| | gene | name | fitness | t score | description | |
|---|
| b1260 | trpA | -6.3 | -4.3 | tryptophan synthase subunit alpha (NCBI) | compare |
| b2026 | hisI | -5.7 | -3.9 | bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI) | compare |
| b0907 | serC | -5.6 | -3.9 | phosphoserine aminotransferase (NCBI) | compare |
| b2476 | purC | -5.6 | -3.8 | phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI) | compare |
| b2025 | hisF | -5.5 | -3.8 | imidazole glycerol phosphate synthase subunit HisF (NCBI) | compare |
| b1261 | trpB | -5.5 | -3.7 | tryptophan synthase subunit beta (NCBI) | compare |
| b3941 | metF | -5.4 | -6.4 | 5,10-methylenetetrahydrofolate reductase (NCBI) | compare |
| b0073 | leuB | -5.3 | -3.6 | 3-isopropylmalate dehydrogenase (VIMSS) | compare |
| b0242 | proB | -5.2 | -3.6 | gamma-glutamyl kinase (NCBI) | compare |
| b2750 | cysC | -5.1 | -5.0 | adenylylsulfate kinase (NCBI) | compare |
| b0243 | proA | -5.1 | -3.5 | gamma-glutamyl phosphate reductase (NCBI) | compare |
| b2414 | cysK | -5.1 | -6.1 | cysteine synthase A, O-acetylserine sulfhydrolase A subunit (NCBI) | compare |
| b2020 | hisD | -5.0 | -5.9 | histidinol dehydrogenase (NCBI) | compare |
| b3774 | ilvC | -4.9 | -7.6 | ketol-acid reductoisomerase (NCBI) | compare |
| b0523 | purE | -4.9 | -3.4 | phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI) | compare |
| b3828 | metR | -4.9 | -4.8 | DNA-binding transcriptional activator, homocysteine-binding (NCBI) | compare |
| b2023 | hisH | -4.9 | -3.4 | imidazole glycerol phosphate synthase subunit HisH (NCBI) | compare |
| b3959 | argB | -4.9 | -5.8 | acetylglutamate kinase (RefSeq) | compare |
| b3960 | argH | -4.9 | -3.4 | argininosuccinate lyase (NCBI) | compare |
| b2312 | purF | -4.9 | -3.3 | amidophosphoribosyltransferase (NCBI) | compare |
| b0078 | ilvH | -4.8 | -8.0 | acetolactate synthase small subunit (NCBI) | compare |
| b0074 | leuA | -4.8 | -6.5 | 2-isopropylmalate synthase (NCBI) | compare |
| b3771 | ilvD | -4.8 | -4.7 | dihydroxy-acid dehydratase (NCBI) | compare |
| b3958 | argC | -4.7 | -9.6 | N-acetyl-gamma-glutamyl-phosphate reductase (NCBI) | compare |
| b3770 | ilvE | -4.7 | -4.6 | branched-chain amino acid aminotransferase (NCBI) | compare |
| b1693 | aroD | -4.7 | -3.2 | 3-dehydroquinate dehydratase (NCBI) | compare |
| b3957 | argE | -4.6 | -10.4 | acetylornithine deacetylase (NCBI) | compare |
| b0071 | leuD | -4.6 | -3.2 | isopropylmalate isomerase small subunit (NCBI) | compare |
| b0033 | carB | -4.6 | -8.8 | carbamoyl-phosphate synthase large subunit (NCBI) | compare |
| b3389 | aroB | -4.6 | -7.0 | 3-dehydroquinate synthase (NCBI) | compare |
| b2022 | hisB | -4.6 | -4.4 | imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS) | compare |
| b3281 | aroE | -4.6 | -8.8 | dehydroshikimate reductase, NAD(P)-binding (NCBI) | compare |
| b2600 | tyrA | -4.6 | -5.4 | fused chorismate mutase T/prephenate dehydrogenase (NCBI) | compare |
