Experiment set2IT089 for Escherichia coli BW25113

Compare to:

LB with L-Lysine 200 mM

200 most important genes:

  gene name fitness t score description  
b0920 ycbC -4.7 -4.5 conserved inner membrane protein (NCBI) compare
b1192 ldcA -3.7 -4.4 L,D-carboxypeptidase A (NCBI) compare
b2567 rnc -3.5 -2.4 ribonuclease III (NCBI) compare
b1863 ruvC -3.2 -4.2 Holliday junction resolvase (NCBI) compare
b0149 mrcB -2.9 -10.3 penicillin-binding protein 1b (NCBI) compare
b3839 tatC -2.8 -8.2 TatABCE protein translocation system subunit (NCBI) compare
b0741 pal -2.6 -4.6 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b1860 ruvB -2.4 -2.6 Holliday junction DNA helicase B (NCBI) compare
b0053 surA -2.3 -1.6 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b1105 ycfM -2.3 -3.6 predicted outer membrane lipoprotein (NCBI) compare
b3613 yibP -2.2 -4.4 putative membrane protein (VIMSS) compare
b0439 lon -2.2 -4.3 DNA-binding ATP-dependent protease La (NCBI) compare
b3150 yraP -2.2 -5.5 hypothetical protein (NCBI) compare
b0737 tolQ -2.1 -3.1 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b2576 srmB -2.1 -3.3 ATP-dependent RNA helicase (NCBI) compare
b2699 recA -1.9 -1.8 recombinase A (NCBI) compare
b0500 ybbD -1.9 -2.7 hypothetical protein (RefSeq) compare
b1104 ycfL -1.9 -2.5 hypothetical protein (NCBI) compare
b1161 ycgX -1.9 -1.7 hypothetical protein (NCBI) compare
b1861 ruvA -1.9 -2.6 Holliday junction DNA helicase motor protein (NCBI) compare
b3463 ftsE -1.9 -3.0 predicted transporter subunit: ATP-binding component of ABC superfamily (NCBI) compare
b3183 obgE -1.8 -1.7 GTPase involved in cell partioning and DNA repair (NCBI) compare
b2330 yfcB -1.8 -2.5 putative adenine-specific methylase (VIMSS) compare
b4171 miaA -1.8 -4.9 tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) compare
b1182 hlyE -1.8 -2.7 hemolysin E (VIMSS) compare
b3636 rpmG -1.8 -2.0 50S ribosomal protein L33 (NCBI) compare
b0145 dksA -1.8 -3.2 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b3792 wzxE -1.7 -6.9 O-antigen translocase (NCBI) compare
b2259 pmrD -1.7 -1.9 polymyxin resistance protein B (VIMSS) compare
b0890 ftsK -1.7 -6.4 DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) compare
b4481 rffT -1.7 -5.4 4-alpha-L-fucosyltransferase (NCBI) compare
b4603 rseX -1.6 -1.3 sRNA regulating ompA and ompC translation, with Hfq (RefSeq) compare
b3462 ftsX -1.6 -4.5 predicted transporter subunit: membrane component of ABC superfamily (NCBI) compare
b3229 sspA -1.6 -3.4 stringent starvation protein A (NCBI) compare
b1429 tehA -1.6 -2.2 potassium-tellurite ethidium and proflavin transporter (NCBI) compare
b1273 yciN -1.6 -1.3 hypothetical protein (NCBI) compare
b4557 yidD -1.6 -3.0 hypothetical protein (NCBI) compare
b3778 rep -1.5 -6.5 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b1291 sapD -1.5 -2.1 predicted antimicrobial peptide transporter subunit (NCBI) compare
