| | gene | name | fitness | t score | description | |
|---|
| b3958 | argC | -5.5 | -5.3 | N-acetyl-gamma-glutamyl-phosphate reductase (NCBI) | compare |
| b1261 | trpB | -5.4 | -3.7 | tryptophan synthase subunit beta (NCBI) | compare |
| b3941 | metF | -5.3 | -7.2 | 5,10-methylenetetrahydrofolate reductase (NCBI) | compare |
| b0073 | leuB | -5.2 | -3.6 | 3-isopropylmalate dehydrogenase (VIMSS) | compare |
| b3774 | ilvC | -5.1 | -6.1 | ketol-acid reductoisomerase (NCBI) | compare |
| b0242 | proB | -5.1 | -3.5 | gamma-glutamyl kinase (NCBI) | compare |
| b2026 | hisI | -5.1 | -4.9 | bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI) | compare |
| b2020 | hisD | -5.1 | -4.9 | histidinol dehydrogenase (NCBI) | compare |
| b0074 | leuA | -5.0 | -4.8 | 2-isopropylmalate synthase (NCBI) | compare |
| b0072 | leuC | -4.9 | -5.9 | isopropylmalate isomerase large subunit (NCBI) | compare |
| b3939 | metB | -4.9 | -5.9 | cystathionine gamma-synthase (NCBI) | compare |
| b1260 | trpA | -4.9 | -4.7 | tryptophan synthase subunit alpha (NCBI) | compare |
| b3957 | argE | -4.8 | -9.3 | acetylornithine deacetylase (NCBI) | compare |
| b2818 | argA | -4.8 | -4.7 | N-acetylglutamate synthase (NCBI) | compare |
| b3281 | aroE | -4.8 | -6.6 | dehydroshikimate reductase, NAD(P)-binding (NCBI) | compare |
| b0907 | serC | -4.8 | -6.5 | phosphoserine aminotransferase (NCBI) | compare |
| b2600 | tyrA | -4.8 | -4.6 | fused chorismate mutase T/prephenate dehydrogenase (NCBI) | compare |
| b3389 | aroB | -4.7 | -7.2 | 3-dehydroquinate synthase (NCBI) | compare |
| b2025 | hisF | -4.7 | -4.6 | imidazole glycerol phosphate synthase subunit HisF (NCBI) | compare |
| b0243 | proA | -4.7 | -5.6 | gamma-glutamyl phosphate reductase (NCBI) | compare |
| b2752 | cysD | -4.7 | -4.5 | sulfate adenylyltransferase subunit 2 (NCBI) | compare |
| b3008 | metC | -4.7 | -5.6 | cystathionine beta-lyase (NCBI) | compare |
| b2414 | cysK | -4.7 | -7.1 | cysteine synthase A, O-acetylserine sulfhydrolase A subunit (NCBI) | compare |
| b4013 | metA | -4.7 | -4.5 | homoserine O-succinyltransferase (NCBI) | compare |
| b3770 | ilvE | -4.7 | -5.5 | branched-chain amino acid aminotransferase (NCBI) | compare |
| b0033 | carB | -4.6 | -7.7 | carbamoyl-phosphate synthase large subunit (NCBI) | compare |
| b2019 | hisG | -4.6 | -4.5 | ATP phosphoribosyltransferase (NCBI) | compare |
| b3771 | ilvD | -4.6 | -7.1 | dihydroxy-acid dehydratase (NCBI) | compare |
| b3959 | argB | -4.6 | -7.0 | acetylglutamate kinase (RefSeq) | compare |
| b3828 | metR | -4.6 | -7.0 | DNA-binding transcriptional activator, homocysteine-binding (NCBI) | compare |
| b0945 | pyrD | -4.6 | -5.4 | dihydroorotate dehydrogenase (NCBI) | compare |
| b3772 | ilvA | -4.6 | -6.2 | threonine dehydratase (NCBI) | compare |
| b0049 | apaH | -4.5 | -4.4 | diadenosinetetraphosphatase (NCBI) | compare |
| b2838 | lysA | -4.5 | -3.1 | diaminopimelate decarboxylase, PLP-binding (NCBI) | compare |
