Experiment set2IT074 for Escherichia coli BW25113

Compare to:

LB with 5-Hydroxymethylfurfural 20 mM

200 most important genes:

  gene name fitness t score description  
b0145 dksA -3.2 -2.2 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b2620 smpB -2.8 -2.7 SsrA-binding protein (NCBI) compare
b0082 mraW -2.8 -3.7 S-adenosyl-methyltransferase (NCBI) compare
b3199 yrbK -2.6 -2.8 hypothetical protein (NCBI) compare
b0630 lipB -2.3 -2.6 protein of lipoate biosynthesis (VIMSS) compare
b3792 wzxE -2.3 -7.7 O-antigen translocase (NCBI) compare
b4436 ryeC -2.2 -1.5 Novel sRNA, function unknown; paralogous to the other QUAD sRNA genes unknown (RefSeq) compare
b3341 rpsG -2.2 -1.5 30S ribosomal protein S7 (NCBI) compare
b4704 arrS -2.2 -1.5 Antisense sRNA ArrS, function unknown (NCBI) compare
b3021 ygiT -2.2 -3.7 predicted DNA-binding transcriptional regulator (NCBI) compare
b0949 uup -2.1 -7.5 fused predicted transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b1514 lsrC -2.1 -1.9 AI2 transporter (NCBI) compare
b2688 gshA -2.0 -6.8 glutamate--cysteine ligase (NCBI) compare
b2808 gcvA -2.0 -4.7 DNA-binding transcriptional dual regulator (NCBI) compare
b2894 xerD -2.0 -1.3 site-specific tyrosine recombinase XerD (NCBI) compare
b3778 rep -2.0 -6.9 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b2820 recB -1.9 -1.3 exonuclease V (RecBCD complex), beta subunit (NCBI) compare
b0705 ybfL -1.9 -3.7 putative receptor protein (VIMSS) compare
b1863 ruvC -1.8 -3.5 Holliday junction resolvase (NCBI) compare
b2236 yfaE -1.8 -3.0 predicted 2Fe-2S cluster-containing protein (NCBI) compare
b2567 rnc -1.8 -2.0 ribonuclease III (NCBI) compare
b2938 speA -1.8 -8.5 arginine decarboxylase (NCBI) compare
b1860 ruvB -1.8 -2.0 Holliday junction DNA helicase B (NCBI) compare
b3121 yhaC -1.8 -2.3 hypothetical protein (NCBI) compare
b1650 nemA -1.8 -3.1 N-ethylmaleimide reductase, FMN-linked (NCBI) compare
b1286 rnb -1.7 -3.3 exoribonuclease II (NCBI) compare
b2699 recA -1.7 -1.9 recombinase A (NCBI) compare
b3871 bipA -1.7 -8.3 GTP-binding protein (NCBI) compare
b1063 yceB -1.7 -2.7 predicted lipoprotein (NCBI) compare
b0118 acnB -1.7 -2.9 aconitate hydratase (NCBI) compare
b2937 speB -1.6 -5.8 agmatinase (NCBI) compare
b4546 ypeB -1.6 -1.6 hypothetical protein (NCBI) compare
b3741 gidA -1.6 -5.8 glucose-inhibited division protein A (NCBI) compare
b0683 fur -1.6 -2.0 ferric uptake regulator (NCBI) compare
b2569 lepA -1.6 -3.4 GTP-binding protein LepA (NCBI) compare
b2318 truA -1.6 -3.6 tRNA pseudouridine synthase A (NCBI) compare
b0431 cyoB -1.6 -7.5 cytochrome o ubiquinol oxidase subunit I (NCBI) compare
b0142 folK -1.6 -1.3 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) compare
b1499 ydeO -1.6 -2.7 predicted DNA-binding transcriptional acfivator (NCBI) compare
b2830 nudH -1.6 -1.8 dinucleoside polyphosphate hydrolase (NCBI) compare
b1861 ruvA -1.6 -2.2 Holliday junction DNA helicase motor protein (NCBI) compare
b3935 priA -1.6 -2.7 primosome assembly protein PriA (NCBI) compare
b1685 ydiH -1.6 -1.5 predicted protein (RefSeq) compare
b0428 cyoE -1.6 -4.8 protoheme IX farnesyltransferase (NCBI) compare
b1001 yccE -1.5 -2.8 hypothetical protein (NCBI) compare
b0432 cyoA -1.5 -7.2 cytochrome o ubiquinol oxidase subunit II (NCBI) compare
b3781 trxA -1.5 -3.3 thioredoxin 1 (VIMSS) compare
b0088 murD -1.5 -1.4 UDP-N-acetylmuramoyl-L-alanyl-D-glutamatesynthetase (NCBI) compare