b3725 pstB -1.5 -2.0 phosphate transporter subunit (NCBI) compare
b4172 hfq -1.5 -1.9 RNA-binding protein Hfq (NCBI) compare
b3341 rpsG -1.5 -1.3 30S ribosomal protein S7 (NCBI) compare
b0738 tolR -1.5 -2.9 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b3169 nusA -1.4 -2.1 transcription elongation factor NusA (NCBI) compare
b2055 wcaE -1.4 -2.2 predicted glycosyl transferase (NCBI) compare
b1347 ydaC -1.4 -1.9 Rac prophage; predicted protein (NCBI) compare
b2297 pta -1.4 -1.5 phosphate acetyltransferase (NCBI) compare
b0630 lipB -1.4 -2.1 protein of lipoate biosynthesis (VIMSS) compare
b3863 polA -1.4 -0.9 DNA polymerase I (NCBI) compare
b1728 ydjM -1.4 -2.8 predicted inner membrane protein regulated by LexA (RefSeq) compare
b1545 pinQ -1.4 -1.5 Qin prophage; predicted site-specific recombinase (NCBI) compare
b2279 nuoK -1.4 -2.1 NADH dehydrogenase subunit K (NCBI) compare
b1103 ycfF -1.4 -1.4 orf, hypothetical protein (VIMSS) compare
b3398 yrfF -1.4 -2.6 predicted inner membrane protein (NCBI) compare
b3790 rffC -1.3 -4.1 TDP-fucosamine acetyltransferase (RefSeq) compare
b3871 bipA -1.3 -7.0 GTP-binding protein (NCBI) compare
b2820 recB -1.3 -2.1 exonuclease V (RecBCD complex), beta subunit (NCBI) compare
b3791 rffA -1.3 -5.6 TDP-4-oxo-6-deoxy-D-glucose transaminase (NCBI) compare
b2531 iscR -1.3 -1.6 DNA-binding transcriptional repressor (NCBI) compare
b2512 yfgL -1.3 -3.4 protein assembly complex, lipoprotein component (NCBI) compare
b1499 ydeO -1.3 -1.6 predicted DNA-binding transcriptional acfivator (NCBI) compare
b0740 tolB -1.3 -3.5 translocation protein TolB precursor (NCBI) compare
b2822 recC -1.3 -3.9 exonuclease V (RecBCD complex), gamma chain (NCBI) compare
b1257 yciE -1.3 -2.9 hypothetical protein (NCBI) compare
b2318 truA -1.3 -3.2 tRNA pseudouridine synthase A (NCBI) compare
b1830 prc -1.3 -4.3 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b0603 ybdO -1.2 -2.8 predicted DNA-binding transcriptional regulator (NCBI) compare
b1304 pspA -1.2 -3.0 regulatory protein for phage-shock-protein operon (NCBI) compare
b1730 ydjO -1.2 -1.9 predicted protein (RefSeq) compare
b0739 tolA -1.2 -3.2 cell envelope integrity inner membrane protein TolA (NCBI) compare
b1363 trkG -1.2 -3.9 Rac prophage; potassium transporter subunit (NCBI) compare
b2934 cmtB -1.2 -2.5 predicted mannitol-specific enzyme IIA component of PTS (NCBI) compare
b2830 nudH -1.2 -1.5 dinucleoside polyphosphate hydrolase (NCBI) compare
b0118 acnB -1.2 -2.3 aconitate hydratase (NCBI) compare
b2642 yfjW -1.2 -2.2 CP4-57 prophage; predicted inner membrane protein (NCBI) compare
b2363 yfdT -1.2 -2.4 CPS-53 (KpLE1) prophage; predicted protein (NCBI) compare
b3121 yhaC -1.2 -1.9 hypothetical protein (NCBI) compare
b2620 smpB -1.2 -1.4 SsrA-binding protein (NCBI) compare
