Experiment set2IT058 for Escherichia coli BW25113

Compare to:

LB with Chloramphenicol 0.005 mg/ml

200 most important genes:

  gene name fitness t score description  
b1070 flgN -3.2 -1.5 export chaperone for FlgK and FlgL (NCBI) compare
b4585 sroB -3.0 -1.4 Novel sRNA, function unknown (RefSeq) compare
b2258 b2258 -3.0 -1.4 putative transport/receptor protein (VIMSS) compare
b4603 rseX -2.8 -1.3 sRNA regulating ompA and ompC translation, with Hfq (RefSeq) compare
b0249 ykfF -2.7 -1.7 CP4-6 prophage; predicted protein (NCBI) compare
b3082 ygjM -2.6 -2.5 predicted DNA-binding transcriptional regulator (NCBI) compare
b1765 ydjA -2.5 -1.1 predicted oxidoreductase (NCBI) compare
b1161 ycgX -2.5 -2.4 hypothetical protein (NCBI) compare
b4402 yjjY -2.4 -1.6 hypothetical protein (NCBI) compare
b1514 lsrC -2.3 -2.1 AI2 transporter (NCBI) compare
b2597 yfiA -2.3 -1.9 cold shock protein associated with 30S ribosomal subunit (NCBI) compare
b1576 ydfD -2.3 -3.3 Qin prophage; predicted protein (NCBI) compare
b3021 ygiT -2.2 -4.1 predicted DNA-binding transcriptional regulator (NCBI) compare
b1074 flgC -2.2 -2.0 flagellar basal-body rod protein C (NCBI) compare
b1977 asnT -2.1 -2.3 tRNA-Asn (NCBI) compare
b2567 rnc -2.1 -1.9 ribonuclease III (NCBI) compare
b2330 yfcB -2.1 -2.7 putative adenine-specific methylase (VIMSS) compare
b0881 clpS -2.0 -2.1 ATP-dependent Clp protease adaptor protein ClpS (NCBI) compare
b1130 phoP -1.8 -5.4 DNA-binding response regulator in two-component regulatory system with PhoQ (NCBI) compare
b1357 ydaS -1.8 -2.3 Rac prophage; predicted DNA-binding transcriptional regulator (NCBI) compare
b0737 tolQ -1.8 -3.4 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b1273 yciN -1.8 -2.3 hypothetical protein (NCBI) compare
b4426 isrA -1.8 -3.0 unknown RNA (NCBI) compare
b1286 rnb -1.8 -3.0 exoribonuclease II (NCBI) compare
b0357 yaiN -1.8 -2.2 putative alpha helix chain (VIMSS) compare
b1263 trpD -1.7 -2.1 bifunctional indole-3-glycerol-phosphate synthase/anthranilate phosphoribosyltransferase (NCBI) compare
b3163 nlpI -1.7 -3.9 hypothetical protein (NCBI) compare
b3725 pstB -1.7 -2.4 phosphate transporter subunit (NCBI) compare
b1842 holE -1.7 -2.3 DNA polymerase III, theta subunit (NCBI) compare
b3636 rpmG -1.7 -2.1 50S ribosomal protein L33 (NCBI) compare
b1515 lsrD -1.6 -3.2 AI2 transporter (NCBI) compare
b1013 ycdC -1.6 -2.5 predicted DNA-binding transcriptional regulator (NCBI) compare
b2617 smpA -1.6 -3.1 small membrane protein A (VIMSS) compare
b2024 hisA -1.6 -2.3 N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-imidazolecarboxamide isomerase (VIMSS) compare
b4045 yjbJ -1.5 -1.6 predicted stress response protein (NCBI) compare
b3504 yhiS -1.5 -2.7 hypothetical protein (RefSeq) compare
b1383 ydbL -1.5 -1.9 orf, hypothetical protein (VIMSS) compare
b1358 ydaT -1.5 -1.3 Rac prophage; predicted protein (NCBI) compare
b1480 sra -1.5 -1.9 30S ribosomal subunit protein S22 (NCBI) compare