b0726 sucA -1.4 -2.7 alpha-ketoglutarate decarboxylase (NCBI) compare
b0407 yajC -1.4 -2.7 preprotein translocase subunit YajC (NCBI) compare
b1865 nudB -1.4 -1.2 dATP pyrophosphohydrolase (NCBI) compare
b0857 potI -1.4 -2.8 putrescine transporter subunit: membrane component of ABC superfamily (NCBI) compare
b1493 gadB -1.4 -1.9 glutamate decarboxylase B, PLP-dependent (NCBI) compare
b2784 relA -1.4 -6.4 (p)ppGpp synthetase I/GTP pyrophosphokinase (NCBI) compare
b2055 wcaE -1.4 -2.2 predicted glycosyl transferase (NCBI) compare
b2822 recC -1.4 -4.0 exonuclease V (RecBCD complex), gamma chain (NCBI) compare
b1279 yciS -1.4 -1.5 conserved inner membrane protein (NCBI) compare
b2114 metG -1.3 -1.2 methionyl-tRNA synthetase (NCBI) compare
b1576 ydfD -1.3 -2.4 Qin prophage; predicted protein (NCBI) compare
b0957 ompA -1.3 -3.2 outer membrane protein A (3a;II*;G;d) (NCBI) compare
b0890 ftsK -1.3 -5.3 DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) compare
b3504 yhiS -1.3 -2.8 hypothetical protein (RefSeq) compare
b3858 yihD -1.3 -1.7 hypothetical protein (NCBI) compare
b2330 yfcB -1.3 -2.2 putative adenine-specific methylase (VIMSS) compare
b3706 trmE -1.3 -4.1 tRNA modification GTPase (NCBI) compare
b3472 b3472 -1.3 -5.0 orf, hypothetical protein (VIMSS) compare
b4172 hfq -1.2 -1.7 RNA-binding protein Hfq (NCBI) compare
b2279 nuoK -1.2 -1.9 NADH dehydrogenase subunit K (NCBI) compare
b1651 gloA -1.2 -2.5 glyoxalase I, Ni-dependent (NCBI) compare
b4375 prfC -1.2 -4.7 peptide chain release factor 3 (NCBI) compare
b1104 ycfL -1.2 -1.6 hypothetical protein (NCBI) compare
b0605 ahpC -1.2 -4.3 alkyl hydroperoxide reductase, C22 subunit (NCBI) compare
b3164 pnp -1.2 -2.0 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b2532 yfhQ -1.2 -2.8 predicted methyltransferase (NCBI) compare
b1551 b1551 -1.2 -1.9 orf, hypothetical protein (VIMSS) compare
b2847 yqeI -1.2 -5.2 predicted transcriptional regulator (NCBI) compare
b3463 ftsE -1.2 -3.2 predicted transporter subunit: ATP-binding component of ABC superfamily (NCBI) compare
b2935 tktA -1.2 -2.1 transketolase 1, thiamin-binding (NCBI) compare
b2506 yfgI -1.2 -1.9 hypothetical protein (NCBI) compare
b1258 yciF -1.2 -2.8 hypothetical protein (NCBI) compare
b2576 srmB -1.2 -2.7 ATP-dependent RNA helicase (NCBI) compare
b4509 ylcG -1.2 -1.6 DLP12 prophage; predicted protein (NCBI) compare
b0888 trxB -1.2 -2.5 thioredoxin reductase, FAD/NAD(P)-binding (NCBI) compare
b3658 selC -1.1 -2.0 tRNA-Sec (NCBI) compare
b2110 yehC -1.1 -2.9 predicted periplasmic pilin chaperone (NCBI) compare
b0053 surA -1.1 -3.2 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b1058 yceO -1.1 -1.5 hypothetical protein (NCBI) compare
b0603 ybdO -1.1 -2.6 predicted DNA-binding transcriptional regulator (NCBI) compare
b4279 yjhB -1.1 -2.2 putative transport protein (VIMSS) compare
b0232 yafN -1.1 -1.0 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b1728 ydjM -1.1 -2.2 predicted inner membrane protein regulated by LexA (RefSeq) compare
b4627 ykfL -1.1 -2.0 no description compare
b3863 polA -1.1 -1.0 DNA polymerase I (NCBI) compare
b1176 minC -1.1 -2.7 septum formation inhibitor (NCBI) compare
b2650 ypjC -1.1 -1.8 hypothetical protein (RefSeq) compare
b0430 cyoC -1.1 -2.4 cytochrome o ubiquinol oxidase subunit III (NCBI) compare
b3500 gor -1.1 -1.0 glutathione reductase (NCBI) compare
b2642 yfjW -1.1 -2.2 CP4-57 prophage; predicted inner membrane protein (NCBI) compare
b2209 eco -1.1 -2.1 ecotin precursor (NCBI) compare