b2263 yfbB -1.1 -2.3 predicted peptidase (NCBI) compare
b1497 b1497 -1.1 -2.5 putative enzyme (VIMSS) compare
b1576 ydfD -1.1 -2.0 Qin prophage; predicted protein (NCBI) compare
b0232 yafN -1.1 -1.0 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b2498 upp -1.1 -2.5 uracil phosphoribosyltransferase (VIMSS) compare
b0683 fur -1.1 -1.2 ferric uptake regulator (NCBI) compare
b3811 xerC -1.1 -1.5 site-specific tyrosine recombinase XerC (NCBI) compare
b0705 ybfL -1.1 -2.7 putative receptor protein (VIMSS) compare
b0049 apaH -1.1 -3.6 diadenosinetetraphosphatase (NCBI) compare
b3390 aroK -1.1 -1.4 shikimate kinase I (NCBI) compare
b2652 ileY -1.1 -3.8 tRNA-Ile (NCBI) compare
b1167 ymgC -1.1 -1.5 hypothetical protein (NCBI) compare
b2350 yfdG -1.1 -3.4 CPS-53 (KpLE1) prophage; bactoprenol-linked glucose translocase (flippase) (NCBI) compare
b3500 gor -1.1 -1.0 glutathione reductase (NCBI) compare
b1286 rnb -1.1 -2.4 exoribonuclease II (NCBI) compare
b1726 yniB -1.1 -1.9 predicted inner membrane protein (NCBI) compare
b3741 gidA -1.0 -4.2 glucose-inhibited division protein A (NCBI) compare
b1642 slyA -1.0 -1.5 transcriptional regulator for cryptic hemolysin (VIMSS) compare
b4410 ecnA -1.0 -1.0 entericidin A membrane lipoprotein, antidote entericidin B (NCBI) compare
b1187 fadR -1.0 -2.8 fatty acid metabolism regulator (NCBI) compare
b4590 ybfK -1.0 -3.7 hypothetical protein (RefSeq) compare
b0589 fepG -1.0 -4.1 iron-enterobactin transporter subunit (NCBI) compare
b4414 tff -1.0 -1.3 unknown RNA (NCBI) compare
b3162 deaD -1.0 -3.0 inducible ATP-independent RNA helicase (VIMSS) compare
b2894 xerD -1.0 -1.2 site-specific tyrosine recombinase XerD (NCBI) compare
b0051 ksgA -1.0 -3.5 dimethyladenosine transferase (NCBI) compare
b4128 yjdK -1.0 -3.2 hypothetical protein (NCBI) compare
b1409 ynbB -1.0 -4.0 predicted CDP-diglyceride synthase (NCBI) compare
b2625 yfjI -1.0 -3.8 CP4-57 prophage; predicted protein (NCBI) compare
b1515 lsrD -1.0 -2.8 AI2 transporter (NCBI) compare
b3261 fis -1.0 -2.1 DNA-binding protein Fis (NCBI) compare
b1462 b1462 -1.0 -2.6 orf, hypothetical protein (VIMSS) compare
b2287 nuoB -1.0 -2.5 NADH dehydrogenase subunit B (NCBI) compare
b0592 fepB -1.0 -4.7 iron-enterobactin transporter subunit (NCBI) compare
b1361 ydaW -1.0 -1.0 orf, hypothetical protein (VIMSS) compare
b0579 ybdF -1.0 -2.5 hypothetical protein (NCBI) compare
b0339 cynT -1.0 -2.8 carbonic anhydrase (NCBI) compare
b1603 pntA -0.9 -1.6 NAD(P) transhydrogenase subunit alpha (NCBI) compare
b1176 minC -0.9 -2.5 septum formation inhibitor (NCBI) compare
b3119 tdcR -0.9 -1.9 threonine dehydratase operon activator protein (VIMSS) compare
b3652 recG -0.9 -5.0 ATP-dependent DNA helicase (NCBI) compare
b4453 ldrD -0.9 -1.1 toxic polypeptide, small (NCBI) compare
b4375 prfC -0.9 -3.8 peptide chain release factor 3 (NCBI) compare
