-(carboxyamino)imidazole ribonucleotide synthase compare
BNILDI_00780 metC -3.0 -10.8 cystathionine beta-lyase compare
BNILDI_20395 ftsK -3.0 -9.6 DNA translocase FtsK compare
BNILDI_05905 Tyr_trna -3.0 -1.2 tRNA-Tyr(gta) compare
BNILDI_08770 aceF -3.0 -1.9 pyruvate dehydrogenase complex dihydrolipoyllysine-residue acetyltransferase compare
BNILDI_22680 clpX -3.0 -4.8 ATP-dependent protease ATP-binding subunit ClpX compare
BNILDI_10735 cysJ -2.9 -13.3 NADPH-dependent assimilatory sulfite reductase flavoprotein subunit compare
BNILDI_01940 mdh -2.9 -5.1 malate dehydrogenase compare
BNILDI_12270 purM -2.9 -6.6 Phosphoribosylformylglycinamidine cyclo-ligase compare
BNILDI_21235 tolB -2.9 -7.3 Tol-Pal system protein TolB compare
BNILDI_04755 ilvA -2.9 -8.8 threonine ammonia-lyase, biosynthetic compare
BNILDI_12700 cysT -2.9 -4.5 sulfate/thiosulfate ABC transporter permease CysT compare
BNILDI_04850 wzxE -2.9 -4.6 lipid III flippase WzxE compare
BNILDI_04750 ilvD -2.9 -10.8 dihydroxy-acid dehydratase compare
BNILDI_13215 pdxB -2.9 -9.5 4-phosphoerythronate dehydrogenase PdxB compare
BNILDI_04760 ilvY -2.8 -7.8 HTH-type transcriptional activator IlvY compare
BNILDI_08765 aceE -2.8 -6.1 pyruvate dehydrogenase (acetyl-transferring), homodimeric type compare
BNILDI_06965 miaA -2.7 -2.6 tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA compare
BNILDI_21230 pal -2.7 -5.6 peptidoglycan-associated lipoprotein Pal compare
BNILDI_08170 thrC -2.6 -2.7 threonine synthase compare
BNILDI_08415 apaH -2.5 -5.6 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH compare
BNILDI_12220 yfgI -2.5 -1.4 Uncharacterized protein YfgI compare
BNILDI_10740 cysI -2.5 -9.0 assimilatory sulfite reductase (NADPH) hemoprotein subunit compare
BNILDI_14710 hisIE -2.5 -5.3 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE compare
BNILDI_08430 pdxA -2.5 -7.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA compare
BNILDI_13935 fruB -2.5 -2.4 fused PTS fructose transporter subunit IIA/HPr protein compare
BNILDI_02205 trkA -2.5 -1.3 Trk system potassium transporter TrkA compare
BNILDI_12400 purC -2.4 -3.5 phosphoribosylaminoimidazolesuccinocarboxamide synthase compare
BNILDI_10415 recB -2.4 -1.5 exodeoxyribonuclease V subunit beta compare
BNILDI_03970 waaO -2.4 -3.3 lipopolysaccharide 3-alpha-galactosyltransferase compare
BNILDI_15520 ruvB -2.4 -1.9 Holliday junction branch migration DNA helicase RuvB compare
BNILDI_09040 yadW -2.3 -1.0 Protein YadW compare
BNILDI_12745 cysK -2.3 -4.9 cysteine synthase A compare
BNILDI_05715 metB -2.3 -10.3 cystathionine gamma-synthase compare
BNILDI_03860 lldR -2.2 -5.8 transcriptional regulator LldR compare
BNILDI_12710 cysA -2.2 -2.4 sulfate/thiosulfate ABC transporter ATP-binding protein CysA compare
BNILDI_21245 tolR -2.2 -1.8 colicin uptake protein TolR compare
BNILDI_13115 sixA -2.2 -3.5 phosphohistidine phosphatase SixA compare