b3261 fis -1.1 -2.1 DNA-binding protein Fis (NCBI) compare
b0406 tgt -1.1 -4.3 queuine tRNA-ribosyltransferase (NCBI) compare
b1731 cedA -1.0 -2.1 cell division modulator (RefSeq) compare
b3950 frwB -1.0 -1.8 predicted enzyme IIB component of PTS (NCBI) compare
b1167 ymgC -1.0 -1.7 hypothetical protein (NCBI) compare
b4552 yrhC -1.0 -1.0 no description compare
b4201 priB -1.0 -1.8 primosomal replication protein N (NCBI) compare
b3609 secB -1.0 -1.9 export protein SecB (NCBI) compare
b2553 glnB -1.0 -3.0 regulatory protein P-II for glutamine synthetase (NCBI) compare
b1130 phoP -1.0 -4.1 DNA-binding response regulator in two-component regulatory system with PhoQ (NCBI) compare
b1269 rluB -1.0 -2.5 23S rRNA pseudouridylate synthase (NCBI) compare
b1686 ydiI -1.0 -1.5 hypothetical protein (NCBI) compare
b1730 ydjO -1.0 -1.8 predicted protein (RefSeq) compare
b2352 yfdI -0.9 -2.9 CPS-53 (KpLE1) prophage; predicted inner membrane protein (NCBI) compare
b1663 mdtK -0.9 -3.5 multidrug efflux protein NorM (NCBI) compare
b1085 b1085 -0.9 -1.7 orf, hypothetical protein (VIMSS) compare
b3146 yraL -0.9 -3.9 predicted methyltransferase (NCBI) compare
b4094 phnN -0.9 -2.6 ribose 1,5-bisphosphokinase (NCBI) compare
b3839 tatC -0.9 -4.8 TatABCE protein translocation system subunit (NCBI) compare
b4585 sroB -0.9 -0.9 Novel sRNA, function unknown (RefSeq) compare
b0738 tolR -0.9 -2.2 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b2912 ygfA -0.9 -1.8 putative ligase (VIMSS) compare
b4177 purA -0.9 -1.8 adenylosuccinate synthetase (NCBI) compare
b2824 ygdB -0.9 -1.8 orf, hypothetical protein (VIMSS) compare
b2635 ypjK -0.9 -1.4 CP4-57 prophage; predicted inner membrane protein (NCBI) compare
b2625 yfjI -0.9 -3.6 CP4-57 prophage; predicted protein (NCBI) compare
b1231 tyrT -0.9 -0.9 tRNA-Tyr (NCBI) compare
b3026 qseC -0.9 -2.7 sensory histidine kinase in two-component regulatory system with QseB (NCBI) compare
b0739 tolA -0.9 -2.5 cell envelope integrity inner membrane protein TolA (NCBI) compare
b3462 ftsX -0.9 -3.5 predicted transporter subunit: membrane component of ABC superfamily (NCBI) compare
b4128 yjdK -0.9 -2.8 hypothetical protein (NCBI) compare
b1919 yedO -0.9 -2.2 putative 1-aminocyclopropane-1-carboxylate deaminase (VIMSS) compare
b0999 cbpM -0.9 -1.8 modulator of CbpA co-chaperone (NCBI) compare
b2287 nuoB -0.9 -2.3 NADH dehydrogenase subunit B (NCBI) compare
b0472 recR -0.9 -3.9 recombination protein RecR (NCBI) compare
b3652 recG -0.9 -4.8 ATP-dependent DNA helicase (NCBI) compare
b1259 yciG -0.9 -1.5 orf, hypothetical protein (VIMSS) compare
b3002 yqhA -0.9 -1.4 hypothetical protein (NCBI) compare
b1977 asnT -0.8 -1.6 tRNA-Asn (NCBI) compare
b1358 ydaT -0.8 -1.3 Rac prophage; predicted protein (NCBI) compare
b4402 yjjY -0.8 -0.9 hypothetical protein (NCBI) compare
b0784 moaD -0.8 -1.5 molybdopterin synthase, small subunit (NCBI) compare
b4571 wbbL -0.8 -2.2 no description compare
b0149 mrcB -0.8 -5.4 penicillin-binding protein 1b (NCBI) compare
b1409 ynbB -0.8 -2.8 predicted CDP-diglyceride synthase (NCBI) compare
b1446 ydcY -0.8 -1.0 hypothetical protein (NCBI) compare
b0767 ybhE -0.8 -2.1 6-phosphogluconolactonase (NCBI) compare
b0028 fkpB -0.8 -2.8 FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase) (NCBI) compare
b3619 rfaD -0.8 -2.1 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b0014 dnaK -0.8 -1.1 molecular chaperone DnaK (NCBI) compare