b0263 afuB -0.9 -1.0 CP4-6 prophage; predicted ferric trasnporter subunit (RefSeq) compare
b3609 secB -0.9 -2.5 export protein SecB (NCBI) compare
b1426 ydcH -0.9 -1.1 orf, hypothetical protein (VIMSS) compare
b2569 lepA -0.9 -2.5 GTP-binding protein LepA (NCBI) compare
b1144 ymfJ -0.9 -1.7 orf, hypothetical protein (VIMSS) compare
b2356 yfdM -0.9 -1.5 orf, hypothetical protein (VIMSS) compare
b2352 yfdI -0.9 -2.8 CPS-53 (KpLE1) prophage; predicted inner membrane protein (NCBI) compare
b1977 asnT -0.9 -1.7 tRNA-Asn (NCBI) compare
b0082 mraW -0.9 -2.2 S-adenosyl-methyltransferase (NCBI) compare
b0627 tatE -0.9 -1.0 twin arginine translocase protein E (NCBI) compare
b2309 hisJ -0.9 -2.0 histidine/lysine/arginine/ornithine transporter subunit (NCBI) compare
b3164 pnp -0.9 -1.5 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b2313 cvpA -0.9 -2.4 membrane protein required for colicin V production (NCBI) compare
b1165 ymgA -0.9 -1.9 hypothetical protein (NCBI) compare
b0585 fes -0.9 -3.2 enterobactin/ferric enterobactin esterase (NCBI) compare
b0888 trxB -0.9 -1.9 thioredoxin reductase, FAD/NAD(P)-binding (NCBI) compare
b2847 yqeI -0.9 -4.0 predicted transcriptional regulator (NCBI) compare
b1850 eda -0.9 -1.5 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) compare
b1918 yecS -0.9 -2.0 predicted transporter subunit: membrane component of ABC superfamily (NCBI) compare
b0212 gloB -0.9 -1.6 predicted hydroxyacylglutathione hydrolase (NCBI) compare
b1164 ycgZ -0.9 -1.8 hypothetical protein (NCBI) compare
b4613 dinQ -0.8 -1.2 Damage inducible, function unknown (RefSeq) compare
b2853 ygeI -0.8 -1.9 hypothetical protein (NCBI) compare
b3977 tyrU -0.8 -0.8 tRNA-Tyr (NCBI) compare
b2285 nuoE -0.8 -1.3 NADH dehydrogenase subunit E (NCBI) compare
b4402 yjjY -0.8 -0.9 hypothetical protein (NCBI) compare
b1335 ogt -0.8 -2.0 O-6-alkylguanine-DNA:cysteine-protein methyltransferase (NCBI) compare
b3838 tatB -0.8 -3.4 sec-independent translocase (NCBI) compare
b3163 nlpI -0.8 -2.6 hypothetical protein (NCBI) compare
b2082 ogrK -0.8 -1.8 DNA-binding transcriptional regulator prophage P2 remnant (NCBI) compare
b4426 isrA -0.8 -1.7 unknown RNA (NCBI) compare
b0580 ybdJ -0.8 -1.3 predicted inner membrane protein (NCBI) compare
b2579 yfiD -0.8 -1.4 pyruvate formate lyase subunit (NCBI) compare
b0588 fepC -0.8 -3.7 iron-enterobactin transporter subunit (NCBI) compare
b4685 yrbN -0.8 -1.5 expressed protein (RefSeq) compare
b2792 yqcC -0.8 -1.4 hypothetical protein (NCBI) compare
b3442 yhhZ -0.8 -1.6 hypothetical protein (NCBI) compare
b0590 fepD -0.8 -2.8 iron-enterobactin transporter subunit (NCBI) compare
b0028 fkpB -0.8 -1.9 FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase) (NCBI) compare
b2959 yggL -0.8 -2.3 orf, hypothetical protein (VIMSS) compare
b0721 sdhC -0.8 -2.4 succinate dehydrogenase cytochrome b556 large membrane subunit (NCBI) compare
