Experiment set2IT074 for Pseudomonas fluorescens GW456-L13

Compare to:

L-Tryptophan carbon source

200 most important genes:

  gene name fitness t score description  
PfGW456L13_3934 -6.5 -4.5 O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) / O-succinylhomoserine sulfhydrylase (EC 2.5.1.48) compare
PfGW456L13_358 -6.4 -3.4 Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-) compare
PfGW456L13_644 -6.4 -4.4 Shikimate 5-dehydrogenase I alpha (EC 1.1.1.25) compare
PfGW456L13_1010 -6.3 -4.3 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) compare
PfGW456L13_362 -6.3 -7.5 Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) compare
PfGW456L13_2842 -6.1 -4.2 required for sulfate utilization, putative electron transport protein for sulfite reductase (from data) compare
PfGW456L13_1472 -5.9 -4.1 Glutamate 5-kinase (EC 2.7.2.11) / RNA-binding C-terminal domain PUA compare
PfGW456L13_2046 -5.8 -4.0 Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) compare
PfGW456L13_303 -5.8 -3.6 phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) (from data) compare
PfGW456L13_1540 -5.8 -5.7 Ketol-acid reductoisomerase (EC 1.1.1.86) compare
PfGW456L13_149 -5.8 -6.9 ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17) compare
PfGW456L13_5001 -5.7 -6.8 ATP phosphoribosyltransferase (EC 2.4.2.17) (from data) compare
PfGW456L13_359 -5.6 -10.0 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase (EC 5.3.1.16) (from data) compare
PfGW456L13_361 -5.6 -12.4 Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-) compare
PfGW456L13_727 -5.6 -10.0 LysR family transcriptional regulator PA5437 compare
PfGW456L13_845 -5.5 -3.8 Diaminopimelate decarboxylase (EC 4.1.1.20) compare
PfGW456L13_172 -5.5 -9.9 Phosphoserine phosphatase (EC 3.1.3.3) compare
PfGW456L13_3948 -5.4 -5.3 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) compare
PfGW456L13_1007 -5.4 -9.7 Homoserine O-acetyltransferase (EC 2.3.1.31) compare
PfGW456L13_3947 -5.4 -5.2 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) compare
PfGW456L13_951 -5.3 -12.4 Phosphoserine phosphatase (EC 3.1.3.3) compare
PfGW456L13_150 -5.3 -2.7 hypothetical protein compare
PfGW456L13_779 -5.1 -12.3 Bona fide RidA/YjgF/TdcF/RutC subgroup compare
PfGW456L13_1739 -5.0 -9.7 Ornithine carbamoyltransferase (EC 2.1.3.3) compare
PfGW456L13_1050 -5.0 -8.4 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) compare
PfGW456L13_1539 -4.9 -10.5 Acetolactate synthase small subunit (EC 2.2.1.6) compare
PfGW456L13_728 -4.9 -15.9 Pyruvate carboxyl transferase subunit A (EC 6.4.1.1) compare
PfGW456L13_757 -4.9 -4.0 Phosphate transport system regulatory protein PhoU compare
PfGW456L13_5000 -4.9 -14.9 Histidinol dehydrogenase (EC 1.1.1.23) compare
PfGW456L13_3945 -4.8 -12.1 3-isopropylmalate dehydrogenase (EC 1.1.1.85) compare
PfGW456L13_4229 -4.8 -16.5 Long-chain fatty acid transport protein compare
