Experiment set2IT076 for Escherichia coli BW25113

Compare to:

LB with syringaldehyde 5 mM

200 most detrimental genes:

  gene name fitness t score description  
b0889 lrp +1.2 3.6 DNA-binding transcriptional dual regulator, leucine-binding (NCBI) compare
b2895 fldB +1.2 2.8 flavodoxin 2 (NCBI) compare
b4370 leuQ +1.1 2.7 tRNA-Leu (NCBI) compare
b1524 yneH +1.1 1.5 predicted glutaminase (NCBI) compare
b1778 yeaA +1.1 2.5 methionine sulfoxide reductase B (NCBI) compare
b2198 ccmD +1.0 2.6 cytochrome c biogenesis protein (NCBI) compare
b4406 yaeP +1.0 2.0 hypothetical protein (NCBI) compare
b4416 rybA +1.0 1.7 unknown RNA (NCBI) compare
b0247 ykfG +1.0 1.6 CP4-6 prophage; predicted DNA repair protein (NCBI) compare
b1448 yncA +1.0 2.0 predicted acyltransferase with acyl-CoA N-acyltransferase domain (NCBI) compare
b0696 kdpC +1.0 1.6 potassium-transporting ATPase subunit C (NCBI) compare
b1572 ydfB +1.0 1.4 orf, hypothetical protein (VIMSS) compare
b1296 ycjJ +0.9 2.7 putative amino acid/amine transport protein (VIMSS) compare
b2114 metG +0.9 1.4 methionyl-tRNA synthetase (NCBI) compare
b2953 yggU +0.9 1.8 orf, hypothetical protein (VIMSS) compare
b1765 ydjA +0.9 1.1 predicted oxidoreductase (NCBI) compare
b1476 fdnI +0.9 1.5 formate dehydrogenase-N, cytochrome B556 (gamma) subunit, nitrate-inducible (NCBI) compare
b4438 cyaR +0.8 1.8 sRNA effector of ompX mRNA instability, cAMP-induced; hfq-dependent (RefSeq) compare
b1550 b1550 +0.8 1.5 orf, hypothetical protein (VIMSS) compare
b2915 yqfE +0.8 2.4 hypothetical protein (RefSeq) compare
b3973 birA +0.8 1.6 biotin--protein ligase (NCBI) compare
b4394 yjjX +0.8 2.0 orf, hypothetical protein (VIMSS) compare
b1511 ydeV +0.8 3.1 putative kinase (VIMSS) compare
b4603 rseX +0.8 1.0 sRNA regulating ompA and ompC translation, with Hfq (RefSeq) compare
b1671 ydhX +0.8 1.5 predicted 4Fe-4S ferridoxin-type protein (RefSeq) compare
b0825 mipB +0.7 2.4 putative transaldolase (VIMSS) compare
b1639 ydhA +0.7 2.2 orf, hypothetical protein (VIMSS) compare
b2377 yfdY +0.7 1.6 predicted inner membrane protein (NCBI) compare
b2080 b2080 +0.7 1.4 orf, hypothetical protein (VIMSS) compare
b4538 yoeF +0.7 1.2 hypothetical protein (RefSeq) compare
b1427 rimL +0.7 1.5 ribosomal-protein-L7/L12-serine acetyltransferase (NCBI) compare
b1426 ydcH +0.7 1.2 orf, hypothetical protein (VIMSS) compare
b2490 b2490 +0.7 2.2 putative protein processing element (VIMSS) compare
b1566 flxA +0.7 2.0 Qin prophage; predicted protein (NCBI) compare
b1359 ydaU +0.7 1.7 Rac prophage; conserved protein (NCBI) compare
b4545 ypdJ +0.6 1.9 no description compare
b1380 ldhA +0.6 1.2 D-lactate dehydrogenase (NCBI) compare
b4457 csrC +0.6 2.0 regulatory RNA (NCBI) compare
b0964 yccT +0.6 2.2 hypothetical protein (NCBI) compare
b4113 basR +0.6 3.3 DNA-binding response regulator in two-component regulatory system with BasS (NCBI) compare