b2518 ndk -0.8 -1.4 nucleoside diphosphate kinase (NCBI) compare
b1426 ydcH -0.8 -0.9 orf, hypothetical protein (VIMSS) compare
b4152 frdC -0.8 -2.4 fumarate reductase subunit C (NCBI) compare
b4497 yeeL -0.8 -3.1 no description compare
b1853 yebK -0.8 -1.4 predicted DNA-binding transcriptional regulator (NCBI) compare
b0527 ybcI -0.8 -2.3 conserved inner membrane protein (NCBI) compare
b0500 ybbD -0.8 -1.4 hypothetical protein (RefSeq) compare
b4631 ykgQ -0.8 -0.9 no description compare
b1497 b1497 -0.8 -2.1 putative enzyme (VIMSS) compare
b3163 nlpI -0.8 -2.4 hypothetical protein (NCBI) compare
b4508 peaD -0.8 -1.7 putative sensory transduction regulator (VIMSS) compare
b0405 queA -0.8 -2.8 S-adenosylmethionine:tRNA ribosyltransferase-isomerase (NCBI) compare
b3387 dam -0.8 -4.9 DNA adenine methylase (NCBI) compare
b4441 glmY -0.8 -1.1 sRNA activator of glmS mRNA (RefSeq) compare
b4151 frdD -0.8 -1.5 fumarate reductase subunit D (NCBI) compare
b4146 yjeK -0.8 -1.7 predicted lysine aminomutase (NCBI) compare
b0113 pdhR -0.7 -2.2 transcriptional regulator of pyruvate dehydrogenase complex (NCBI) compare
b1830 prc -0.7 -2.7 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b2579 yfiD -0.7 -1.3 pyruvate formate lyase subunit (NCBI) compare
b0627 tatE -0.7 -1.0 twin arginine translocase protein E (NCBI) compare
b0471 ybaB -0.7 -1.7 hypothetical protein (NCBI) compare
b0724 sdhB -0.7 -2.5 succinate dehydrogenase, FeS subunit (NCBI) compare
b3183 obgE -0.7 -0.9 GTPase involved in cell partioning and DNA repair (NCBI) compare
b4592 yccB -0.7 -1.0 hypothetical protein (RefSeq) compare
b2947 gshB -0.7 -2.2 glutathione synthetase (NCBI) compare
b4042 dgkA -0.7 -1.7 diacylglycerol kinase (NCBI) compare
b4058 uvrA -0.7 -5.3 excinuclease ABC subunit A (NCBI) compare
b2393 nupC -0.7 -2.8 nucleoside (except guanosine) transporter (NCBI) compare
b3493 pitA -0.7 -3.7 phosphate transporter, low-affinity (NCBI) compare
b1238 tdk -0.7 -3.4 thymidine kinase (NCBI) compare
b0721 sdhC -0.7 -2.2 succinate dehydrogenase cytochrome b556 large membrane subunit (NCBI) compare
b1567 intK -0.7 -1.4 Qin prophage; predicted protein (RefSeq) compare
b2959 yggL -0.7 -1.9 orf, hypothetical protein (VIMSS) compare
b0222 lpcA -0.7 -1.5 phosphoheptose isomerase (NCBI) compare
b4598 yncL -0.7 -1.2 hypothetical protein (RefSeq) compare
b1989 asnV -0.7 -1.4 tRNA-Asn (NCBI) compare
b4480 hdfR -0.7 -2.6 transcriptional regulator HdfR (NCBI) compare
b3780 rhlB -0.7 -4.4 ATP-dependent RNA helicase (NCBI) compare
b0806 ybiM -0.7 -1.5 orf, hypothetical protein (VIMSS) compare
b1179 ycgL -0.7 -1.4 conserved protein (NCBI) compare
b2510 b2510 -0.7 -2.1 orf, hypothetical protein (VIMSS) compare
b0226 dinJ -0.7 -1.5 predicted antitoxin of YafQ-DinJ toxin-antitoxin system (NCBI) compare
b0051 ksgA -0.7 -2.6 dimethyladenosine transferase (NCBI) compare
b3348 slyX -0.7 -1.8 hypothetical protein (NCBI) compare
b4239 treC -0.7 -2.3 trehalose-6-P hydrolase (NCBI) compare
b4203 rplI -0.7 -1.5 50S ribosomal protein L9 (NCBI) compare
b0436 tig -0.7 -3.4 trigger factor (NCBI) compare
b1691 ydiN -0.7 -3.4 predicted transporter (RefSeq) compare
b1505 ydeT -0.7 -2.6 hypothetical protein (RefSeq) compare
b2021 hisC -0.7 -2.4 histidinol-phosphate aminotransferase (NCBI) compare
b4188 yjfN -0.7 -2.0 orf, hypothetical protein (VIMSS) compare


Specific Phenotypes

None in this experiment

For Escherichia coli BW25113 in stress experiments

For stress 5-Hydroxymethylfurfural across organisms