b2614 grpE -1.5 -0.9 heat shock protein (NCBI) compare
b4538 yoeF -1.5 -1.3 hypothetical protein (RefSeq) compare
b3035 tolC -1.4 -6.3 outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) compare
b2518 ndk -1.4 -2.0 nucleoside diphosphate kinase (NCBI) compare
b1984 asnW -1.4 -1.1 tRNA-Asn (NCBI) compare
b1531 marA -1.4 -2.5 multiple antibiotic resistance; transcriptional activator of defense systems (VIMSS) compare
b3164 pnp -1.4 -2.1 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b2820 recB -1.4 -2.2 exonuclease V (RecBCD complex), beta subunit (NCBI) compare
b1644 b1644 -1.4 -3.2 putative membrane protein (VIMSS) compare
b1545 pinQ -1.4 -1.2 Qin prophage; predicted site-specific recombinase (NCBI) compare
b4436 ryeC -1.4 -1.2 Novel sRNA, function unknown; paralogous to the other QUAD sRNA genes unknown (RefSeq) compare
b2055 wcaE -1.3 -2.6 predicted glycosyl transferase (NCBI) compare
b3842 rfaH -1.3 -3.8 transcriptional activator RfaH (NCBI) compare
b2287 nuoB -1.3 -2.6 NADH dehydrogenase subunit B (NCBI) compare
b1612 fumA -1.3 -3.0 fumarate hydratase (fumarase A), aerobic Class I (NCBI) compare
b3871 bipA -1.3 -7.0 GTP-binding protein (NCBI) compare
b4631 ykgQ -1.3 -1.1 no description compare
b0145 dksA -1.3 -2.7 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b1778 yeaA -1.3 -1.6 methionine sulfoxide reductase B (NCBI) compare
b0404 yajB -1.3 -2.9 hypothetical protein (NCBI) compare
b1382 ynbE -1.2 -1.4 predicted lipoprotein (NCBI) compare
b1129 phoQ -1.2 -4.9 sensory histidine kinase in two-compoent regulatory system with PhoP (NCBI) compare
b1063 yceB -1.2 -2.1 predicted lipoprotein (NCBI) compare
b0463 acrA -1.2 -5.4 multidrug efflux system (NCBI) compare
b1086 rluC -1.2 -4.1 23S rRNA pseudouridylate synthase (NCBI) conserved
b2506 yfgI -1.2 -1.6 hypothetical protein (NCBI) compare
b1685 ydiH -1.2 -1.0 predicted protein (RefSeq) compare
b0605 ahpC -1.2 -3.5 alkyl hydroperoxide reductase, C22 subunit (NCBI) compare
b3120 yhaB -1.2 -3.5 orf, hypothetical protein (VIMSS) compare
b1942 fliJ -1.2 -1.2 flagellar biosynthesis chaperone (NCBI) compare
b3741 gidA -1.2 -5.5 glucose-inhibited division protein A (NCBI) compare
b2990 hybG -1.2 -1.6 hydrogenase 2 accessory protein (NCBI) compare
b4458 oxyS -1.2 -0.9 global regulatory RNA (NCBI) compare
b1598 ydgD -1.2 -3.9 predicted peptidase (NCBI) compare
b4550 yhdL -1.1 -3.1 hypothetical protein (NCBI) compare
b4179 vacB -1.1 -5.3 putative enzyme (VIMSS) compare
b2969 yghE -1.1 -2.2 predicted secretion pathway protein, L-type protein (pseudogene) (RefSeq) compare
b1953 b1953 -1.1 -1.8 orf, hypothetical protein (VIMSS) compare
b2699 recA -1.1 -1.6 recombinase A (NCBI) compare
b1591 b1591 -1.1 -1.6 putative oxidoreductase component (VIMSS) compare
b2279 nuoK -1.1 -1.3 NADH dehydrogenase subunit K (NCBI) compare
b2804 fucU -1.1 -2.2 L-fucose mutarotase (NCBI) compare
