Experiment set2S747 for Escherichia coli ECOR38

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Casamino-acids

200 most important genes:

  gene name fitness t score description  
HEPCGN_20900 guaB -7.4 -5.1 IMP dehydrogenase compare
HEPCGN_08815 surA -6.8 -4.7 peptidylprolyl isomerase SurA compare
HEPCGN_21100 purC -6.2 -9.8 phosphoribosylaminoimidazolesuccinocarboxamide synthase compare
HEPCGN_11950 purH -6.1 -14.5 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase compare
HEPCGN_00215 -6.0 -3.4 DNA-binding protein compare
HEPCGN_10460 purA -6.0 -7.1 adenylosuccinate synthase compare
HEPCGN_16680 zapG -5.8 -3.4 Z-ring associated protein ZapG compare
HEPCGN_25325 -5.4 -2.2 SAR-endolysin compare
HEPCGN_01010 ubiF -5.2 -2.5 3-demethoxyubiquinol 3-hydroxylase compare
HEPCGN_02315 -5.1 -1.5 MarR family transcriptional regulator compare
HEPCGN_20975 purM -5.0 -9.1 Phosphoribosylformylglycinamidine cyclo-ligase compare
HEPCGN_10145 fbp -4.9 -12.8 class 1 fructose-bisphosphatase compare
HEPCGN_06475 purE -4.9 -4.8 N5-carboxyaminoimidazole ribonucleotide mutase compare
HEPCGN_20905 guaA -4.8 -7.3 glutamine-hydrolyzing GMP synthase compare
HEPCGN_14540 rfaF -4.8 -3.3 ADP-heptose--LPS heptosyltransferase RfaF compare
HEPCGN_20615 purL -4.7 -17.3 phosphoribosylformylglycinamidine synthase compare
HEPCGN_12205 sthA -4.7 -13.2 Si-specific NAD(P)(+) transhydrogenase compare
HEPCGN_01305 sucA -4.6 -10.2 2-oxoglutarate dehydrogenase E1 component compare
HEPCGN_01310 odhB -4.5 -4.8 2-oxoglutarate dehydrogenase complex dihydrolipoyllysine-residue succinyltransferase compare
HEPCGN_27400 -4.3 -1.3 transcriptional regulator compare
HEPCGN_01460 tolA -4.2 -6.9 cell envelope integrity protein TolA compare
HEPCGN_23760 pyrC -4.0 -9.2 dihydroorotase compare
HEPCGN_21910 purF -4.0 -10.8 amidophosphoribosyltransferase compare
HEPCGN_12935 ubiE -4.0 -2.3 bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE compare
HEPCGN_06935 lon_P403L -4.0 -8.5 Lon protease compare
HEPCGN_14420 pyrE -3.9 -10.7 Orotate phosphoribosyltransferase compare
HEPCGN_13320 rep -3.9 -5.9 DNA helicase Rep compare
HEPCGN_16670 degS -3.8 -2.6 outer membrane-stress sensor serine endopeptidase DegS compare
HEPCGN_23225 pyrD -3.8 -6.6 quinone-dependent dihydroorotate dehydrogenase compare
HEPCGN_08480 aceE -3.8 -6.4 pyruvate dehydrogenase (acetyl-transferring), homodimeric type compare
HEPCGN_01320 sucD -3.6 -6.5 succinate--CoA ligase subunit alpha compare
HEPCGN_04675 ruvC -3.6 -4.0 crossover junction endodeoxyribonuclease RuvC compare
HEPCGN_23030 serC -3.6 -7.4 3-phosphoserine/phosphohydroxythreonine transaminase compare
HEPCGN_25650 pyrF -3.6 -4.6 orotidine-5'-phosphate decarboxylase compare
HEPCGN_01455 tolR -3.5 -3.9 colicin uptake protein TolR compare
HEPCGN_01295 sdhA -3.4 -10.1 succinate dehydrogenase flavoprotein subunit compare
HEPCGN_20570 pdxJ -3.4 -3.7 pyridoxine 5'-phosphate synthase compare