| b3956 | ppc | -4.5 | -9.6 | phosphoenolpyruvate carboxylase (NCBI) | compare |
| b3172 | argG | -4.5 | -4.3 | argininosuccinate synthase (NCBI) | compare |
| b2750 | cysC | -4.5 | -6.1 | adenylylsulfate kinase (NCBI) | compare |
| b4005 | purD | -4.4 | -5.3 | phosphoribosylamine--glycine ligase (NCBI) | compare |
| b0386 | proC | -4.4 | -3.0 | pyrroline-5-carboxylate reductase (NCBI) | compare |
| b1693 | aroD | -4.4 | -4.3 | 3-dehydroquinate dehydratase (NCBI) | compare |
| b0928 | aspC | -4.4 | -5.2 | aspartate aminotransferase, PLP-dependent (NCBI) | compare |
| b4006 | purH | -4.4 | -7.3 | bifunctionalphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI) | compare |
| b2764 | cysJ | -4.4 | -5.2 | sulfite reductase, alpha subunit, flavoprotein (NCBI) | compare |
| b4245 | pyrB | -4.4 | -8.8 | aspartate carbamoyltransferase catalytic subunit (NCBI) | compare |
| b2021 | hisC | -4.3 | -5.1 | histidinol-phosphate aminotransferase (NCBI) | compare |
| b2762 | cysH | -4.3 | -4.2 | phosphoadenosine phosphosulfate reductase (NCBI) | compare |
| b2022 | hisB | -4.3 | -5.1 | imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS) | compare |
| b2913 | serA | -4.3 | -3.0 | D-3-phosphoglycerate dehydrogenase (NCBI) | compare |
| b3368 | cysG | -4.3 | -10.7 | fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase (NCBI) | compare |
| b2320 | pdxB | -4.3 | -7.6 | erythronate-4-phosphate dehydrogenase (NCBI) | compare |
| b2839 | lysR | -4.3 | -5.8 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b3960 | argH | -4.3 | -7.7 | argininosuccinate lyase (NCBI) | compare |
| b3829 | metE | -4.3 | -12.3 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (NCBI) | compare |
| b1262 | trpC | -4.3 | -6.4 | N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase (VIMSS) | compare |
| b1281 | pyrF | -4.3 | -2.9 | orotidine 5'-phosphate decarboxylase (NCBI) | compare |
| b0032 | carA | -4.3 | -5.0 | carbamoyl-phosphate synthase small subunit (NCBI) | compare |
| b4388 | serB | -4.2 | -2.9 | 3-phosphoserine phosphatase (NCBI) | compare |
| b0004 | thrC | -4.2 | -5.0 | threonine synthase (NCBI) | compare |
| b0002 | thrA | -4.2 | -10.8 | bifunctional aspartokinase I/homeserine dehydrogenase I (NCBI) | compare |
| b2557 | purL | -4.2 | -4.1 | phosphoribosylformylglycinamidine synthase (NCBI) | compare |
| b0522 | purK | -4.1 | -4.0 | phosphoribosylaminoimidazole carboxylase (NCBI) | compare |
| b4214 | cysQ | -4.1 | -8.7 | PAPS (adenosine 3'-phosphate 5'-phosphosulfate) 3'(2'),5'-bisphosphate nucleotidase (NCBI) | compare |
| b0052 | pdxA | -4.1 | -6.2 | 4-hydroxythreonine-4-phosphate dehydrogenase (NCBI) | compare |
| b0908 | aroA | -4.1 | -4.8 | 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) | compare |
| b2763 | cysI | -4.1 | -2.8 | sulfite reductase, beta subunit, NAD(P)-binding, heme-binding (NCBI) | compare |
| b2023 | hisH | -4.0 | -4.7 | imidazole glycerol phosphate synthase subunit HisH (NCBI) | compare |