b1090 plsX -0.8 -2.6 glycerolphosphate auxotrophy in plsB background (VIMSS) compare
b3250 mreC -0.8 -0.8 cell wall structural complex MreBCD transmembrane component MreC (NCBI) compare
b0303 ykgI -0.8 -2.4 orf, hypothetical protein (VIMSS) compare
b3205 yhbJ -0.8 -2.0 hypothetical protein (NCBI) compare
b1259 yciG -0.8 -1.6 orf, hypothetical protein (VIMSS) compare
b2195 ccmG -0.8 -1.5 periplasmic thioredoxin of cytochrome c-type biogenesis (NCBI) compare
b2479 gcvR -0.8 -2.2 transcriptional regulation of gcv operon (VIMSS) compare
b1848 yebG -0.8 -0.9 conserved protein regulated by LexA (NCBI) compare
b4515 ybgT -0.8 -1.0 hypothetical protein (NCBI) compare
b2912 ygfA -0.8 -1.5 putative ligase (VIMSS) compare
b2277 nuoM -0.8 -3.1 NADH dehydrogenase subunit M (NCBI) compare
b2110 yehC -0.8 -2.3 predicted periplasmic pilin chaperone (NCBI) compare
b4497 yeeL -0.8 -3.0 no description compare
b2684 mprA -0.8 -1.9 DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux (NCBI) compare
b1696 ydiP -0.8 -2.4 predicted DNA-binding transcriptional regulator (NCBI) compare
b0767 ybhE -0.7 -2.1 6-phosphogluconolactonase (NCBI) compare
b4155 yjeA -0.7 -0.7 putative lysyl-tRNA synthetase (VIMSS) compare
b1382 ynbE -0.7 -1.2 predicted lipoprotein (NCBI) compare
b1292 sapC -0.7 -1.4 predicted antimicrobial peptide transporter subunit (NCBI) compare
b3414 gntY -0.7 -2.9 predicted gluconate transport associated protein (NCBI) compare
b3405 ompR -0.7 -2.3 osmolarity response regulator (NCBI) compare
b1351 racC -0.7 -1.8 Rac prophage; predicted protein (NCBI) compare
b2650 ypjC -0.7 -1.3 hypothetical protein (RefSeq) compare
b3706 trmE -0.7 -2.7 tRNA modification GTPase (NCBI) compare
b4552 yrhC -0.7 -1.2 no description compare
b2736 ygbJ -0.7 -2.7 predicted dehydrogenase, with NAD(P)-binding Rossmann-fold domain (NCBI) compare
b0957 ompA -0.7 -2.1 outer membrane protein A (3a;II*;G;d) (NCBI) compare
b2208 napF -0.7 -2.5 ferredoxin-type protein, predicted role in electron transfer to periplasmic nitrate reductase (NapA) (NCBI) compare
b4462 ygaQ -0.7 -3.6 hypothetical protein (RefSeq) compare
b1045 ymdB -0.7 -2.8 hypothetical protein (NCBI) compare
b4551 yheV -0.7 -1.3 hypothetical protein (NCBI) compare
b3155 yhbQ -0.7 -2.2 hypothetical protein (NCBI) compare
b3035 tolC -0.7 -3.6 outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) compare
b1177 ycgJ -0.7 -2.7 hypothetical protein (NCBI) compare
b4679 yohP -0.7 -1.9 expressed protein (RefSeq) compare
b1984 asnW -0.7 -0.8 tRNA-Asn (NCBI) compare
b3836 b3836 -0.7 -1.5 orf, hypothetical protein (VIMSS) compare
b3290 trkA -0.7 -1.8 potassium transporter peripheral membrane component (NCBI) compare


Specific Phenotypes

For 1 genes in this experiment

For stress L-Lysine in Escherichia coli BW25113

For stress L-Lysine across organisms