Experiment set2S734 for Escherichia coli ECOR27

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Casamino-acids

200 most important genes:

  gene name fitness t score description  
NOLOHH_13410 guaB -7.1 -8.5 IMP dehydrogenase compare
NOLOHH_00825 purE -6.7 -5.8 N5-carboxyaminoimidazole ribonucleotide mutase compare
NOLOHH_04205 fbp -6.2 -12.7 class 1 fructose-bisphosphatase compare
NOLOHH_20215 pyrF -5.8 -7.3 orotidine-5'-phosphate decarboxylase compare
NOLOHH_23315 sucA -5.6 -2.5 2-oxoglutarate dehydrogenase E1 component compare
NOLOHH_05455 purH -5.6 -17.4 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase compare
NOLOHH_23310 odhB -5.4 -2.9 2-oxoglutarate dehydrogenase complex dihydrolipoyllysine-residue succinyltransferase compare
NOLOHH_13145 purL -5.3 -20.8 phosphoribosylformylglycinamidine synthase compare
NOLOHH_13590 purC -5.1 -3.8 phosphoribosylaminoimidazolesuccinocarboxamide synthase compare
NOLOHH_23300 sucD -5.1 -10.2 succinate--CoA ligase subunit alpha compare
NOLOHH_13455 purN -5.1 -12.0 phosphoribosylglycinamide formyltransferase compare
NOLOHH_05490 hupA -5.1 -2.7 DNA-binding protein HU-alpha compare
NOLOHH_13460 purM -5.0 -7.0 Phosphoribosylformylglycinamidine cyclo-ligase compare
NOLOHH_14335 purF -4.9 -8.5 amidophosphoribosyltransferase compare
NOLOHH_21260 pyrC -4.8 -5.6 dihydroorotase compare
NOLOHH_13100 pdxJ -4.7 -3.5 pyridoxine 5'-phosphate synthase compare
NOLOHH_24225 traJ -4.7 -1.3 conjugal transfer transcriptional regulator TraJ compare
NOLOHH_05460 purD -4.5 -10.7 Phosphoribosylamine--glycine ligase compare
NOLOHH_13415 guaA -4.5 -2.7 glutamine-hydrolyzing GMP synthase compare
NOLOHH_22045 aroA -4.5 -6.1 3-phosphoshikimate 1-carboxyvinyltransferase compare
NOLOHH_13865 crr -4.4 -1.7 PTS glucose transporter subunit IIA compare
NOLOHH_08900 aroK -4.4 -1.7 shikimate kinase AroK compare
NOLOHH_03270 carB -4.4 -13.5 carbamoyl-phosphate synthase large subunit compare
NOLOHH_14340 ubiX -4.4 -4.2 flavin prenyltransferase UbiX compare
NOLOHH_03275 carA -4.2 -10.2 carbamoyl phosphate synthase small subunit compare
NOLOHH_07480 pyrE -4.2 -7.4 Orotate phosphoribosyltransferase compare
NOLOHH_04125 pyrB -4.1 -12.8 aspartate carbamoyltransferase compare
NOLOHH_05695 sthA -4.1 -11.7 Si-specific NAD(P)(+) transhydrogenase compare
NOLOHH_14295 pdxB -4.0 -6.0 4-phosphoerythronate dehydrogenase PdxB compare
NOLOHH_02845 aceE -4.0 -2.8 pyruvate dehydrogenase (acetyl-transferring), homodimeric type compare
NOLOHH_11365 rpiA -4.0 -2.8 ribose-5-phosphate isomerase RpiA compare
NOLOHH_21850 pyrD -3.9 -4.7 quinone-dependent dihydroorotate dehydrogenase compare
NOLOHH_23305 sucC -3.6 -5.3 ADP-forming succinate--CoA ligase subunit beta compare
NOLOHH_00830 purK -3.6 -4.7 5-(carboxyamino)imidazole ribonucleotide synthase compare
NOLOHH_11770 yqeL -3.5 -2.3 Uncharacterized protein YqeL compare
NOLOHH_23320 sdhB -3.4 -6.9 succinate dehydrogenase iron-sulfur subunit SdhB compare
NOLOHH_22050 serC -3.4 -9.1 3-phosphoserine/phosphohydroxythreonine transaminase compare