BNILDI_10810 cysN -2.1 -9.4 sulfate adenylyltransferase subunit CysN compare
BNILDI_06185 pgi -2.1 -9.2 glucose-6-phosphate isomerase compare
BNILDI_10805 cysD -2.0 -9.6 sulfate adenylyltransferase subunit CysD compare
BNILDI_21330 sdhC -2.0 -1.1 succinate dehydrogenase cytochrome b556 subunit compare
BNILDI_19545 cgsF -2.0 -1.7 curli production assembly/transport protein CsgF compare
BNILDI_01805 ptsN -1.9 -4.4 PTS IIA-like nitrogen regulatory protein PtsN compare
BNILDI_02540 cysG -1.9 -9.7 siroheme synthase CysG compare
BNILDI_11695 aroF -1.8 -6.0 3-deoxy-7-phosphoheptulonate synthase AroF compare
BNILDI_21835 -1.8 -1.3 citrate lyase acyl carrier protein 1 compare
BNILDI_08785 acnB -1.8 -2.2 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase compare
BNILDI_15485 nudB -1.8 -3.6 dihydroneopterin triphosphate diphosphatase compare
BNILDI_06100 metA -1.8 -5.4 homoserine O-succinyltransferase compare
BNILDI_10405 recC -1.8 -3.2 exodeoxyribonuclease V subunit gamma compare
BNILDI_04515 pstS -1.7 -4.5 phosphate ABC transporter substrate-binding protein PstS compare
BNILDI_04720 maoP -1.6 -6.1 macrodomain Ori organization protein MaoP compare
BNILDI_18420 -1.6 -1.9 type I DNA topoisomerase compare
BNILDI_10365 rppH -1.6 -1.3 RNA pyrophosphohydrolase compare
BNILDI_14525 dcd -1.6 -2.0 dCTP deaminase compare
BNILDI_04735 ilvG -1.6 -6.9 acetolactate synthase 2 catalytic subunit compare
BNILDI_21320 sdhA -1.6 -7.8 succinate dehydrogenase flavoprotein subunit compare
BNILDI_19310 rne -1.6 -1.9 ribonuclease E compare
BNILDI_18760 prmC -1.5 -4.4 peptide chain release factor N(5)-glutamine methyltransferase compare
BNILDI_16180 ynjA -1.5 -0.9 Uncharacterized protein YnjA compare
BNILDI_06295 dgkA -1.5 -2.0 diacylglycerol kinase compare
BNILDI_05145 fre -1.5 -4.3 NAD(P)H-flavin reductase compare
BNILDI_13250 cvpA -1.4 -2.6 colicin V production protein compare
BNILDI_18970 minE -1.4 -1.6 cell division topological specificity factor MinE compare
BNILDI_04510 pstC -1.4 -4.1 phosphate ABC transporter permease PstC compare
BNILDI_12265 purN -1.4 -3.0 phosphoribosylglycinamide formyltransferase compare
BNILDI_09960 ubiI -1.4 -2.9 FAD-dependent 2-octaprenylphenol hydroxylase compare
BNILDI_12695 cysP -1.3 -6.4 thiosulfate/sulfate ABC transporter substrate-binding protein CysP compare
BNILDI_21965 fepB -1.3 -4.8 ferrienterobactin ABC transporter periplasmic binding protein compare
BNILDI_12705 cysW -1.3 -3.0 sulfate/thiosulfate ABC transporter permease CysW compare
BNILDI_01850 gltB -1.3 -9.7 glutamate synthase large subunit compare
BNILDI_08435 surA -1.3 -2.6 peptidylprolyl isomerase SurA compare
BNILDI_04985 xerC -1.3 -1.3 tyrosine recombinase XerC compare
BNILDI_22770 thiI -1.3 -5.7 tRNA sulfurtransferase compare
BNILDI_01230 yqiM -1.3 -0.7 Protein YqiM compare
BNILDI_06320 yjbM -1.3 -1.0 Uncharacterized protein YjbM compare