HEPCGN_08925 carB -3.3 -12.4 carbamoyl-phosphate synthase large subunit compare
HEPCGN_08475 aceF -3.3 -2.6 pyruvate dehydrogenase complex dihydrolipoyllysine-residue acetyltransferase compare
HEPCGN_10060 pyrB -3.3 -7.0 aspartate carbamoyltransferase compare
HEPCGN_08930 carA -3.2 -8.9 carbamoyl phosphate synthase small subunit compare
HEPCGN_01300 sdhB -3.2 -7.1 succinate dehydrogenase iron-sulfur subunit SdhB compare
HEPCGN_06480 purK -3.1 -8.9 5-(carboxyamino)imidazole ribonucleotide synthase compare
HEPCGN_01470 pal -3.1 -4.2 peptidoglycan-associated lipoprotein Pal compare
HEPCGN_20525 rseA -3.1 -4.1 anti-sigma-E factor RseA compare
HEPCGN_21865 pdxB -3.1 -9.1 4-phosphoerythronate dehydrogenase PdxB compare
HEPCGN_20780 hscA -3.1 -3.8 Fe-S protein assembly chaperone HscA compare
HEPCGN_06950 clpP -3.1 -6.7 ATP-dependent Clp endopeptidase proteolytic subunit ClpP compare
HEPCGN_20970 purN -3.0 -9.2 phosphoribosylglycinamide formyltransferase conserved
HEPCGN_01450 tolQ -3.0 -7.9 Tol-Pal system protein TolQ compare
HEPCGN_11955 purD -3.0 -7.5 Phosphoribosylamine--glycine ligase compare
HEPCGN_01290 sdhD -3.0 -5.4 succinate dehydrogenase membrane anchor subunit compare
HEPCGN_08820 pdxA -2.8 -5.2 4-hydroxythreonine-4-phosphate dehydrogenase PdxA compare
HEPCGN_19305 recB -2.8 -6.9 exodeoxyribonuclease V subunit beta compare
HEPCGN_13290 wecA -2.8 -7.2 UDP-N-acetylglucosamine--undecaprenyl-phosphate N-acetylglucosaminephosphotransferase compare
HEPCGN_15945 dam -2.8 -4.2 adenine-specific DNA-methyltransferase compare
HEPCGN_21370 ptsI -2.8 -5.8 phosphoenolpyruvate-protein phosphotransferase PtsI compare
HEPCGN_22065 nuoF -2.8 -8.1 NADH-quinone oxidoreductase subunit NuoF compare
HEPCGN_25515 trpA -2.7 -6.7 tryptophan synthase subunit alpha compare
HEPCGN_00885 lipB -2.6 -3.5 lipoyl(octanoyl) transferase LipB compare
HEPCGN_01315 sucC -2.6 -4.5 ADP-forming succinate--CoA ligase subunit beta compare
HEPCGN_05580 aroD -2.6 -4.9 3-dehydroquinate dehydratase compare
HEPCGN_20770 iscA -2.6 -3.2 iron-sulfur cluster assembly protein IscA compare
HEPCGN_16660 mdh -2.6 -6.1 malate dehydrogenase compare
HEPCGN_26785 -2.6 -2.5 Phage small terminase subunit compare
HEPCGN_22940 ftsK -2.5 -5.8 DNA translocase FtsK compare
HEPCGN_01120 seqA -2.5 -2.6 replication initiation negative regulator SeqA compare
HEPCGN_20250 ratA -2.4 -1.9 type II toxin-antitoxin system toxin RatA compare
HEPCGN_01285 sdhC -2.4 -3.6 succinate dehydrogenase cytochrome b556 subunit compare
HEPCGN_25530 trpD -2.3 -8.0 bifunctional anthranilate synthase glutamate amidotransferase component TrpG/anthranilate phosphoribosyltransferase TrpD compare
HEPCGN_25525 trpCF -2.3 -7.9 bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase TrpF compare
HEPCGN_22095 nuoL -2.3 -6.5 NADH-quinone oxidoreductase subunit L compare
HEPCGN_23890 plsX -2.3 -5.8 phosphate acyltransferase PlsX compare
HEPCGN_22070 nuoG -2.2 -6.7 NADH-quinone oxidoreductase subunit NuoG compare