| b4214 | cysQ | -4.5 | -6.9 | PAPS (adenosine 3'-phosphate 5'-phosphosulfate) 3'(2'),5'-bisphosphate nucleotidase (NCBI) | compare |
| b0072 | leuC | -4.5 | -7.5 | isopropylmalate isomerase large subunit (NCBI) | compare |
| b1192 | ldcA | -4.5 | -3.1 | L,D-carboxypeptidase A (NCBI) | compare |
| b4005 | purD | -4.5 | -4.4 | phosphoribosylamine--glycine ligase (NCBI) | compare |
| b4006 | purH | -4.5 | -5.4 | bifunctionalphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI) | compare |
| b3091 | uxaA | -4.5 | -10.0 | altronate hydrolase (NCBI) | conserved |
| b2735 | ygbI | -4.5 | -5.3 | predicted DNA-binding transcriptional regulator (RefSeq) | compare |
| b0049 | apaH | -4.5 | -4.3 | diadenosinetetraphosphatase (NCBI) | compare |
| b3829 | metE | -4.4 | -11.7 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (NCBI) | compare |
| b1281 | pyrF | -4.4 | -3.0 | orotidine 5'-phosphate decarboxylase (NCBI) | compare |
| b2838 | lysA | -4.4 | -4.3 | diaminopimelate decarboxylase, PLP-binding (NCBI) | compare |
| b3172 | argG | -4.3 | -5.9 | argininosuccinate synthase (NCBI) | compare |
| b3008 | metC | -4.3 | -7.7 | cystathionine beta-lyase (NCBI) | compare |
| b2557 | purL | -4.3 | -3.0 | phosphoribosylformylglycinamidine synthase (NCBI) | compare |
| b0032 | carA | -4.3 | -5.1 | carbamoyl-phosphate synthase small subunit (NCBI) | compare |
| b0004 | thrC | -4.3 | -5.1 | threonine synthase (NCBI) | compare |
| b0386 | proC | -4.3 | -4.1 | pyrroline-5-carboxylate reductase (NCBI) | compare |
| b2762 | cysH | -4.3 | -5.1 | phosphoadenosine phosphosulfate reductase (NCBI) | compare |
| b2499 | purM | -4.3 | -2.9 | phosphoribosylaminoimidazole synthetase (NCBI) | compare |
| b0522 | purK | -4.3 | -4.1 | phosphoribosylaminoimidazole carboxylase (NCBI) | compare |
| b4388 | serB | -4.2 | -2.9 | 3-phosphoserine phosphatase (NCBI) | compare |
| b2021 | hisC | -4.2 | -5.0 | histidinol-phosphate aminotransferase (NCBI) | compare |
| b3992 | thiF | -4.2 | -8.0 | thiamin biosynthesis, thiazole moiety (VIMSS) | compare |
| b2913 | serA | -4.2 | -4.1 | D-3-phosphoglycerate dehydrogenase (NCBI) | compare |
| b0002 | thrA | -4.2 | -12.8 | bifunctional aspartokinase I/homeserine dehydrogenase I (NCBI) | compare |
| b0003 | thrB | -4.2 | -8.9 | homoserine kinase (NCBI) | compare |
| b4013 | metA | -4.2 | -5.7 | homoserine O-succinyltransferase (NCBI) | compare |
| b2818 | argA | -4.1 | -7.8 | N-acetylglutamate synthase (NCBI) | compare |
| b0908 | aroA | -4.1 | -5.6 | 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) | compare |
| b3772 | ilvA | -4.1 | -8.3 | threonine dehydratase (NCBI) | compare |
| b4232 | fbp | -4.1 | -9.0 | fructose-1,6-bisphosphatase (NCBI) | compare |
| b3956 | ppc | -4.1 | -11.7 | phosphoenolpyruvate carboxylase (NCBI) | compare |
| b1850 | eda | -4.1 | -2.7 | keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) | compare |