BNILDI_10025 xerD -1.3 -2.1 site-specific tyrosine recombinase XerD compare
BNILDI_15535 znuA -1.3 -2.9 zinc ABC transporter substrate-binding protein ZnuA compare
BNILDI_18620 rssB -1.3 -4.5 two-component system response regulator RssB compare
BNILDI_01690 greA -1.3 -1.6 transcription elongation factor GreA compare
BNILDI_16610 ydhY -1.2 -2.4 ferredoxin-like protein compare
BNILDI_04970 yifL -1.2 -2.9 Uncharacterized lipoprotein YifL compare
BNILDI_08155 -1.2 -1.2 thr operon leader peptide compare
BNILDI_04715 hdfR -1.2 -6.8 HTH-type transcriptional regulator HdfR compare
BNILDI_15525 znuB -1.2 -2.3 zinc ABC transporter permease subunit ZnuB compare
BNILDI_22735 -1.2 -0.7 DUF1778 domain-containing protein compare
BNILDI_21985 fepC -1.2 -3.0 ferrienterobactin ABC transporter ATPase compare
BNILDI_01595 pnp -1.2 -5.4 polyribonucleotide nucleotidyltransferase compare
BNILDI_21295 sucD -1.2 -4.4 succinate--CoA ligase subunit alpha compare
BNILDI_11855 rseA -1.2 -1.9 anti-sigma-E factor RseA compare
BNILDI_02740 -1.2 -2.4 NfuA family Fe-S biogenesis protein compare
BNILDI_09590 -1.1 -1.7 IS1 family transposase compare
BNILDI_14375 gatA -1.1 -1.1 PTS galactitol transporter subunit IIA compare
BNILDI_04405 -1.1 -2.6 tRNA modification GTPase MnmE compare
BNILDI_05170 trkH -1.1 -3.2 Trk system potassium transporter TrkH compare
BNILDI_00265 gpt -1.1 -0.8 xanthine phosphoribosyltransferase compare
BNILDI_17810 yncP -1.1 -0.8 Protein YncP compare
BNILDI_02035 yhdT -1.1 -1.4 Uncharacterized membrane protein YhdT compare
BNILDI_04555 atpC -1.1 -1.7 F0F1 ATP synthase subunit epsilon compare
BNILDI_21325 sdhD -1.1 -4.5 succinate dehydrogenase membrane anchor subunit compare
BNILDI_01555 ubiU -1.1 -1.5 Ubiquinone biosynthesis protein UbiU compare
BNILDI_13420 nuoJ -1.1 -2.5 NADH-quinone oxidoreductase subunit J compare
BNILDI_14285 yehA -1.1 -0.6 putative fimbrial-like adhesin protein compare
BNILDI_22725 cyoD -1.1 -2.9 cytochrome o ubiquinol oxidase subunit III compare
BNILDI_15170 fliT -1.0 -3.6 flagella biosynthesis regulatory protein FliT compare
BNILDI_09775 tkt -1.0 -2.2 transketolase compare
BNILDI_11835 srmB -1.0 -3.5 ATP-dependent RNA helicase SrmB compare
BNILDI_16725 grxD -1.0 -0.8 monothiol glutaredoxin 4 compare
BNILDI_03590 yiaG -1.0 -1.2 HTH-type transcriptional regulator compare
BNILDI_05990 thiF -1.0 -4.2 thiazole biosynthesis adenylyltransferase ThiF compare
BNILDI_07450 holC -1.0 -2.1 DNA polymerase III subunit chi compare
BNILDI_05720 metL -1.0 -5.1 bifunctional aspartate kinase/homoserine dehydrogenase II compare
BNILDI_09205 yaeR -1.0 -1.3 VOC family protein compare
BNILDI_15405 flhe -1.0 -2.6 flagellar protein FlhE compare
BNILDI_20330 pflA -1.0 -1.5 pyruvate formate lyase 1-activating protein compare


Specific Phenotypes

None in this experiment

For Escherichia coli ECRC62 in carbon source experiments

For carbon source Sodium-DL-Lactate across organisms