NOLOHH_04655 epmB -3.4 -2.2 EF-P beta-lysylation protein EpmB compare
NOLOHH_13310 hscA -3.3 -5.0 Fe-S protein assembly chaperone HscA compare
NOLOHH_14515 nuoM -3.3 -6.3 NADH-quinone oxidoreductase subunit M compare
NOLOHH_23325 sdhA -3.2 -8.7 succinate dehydrogenase flavoprotein subunit compare
NOLOHH_09595 mdh -3.2 -8.5 malate dehydrogenase compare
NOLOHH_01270 clpP -3.1 -5.4 ATP-dependent Clp endopeptidase proteolytic subunit ClpP compare
NOLOHH_23510 fur -3.1 -3.1 ferric iron uptake transcriptional regulator compare
NOLOHH_14495 nuoI -3.1 -4.7 NADH-quinone oxidoreductase subunit NuoI compare
NOLOHH_20905 hflD -3.1 -2.0 high frequency lysogenization protein HflD compare
NOLOHH_09355 aroE -3.1 -6.7 shikimate dehydrogenase compare
NOLOHH_05830 metJ -3.1 -2.0 met regulon transcriptional regulator MetJ compare
NOLOHH_03175 pdxA -3.0 -6.5 4-hydroxythreonine-4-phosphate dehydrogenase PdxA compare
NOLOHH_23190 nadA -3.0 -5.5 quinolinate synthase NadA compare
NOLOHH_06385 fre -2.9 -10.4 NAD(P)H-flavin reductase compare
NOLOHH_02390 gmhB -2.9 -2.4 D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase compare
NOLOHH_23335 sdhC -2.9 -3.6 succinate dehydrogenase cytochrome b556 subunit compare
NOLOHH_02875 nadC -2.9 -7.4 carboxylating nicotinate-nucleotide diphosphorylase conserved
NOLOHH_20735 fadR -2.9 -1.7 fatty acid metabolism transcriptional regulator FadR compare
NOLOHH_06520 -2.7 -1.7 DUF3289 domain-containing protein compare
NOLOHH_16080 -2.7 -1.3 hypothetical protein compare
NOLOHH_20320 trpD -2.7 -4.5 bifunctional anthranilate synthase glutamate amidotransferase component TrpG/anthranilate phosphoribosyltransferase TrpD compare
NOLOHH_03170 surA -2.7 -6.2 peptidylprolyl isomerase SurA compare
NOLOHH_20335 trpA -2.6 -4.8 tryptophan synthase subunit alpha compare
NOLOHH_00445 -2.6 -4.1 peptidyl-arginine deiminase compare
NOLOHH_19330 ydcJ -2.5 -2.2 Uncharacterized protein YdcJ compare
NOLOHH_14480 nuoF -2.5 -6.3 NADH-quinone oxidoreductase subunit NuoF compare
NOLOHH_00405 hipB -2.4 -0.9 XRE family transcriptional regulator compare
NOLOHH_06550 xerC -2.4 -2.0 tyrosine recombinase XerC compare
NOLOHH_18730 marC -2.4 -2.4 NAAT family transporter MarC compare
NOLOHH_14485 nuoG -2.4 -5.6 NADH-quinone oxidoreductase subunit NuoG compare
NOLOHH_09730 ptsN -2.3 -2.6 PTS IIA-like nitrogen regulatory protein PtsN compare
NOLOHH_14500 nuoJ -2.3 -4.5 NADH-quinone oxidoreductase subunit J compare
NOLOHH_14510 nuoL -2.3 -5.3 NADH-quinone oxidoreductase subunit L compare
NOLOHH_02745 panB -2.3 -5.9 3-methyl-2-oxobutanoate hydroxymethyltransferase compare
NOLOHH_18220 ydgD -2.2 -1.5 Uncharacterized serine protease YdgD compare
NOLOHH_14520 nuoN -2.2 -5.4 NADH-quinone oxidoreductase subunit NuoN compare
NOLOHH_02690 dksA -2.2 -4.4 RNA polymerase-binding protein DksA compare
NOLOHH_23330 sdhD -2.2 -6.2 succinate dehydrogenase membrane anchor subunit compare