b3463 ftsE -1.1 -3.2 predicted transporter subunit: ATP-binding component of ABC superfamily (NCBI) compare
b2025 hisF -1.1 -2.5 imidazole glycerol phosphate synthase subunit HisF (NCBI) compare
b1822 rrmA -1.1 -1.8 23S rRNA m1G745 methyltransferase (NCBI) compare
b1008 ycdI -1.1 -2.4 hypothetical protein (NCBI) compare
b1547 stfQ -1.1 -2.7 Qin prophage; predicted side tail fibre assembly protein (NCBI) compare
b0462 acrB -1.1 -6.8 multidrug efflux system protein (NCBI) compare
b1533 ydeD -1.1 -2.8 orf, hypothetical protein (VIMSS) compare
b3121 yhaC -1.1 -1.7 hypothetical protein (NCBI) compare
b0547 ybcN -1.1 -2.3 DLP12 prophage; predicted protein (NCBI) compare
b1792 yeaO -1.1 -1.9 orf, hypothetical protein (VIMSS) compare
b0178 hlpA -1.1 -2.3 periplasmic chaperone (NCBI) compare
b0957 ompA -1.1 -2.7 outer membrane protein A (3a;II*;G;d) (NCBI) compare
b1818 manY -1.0 -1.6 mannose-specific enzyme IIC component of PTS (NCBI) compare
b1085 b1085 -1.0 -1.5 orf, hypothetical protein (VIMSS) compare
b4573 insZ -1.0 -2.6 no description compare
b3462 ftsX -1.0 -4.4 predicted transporter subunit: membrane component of ABC superfamily (NCBI) compare
b1347 ydaC -1.0 -1.3 Rac prophage; predicted protein (NCBI) compare
b1120 cobB -1.0 -2.5 deacetylase of acs and cheY, regulates chemotaxis (NCBI) compare
b3784 rfe -1.0 -6.0 UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase (NCBI) compare
b2189 proL -1.0 -1.3 tRNA-Pro (NCBI) compare
b0500 ybbD -1.0 -0.9 hypothetical protein (RefSeq) compare
b3026 qseC -1.0 -3.3 sensory histidine kinase in two-component regulatory system with QseB (NCBI) compare
b0429 cyoD -1.0 -2.7 cytochrome o ubiquinol oxidase subunit IV (NCBI) compare
b1351 racC -1.0 -2.3 Rac prophage; predicted protein (NCBI) compare
b2058 wcaB -1.0 -0.7 predicted acyl transferase (NCBI) compare
b4613 dinQ -1.0 -1.0 Damage inducible, function unknown (RefSeq) compare
b1647 ydhF -1.0 -2.4 predicted oxidoreductase (NCBI) compare
b3068 ygjF -1.0 -1.5 G/U mismatch-specific DNA glycosylase (NCBI) compare
b1388 paaA -1.0 -2.3 predicted multicomponent oxygenase/reductase subunit for phenylacetic acid degradation (NCBI) compare
b1317 ycjU -1.0 -2.2 predicted beta-phosphoglucomutase (NCBI) compare
b4589 ylcI -1.0 -1.8 hypothetical protein (RefSeq) compare
b2650 ypjC -1.0 -1.6 hypothetical protein (RefSeq) compare
b1147 ymfL -1.0 -1.5 e14 prophage; predicted DNA-binding transcriptional regulator (RefSeq) compare
b2512 yfgL -1.0 -2.8 protein assembly complex, lipoprotein component (NCBI) compare
b3726 pstA -0.9 -4.0 phosphate transporter subunit (NCBI) compare
b3728 pstS -0.9 -3.0 phosphate transporter subunit (NCBI) compare
b2277 nuoM -0.9 -3.6 NADH dehydrogenase subunit M (NCBI) compare
b2447 yffP -0.9 -2.4 CPZ-55 prophage; predicted protein (NCBI) compare
b1257 yciE -0.9 -1.6 hypothetical protein (NCBI) compare
b0560 nohB -0.9 -1.3 DLP12 prophage; DNA packaging protein (NCBI) compare
b1361 ydaW -0.9 -0.8 orf, hypothetical protein (VIMSS) compare