| b0720 | gltA | -4.0 | -4.7 | citrate synthase (NCBI) | compare |
| b0003 | thrB | -4.0 | -8.8 | homoserine kinase (NCBI) | compare |
| b2499 | purM | -4.0 | -3.8 | phosphoribosylaminoimidazole synthetase (NCBI) | compare |
| b2312 | purF | -3.9 | -5.9 | amidophosphoribosyltransferase (NCBI) | compare |
| b2751 | cysN | -3.9 | -6.9 | sulfate adenylyltransferase subunit 1 (NCBI) | compare |
| b2784 | relA | -3.9 | -4.6 | (p)ppGpp synthetase I/GTP pyrophosphokinase (NCBI) | compare |
| b2024 | hisA | -3.8 | -2.6 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-imidazolecarboxamide isomerase (VIMSS) | compare |
| b3773 | ilvY | -3.8 | -8.4 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b2329 | aroC | -3.8 | -2.6 | chorismate synthase (NCBI) | compare |
| b2476 | purC | -3.7 | -3.5 | phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI) | compare |
| b3642 | pyrE | -3.7 | -2.5 | orotate phosphoribosyltransferase (NCBI) | compare |
| b0071 | leuD | -3.6 | -5.5 | isopropylmalate isomerase small subunit (NCBI) | compare |
| b1062 | pyrC | -3.6 | -6.4 | dihydroorotase (NCBI) | compare |
| b2188 | yejM | -3.6 | -7.2 | predicted hydrolase, inner membrane (NCBI) | compare |
| b2564 | pdxJ | -3.5 | -4.1 | pyridoxal phosphate biosynthetic protein (NCBI) | compare |
| b0523 | purE | -3.5 | -4.0 | phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI) | compare |
| b0133 | panC | -3.4 | -8.1 | pantoate--beta-alanine ligase (NCBI) | conserved |
| b4025 | pgi | -3.4 | -6.8 | glucose-6-phosphate isomerase (NCBI) | compare |
| b1192 | ldcA | -3.4 | -5.0 | L,D-carboxypeptidase A (NCBI) | compare |
| b0134 | panB | -3.3 | -7.1 | 3-methyl-2-oxobutanoate hydroxymethyltransferase (NCBI) | conserved |
| b3390 | aroK | -3.2 | -2.2 | shikimate kinase I (NCBI) | compare |
| b3204 | ptsN | -3.2 | -5.7 | sugar-specific enzyme IIA component of PTS (NCBI) | compare |
| b0145 | dksA | -3.2 | -3.1 | DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) | compare |
| b1264 | trpE | -3.2 | -6.6 | anthranilate synthase component I (NCBI) | compare |
| b2501 | ppk | -3.2 | -8.3 | polyphosphate kinase (NCBI) | compare |
| b0142 | folK | -3.1 | -1.9 | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) | compare |
| b0423 | thiI | -3.1 | -5.8 | thiamine biosynthesis protein ThiI (NCBI) | compare |
| b0630 | lipB | -3.1 | -2.1 | protein of lipoate biosynthesis (VIMSS) | compare |
| b0131 | panD | -3.0 | -3.6 | aspartate 1-decarboxylase precursor (NCBI) | compare |
| b0737 | tolQ | -2.9 | -2.8 | membrane spanning protein in TolA-TolQ-TolR complex (NCBI) | compare |
| b2599 | pheA | -2.9 | -8.2 | fused chorismate mutase P/prephenate dehydratase (NCBI) | compare |
| b3781 | trxA | -2.9 | -3.9 | thioredoxin 1 (VIMSS) | compare |
| b3992 | thiF | -2.8 | -8.5 | thiamin biosynthesis, thiazole moiety (VIMSS) | compare |
| b0726 | sucA | -2.8 | -1.9 | alpha-ketoglutarate decarboxylase (NCBI) | compare |