b4445 omrB +0.6 1.9 sRNA down regulates OM proteins; positively regulated by OmpR/EnvZ; binds Hfq (RefSeq) compare
b0014 dnaK +0.6 0.9 molecular chaperone DnaK (NCBI) compare
b4277 yjgZ +0.6 2.5 KpLE2 phage-like element; predicted protein (NCBI) compare
b1302 puuE +0.6 1.5 GABA aminotransferase, PLP-dependent (NCBI) compare
b0714 nei +0.6 2.2 endonuclease VIII/ 5-formyluracil/5-hydroxymethyluracil DNA glycosylase (NCBI) compare
b4653 yicT +0.6 1.4 no description compare
b1400 paaY +0.6 1.1 predicted hexapeptide repeat acetyltransferase (NCBI) compare
b4630 ykgP +0.6 1.3 no description compare
b2614 grpE +0.6 0.9 heat shock protein (NCBI) compare
b0450 glnK +0.6 1.1 nitrogen assimilation regulatory protein for GlnL, GlnE, and AmtB (NCBI) compare
b4195 ulaC +0.6 1.5 L-ascorbate-specific enzyme IIA component of PTS (NCBI) compare
b0967 yccW +0.6 2.8 predicted methyltransferase (RefSeq) compare
b4151 frdD +0.6 1.5 fumarate reductase subunit D (NCBI) compare
b2096 gatY +0.6 1.7 tagatose-bisphosphate aldolase 1 (VIMSS) compare
b2939 yqgB +0.6 0.7 predicted protein (RefSeq) compare
b1346 ydaQ +0.6 1.7 orf, hypothetical protein (VIMSS) compare
b1988 nac +0.6 2.4 DNA-binding transcriptional dual regulator of nitrogen assimilation (NCBI) compare
b0880 cspD +0.6 1.1 cold shock protein homolog (NCBI) compare
b1362 rzpR +0.6 1.5 putative Rac prophage endopeptidase (VIMSS) compare
b3134 agaW +0.6 1.7 N-acetylgalactosamine-specific enzyme IIC component of PTS, fragment (pseudogene) (RefSeq) compare
b0828 iaaA +0.6 1.6 L-asparaginase (NCBI) compare
b2905 gcvT +0.6 2.9 glycine cleavage system aminomethyltransferase T (NCBI) compare
b3537 yhjT +0.6 2.0 orf, hypothetical protein (VIMSS) compare
b1724 ydiZ +0.5 1.2 hypothetical protein (NCBI) compare
b1865 nudB +0.5 0.7 dATP pyrophosphohydrolase (NCBI) compare
b2393 nupC +0.5 2.8 nucleoside (except guanosine) transporter (NCBI) compare
b2009 sbmC +0.5 1.7 DNA gyrase inhibitor (NCBI) compare
b0238 gpt +0.5 1.7 xanthine phosphoribosyltransferase (NCBI) compare
b1295 ymjA +0.5 1.2 hypothetical protein (NCBI) compare
b4646 yrdE +0.5 1.5 no description compare
b0778 bioD +0.5 1.7 dethiobiotin synthetase (NCBI) compare
b2586 yfiM +0.5 1.4 predicted protein (RefSeq) compare
b1531 marA +0.5 1.5 multiple antibiotic resistance; transcriptional activator of defense systems (VIMSS) compare
b1609 rstB +0.5 2.0 sensory histidine kinase in two-component regulatory system with RstA (NCBI) compare
b4381 deoC +0.5 1.9 deoxyribose-phosphate aldolase (NCBI) compare
b1758 b1758 +0.5 0.9 putative cytochrome oxidase (VIMSS) compare
b1278 pgpB +0.5 1.1 phosphatidylglycerophosphatase B (NCBI) compare
b1518 lsrG +0.5 1.2 autoinducer-2 (AI-2) modifying protein LsrG (NCBI) compare
b4196 ulaD +0.5 2.2 3-keto-L-gulonate 6-phosphate decarboxylase (NCBI) compare
b2433 b2433 +0.5 1.7 orf, hypothetical protein (VIMSS) compare