b2188 yejM -0.9 -4.1 predicted hydrolase, inner membrane (NCBI) compare
b0729 sucD -0.9 -1.9 succinyl-CoA synthetase subunit alpha (NCBI) compare
b0440 hupB -0.9 -2.4 HU, DNA-binding transcriptional regulator, beta subunit (NCBI) compare
b1513 lsrA -0.9 -1.9 fused AI2 transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b3098 yqjD -0.9 -1.5 hypothetical protein (NCBI) compare
b2980 glcC -0.9 -2.9 DNA-binding transcriptional dual regulator, glycolate-binding (NCBI) compare
b2064 asmA -0.9 -3.1 predicted assembly protein (NCBI) compare
b3652 recG -0.9 -4.7 ATP-dependent DNA helicase (NCBI) compare
b1656 sodB -0.9 -1.7 superoxide dismutase, Fe (NCBI) compare
b0013 yaaI -0.9 -3.0 hypothetical protein (NCBI) compare
b4155 yjeA -0.9 -0.8 putative lysyl-tRNA synthetase (VIMSS) compare
b4454 rdlD -0.9 -2.8 sRNA antisense regulator affects LdrD translation; proposed addiction module in LDR-D repeat, with toxic peptide LdrD (RefSeq) compare
b3706 trmE -0.9 -3.7 tRNA modification GTPase (NCBI) compare
b1344 ydaO -0.9 -2.1 predicted C32 tRNA thiolase (NCBI) compare
b2822 recC -0.9 -3.0 exonuclease V (RecBCD complex), gamma chain (NCBI) compare
b4407 thiS -0.9 -1.2 sulfur carrier protein ThiS (NCBI) compare
b3414 gntY -0.9 -2.9 predicted gluconate transport associated protein (NCBI) compare
b0739 tolA -0.9 -2.5 cell envelope integrity inner membrane protein TolA (NCBI) compare
b1752 ydjZ -0.9 -1.2 conserved inner membrane protein (NCBI) compare
b1434 ydcN -0.9 -1.2 predicted DNA-binding transcriptional regulator (NCBI) compare
b1650 nemA -0.9 -1.9 N-ethylmaleimide reductase, FMN-linked (NCBI) compare
b4685 yrbN -0.9 -1.5 expressed protein (RefSeq) compare
b2236 yfaE -0.8 -1.7 predicted 2Fe-2S cluster-containing protein (NCBI) compare
b3195 yrbF -0.8 -4.5 predicted toluene transporter subunit: ATP-binding component of ABC superfamily (NCBI) compare
b0580 ybdJ -0.8 -1.4 predicted inner membrane protein (NCBI) compare
b4648 ysaC -0.8 -1.8 no description compare
b1658 purR -0.8 -2.7 DNA-binding transcriptional repressor, hypoxanthine-binding (NCBI) compare
b4462 ygaQ -0.8 -4.3 hypothetical protein (RefSeq) compare
b0232 yafN -0.8 -0.8 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b2569 lepA -0.8 -2.5 GTP-binding protein LepA (NCBI) compare
b3630 rfaP -0.8 -5.3 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b1368 ynaA -0.8 -2.2 Rac prophage; predicted tail protein (RefSeq) compare
b0976 hyaE -0.8 -1.8 protein involved in processing of HyaA and HyaB proteins (NCBI) compare
b1739 osmE -0.8 -1.6 DNA-binding transcriptional activator (NCBI) compare
b1290 sapF -0.8 -1.1 predicted antimicrobial peptide transporter subunit (NCBI) compare
b4679 yohP -0.8 -1.8 expressed protein (RefSeq) compare
b0603 ybdO -0.8 -2.2 predicted DNA-binding transcriptional regulator (NCBI) compare
b3778 rep -0.8 -4.1 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b3863 polA -0.8 -0.8 DNA polymerase I (NCBI) compare