| b2019 | hisG | -4.0 | -5.4 | ATP phosphoribosyltransferase (NCBI) | compare |
| b2564 | pdxJ | -4.0 | -2.7 | pyridoxal phosphate biosynthetic protein (NCBI) | compare |
| b3236 | mdh | -4.0 | -4.7 | malate dehydrogenase (NCBI) | compare |
| b0077 | ilvI | -3.9 | -7.1 | acetolactate synthase III large subunit (NCBI) | compare |
| b0928 | aspC | -3.9 | -6.5 | aspartate aminotransferase, PLP-dependent (NCBI) | compare |
| b0437 | clpP | -3.9 | -7.0 | ATP-dependent Clp protease proteolytic subunit (NCBI) | compare |
| b2024 | hisA | -3.9 | -2.7 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-imidazolecarboxamide isomerase (VIMSS) | compare |
| b2329 | aroC | -3.9 | -2.7 | chorismate synthase (NCBI) | compare |
| b2188 | yejM | -3.9 | -6.9 | predicted hydrolase, inner membrane (NCBI) | compare |
| b2839 | lysR | -3.9 | -6.0 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b3939 | metB | -3.9 | -9.2 | cystathionine gamma-synthase (NCBI) | compare |
| b3526 | kdgK | -3.9 | -12.5 | ketodeoxygluconokinase (VIMSS) | conserved |
| b3991 | thiG | -3.8 | -5.8 | thiamin biosynthesis, thiazole moiety (VIMSS) | compare |
| b3368 | cysG | -3.8 | -13.6 | fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase (NCBI) | compare |
| b2320 | pdxB | -3.7 | -8.2 | erythronate-4-phosphate dehydrogenase (NCBI) | compare |
| b3994 | thiC | -3.7 | -10.4 | thiamine biosynthesis protein ThiC (NCBI) | compare |
| b0720 | gltA | -3.7 | -5.0 | citrate synthase (NCBI) | compare |
| b2103 | thiD | -3.7 | -6.5 | phosphomethylpyrimidine kinase (NCBI) | compare |
| b3993 | thiE | -3.7 | -5.0 | thiamine-phosphate pyrophosphorylase (NCBI) | compare |
| b2751 | cysN | -3.7 | -6.9 | sulfate adenylyltransferase subunit 1 (NCBI) | compare |
| b1262 | trpC | -3.7 | -7.4 | N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase (VIMSS) | compare |
| b2501 | ppk | -3.6 | -7.7 | polyphosphate kinase (NCBI) | compare |
| b3990 | thiH | -3.6 | -8.4 | thiamine biosynthesis protein ThiH (NCBI) | compare |
| b1236 | galU | -3.6 | -2.5 | glucose-1-phosphate uridylyltransferase (NCBI) | compare |
| b2764 | cysJ | -3.6 | -6.8 | sulfite reductase, alpha subunit, flavoprotein (NCBI) | compare |
| b3204 | ptsN | -3.5 | -4.8 | sugar-specific enzyme IIA component of PTS (NCBI) | compare |
| b2784 | relA | -3.5 | -8.3 | (p)ppGpp synthetase I/GTP pyrophosphokinase (NCBI) | compare |
| b1062 | pyrC | -3.5 | -6.9 | dihydroorotase (NCBI) | compare |
| b0945 | pyrD | -3.4 | -10.6 | dihydroorotate dehydrogenase (NCBI) | compare |
| b0145 | dksA | -3.4 | -2.4 | DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) | compare |
| b3092 | uxaC | -3.4 | -11.4 | glucuronate isomerase (NCBI) | conserved |
| b0052 | pdxA | -3.4 | -7.8 | 4-hydroxythreonine-4-phosphate dehydrogenase (NCBI) | compare |
| b2340 | sixA | -3.4 | -4.5 | phosphohistidine phosphatase (NCBI) | compare |