NOLOHH_20325 trpD -2.1 -7.0 bifunctional anthranilate synthase glutamate amidotransferase component TrpG/anthranilate phosphoribosyltransferase TrpD compare
NOLOHH_04695 aspA -2.1 -10.9 aspartate ammonia-lyase conserved
NOLOHH_14465 nuoB -2.1 -5.4 NADH-quinone oxidoreductase subunit NuoB compare
NOLOHH_06920 mnmG -2.0 -5.9 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG compare
NOLOHH_03030 cra -2.0 -4.6 catabolite repressor/activator compare
NOLOHH_14505 nuoK -2.0 -2.8 NADH-quinone oxidoreductase subunit NuoK compare
NOLOHH_20330 trpB -2.0 -4.0 tryptophan synthase subunit beta compare
NOLOHH_00385 -2.0 -1.3 hypothetical protein compare
NOLOHH_15490 yegR -2.0 -1.7 Uncharacterized protein YegR compare
NOLOHH_08530 panM -2.0 -5.6 aspartate 1-decarboxylase autocleavage activator PanM compare
NOLOHH_14470 nuoC -2.0 -4.2 NADH-quinone oxidoreductase subunit C/D compare
NOLOHH_02750 panC -2.0 -6.7 pantoate--beta-alanine ligase compare
NOLOHH_12800 ratA -2.0 -2.0 type II toxin-antitoxin system toxin RatA compare
NOLOHH_14490 nuoH -1.9 -4.9 NADH-quinone oxidoreductase subunit NuoH compare
NOLOHH_08905 aroB -1.9 -4.6 3-dehydroquinate synthase compare
NOLOHH_01255 lon_P403L -1.9 -6.2 Lon protease compare
NOLOHH_13035 srmB -1.9 -7.0 ATP-dependent RNA helicase SrmB compare
NOLOHH_17440 astE -1.9 -1.7 succinylglutamate desuccinylase compare
NOLOHH_07015 pstC -1.9 -3.6 phosphate ABC transporter permease PstC compare
NOLOHH_17785 sufD -1.8 -2.0 Fe-S cluster assembly protein SufD compare
NOLOHH_20785 ycgL -1.8 -2.2 Protein YcgL compare
NOLOHH_16015 pduF -1.8 -1.5 propanediol diffusion facilitator PduF compare
NOLOHH_06805 maoP -1.8 -9.4 macrodomain Ori organization protein MaoP compare
NOLOHH_06810 hdfR -1.8 -11.8 HTH-type transcriptional regulator HdfR compare
NOLOHH_20275 yciN -1.8 -4.0 Protein YciN compare
NOLOHH_20315 trpE -1.8 -4.8 anthranilate synthase component I compare
NOLOHH_06590 cyaA -1.7 -7.4 class I adenylate cyclase compare
NOLOHH_09955 deaD -1.7 -2.5 ATP-dependent RNA helicase DeaD compare
NOLOHH_14460 nuoA -1.7 -1.6 NADH-quinone oxidoreductase subunit NuoA compare
NOLOHH_02185 ydcD -1.7 -1.2 Uncharacterized protein YdcD compare
NOLOHH_17655 aroH -1.7 -2.7 3-deoxy-7-phosphoheptulonate synthase AroH compare
NOLOHH_13055 rseA -1.7 -1.9 anti-sigma-E factor RseA compare
NOLOHH_08775 -1.7 -4.2 NfuA family Fe-S biogenesis protein compare
NOLOHH_02760 panD -1.6 -5.8 aspartate 1-decarboxylase compare
NOLOHH_02825 acnB -1.6 -2.0 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase compare
NOLOHH_15015 fruB -1.6 -3.6 fused PTS fructose transporter subunit IIA/HPr protein compare
NOLOHH_15415 -1.6 -4.5 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase compare
NOLOHH_22310 ybjO -1.6 -3.1 Inner membrane protein YbjO compare
NOLOHH_19240 potB -1.6 -1.1 spermidine/putrescine ABC transporter permease compare
NOLOHH_07575 rfaF -1.6 -2.1 ADP-heptose--LPS heptosyltransferase RfaF compare
NOLOHH_11425 ubiI -1.5 -1.4 FAD-dependent 2-octaprenylphenol hydroxylase compare
NOLOHH_11480 sdhE -1.5 -1.1 FAD assembly factor SdhE compare