HEPCGN_01515 nadA -2.2 -6.2 quinolinate synthase NadA compare
HEPCGN_25535 trpE -2.2 -6.9 anthranilate synthase component I compare
HEPCGN_03670 -2.2 -2.5 Putative bacterial toxin ydaT compare
HEPCGN_27375 repA -2.2 -2.5 incFII family plasmid replication initiator RepA compare
HEPCGN_22045 nuoA -2.1 -2.5 NADH-quinone oxidoreductase subunit NuoA compare
HEPCGN_25600 cysB -2.1 -2.8 HTH-type transcriptional regulator CysB compare
HEPCGN_25520 trpB -2.1 -10.9 tryptophan synthase subunit beta compare
HEPCGN_22100 nuoM -2.1 -5.1 NADH-quinone oxidoreductase subunit M compare
HEPCGN_01465 tolB -2.1 -4.5 Tol-Pal system protein TolB compare
HEPCGN_08665 cra -2.1 -4.8 catabolite repressor/activator compare
HEPCGN_08510 nadC -2.0 -7.0 carboxylating nicotinate-nucleotide diphosphorylase compare
HEPCGN_20655 glyA -2.0 -2.8 serine hydroxymethyltransferase compare
HEPCGN_19505 mazE -2.0 -2.7 type II toxin-antitoxin system antitoxin MazE compare
HEPCGN_06945 clpX -2.0 -6.4 ATP-dependent protease ATP-binding subunit ClpX compare
HEPCGN_16490 yhdU -2.0 -2.1 Inner membrane protein YhdU compare
HEPCGN_15935 aroB -1.9 -4.6 3-dehydroquinate synthase compare
HEPCGN_21820 aroC -1.9 -2.0 chorismate synthase compare
HEPCGN_23880 yceD -1.9 -3.2 23S rRNA accumulation protein YceD compare
HEPCGN_03335 -1.9 -1.3 restriction endonuclease compare
HEPCGN_13165 cyaA -1.9 -6.4 class I adenylate cyclase compare
HEPCGN_22105 nuoN -1.9 -5.3 NADH-quinone oxidoreductase subunit NuoN compare
HEPCGN_11980 hupA -1.8 -3.7 DNA-binding protein HU-alpha compare
HEPCGN_19295 recC -1.8 -6.1 exodeoxyribonuclease V subunit gamma compare
HEPCGN_23035 aroA -1.8 -9.2 3-phosphoshikimate 1-carboxyvinyltransferase compare
HEPCGN_13605 pstB -1.8 -1.4 phosphate ABC transporter ATP-binding protein PstB compare
HEPCGN_04695 ruvB -1.8 -3.2 Holliday junction branch migration DNA helicase RuvB compare
HEPCGN_08460 acnB -1.8 -4.7 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase compare
HEPCGN_22050 nuoB -1.7 -5.4 NADH-quinone oxidoreductase subunit NuoB compare
HEPCGN_22060 nuoE -1.7 -2.0 NADH-quinone oxidoreductase subunit NuoE compare
HEPCGN_25055 hns -1.7 -2.0 DNA-binding transcriptional regulator H-NS compare
HEPCGN_03185 wzzB -1.7 -3.1 LPS O-antigen chain length determinant protein WzzB compare
HEPCGN_18620 speB -1.7 -4.2 agmatinase compare
HEPCGN_24920 prmC -1.7 -2.6 peptide chain release factor N(5)-glutamine methyltransferase compare
HEPCGN_10565 epmA -1.7 -3.2 elongation factor P--(R)-beta-lysine ligase compare
HEPCGN_05500 aroH -1.7 -7.2 3-deoxy-7-phosphoheptulonate synthase AroH compare
HEPCGN_01100 uof -1.7 -1.0 fur leader peptide compare
HEPCGN_22055 nuoC -1.7 -5.8 NADH-quinone oxidoreductase subunit C/D compare
HEPCGN_17495 Ile2_trna -1.7 -1.3 tRNA-Ile2(cat) compare
HEPCGN_20515 nadB -1.7 -9.5 L-aspartate oxidase conserved
HEPCGN_20765 iscU -1.7 -1.3 Iron-sulfur cluster assembly scaffold protein IscU compare
HEPCGN_00825 -1.7 -1.5 citrate lyase acyl carrier protein 1 compare