| b3671 | ilvB | -2.7 | -12.3 | acetolactate synthase large subunit (NCBI) | compare |
| b1263 | trpD | -2.6 | -2.5 | bifunctional indole-3-glycerol-phosphate synthase/anthranilate phosphoribosyltransferase (NCBI) | compare |
| b3236 | mdh | -2.6 | -7.2 | malate dehydrogenase (NCBI) | compare |
| b3993 | thiE | -2.5 | -6.3 | thiamine-phosphate pyrophosphorylase (NCBI) | compare |
| b0912 | ihfB | -2.5 | -4.0 | integration host factor subunit beta (NCBI) | compare |
| b0750 | nadA | -2.5 | -6.5 | quinolinate synthetase (NCBI) | compare |
| b0888 | trxB | -2.5 | -3.3 | thioredoxin reductase, FAD/NAD(P)-binding (NCBI) | compare |
| b0889 | lrp | -2.5 | -2.8 | DNA-binding transcriptional dual regulator, leucine-binding (NCBI) | compare |
| b4246 | pyrL | -2.5 | -3.2 | pyrBI operon leader peptide (NCBI) | compare |
| b3994 | thiC | -2.5 | -11.4 | thiamine biosynthesis protein ThiC (NCBI) | compare |
| b1712 | ihfA | -2.4 | -3.5 | integration host factor subunit alpha (NCBI) | compare |
| b3082 | ygjM | -2.4 | -2.7 | predicted DNA-binding transcriptional regulator (NCBI) | compare |
| b0740 | tolB | -2.4 | -3.9 | translocation protein TolB precursor (NCBI) | compare |
| b2318 | truA | -2.4 | -4.4 | tRNA pseudouridine synthase A (NCBI) | compare |
| b4451 | ryhB | -2.4 | -1.6 | Regulatory sRNA mediating positive Fur regulon response; requires Hfq for function; global iron regulator; degraded by RNase E when bound to target (RefSeq) | compare |
| b3237 | argR | -2.4 | -4.9 | arginine repressor (NCBI) | compare |
| b0739 | tolA | -2.4 | -4.1 | cell envelope integrity inner membrane protein TolA (NCBI) | compare |
| b0118 | acnB | -2.3 | -2.2 | aconitate hydratase (NCBI) | compare |
| b2479 | gcvR | -2.3 | -3.7 | transcriptional regulation of gcv operon (VIMSS) | compare |
| b0439 | lon | -2.3 | -4.7 | DNA-binding ATP-dependent protease La (NCBI) | compare |
| b3916 | pfkA | -2.3 | -1.6 | 6-phosphofructokinase (NCBI) | compare |
| b0078 | ilvH | -2.2 | -8.8 | acetolactate synthase small subunit (NCBI) | compare |
| b4171 | miaA | -2.2 | -5.6 | tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) | compare |
| b3990 | thiH | -2.2 | -7.9 | thiamine biosynthesis protein ThiH (NCBI) | compare |
| b3398 | yrfF | -2.2 | -3.8 | predicted inner membrane protein (NCBI) | compare |
| b2103 | thiD | -2.2 | -6.1 | phosphomethylpyrimidine kinase (NCBI) | compare |
| b2330 | yfcB | -2.2 | -3.1 | putative adenine-specific methylase (VIMSS) | compare |
| b0683 | fur | -2.2 | -2.4 | ferric uptake regulator (NCBI) | compare |
| b0109 | nadC | -2.2 | -6.2 | nicotinate-nucleotide pyrophosphorylase (NCBI) | compare |
| b3459 | yhhK | -2.2 | -5.1 | hypothetical protein (NCBI) | conserved |
| b2340 | sixA | -2.1 | -4.5 | phosphohistidine phosphatase (NCBI) | compare |
| b0437 | clpP | -2.1 | -7.4 | ATP-dependent Clp protease proteolytic subunit (NCBI) | compare |
| b3650 | spoT | -2.1 | -6.9 | bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase (NCBI) | compare |