b0965 b0965 +0.5 1.2 orf, hypothetical protein (VIMSS) compare
b4066 yjcF +0.5 1.6 hypothetical protein (NCBI) compare
b1214 ychA +0.5 1.8 predicted transcriptional regulator (NCBI) compare
b3437 gntK +0.5 2.4 gluconokinase 2, thermoresistant (VIMSS) compare
b2173 yeiR +0.5 2.6 predicted enzyme (NCBI) compare
b2261 menC +0.5 2.2 O-succinylbenzoate synthase (NCBI) compare
b0365 tauA +0.5 2.0 taurine transport system periplasmic protein (VIMSS) compare
b4373 rimI +0.5 1.2 ribosomal-protein-alanine N-acetyltransferase (NCBI) compare
b0384 psiF +0.5 1.5 induced by phosphate starvation (VIMSS) compare
b2506 yfgI +0.5 1.2 hypothetical protein (NCBI) compare
b2356 yfdM +0.5 1.2 orf, hypothetical protein (VIMSS) compare
b2904 gcvH +0.5 0.9 glycine cleavage system protein H (NCBI) compare
b4544 yfbW +0.5 1.6 hypothetical protein (NCBI) compare
b0712 ybgK +0.5 2.2 predicted enzyme subunit (NCBI) compare
b4704 arrS +0.5 0.8 Antisense sRNA ArrS, function unknown (NCBI) compare
b4203 rplI +0.5 1.6 50S ribosomal protein L9 (NCBI) compare
b2954 yggV +0.5 1.9 putative deoxyribonucleotide triphosphate pyrophosphatase (NCBI) compare
b1958 yedI +0.5 1.7 conserved inner membrane protein (NCBI) compare
b3676 yidH +0.5 1.7 conserved inner membrane protein (NCBI) compare
b4137 cutA +0.5 2.6 copper binding protein, copper sensitivity (NCBI) compare
b2258 b2258 +0.5 0.7 putative transport/receptor protein (VIMSS) compare
b1661 cfa +0.5 1.6 cyclopropane fatty acyl phospholipid synthase (unsaturated-phospholipid methyltransferase) (NCBI) compare
b1251 yciI +0.5 1.3 orf, hypothetical protein (VIMSS) compare
b3085 ygjP +0.5 1.9 orf, hypothetical protein (VIMSS) compare
b0228 yafM +0.5 1.9 hypothetical protein (NCBI) compare
b1431 ydcL +0.5 1.4 predicted lipoprotein (NCBI) compare
b2293 yfbT +0.5 1.1 putative phosphatase (VIMSS) compare
b1216 chaA +0.5 2.8 calcium/sodium:proton antiporter (NCBI) compare
b1617 uidA +0.5 2.2 beta-D-glucuronidase (NCBI) compare
b1672 ydhW +0.5 1.2 hypothetical protein (NCBI) compare
b3206 npr +0.5 2.1 phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) (NCBI) compare
b0851 nfsA +0.5 1.8 nitroreductase A, NADPH-dependent, FMN-dependent (NCBI) compare
b1010 ycdK +0.5 1.6 hypothetical protein (NCBI) compare
b2798 ygdG +0.5 1.8 Ssb-binding protein, misidentified as ExoIX (RefSeq) compare
b2539 hcaF +0.5 1.6 3-phenylpropionate dioxygenase, small (beta) subunit (NCBI) compare
b0831 yliC +0.5 1.7 predicted peptide transporter subunit: membrane component of ABC superfamily (NCBI) compare
b1392 paaE +0.5 1.7 predicted multicomponent oxygenase/reductase subunit for phenylacetic acid degradation (NCBI) compare
b2637 yfjT +0.5 1.5 CP4-57 prophage; predicted protein (NCBI) compare
b1396 paaI +0.5 1.7 predicted thioesterase (NCBI) compare
b2903 gcvP +0.5 3.3 glycine dehydrogenase (NCBI) compare
b1999 yeeP +0.5 1.6 putative histone (VIMSS) compare