HEPCGN_00245 -1.6 -0.8 Phage tail protein compare
HEPCGN_15800 -1.6 -6.5 NfuA family Fe-S biogenesis protein compare
HEPCGN_14780 yiaL -1.6 -2.2 Protein YiaL compare
HEPCGN_19900 recA -1.6 -2.9 recombinase RecA compare
HEPCGN_03635 -1.6 -1.5 DUF1482 domain-containing protein compare
HEPCGN_12025 thiF -1.6 -4.2 thiazole biosynthesis adenylyltransferase ThiF compare
HEPCGN_04760 yebG -1.6 -1.1 DNA damage-inducible protein YebG compare
HEPCGN_16385 aroE -1.6 -4.3 shikimate dehydrogenase compare
HEPCGN_21365 crr -1.6 -2.8 PTS glucose transporter subunit IIA compare
HEPCGN_22080 nuoI -1.6 -3.6 NADH-quinone oxidoreductase subunit NuoI compare
HEPCGN_25045 rssB -1.6 -7.6 two-component system response regulator RssB compare
HEPCGN_14480 rfaG -1.6 -6.5 Lipopolysaccharide core biosynthesis protein RfaG compare
HEPCGN_22090 nuoK -1.6 -1.8 NADH-quinone oxidoreductase subunit NuoK compare
HEPCGN_14495 rfaJ -1.5 -3.8 lipopolysaccharide 1,2-glucosyltransferase compare
HEPCGN_10655 aspA -1.5 -6.6 aspartate ammonia-lyase compare
HEPCGN_13550 atpC -1.5 -1.5 F0F1 ATP synthase subunit epsilon compare
HEPCGN_12030 thiG -1.5 -5.4 thiazole synthase compare
HEPCGN_12350 metJ -1.5 -1.2 met regulon transcriptional regulator MetJ compare
HEPCGN_13250 wzxE -1.5 -4.5 lipid III flippase WzxE compare
HEPCGN_25720 sapF -1.5 -1.3 peptide ABC transporter ATP-binding protein SapF compare
HEPCGN_04405 -1.5 -1.2 DUF4754 domain-containing protein compare
HEPCGN_13595 pstC -1.5 -2.5 phosphate ABC transporter permease PstC compare
HEPCGN_19700 pphB -1.4 -2.4 protein-serine/threonine phosphatase compare
HEPCGN_08375 panB -1.4 -4.0 3-methyl-2-oxobutanoate hydroxymethyltransferase compare
HEPCGN_03425 -1.4 -1.2 acetyltransferase compare
HEPCGN_14490 waaO -1.4 -4.2 lipopolysaccharide 3-alpha-galactosyltransferase compare
HEPCGN_25140 tonB -1.4 -3.7 TonB system transport protein TonB compare
HEPCGN_10610 ecnA -1.3 -1.6 lipoprotein antitoxin entericidin A compare
HEPCGN_08835 apaH -1.3 -5.2 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH compare
HEPCGN_04280 -1.3 -3.8 phage virion morphogenesis protein compare
HEPCGN_27465 -1.3 -0.9 colicin transporter compare
HEPCGN_00405 -1.3 -1.3 hypothetical protein compare
HEPCGN_08380 panC -1.3 -6.0 pantoate--beta-alanine ligase compare
HEPCGN_21905 cvpA -1.3 -2.7 colicin V production protein compare
HEPCGN_13680 -1.3 -2.9 tRNA modification GTPase MnmE compare
HEPCGN_22000 ackA -1.3 -2.2 acetate kinase compare
HEPCGN_20505 srmB -1.3 -6.1 ATP-dependent RNA helicase SrmB compare
HEPCGN_14415 pyrL -1.3 -1.3 Putative PyrE leader peptide compare
HEPCGN_12860 trkH -1.2 -5.7 Trk system potassium transporter TrkH compare
HEPCGN_23140 aspC -1.2 -3.9 aspartate transaminase compare
HEPCGN_25595 -1.2 -3.9 type I DNA topoisomerase compare
HEPCGN_27165 -1.2 -0.9 hypothetical protein compare
HEPCGN_19290 ppdC -1.2 -1.7 prepilin-type N-terminal cleavage/methylation domain-containing protein compare