PfGW456L13_2032 -4.7 -5.6 Cysteine synthase B (EC 2.5.1.47) compare
PfGW456L13_4026 -4.7 -2.9 NADPH-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.13) compare
PfGW456L13_1368 -4.7 -5.9 Muramoyltetrapeptide carboxypeptidase (EC 3.4.17.13) compare
PfGW456L13_4999 -4.7 -12.0 Histidinol-phosphate aminotransferase (EC 2.6.1.9) compare
PfGW456L13_2034 -4.6 -2.8 hypothetical protein compare
PfGW456L13_1603 -4.6 -3.2 Malate:quinone oxidoreductase (EC 1.1.5.4) compare
PfGW456L13_913 -4.6 -8.8 N-acetylglutamate synthase (EC 2.3.1.1) compare
PfGW456L13_2843 -4.6 -11.1 Sulfite reductase [NADPH] hemoprotein beta-component (EC 1.8.1.2) compare
PfGW456L13_1233 -4.6 -3.2 N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38) compare
PfGW456L13_1749 -4.6 -3.2 Argininosuccinate synthase (EC 6.3.4.5) compare
PfGW456L13_1538 -4.6 -11.8 Acetolactate synthase large subunit (EC 2.2.1.6) compare
PfGW456L13_5082 -4.6 -4.4 Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19) compare
PfGW456L13_973 -4.5 -13.5 Dihydroxy-acid dehydratase (EC 4.2.1.9) compare
PfGW456L13_729 -4.5 -12.5 Pyruvate carboxyl transferase subunit B (EC 6.4.1.1) compare
PfGW456L13_943 -4.5 -9.9 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) compare
PfGW456L13_302 -4.4 -5.8 Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) compare
PfGW456L13_2656 -4.4 -8.9 Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) / Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) compare
PfGW456L13_854 -4.4 -3.0 Argininosuccinate lyase (EC 4.3.2.1) compare
PfGW456L13_1153 -4.3 -13.3 Acyl-CoA dehydrogenase (EC 1.3.8.7) compare
PfGW456L13_1006 -4.3 -6.1 Homoserine O-acetyltransferase (EC 2.3.1.31) compare
PfGW456L13_1972 -4.3 -2.9 Arginine N-succinyltransferase, alpha subunit (EC 2.3.1.109) compare
PfGW456L13_1524 -4.2 -7.0 Two-component sensor CbrB: intrcellular carbon:nitrogen balance compare
PfGW456L13_4859 -4.2 -2.9 Outer membrane protein YfgL, lipoprotein component of the protein assembly complex (forms a complex with YaeT, YfiO, and NlpB) compare
PfGW456L13_50 -4.2 -10.7 3-dehydroquinate dehydratase II (EC 4.2.1.10) compare
PfGW456L13_2176 -4.1 -6.0 Chorismate mutase I (EC 5.4.99.5) / Prephenate dehydratase (EC 4.2.1.51) compare
PfGW456L13_3960 -4.1 -10.0 Biosynthetic Aromatic amino acid aminotransferase alpha (EC 2.6.1.57) @ Aromatic-amino-acid aminotransferase (EC 2.6.1.57) compare
PfGW456L13_4590 -4.0 -5.8 Beta-ketoadipyl CoA thiolase (EC 2.3.1.-) compare
PfGW456L13_812 -4.0 -3.9 D-amino acid dehydrogenase small subunit (EC 1.4.99.1) compare
PfGW456L13_1151 -3.9 -10.9 Dethiobiotin synthetase (EC 6.3.3.3) compare
PfGW456L13_1148 -3.9 -17.6 8-amino-7-oxononanoate synthase (EC 2.3.1.47) compare
PfGW456L13_275 -3.9 -2.6 3-dehydroquinate synthase (EC 4.2.3.4) compare
PfGW456L13_4740 -3.9 -13.3 Phosphoenolpyruvate carboxylase (EC 4.1.1.31) compare