| b2763 | cysI | -3.4 | -6.4 | sulfite reductase, beta subunit, NAD(P)-binding, heme-binding (NCBI) | compare |
| b1860 | ruvB | -3.4 | -2.3 | Holliday junction DNA helicase B (NCBI) | compare |
| b3124 | garK | -3.3 | -8.7 | glycerate kinase I (RefSeq) | compare |
| b3642 | pyrE | -3.3 | -3.2 | orotate phosphoribosyltransferase (NCBI) | compare |
| b0630 | lipB | -3.2 | -2.1 | protein of lipoate biosynthesis (VIMSS) | compare |
| b2599 | pheA | -3.1 | -8.8 | fused chorismate mutase P/prephenate dehydratase (NCBI) | compare |
| b0142 | folK | -3.1 | -1.9 | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) | compare |
| b1789 | yeaL | -3.1 | -4.1 | conserved inner membrane protein (NCBI) | compare |
| b2479 | gcvR | -3.0 | -2.9 | transcriptional regulation of gcv operon (VIMSS) | compare |
| b0912 | ihfB | -2.9 | -4.3 | integration host factor subunit beta (NCBI) | compare |
| b1712 | ihfA | -2.9 | -3.3 | integration host factor subunit alpha (NCBI) | compare |
| b0439 | lon | -2.9 | -3.4 | DNA-binding ATP-dependent protease La (NCBI) | compare |
| b3650 | spoT | -2.9 | -7.1 | bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase (NCBI) | compare |
| b1865 | nudB | -2.8 | -1.8 | dATP pyrophosphohydrolase (NCBI) | compare |
| b1264 | trpE | -2.8 | -6.5 | anthranilate synthase component I (NCBI) | compare |
| b3773 | ilvY | -2.8 | -8.9 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b0133 | panC | -2.8 | -7.8 | pantoate--beta-alanine ligase (NCBI) | compare |
| b1263 | trpD | -2.8 | -2.6 | bifunctional indole-3-glycerol-phosphate synthase/anthranilate phosphoribosyltransferase (NCBI) | compare |
| b2752 | cysD | -2.7 | -5.7 | sulfate adenylyltransferase subunit 2 (NCBI) | compare |
| b0739 | tolA | -2.7 | -4.0 | cell envelope integrity inner membrane protein TolA (NCBI) | compare |
| b3390 | aroK | -2.7 | -2.5 | shikimate kinase I (NCBI) | compare |
| b0080 | fruR | -2.6 | -6.0 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b0726 | sucA | -2.6 | -3.0 | alpha-ketoglutarate decarboxylase (NCBI) | compare |
| b0423 | thiI | -2.6 | -6.2 | thiamine biosynthesis protein ThiI (NCBI) | compare |
| b1060 | yceP | -2.6 | -5.9 | orf, hypothetical protein (VIMSS) | compare |
| b0889 | lrp | -2.6 | -3.3 | DNA-binding transcriptional dual regulator, leucine-binding (NCBI) | compare |
| b0998 | torD | -2.5 | -2.1 | chaperone protein TorD (NCBI) | compare |
| b0722 | sdhD | -2.5 | -4.0 | succinate dehydrogenase cytochrome b556 small membrane subunit (NCBI) | compare |
| b4407 | thiS | -2.4 | -2.3 | sulfur carrier protein ThiS (NCBI) | compare |
| b4171 | miaA | -2.4 | -6.0 | tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) | compare |
| b0740 | tolB | -2.4 | -4.2 | translocation protein TolB precursor (NCBI) | compare |
| b0759 | galE | -2.3 | -6.6 | UDP-galactose-4-epimerase (VIMSS) | compare |
| b3237 | argR | -2.3 | -4.8 | arginine repressor (NCBI) | compare |