NOLOHH_09905 nusA -1.5 -2.1 Transcription termination/antitermination protein NusA compare
NOLOHH_13045 nadB -1.5 -9.7 L-aspartate oxidase conserved
NOLOHH_15110 mglA -1.5 -1.3 galactose/methyl galactoside ABC transporter ATP-binding protein MglA compare
NOLOHH_15920 eutP -1.5 -1.2 propanediol utilization protein compare
NOLOHH_05540 thiG -1.5 -6.6 thiazole synthase compare
NOLOHH_07710 yibG -1.5 -1.0 Uncharacterized protein YibG compare
NOLOHH_13015 grcA -1.4 -1.3 autonomous glycyl radical cofactor GrcA compare
NOLOHH_20455 hns -1.4 -2.3 DNA-binding transcriptional regulator H-NS compare
NOLOHH_20550 chaC -1.4 -1.7 glutathione-specific gamma-glutamylcyclotransferase compare
NOLOHH_11120 yggT -1.4 -1.3 osmotic shock tolerance protein YggT compare
NOLOHH_11185 speB -1.4 -4.3 agmatinase compare
NOLOHH_14250 aroC -1.4 -2.6 chorismate synthase compare
NOLOHH_01310 cyoD -1.4 -4.4 cytochrome o ubiquinol oxidase subunit III compare
NOLOHH_20460 galU -1.4 -1.7 UTP--glucose-1-phosphate uridylyltransferase GalU compare
NOLOHH_24515 -1.4 -1.0 prepilin peptidase compare
NOLOHH_24115 -1.4 -0.9 hypothetical protein compare
NOLOHH_19640 -1.4 -2.0 Phage tail tube protein compare
NOLOHH_16865 yebG -1.4 -1.0 DNA damage-inducible protein YebG compare
NOLOHH_20425 -1.4 -1.5 hypothetical protein compare
NOLOHH_24620 -1.4 -1.9 ISSfl4 ORF1 compare
NOLOHH_19570 sitB -1.4 -2.2 iron/manganese ABC transporter ATP-binding protein SitB compare
NOLOHH_05535 thiF -1.3 -2.9 thiazole biosynthesis adenylyltransferase ThiF compare
NOLOHH_21095 fabF -1.3 -2.0 beta-ketoacyl-ACP synthase II compare
NOLOHH_22795 -1.3 -0.9 toxin-antitoxin system HicB family antitoxin compare
NOLOHH_18245 mlc -1.3 -1.8 DNA-binding transcriptional repressor Mlc compare
NOLOHH_03300 fkpB -1.3 -1.3 FKBP-type peptidyl-prolyl cis-trans isomerase compare
NOLOHH_16470 yecA -1.3 -2.5 UPF0149 family protein YecA compare
NOLOHH_19835 racC -1.3 -1.8 Protein RacC compare
NOLOHH_11175 speA -1.3 -6.2 biosynthetic arginine decarboxylase compare
NOLOHH_05520 thiC -1.3 -8.2 phosphomethylpyrimidine synthase ThiC compare
NOLOHH_20845 pdeG -1.3 -1.0 putative cyclic di-GMP phosphodiesterase PdeG compare
NOLOHH_23425 ybfC -1.3 -1.5 Uncharacterized protein YbfC compare
NOLOHH_22585 mcbA -1.3 -1.4 DUF1471 domain-containing protein compare
NOLOHH_21675 cbdX -1.2 -1.2 cytochrome bd-II oxidase subunit CbdX compare
NOLOHH_22770 bioB -1.2 -3.6 biotin synthase BioB compare
NOLOHH_09940 pnp -1.2 -6.1 polyribonucleotide nucleotidyltransferase compare
NOLOHH_23735 rlmH -1.2 -1.0 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH compare
NOLOHH_08510 ftsE -1.2 -2.7 cell division ATP-binding protein FtsE compare
NOLOHH_05935 yiiR -1.2 -2.3 Uncharacterized protein YiiR compare
NOLOHH_18935 digH -1.2 -1.6 Glycosyl hydrolase DigH compare
NOLOHH_05530 thiF -1.2 -5.6 thiazole biosynthesis adenylyltransferase ThiF compare
NOLOHH_21290 yceI -1.2 -1.2 YceI family protein compare
NOLOHH_18085 ydgT -1.2 -1.8 transcription modulator YdgT compare