PfGW456L13_350 -3.8 -5.8 Protein export cytoplasm chaperone protein (SecB, maintains protein to be exported in unfolded state) compare
PfGW456L13_793 -3.7 -4.2 Acetylglutamate kinase (EC 2.7.2.8) compare
PfGW456L13_811 -3.7 -5.7 Leucine-responsive regulatory protein, regulator for leucine (or lrp) regulon and high-affinity branched-chain amino acid transport system compare
PfGW456L13_4594 -3.7 -15.8 Pca regulon regulatory protein PcaR conserved
PfGW456L13_2230 -3.6 -8.5 Cys regulon transcriptional activator CysB compare
PfGW456L13_4041 -3.5 -2.4 Enoyl-CoA hydratase (EC 4.2.1.17) / Delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase (EC 5.3.3.8) / 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35) / 3-hydroxybutyryl-CoA epimerase (EC 5.1.2.3) compare
PfGW456L13_1147 -3.5 -15.2 Biotin synthase (EC 2.8.1.6) compare
PfGW456L13_3894 -3.5 -2.2 Integration host factor alpha subunit compare
PfGW456L13_1574 -3.5 -4.1 GTP-binding and nucleic acid-binding protein YchF compare
PfGW456L13_2551 -3.4 -3.8 Cell division trigger factor (EC 5.2.1.8) compare
PfGW456L13_4854 -3.4 -9.1 2-isopropylmalate synthase (EC 2.3.3.13) compare
PfGW456L13_2552 -3.4 -8.4 ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) compare
PfGW456L13_2623 -3.4 -2.9 NADH-ubiquinone oxidoreductase chain L (EC 1.6.5.3) compare
PfGW456L13_427 -3.4 -2.3 Two-component system response regulator OmpR compare
PfGW456L13_4585 -3.4 -4.1 Beta-ketoadipate enol-lactone hydrolase (EC 3.1.1.24) compare
PfGW456L13_3535 -3.4 -2.1 membrane protein, putative compare
PfGW456L13_276 -3.4 -1.5 Shikimate kinase I (EC 2.7.1.71) compare
PfGW456L13_1150 -3.4 -15.4 Biotin synthesis protein BioC compare
PfGW456L13_1044 -3.3 -12.5 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62) compare
PfGW456L13_5006 -3.3 -2.3 Uncharacterized ABC transporter, periplasmic component YrbD compare
PfGW456L13_5067 -3.3 -12.3 Ornithine decarboxylase (EC 4.1.1.17) / Arginine decarboxylase (EC 4.1.1.19) compare
PfGW456L13_5086 -3.3 -4.9 tRNA pseudouridine synthase B (EC 4.2.1.70) compare
PfGW456L13_329 -3.2 -5.3 Histidine utilization repressor compare
PfGW456L13_3179 -3.2 -5.6 Organic hydroperoxide resistance transcriptional regulator compare
PfGW456L13_4012 -3.2 -3.1 VacJ-like lipoprotein precursor compare
PfGW456L13_2035 -3.2 -10.1 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I / Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2) compare
PfGW456L13_1845 -3.2 -5.2 Cold shock protein CspC compare
PfGW456L13_1553 -3.2 -9.5 Carbonic anhydrase (EC 4.2.1.1) compare
PfGW456L13_1863 -3.1 -10.4 Quinolinate synthetase (EC 2.5.1.72) compare
PfGW456L13_1911 -3.1 -10.7 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) compare
PfGW456L13_4040 -3.1 -3.5 3-ketoacyl-CoA thiolase (EC 2.3.1.16) @ Acetyl-CoA acetyltransferase (EC 2.3.1.9) compare
PfGW456L13_4842 -3.1 -2.1 Translation elongation factor LepA compare