| b3991 | thiG | -2.1 | -6.2 | thiamin biosynthesis, thiazole moiety (VIMSS) | compare |
| b3870 | glnA | -2.1 | -1.4 | glutamine synthetase (NCBI) | compare |
| b2500 | purN | -2.1 | -4.8 | phosphoribosylglycinamide formyltransferase (NCBI) | compare |
| b2424 | cysU | -2.0 | -2.5 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b0077 | ilvI | -2.0 | -8.2 | acetolactate synthase III large subunit (NCBI) | compare |
| b0755 | gpmA | -2.0 | -5.9 | phosphoglyceromutase (NCBI) | compare |
| b1084 | rne | -1.9 | -4.7 | fused ribonucleaseE: endoribonuclease/RNA-binding protein/RNA degradosome binding protein (NCBI) | compare |
| b2567 | rnc | -1.9 | -2.1 | ribonuclease III (NCBI) | compare |
| b1860 | ruvB | -1.8 | -2.0 | Holliday junction DNA helicase B (NCBI) | compare |
| b2894 | xerD | -1.8 | -1.7 | site-specific tyrosine recombinase XerD (NCBI) | compare |
| b2574 | nadB | -1.8 | -7.7 | L-aspartate oxidase (NCBI) | compare |
| b0738 | tolR | -1.8 | -3.1 | membrane spanning protein in TolA-TolQ-TolR complex (NCBI) | compare |
| b2820 | recB | -1.8 | -2.1 | exonuclease V (RecBCD complex), beta subunit (NCBI) | compare |
| b4177 | purA | -1.8 | -1.7 | adenylosuccinate synthetase (NCBI) | compare |
| b4585 | sroB | -1.8 | -1.5 | Novel sRNA, function unknown (RefSeq) | compare |
| b0767 | ybhE | -1.8 | -3.9 | 6-phosphogluconolactonase (NCBI) | compare |
| b2518 | ndk | -1.7 | -2.4 | nucleoside diphosphate kinase (NCBI) | compare |
| b0890 | ftsK | -1.7 | -6.2 | DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) | compare |
| b0588 | fepC | -1.7 | -6.5 | iron-enterobactin transporter subunit (NCBI) | compare |
| b1861 | ruvA | -1.6 | -2.5 | Holliday junction DNA helicase motor protein (NCBI) | compare |
| b1865 | nudB | -1.6 | -1.4 | dATP pyrophosphohydrolase (NCBI) | compare |
| b2822 | recC | -1.6 | -4.5 | exonuclease V (RecBCD complex), gamma chain (NCBI) | compare |
| b2029 | gnd | -1.6 | -6.7 | 6-phosphogluconate dehydrogenase (NCBI) | compare |
| b0585 | fes | -1.6 | -5.2 | enterobactin/ferric enterobactin esterase (NCBI) | compare |
| b0741 | pal | -1.5 | -4.1 | peptidoglycan-associated outer membrane lipoprotein (NCBI) | compare |
| b3463 | ftsE | -1.5 | -4.0 | predicted transporter subunit: ATP-binding component of ABC superfamily (NCBI) | compare |
| b2189 | proL | -1.5 | -2.3 | tRNA-Pro (NCBI) | compare |
| b1591 | b1591 | -1.5 | -2.0 | putative oxidoreductase component (VIMSS) | compare |
| b0088 | murD | -1.5 | -1.6 | UDP-N-acetylmuramoyl-L-alanyl-D-glutamatesynthetase (NCBI) | compare |
| b1863 | ruvC | -1.5 | -3.2 | Holliday junction resolvase (NCBI) | compare |
| b2313 | cvpA | -1.5 | -2.7 | membrane protein required for colicin V production (NCBI) | compare |
| b0592 | fepB | -1.5 | -6.7 | iron-enterobactin transporter subunit (NCBI) | compare |
| b1101 | ptsG | -1.5 | -7.6 | fused glucose-specific PTS enzymes: IIB component/IIC component (NCBI) | compare |