NOLOHH_14450 lrhA -1.2 -6.4 transcriptional regulator LrhA compare
NOLOHH_00520 -1.1 -1.4 Tail tube protein compare
NOLOHH_17665 ppsA -1.1 -2.3 phosphoenolpyruvate synthase compare
NOLOHH_21000 ldtC -1.1 -1.6 L,D-transpeptidase LdtC compare
NOLOHH_15885 yeeD -1.1 -2.3 Putative sulfur carrier protein YeeD compare
NOLOHH_20870 bluR -1.1 -2.6 DNA-binding transcriptional repressor BluR compare
NOLOHH_06525 -1.1 -2.4 DUF943 domain-containing protein compare
NOLOHH_18150 fumB -1.1 -4.7 class I fumarate hydratase compare
NOLOHH_14475 nuoE -1.1 -1.7 NADH-quinone oxidoreductase subunit NuoE compare
NOLOHH_05525 thiE -1.1 -5.7 thiamine phosphate synthase compare
NOLOHH_12545 recA -1.1 -2.1 recombinase RecA compare
NOLOHH_01300 cyoB -1.1 -7.3 cytochrome o ubiquinol oxidase subunit I compare
NOLOHH_19740 tolA -1.1 -1.5 cell envelope integrity protein TolA compare
NOLOHH_11295 epd -1.1 -5.7 erythrose-4-phosphate dehydrogenase compare
NOLOHH_11515 lysS -1.1 -1.7 lysine--tRNA ligase compare
NOLOHH_03190 apaH -1.1 -3.8 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH compare
NOLOHH_19260 hicB -1.1 -1.1 type II toxin-antitoxin system antitoxin HicB compare
NOLOHH_14760 rcsB -1.1 -1.9 transcriptional regulator RcsB compare
NOLOHH_01305 cyoC -1.1 -4.2 cytochrome o ubiquinol oxidase subunit III compare
NOLOHH_12165 -1.1 -1.0 LemA family compare
NOLOHH_20865 bluF -1.1 -0.9 blue light-responsive regulator BluF compare
NOLOHH_24290 ssb -1.1 -1.7 single-stranded DNA-binding protein compare
NOLOHH_01380 pgpA -1.1 -1.2 phosphatidylglycerophosphatase A compare
NOLOHH_06715 wecA -1.1 -8.1 UDP-N-acetylglucosamine--undecaprenyl-phosphate N-acetylglucosaminephosphotransferase compare
NOLOHH_16505 ftnB -1.1 -0.9 non-heme ferritin-like protein compare
NOLOHH_17270 yeaC -1.1 -1.2 Uncharacterized protein YeaC compare
NOLOHH_21655 gfcE -1.0 -4.5 Putative polysaccharide export protein GfcE compare
NOLOHH_16695 nudB -1.0 -5.8 dihydroneopterin triphosphate diphosphatase compare
NOLOHH_22430 rimO -1.0 -2.0 30S ribosomal protein S12 methylthiotransferase RimO compare
NOLOHH_07610 envC -1.0 -5.5 murein hydrolase activator EnvC compare
NOLOHH_17690 ydiQ -1.0 -1.3 electron transfer flavoprotein compare
NOLOHH_18920 pqqL -1.0 -1.4 putative zinc protease PqqL compare
NOLOHH_11940 recD -1.0 -3.2 exodeoxyribonuclease V subunit alpha compare
NOLOHH_23690 ybeR -1.0 -1.6 Uncharacterized protein YbeR compare
NOLOHH_01345 panE -1.0 -5.2 2-dehydropantoate 2-reductase conserved
NOLOHH_13450 ppk1 -1.0 -3.4 polyphosphate kinase 1 compare
NOLOHH_18810 lsrD -1.0 -2.4 autoinducer 2 ABC transporter permease LsrD compare
NOLOHH_01295 cyoA -1.0 -5.8 cytochrome o ubiquinol oxidase subunit II compare
NOLOHH_14330 cvpA -1.0 -1.3 colicin V production protein compare
NOLOHH_18620 ydfJ -1.0 -0.9 Putative transporter YdfJ compare


Specific Phenotypes

For 4 genes in this experiment

For carbon source Casamino-acids in Escherichia coli ECOR27

For carbon source Casamino-acids across organisms