HEPCGN_18845 sdhE -1.2 -1.7 FAD assembly factor SdhE compare
HEPCGN_26905 mgtS -1.2 -1.2 protein MgtS compare
HEPCGN_22085 nuoJ -1.2 -2.0 NADH-quinone oxidoreductase subunit J compare
HEPCGN_15555 panM -1.2 -2.9 aspartate 1-decarboxylase autocleavage activator PanM compare
HEPCGN_16885 sfsB -1.1 -1.5 DNA-binding transcriptional regulator SfsB compare
HEPCGN_10840 tetR(B -1.1 -2.4 tetracycline resistance transcriptional repressor TetR(B) compare
HEPCGN_15930 aroK -1.1 -1.2 shikimate kinase AroK compare
HEPCGN_10620 epmB -1.1 -5.1 EF-P beta-lysylation protein EpmB compare
HEPCGN_15950 rpe -1.1 -2.0 ribulose-phosphate 3-epimerase compare
HEPCGN_14525 -1.1 -2.4 beta1,3-glucosyltransferase compare
HEPCGN_02855 -1.1 -0.9 type II toxin-antitoxin system ParD family antitoxin compare
HEPCGN_27235 -1.1 -1.3 plasmid stability protein compare
HEPCGN_12015 thiE -1.1 -4.5 thiamine phosphate synthase compare
HEPCGN_25320 -1.1 -1.8 Ybl58 compare
HEPCGN_05905 -1.0 -1.4 hypothetical protein compare
HEPCGN_02760 -1.0 -6.1 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase compare
HEPCGN_11605 ubiC -1.0 -1.3 chorismate lyase compare
HEPCGN_19255 rppH -1.0 -1.9 RNA pyrophosphohydrolase compare
HEPCGN_20860 bamB -1.0 -3.1 outer membrane protein assembly factor BamB compare
HEPCGN_25225 dnaC -1.0 -1.9 DNA replication protein DnaC compare
HEPCGN_08395 panD -1.0 -4.0 aspartate 1-decarboxylase compare
HEPCGN_18695 epd -1.0 -4.8 erythrose-4-phosphate dehydrogenase compare
HEPCGN_12010 thiC -1.0 -6.6 phosphomethylpyrimidine synthase ThiC compare
HEPCGN_23860 rne -1.0 -2.2 ribonuclease E compare
HEPCGN_13125 xerC -1.0 -2.5 tyrosine recombinase XerC compare
HEPCGN_03710 -1.0 -0.8 Uncharacterized protein Rem compare
HEPCGN_21995 pta -1.0 -2.4 phosphate acetyltransferase compare
HEPCGN_14570 envC -1.0 -4.2 murein hydrolase activator EnvC compare
HEPCGN_14410 rph -1.0 -2.5 ribonuclease PH compare
HEPCGN_12650 csqR -1.0 -5.0 HTH-type transcriptional repressor CsqR compare
HEPCGN_17760 mqsA -1.0 -1.5 type II toxin-antitoxin system antitoxin MqsA compare
HEPCGN_18860 xerD -1.0 -2.1 site-specific tyrosine recombinase XerD compare
HEPCGN_23470 -1.0 -0.9 YccE family protein compare
HEPCGN_24740 fadR -0.9 -2.4 fatty acid metabolism transcriptional regulator FadR compare
HEPCGN_00690 fepD -0.9 -4.0 ferrienterobactin ABC transporter permease compare
HEPCGN_02310 -0.9 -1.8 DUF4752 domain-containing protein compare
HEPCGN_00355 -0.9 -2.1 head decoration protein compare
HEPCGN_00190 -0.9 -0.5 DUF2726 domain-containing protein compare
HEPCGN_20545 lepA -0.9 -4.4 translation elongation factor 4 compare
HEPCGN_07085 nrdR -0.9 -2.9 transcriptional regulator NrdR compare
HEPCGN_16800 rapZ -0.9 -5.2 RNase adapter RapZ compare
HEPCGN_03905 zinT -0.9 -0.9 metal-binding protein ZinT compare


Specific Phenotypes

For 2 genes in this experiment

For carbon source Casamino-acids in Escherichia coli ECOR38

For carbon source Casamino-acids across organisms