PfGW456L13_3825 -3.1 -4.2 Aromatic hydrocarbon utilization transcriptional regulator CatR (LysR family) compare
PfGW456L13_4288 -3.1 -14.3 Kynureninase (EC 3.7.1.3) (from data) conserved
PfGW456L13_4592 -3.0 -7.3 3-oxoadipate CoA-transferase subunit A (EC 2.8.3.6) (from data) conserved
PfGW456L13_4038 -3.0 -3.0 DNA topoisomerase I (EC 5.99.1.2) compare
PfGW456L13_3181 -3.0 -3.1 Organic hydroperoxide resistance protein compare
PfGW456L13_3824 -3.0 -3.8 Muconate cycloisomerase (EC 5.5.1.1) compare
PfGW456L13_4145 -3.0 -7.3 Para-aminobenzoate synthase, amidotransferase component (EC 2.6.1.85) compare
PfGW456L13_1615 -2.8 -1.9 Probable transmembrane protein compare
PfGW456L13_1198 -2.7 -4.4 Bis(5'-nucleosyl)-tetraphosphatase, symmetrical (EC 3.6.1.41) compare
PfGW456L13_784 -2.7 -7.3 Ribonuclease PH (EC 2.7.7.56) compare
PfGW456L13_62 -2.7 -1.6 hypothetical protein compare
PfGW456L13_5005 -2.6 -5.0 Uncharacterized ABC transporter, auxiliary component YrbC compare
PfGW456L13_5060 -2.6 -5.9 Peptide chain release factor 3 compare
PfGW456L13_1973 -2.6 -7.0 Arginine N-succinyltransferase (EC 2.3.1.109) compare
PfGW456L13_4162 -2.6 -4.0 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase (EC 1.13.11.54) compare
PfGW456L13_4476 -2.6 -3.9 Allophanate hydrolase 2 subunit 2 (EC 3.5.1.54) compare
PfGW456L13_2885 -2.5 -7.4 BarA-associated response regulator UvrY (= GacA = SirA) compare
PfGW456L13_5017 -2.5 -3.7 Hypothetical ATP-binding protein UPF0042, contains P-loop compare
PfGW456L13_66 -2.5 -1.9 Cobalt-precorrin-8x methylmutase (EC 5.4.1.2) compare
PfGW456L13_949 -2.5 -10.9 Threonine dehydratase biosynthetic (EC 4.3.1.19) compare
PfGW456L13_751 -2.5 -4.4 cytosolic long-chain acyl-CoA thioester hydrolase family protein compare
PfGW456L13_2029 -2.4 -12.5 BarA sensory histidine kinase (= VarS = GacS) compare
PfGW456L13_4165 -2.4 -3.8 Chorismate synthase (EC 4.2.3.5) compare
PfGW456L13_5150 -2.4 -3.5 Exodeoxyribonuclease V alpha chain (EC 3.1.11.5) compare
PfGW456L13_1735 -2.4 -4.1 Glycerol uptake facilitator protein compare
PfGW456L13_3823 -2.4 -7.1 Muconolactone isomerase (EC 5.3.3.4) (from data) conserved
PfGW456L13_2103 -2.4 -5.4 Phosphate:acyl-ACP acyltransferase PlsX compare
PfGW456L13_3808 -2.4 -3.5 Predicted transcriptional regulator of NADH dehydrogenase, Rrf2 family compare
PfGW456L13_2632 -2.3 -2.7 NADH-ubiquinone oxidoreductase chain B (EC 1.6.5.3) compare
PfGW456L13_4598 -2.3 -1.4 Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) compare
PfGW456L13_1453 -2.3 -8.9 Glutathione-regulated potassium-efflux system ATP-binding protein compare
PfGW456L13_1981 -2.2 -5.6 Aspartokinase (EC 2.7.2.4) compare
PfGW456L13_4088 -2.2 -3.0 Transcriptional regulator, GntR family compare
PfGW456L13_4961 -2.2 -6.8 Fumarylacetoacetase (EC 3.7.1.2) compare
PfGW456L13_1612 -2.2 -3.5 FIG00956396: hypothetical protein compare