b2203 napB +0.4 2.0 cytochrome c-type protein (VIMSS) compare
b0018 mokC +0.4 0.5 regulatory protein for HokC, overlaps CDS of hokC (NCBI) compare
b4063 soxR +0.4 1.5 DNA-binding transcriptional dual regulator, Fe-S center for redox-sensing (NCBI) compare
b0044 fixX +0.4 1.4 predicted 4Fe-4S ferredoxin-type protein (NCBI) compare
b1151 ymfO +0.4 1.2 e14 prophage; conserved protein (RefSeq) compare
b1618 uidR +0.4 1.4 DNA-binding transcriptional repressor (NCBI) compare
b1248 b1248 +0.4 0.4 orf, hypothetical protein (VIMSS) compare
b0758 galT +0.4 2.1 galactose-1-phosphate uridylyltransferase (NCBI) compare
b2886 ygfS +0.4 1.9 putative oxidoreductase, Fe-S subunit (VIMSS) compare
b1684 sufA +0.4 0.9 iron-sulfur cluster assembly scaffold protein (NCBI) compare
b1565 ydfV +0.4 1.4 Qin prophage; predicted protein (NCBI) compare
b0968 yccX +0.4 1.5 predicted acylphosphatase (NCBI) compare
b4513 kdpF +0.4 1.0 potassium ion accessory transporter subunit (NCBI) compare
b1530 marR +0.4 1.2 multiple antibiotic resistance protein; repressor of mar operon (VIMSS) compare
b1134 ymfB +0.4 0.7 bifunctional thiamin pyrimidine pyrophosphate hydrolase/ thiamin pyrophosphate hydrolase (NCBI) compare
b1190 dadX +0.4 1.8 alanine racemase (NCBI) compare
b3466 yhhL +0.4 1.8 conserved inner membrane protein (NCBI) compare
b1360 ydaV +0.4 0.7 Rac prophage; predicted DNA replication protein (NCBI) compare
b0443 ybaW +0.4 1.9 hypothetical protein (NCBI) compare
b3223 nanE +0.4 2.4 predicted N-acetylmannosamine-6-P epimerase (NCBI) compare
b3257 yhdT +0.4 0.8 conserved inner membrane protein (NCBI) compare
b0520 ylbF +0.4 1.7 hypothetical protein (NCBI) compare
b1589 ynfG +0.4 1.0 oxidoreductase, Fe-S subunit (NCBI) compare
b4413 sokC +0.4 0.8 regulatory antisense RNA (NCBI) compare
b1920 fliY +0.4 1.0 cystine transporter subunit (NCBI) compare
b1422 ydcI +0.4 2.1 putative transcriptional regulator LYSR-type (VIMSS) compare
b1590 ynfH +0.4 1.4 oxidoreductase, membrane subunit (NCBI) compare
b0435 bolA +0.4 1.9 possible regulator of murein genes (VIMSS) compare
b4376 osmY +0.4 1.6 periplasmic protein (NCBI) compare
b4468 glcE +0.4 1.6 glycolate oxidase FAD binding subunit (NCBI) compare
b1266 yciV +0.4 1.1 hypothetical protein (NCBI) compare
b0183 rnhB +0.4 1.4 ribonuclease HII (NCBI) compare
b2951 yggS +0.4 1.4 predicted enzyme (NCBI) compare
b0097 yacA +0.4 1.2 orf, hypothetical protein (VIMSS) compare
b0854 potF +0.4 1.7 putrescine transporter subunit: periplasmic-binding component of ABC superfamily (NCBI) compare
b4436 ryeC +0.4 0.6 Novel sRNA, function unknown; paralogous to the other QUAD sRNA genes unknown (RefSeq) compare
b4176 yjeT +0.4 1.1 conserved inner membrane protein (NCBI) compare
b4371 rsmC +0.4 1.9 16S ribosomal RNA m2G1207 methyltransferase (NCBI) compare
b1657 ydhP +0.4 1.8 predicted transporter (NCBI) compare
b1154 ycfK +0.4 1.9 e14 prophage; predicted protein (NCBI) compare