| b1521 | uxaB | -2.3 | -7.0 | tagaturonate reductase (NCBI) | conserved |
| b0758 | galT | -2.3 | -4.8 | galactose-1-phosphate uridylyltransferase (NCBI) | compare |
| b4245 | pyrB | -2.3 | -9.3 | aspartate carbamoyltransferase catalytic subunit (NCBI) | compare |
| b2531 | iscR | -2.3 | -2.5 | DNA-binding transcriptional repressor (NCBI) | compare |
| b0738 | tolR | -2.2 | -3.3 | membrane spanning protein in TolA-TolQ-TolR complex (NCBI) | compare |
| b3781 | trxA | -2.2 | -4.3 | thioredoxin 1 (VIMSS) | compare |
| b2894 | xerD | -2.2 | -1.5 | site-specific tyrosine recombinase XerD (NCBI) | compare |
| b3483 | yhhH | -2.1 | -2.4 | orf, hypothetical protein (VIMSS) | compare |
| b3459 | yhhK | -2.1 | -4.9 | hypothetical protein (NCBI) | compare |
| b0750 | nadA | -2.1 | -6.0 | quinolinate synthetase (NCBI) | compare |
| b2830 | nudH | -2.1 | -1.9 | dinucleoside polyphosphate hydrolase (NCBI) | compare |
| b2318 | truA | -2.1 | -4.3 | tRNA pseudouridine synthase A (NCBI) | compare |
| b0131 | panD | -2.1 | -4.0 | aspartate 1-decarboxylase precursor (NCBI) | compare |
| b1863 | ruvC | -2.1 | -4.0 | Holliday junction resolvase (NCBI) | compare |
| b0737 | tolQ | -2.0 | -3.0 | membrane spanning protein in TolA-TolQ-TolR complex (NCBI) | compare |
| b3870 | glnA | -2.0 | -1.4 | glutamine synthetase (NCBI) | compare |
| b0741 | pal | -2.0 | -4.7 | peptidoglycan-associated outer membrane lipoprotein (NCBI) | compare |
| b2528 | iscA | -2.0 | -1.8 | iron-sulfur cluster assembly protein (NCBI) | compare |
| b0109 | nadC | -2.0 | -6.3 | nicotinate-nucleotide pyrophosphorylase (NCBI) | compare |
| b2297 | pta | -1.9 | -1.8 | phosphate acetyltransferase (NCBI) | compare |
| b4177 | purA | -1.9 | -1.3 | adenylosuccinate synthetase (NCBI) | compare |
| b1290 | sapF | -1.9 | -2.6 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b0134 | panB | -1.8 | -5.1 | 3-methyl-2-oxobutanoate hydroxymethyltransferase (NCBI) | compare |
| b2574 | nadB | -1.8 | -7.9 | L-aspartate oxidase (NCBI) | compare |
| b0890 | ftsK | -1.8 | -6.5 | DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) | compare |
| b3463 | ftsE | -1.8 | -4.0 | predicted transporter subunit: ATP-binding component of ABC superfamily (NCBI) | compare |
| b0114 | aceE | -1.8 | -1.2 | pyruvate dehydrogenase subunit E1 (NCBI) | compare |
| b2820 | recB | -1.8 | -2.3 | exonuclease V (RecBCD complex), beta subunit (NCBI) | compare |
| b4025 | pgi | -1.7 | -7.6 | glucose-6-phosphate isomerase (NCBI) | compare |
| b3806 | cyaA | -1.7 | -5.4 | adenylate cyclase (NCBI) | compare |
| b0817 | mntR | -1.7 | -3.4 | DNA-binding transcriptional regulator of mntH (NCBI) | compare |
| b0118 | acnB | -1.7 | -2.5 | aconitate hydratase (NCBI) | compare |
| b0963 | mgsA | -1.7 | -7.3 | methylglyoxal synthase (VIMSS) | compare |
| b3811 | xerC | -1.7 | -1.2 | site-specific tyrosine recombinase XerC (NCBI) | compare |