PfGW456L13_1763 -2.2 -4.2 FxsA protein compare
PfGW456L13_1580 -2.1 -7.6 FIG140336: TPR domain protein compare
PfGW456L13_2221 -2.1 -10.1 ErfK/YbiS/YcfS/YnhG family protein compare
PfGW456L13_4293 -2.1 -7.5 Kynurenine formamidase, bacterial (EC 3.5.1.9) (from data) conserved
PfGW456L13_600 -2.1 -6.9 Zinc ABC transporter, inner membrane permease protein ZnuB compare
PfGW456L13_4009 -2.0 -8.8 Transaldolase (EC 2.2.1.2) compare
PfGW456L13_360 -2.0 -2.3 FIG00956267: hypothetical protein compare
PfGW456L13_3299 -2.0 -3.2 FIG00954580: hypothetical protein compare
PfGW456L13_4170 -2.0 -4.9 Isochorismatase (EC 3.3.2.1) compare
PfGW456L13_2856 -2.0 -2.9 ChlI component of cobalt chelatase involved in B12 biosynthesis compare
PfGW456L13_5096 -2.0 -2.3 FIG004454: RNA binding protein compare
PfGW456L13_926 -1.9 -6.7 glutamine synthetase family protein compare
PfGW456L13_4289 -1.9 -7.7 Leucine-responsive regulatory protein, regulator for leucine (or lrp) regulon and high-affinity branched-chain amino acid transport system conserved
PfGW456L13_430 -1.9 -8.4 Glutamate--cysteine ligase (EC 6.3.2.2) compare
PfGW456L13_4591 -1.9 -3.0 3-oxoadipate CoA-transferase subunit B (EC 2.8.3.6) (from data) compare
PfGW456L13_4125 -1.9 -2.7 Phosphoadenylyl-sulfate reductase [thioredoxin] (EC 1.8.4.8) / Adenylyl-sulfate reductase [thioredoxin] (EC 1.8.4.10) compare
PfGW456L13_4292 -1.9 -4.3 Tryptophan 2,3-dioxygenase (EC 1.13.11.11) (from data) conserved
PfGW456L13_1852 -1.9 -6.0 Holliday junction DNA helicase RuvA compare
PfGW456L13_5008 -1.9 -2.4 Uncharacterized ABC transporter, ATP-binding protein YrbF compare
PfGW456L13_322 -1.9 -3.9 Histidine ABC transporter, ATP-binding protein (TC 3.A.1) compare
PfGW456L13_3305 -1.8 -3.7 BatD compare
PfGW456L13_874 -1.8 -11.7 Polyphosphate kinase (EC 2.7.4.1) compare
PfGW456L13_4946 -1.8 -2.1 hypothetical protein compare
PfGW456L13_2237 -1.8 -3.0 Organic hydroperoxide resistance transcriptional regulator compare
PfGW456L13_902 -1.8 -8.5 Aminomethyltransferase (glycine cleavage system T protein) (EC 2.1.2.10) compare
PfGW456L13_726 -1.7 -6.3 Phosphogluconate repressor HexR, RpiR family compare
PfGW456L13_4579 -1.7 -7.1 Transcription repressor of multidrug efflux pump acrAB operon, TetR (AcrR) family compare
PfGW456L13_1067 -1.7 -2.7 FIG00955006: hypothetical protein compare
PfGW456L13_2556 -1.7 -2.2 Peptidyl-prolyl cis-trans isomerase PpiD (EC 5.2.1.8) compare
PfGW456L13_1584 -1.7 -3.6 Molybdopterin biosynthesis protein MoeB compare
PfGW456L13_468 -1.7 -1.6 FIG00953394: hypothetical protein compare
PfGW456L13_4451 -1.7 -5.2 ATP-dependent RNA helicase SrmB compare
PfGW456L13_2553 -1.7 -6.4 ATP-dependent Clp protease ATP-binding subunit ClpX compare
PfGW456L13_3822 -1.7 -6.0 Catechol 1,2-dioxygenase (EC 1.13.11.1) (from data) conserved
PfGW456L13_2768 -1.7 -3.3 FIG00959468: hypothetical protein compare
PfGW456L13_140 -1.7 -3.0 FIG003573: hypothetical protein compare