b1297 b1297 -0.8 -3.3 putative glutamine synthetase (EC 6.3.1.2) (VIMSS) compare
b3194 yrbE -0.8 -4.7 predicted toluene transporter subunit: membrane component of ABC superfamily (NCBI) compare
b3632 rfaQ -0.8 -6.5 lipopolysaccharide core biosynthesis protein (NCBI) compare
b2713 hydN -0.8 -3.3 formate dehydrogenase-H, [4Fe-4S] ferredoxin subunit (NCBI) compare
b0842 cmr -0.8 -3.4 multidrug efflux system protein (NCBI) compare
b3193 yrbD -0.8 -4.1 predicted ABC-type organic solvent transporter (NCBI) compare
b0279 yagM -0.8 -2.8 CP4-6 prophage; predicted protein (NCBI) compare
b0721 sdhC -0.8 -1.9 succinate dehydrogenase cytochrome b556 large membrane subunit (NCBI) compare
b0949 uup -0.8 -3.3 fused predicted transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b0617 citD -0.8 -1.4 citrate lyase, acyl carrier (gamma) subunit (NCBI) compare
b2051 wcaH -0.8 -1.0 GDP-mannose mannosyl hydrolase (VIMSS) compare
b4375 prfC -0.8 -3.5 peptide chain release factor 3 (NCBI) compare
b2457 cchA -0.8 -1.6 detox protein (VIMSS) compare
b4279 yjhB -0.8 -2.3 putative transport protein (VIMSS) compare
b1830 prc -0.8 -2.8 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b4444 rygA -0.7 -1.8 unknown RNA (NCBI) compare
b1113 ycfS -0.7 -2.0 hypothetical protein (NCBI) compare
b3613 yibP -0.7 -2.6 putative membrane protein (VIMSS) compare
b2026 hisI -0.7 -3.2 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI) compare
b3192 yrbC -0.7 -4.1 predicted ABC-type organic solvent transporter (NCBI) compare
b2510 b2510 -0.7 -1.8 orf, hypothetical protein (VIMSS) compare
b2213 ada -0.7 -1.3 fused DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase (NCBI) compare
b2017 yefM -0.7 -1.1 orf, hypothetical protein (VIMSS) compare
b3844 fre -0.7 -2.4 NAD(P)H-flavin reductase (NCBI) compare
b2278 nuoL -0.7 -4.0 NADH dehydrogenase subunit L (NCBI) compare
b4527 b1354 -0.7 -1.6 orf, hypothetical protein (VIMSS) compare
b4418 sraB -0.7 -0.9 unknown RNA (NCBI) compare
b3442 yhhZ -0.7 -1.2 hypothetical protein (NCBI) compare
b3839 tatC -0.7 -3.8 TatABCE protein translocation system subunit (NCBI) compare
b1164 ycgZ -0.7 -1.3 hypothetical protein (NCBI) compare
b4414 tff -0.7 -1.3 unknown RNA (NCBI) compare
b1160 elbA -0.7 -1.1 hypothetical protein (NCBI) compare
b1563 relE -0.7 -0.8 Qin prophage; toxin of the RelE-RelB toxin-antitoxin system (NCBI) compare
b3207 yrbL -0.7 -3.1 hypothetical protein (NCBI) compare
b4243 yjgF -0.7 -2.0 orf, hypothetical protein (VIMSS) compare
b3787 rffD -0.7 -4.0 UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase (NCBI) compare
b4041 plsB -0.7 -1.0 glycerol-3-phosphate acyltransferase (VIMSS) compare
b3884 yihW -0.7 -3.1 putative DEOR-type transcriptional regulator (VIMSS) compare
b0766 ybhA -0.7 -2.6 predicted hydrolase (NCBI) compare


Specific Phenotypes

None in this experiment

For Escherichia coli BW25113 in stress experiments

For stress Chloramphenicol across organisms