| b1279 | yciS | -1.7 | -1.9 | conserved inner membrane protein (NCBI) | compare |
| b1231 | tyrT | -1.7 | -1.6 | tRNA-Tyr (NCBI) | compare |
| b2567 | rnc | -1.6 | -2.1 | ribonuclease III (NCBI) | compare |
| b2738 | ygbL | -1.6 | -2.7 | hypothetical protein (NCBI) | compare |
| b1361 | ydaW | -1.6 | -1.6 | orf, hypothetical protein (VIMSS) | compare |
| b3671 | ilvB | -1.6 | -9.6 | acetolactate synthase large subunit (NCBI) | compare |
| b3032 | cpdA | -1.6 | -5.9 | cyclic 3',5'-adenosine monophosphate phosphodiesterase (NCBI) | compare |
| b1217 | chaB | -1.6 | -2.1 | cation transport regulator (NCBI) | compare |
| b2313 | cvpA | -1.6 | -4.0 | membrane protein required for colicin V production (NCBI) | compare |
| b0767 | ybhE | -1.5 | -3.6 | 6-phosphogluconolactonase (NCBI) | compare |
| b2279 | nuoK | -1.5 | -2.3 | NADH dehydrogenase subunit K (NCBI) | compare |
| b2506 | yfgI | -1.5 | -2.4 | hypothetical protein (NCBI) | compare |
| b1084 | rne | -1.5 | -4.3 | fused ribonucleaseE: endoribonuclease/RNA-binding protein/RNA degradosome binding protein (NCBI) | compare |
| b0729 | sucD | -1.5 | -3.0 | succinyl-CoA synthetase subunit alpha (NCBI) | compare |
| b2424 | cysU | -1.5 | -2.4 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b3778 | rep | -1.5 | -6.9 | DNA helicase and single-stranded DNA-dependent ATPase (NCBI) | compare |
| b0053 | surA | -1.5 | -3.8 | peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) | compare |
| b3093 | exuT | -1.5 | -7.7 | hexuronate transporter (NCBI) | conserved |
| b1677 | lpp | -1.5 | -2.8 | murein lipoprotein (NCBI) | compare |
| b3163 | nlpI | -1.4 | -4.2 | hypothetical protein (NCBI) | compare |
| b1830 | prc | -1.4 | -4.8 | carboxy-terminal protease for penicillin-binding protein 3 (NCBI) | compare |
| b0721 | sdhC | -1.4 | -3.9 | succinate dehydrogenase cytochrome b556 large membrane subunit (NCBI) | compare |
| b0888 | trxB | -1.4 | -3.0 | thioredoxin reductase, FAD/NAD(P)-binding (NCBI) | compare |
| b2029 | gnd | -1.4 | -6.1 | 6-phosphogluconate dehydrogenase (NCBI) | compare |
| b3398 | yrfF | -1.3 | -2.9 | predicted inner membrane protein (NCBI) | compare |
| b1235 | rssB | -1.3 | -5.3 | response regulator of RpoS (NCBI) | compare |
| b0585 | fes | -1.3 | -4.7 | enterobactin/ferric enterobactin esterase (NCBI) | compare |
| b4480 | hdfR | -1.3 | -4.6 | transcriptional regulator HdfR (NCBI) | compare |
| b2422 | cysA | -1.3 | -5.0 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b3169 | nusA | -1.3 | -2.2 | transcription elongation factor NusA (NCBI) | compare |
| b2601 | aroF | -1.3 | -4.8 | 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tyrosine-repressible (NCBI) | compare |
| b4651 | yibW | -1.3 | -1.8 | no description | compare |
| b3247 | cafA | -1.3 | -7.2 | bundles of cytoplasmic filaments (VIMSS) | compare |
| b0075 | leuL | -1.3 | -3.3 | leu operon leader peptide (NCBI) | compare |