b2540 hcaC +0.4 1.3 3-phenylpropionate dioxygenase, predicted ferredoxin subunit (NCBI) compare
b1411 ynbD +0.4 1.6 predicted phosphatase, inner membrane protein (NCBI) compare
b2432 yfeY +0.4 0.9 hypothetical protein (NCBI) compare
b3361 fic +0.4 1.2 stationary-phase protein, cell division (NCBI) compare
b2124 yehS +0.4 2.0 hypothetical protein (NCBI) compare
b4121 yjdF +0.4 2.2 conserved inner membrane protein (NCBI) compare
b1582 ynfA +0.4 1.2 hypothetical protein (NCBI) compare
b1141 ymfG +0.4 1.2 e14 prophage; predicted excisionase (NCBI) compare
b0675 nagD +0.4 1.8 UMP phosphatase (NCBI) compare
b1242 ychE +0.4 1.4 predicted inner membrane protein (NCBI) compare
b4687 shoB +0.4 1.5 toxic membrane protein (RefSeq) compare
b3860 dsbA +0.4 2.6 periplasmic protein disulfide isomerase I (NCBI) compare
b0189 yaeO +0.4 1.4 orf, hypothetical protein (VIMSS) compare
b4171 miaA +0.4 1.8 tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) compare
b2187 yejL +0.4 1.0 hypothetical protein (NCBI) compare
b2128 yehW +0.4 1.3 predicted transporter subunit: membrane component of ABC superfamily (NCBI) compare
b2720 hycF +0.4 1.9 formate hydrogenlyase complex iron-sulfur protein (NCBI) compare
b1812 pabB +0.4 1.3 para-aminobenzoate synthase component I (NCBI) compare
b0707 ybgA +0.4 1.1 hypothetical protein (NCBI) compare
b2022 hisB +0.4 1.8 imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS) compare
b0809 glnQ +0.4 1.4 glutamine ABC transporter ATP-binding protein (NCBI) compare
b0258 ykfC +0.4 2.1 orf, hypothetical protein (VIMSS) compare
b1412 azoR +0.4 0.7 acyl carrier protein phosphodiesterase (NCBI) compare
b2038 rfbC +0.4 2.0 dTDP-4-deoxyrhamnose-3,5-epimerase (NCBI) compare
b4217 ytfK +0.4 1.5 orf, hypothetical protein (VIMSS) compare
b1079 flgH +0.4 1.2 flagellar L-ring protein precursor H (NCBI) compare
b0839 dacC +0.4 1.9 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 6a) (NCBI) compare
b3397 nudE +0.4 2.2 ADP-ribose diphosphatase (NCBI) compare
b1622 malY +0.4 1.3 bifunctional beta-cystathionase, PLP-dependent/ regulator of maltose regulon (NCBI) compare
b3148 yraN +0.4 1.0 hypothetical protein (NCBI) compare
b4533 ynfO +0.4 0.6 Qin prophage; predicted protein (NCBI) compare
b2325 yfcL +0.4 1.1 hypothetical protein (NCBI) compare
b3393 yrfB +0.4 1.3 hypothetical protein (NCBI) compare
b0943 b0943 +0.4 1.7 putative fimbrial-like protein (VIMSS) compare
b3995 rsd +0.4 1.6 stationary phase protein, binds sigma 70 RNA polymerase subunit (NCBI) compare
b1361 ydaW +0.4 0.5 orf, hypothetical protein (VIMSS) compare
b3129 sohA +0.4 0.9 predicted regulator (NCBI) compare
b1009 rarA +0.4 1.4 predicted hydrolase (NCBI) compare
b4522 yciX_1 +0.4 0.7 hypothetical protein (NCBI) compare


Specific Phenotypes

None in this experiment

For Escherichia coli BW25113 in stress experiments

For stress syringaldehyde across organisms