| b3098 | yqjD | -1.4 | -2.1 | hypothetical protein (NCBI) | compare |
| b3131 | agaR | -1.4 | -3.7 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b1307 | pspD | -1.4 | -2.0 | peripheral inner membrane phage-shock protein (NCBI) | compare |
| b2422 | cysA | -1.4 | -5.2 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b2642 | yfjW | -1.4 | -2.7 | CP4-57 prophage; predicted inner membrane protein (NCBI) | compare |
| b0113 | pdhR | -1.4 | -3.6 | transcriptional regulator of pyruvate dehydrogenase complex (NCBI) | compare |
| b3163 | nlpI | -1.4 | -4.1 | hypothetical protein (NCBI) | compare |
| b0053 | surA | -1.3 | -3.6 | peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) | compare |
| b2830 | nudH | -1.3 | -1.7 | dinucleoside polyphosphate hydrolase (NCBI) | compare |
| b3778 | rep | -1.3 | -6.5 | DNA helicase and single-stranded DNA-dependent ATPase (NCBI) | compare |
| b1060 | yceP | -1.3 | -4.2 | orf, hypothetical protein (VIMSS) | compare |
| b1942 | fliJ | -1.3 | -1.4 | flagellar biosynthesis chaperone (NCBI) | compare |
| b2279 | nuoK | -1.3 | -1.5 | NADH dehydrogenase subunit K (NCBI) | compare |
| b0200 | gmhB | -1.3 | -1.6 | hypothetical protein (NCBI) | compare |
| b3359 | argD | -1.3 | -8.1 | bifunctional acetylornithine aminotransferase/ succinyldiaminopimelate aminotransferase (NCBI) | compare |
| b1434 | ydcN | -1.3 | -1.7 | predicted DNA-binding transcriptional regulator (NCBI) | compare |
| b0075 | leuL | -1.2 | -3.4 | leu operon leader peptide (NCBI) | compare |
| b4699 | fnrS | -1.2 | -1.3 | FNR-activated anaerobic sRNA antisense regulator down regulates cydDC, metE, sodA, sodB, Hfq-dependent; mediates negative FNR regulation (RefSeq) | compare |
| b1677 | lpp | -1.2 | -2.3 | murein lipoprotein (NCBI) | compare |
| b2601 | aroF | -1.2 | -4.8 | 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tyrosine-repressible (NCBI) | compare |
| b3672 | ivbL | -1.2 | -2.4 | ilvB operon leader peptide (NCBI) | compare |
| b2948 | yqgE | -1.2 | -2.2 | orf, hypothetical protein (VIMSS) | compare |
| b4578 | insP | -1.2 | -1.5 | no description | compare |
| b4480 | hdfR | -1.2 | -4.1 | transcriptional regulator HdfR (NCBI) | compare |
| b1984 | asnW | -1.2 | -1.3 | tRNA-Asn (NCBI) | compare |
| b3429 | glgA | -1.1 | -6.5 | glycogen synthase (NCBI) | compare |
| b3764 | yifE | -1.1 | -3.5 | hypothetical protein (NCBI) | compare |
| b3405 | ompR | -1.1 | -3.6 | osmolarity response regulator (NCBI) | compare |
| b2935 | tktA | -1.1 | -2.1 | transketolase 1, thiamin-binding (NCBI) | compare |
| b1499 | ydeO | -1.1 | -2.1 | predicted DNA-binding transcriptional acfivator (NCBI) | compare |
| b0953 | rmf | -1.1 | -1.6 | ribosome modulation factor (NCBI) | compare |
| b1361 | ydaW | -1.1 | -1.2 | orf, hypothetical protein (VIMSS) | compare |
| b3205 | yhbJ | -1.1 | -2.8 | hypothetical protein (NCBI) | compare |
| b3741 | gidA | -1.1 | -4.8 | glucose-inhibited division protein A (NCBI) | compare |