PfGW456L13_426 -1.6 -6.0 Osmolarity sensory histidine kinase EnvZ compare
PfGW456L13_777 -1.6 -9.1 Nucleoside-diphosphate-sugar epimerases compare
PfGW456L13_3300 -1.6 -8.3 MoxR-like ATPase in aerotolerance operon compare
PfGW456L13_4944 -1.6 -1.1 FIG00963370: hypothetical protein compare
PfGW456L13_2636 -1.6 -3.6 FIG002776: hypothetical protein compare
PfGW456L13_4478 -1.6 -3.2 Lactam utilization protein LamB compare
PfGW456L13_1009 -1.6 -2.2 Integral membrane protein YggT, involved in response to extracytoplasmic stress (osmotic shock) compare
PfGW456L13_4171 -1.6 -2.5 FIG00956876: hypothetical protein compare
PfGW456L13_4576 -1.6 -2.1 Transcriptional regulator, ArsR family compare
PfGW456L13_4819 -1.6 -4.2 ABC-type sugar transport systems, ATPase components compare
PfGW456L13_67 -1.5 -4.0 Cobalamin biosynthesis protein CobG compare
PfGW456L13_2436 -1.5 -4.2 Phenylacetic acid degradation operon negative regulatory protein PaaX compare
PfGW456L13_111 -1.5 -2.8 Urease accessory protein UreE compare
PfGW456L13_852 -1.5 -1.4 FIG00954215: hypothetical protein compare
PfGW456L13_213 -1.5 -9.7 Glutamate-ammonia-ligase adenylyltransferase (EC 2.7.7.42) compare
PfGW456L13_4512 -1.5 -4.9 Exported zinc metalloprotease YfgC precursor compare
PfGW456L13_2250 -1.4 -5.7 Probable protease htpX homolog (EC 3.4.24.-) compare
PfGW456L13_323 -1.4 -4.3 Histidine ABC transporter, permease protein (TC 3.A.1) compare
PfGW456L13_1824 -1.4 -1.7 transcriptional regulator MvaT, P16 subunit compare
PfGW456L13_4113 -1.4 -6.8 FIG137360: hypothetical protein compare
PfGW456L13_4112 -1.4 -8.3 Phosphoenolpyruvate synthase (EC 2.7.9.2) compare
PfGW456L13_4042 -1.4 -2.1 FIG00953628: hypothetical protein compare
PfGW456L13_3704 -1.4 -2.3 Transcriptional regulator RpiR in protein degradation cluster compare
PfGW456L13_1139 -1.4 -7.4 Malate synthase G (EC 2.3.3.9) compare
PfGW456L13_3304 -1.4 -4.1 TPR domain protein in aerotolerance operon compare
PfGW456L13_1842 -1.3 -6.6 Outer membrane porin, OprD family compare
PfGW456L13_351 -1.3 -2.2 Glutaredoxin 3 (Grx3) compare
PfGW456L13_2084 -1.3 -1.4 MotA/TolQ/ExbB proton channel family protein compare
PfGW456L13_1525 -1.3 -5.6 Two-component sensor CbrA: intrcellular carbon:nitrogen balance compare
PfGW456L13_2597 -1.3 -3.8 Isovaleryl-CoA dehydrogenase (EC 1.3.8.4) compare
PfGW456L13_1975 -1.3 -2.8 Succinylarginine dihydrolase (EC 3.5.3.23) compare
PfGW456L13_2739 -1.3 -6.6 Anthranilate 1,2-dioxygenase (deaminating, decarboxylating) (EC 1.14.12.1) (from data) conserved
PfGW456L13_4882 -1.3 -2.1 tRNA-guanine transglycosylase (EC 2.4.2.29) compare
PfGW456L13_558 -1.3 -2.1 NAD(P) transhydrogenase subunit beta (EC 1.6.1.2) compare


Specific Phenotypes

For 19 genes in this experiment

For carbon source L-Tryptophan in Pseudomonas fluorescens GW456-L13

For carbon source L-Tryptophan across organisms