Experiment set2IT054 for Pseudomonas fluorescens GW456-L13

Compare to:

a-Ketoglutaric acid disodium salt hydrate carbon source

200 most detrimental genes:

  gene name fitness t score description  
PfGW456L13_200 +7.6 67.3 Glycosyl transferase in large core OS assembly cluster compare
PfGW456L13_199 +7.6 46.3 alpha-1,3-rhamnosyltransferase compare
PfGW456L13_2190 +6.0 24.9 Undecaprenyl-phosphate N-acetylglucosaminyl 1-phosphate transferase (EC 2.7.8.-) compare
PfGW456L13_2185 +5.0 7.0 putative colanic acid biosynthesis glycosyl transferase compare
PfGW456L13_203 +5.0 9.6 Glycosyl transferase in large core OS assembly cluster compare
PfGW456L13_2184 +5.0 11.3 putative polysaccharide polymerase compare
PfGW456L13_2192 +3.5 11.4 regulator of length of O-antigen component of lipopolysaccharide chains compare
PfGW456L13_4900 +2.2 3.3 2-hydroxychromene-2-carboxylate isomerase/DsbA-like thioredoxin domain compare
PfGW456L13_202 +2.2 5.5 Probable transcription regulator Mig-14 compare
PfGW456L13_204 +1.9 4.8 Carbamoyltransferase in large core OS assembly cluster compare
PfGW456L13_3712 +1.8 3.5 hypothetical protein compare
PfGW456L13_2992 +1.8 2.0 hypothetical protein compare
PfGW456L13_2186 +1.8 5.3 UDP-N-acetylglucosamine 4,6-dehydratase (EC 4.2.1.-) compare
PfGW456L13_4863 +1.8 2.1 FIG021952: putative membrane protein compare
PfGW456L13_2969 +1.7 3.1 FIG00956898: hypothetical protein compare
PfGW456L13_1848 +1.7 1.6 hypothetical protein compare
PfGW456L13_3931 +1.7 1.6 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase (EC 4.1.2.n4) compare
PfGW456L13_2538 +1.7 1.5 3-ketoacyl-CoA thiolase (EC 2.3.1.16) @ Acetyl-CoA acetyltransferase (EC 2.3.1.9) compare
PfGW456L13_1311 +1.6 2.3 Phosphonate ABC transporter phosphate-binding periplasmic component (TC 3.A.1.9.1) compare
PfGW456L13_1705 +1.6 1.9 FIG00955494: hypothetical protein compare
PfGW456L13_205 +1.6 1.9 hypothetical protein compare
PfGW456L13_2015 +1.6 1.8 hypothetical protein compare
PfGW456L13_2191 +1.5 8.1 nucleotide sugar epimerase/dehydratase WbpM compare
PfGW456L13_1465 +1.5 2.1 hypothetical protein compare
PfGW456L13_3577 +1.5 1.8 hypothetical protein compare
PfGW456L13_2968 +1.4 3.1 hypothetical protein compare
PfGW456L13_2034 +1.4 1.7 hypothetical protein compare
PfGW456L13_3774 +1.4 1.4 Organic hydroperoxide resistance protein compare
PfGW456L13_1770 +1.3 5.4 InaA protein compare
PfGW456L13_4511 +1.3 0.8 Rhodanese-like domain protein compare
PfGW456L13_1501 +1.3 2.4 Benzoate transport protein compare
PfGW456L13_3845 +1.3 1.2 Predicted secretion system X transmembrane protein 1 compare
PfGW456L13_1968 +1.3 5.4 Arginine pathway regulatory protein ArgR, repressor of arg regulon compare
PfGW456L13_4662 +1.3 1.3 Transcriptional regulator, LuxR family compare
PfGW456L13_4729 +1.3 2.7 hypothetical protein compare
PfGW456L13_4665 +1.3 1.9 FIG00957354: hypothetical protein compare
PfGW456L13_3996 +1.3 3.4 UDP-glucose dehydrogenase (EC 1.1.1.22) compare
PfGW456L13_2369 +1.2 1.9 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain compare
PfGW456L13_2279 +1.2 1.3 FIG00953472: hypothetical protein compare
PfGW456L13_1847 +1.2 1.0 Glycerate kinase (EC 2.7.1.31) compare
PfGW456L13_4134 +1.2 1.4 hypothetical protein compare
PfGW456L13_4412 +1.2 1.9 Nitroreductase family protein compare
PfGW456L13_858 +1.2 3.1 Uroporphyrinogen-III synthase (EC 4.2.1.75) compare
PfGW456L13_864 +1.2 2.5 hypothetical protein compare
PfGW456L13_4014 +1.2 0.7 Chromosome segregation ATPases compare
PfGW456L13_820 +1.2 4.2 GGDEF domain/EAL domain protein compare
PfGW456L13_2492 +1.1 1.3 Virulence factor mviM compare
PfGW456L13_2159 +1.1 1.2 hypothetical protein compare
PfGW456L13_4545 +1.1 1.2 Integral membrane protein compare
PfGW456L13_1864 +1.1 4.7 FIG023103: Predicted transmembrane protein compare
PfGW456L13_1883 +1.1 1.7 Heme oxygenase HemO, associated with heme uptake compare
PfGW456L13_1099 +1.1 1.4 FIG00953563: hypothetical protein compare
PfGW456L13_1662 +1.1 3.0 Heavy metal sensor histidine kinase compare
PfGW456L13_1223 +1.1 2.2 Lipoate-protein ligase A compare
PfGW456L13_4040 +1.1 2.6 3-ketoacyl-CoA thiolase (EC 2.3.1.16) @ Acetyl-CoA acetyltransferase (EC 2.3.1.9) compare
PfGW456L13_1536 +1.1 2.4 FOG: TPR repeat compare
PfGW456L13_1990 +1.0 2.0 hypothetical protein compare
PfGW456L13_1238 +1.0 1.7 Biotin operon repressor / Biotin-protein ligase (EC 6.3.4.15) compare
PfGW456L13_348 +1.0 1.8 FIG00955429: hypothetical protein compare
PfGW456L13_514 +1.0 1.6 Adenylylsulfate kinase (EC 2.7.1.25) compare
PfGW456L13_111 +1.0 1.2 Urease accessory protein UreE compare
PfGW456L13_4483 +1.0 1.5 Permeases of the major facilitator superfamily compare
PfGW456L13_4514 +1.0 3.2 Sigma factor RpoE negative regulatory protein RseB precursor compare
PfGW456L13_4354 +1.0 1.9 Flagellar hook-basal body complex protein FliE compare
PfGW456L13_3581 +1.0 2.2 Transcriptional regulator, AraC family compare
PfGW456L13_3610 +1.0 1.2 3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100) compare
PfGW456L13_1985 +1.0 2.0 Alginate biosynthesis transcriptional activator compare
PfGW456L13_3811 +1.0 1.3 hypothetical protein compare
PfGW456L13_5121 +1.0 0.8 hypothetical protein compare
PfGW456L13_2508 +1.0 2.4 ADP compounds hydrolase NudE (EC 3.6.1.-) compare
PfGW456L13_1689 +1.0 1.6 Molybdenum cofactor biosynthesis protein MoaC compare
PfGW456L13_4041 +0.9 1.3 Enoyl-CoA hydratase (EC 4.2.1.17) / Delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase (EC 5.3.3.8) / 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35) / 3-hydroxybutyryl-CoA epimerase (EC 5.1.2.3) compare
PfGW456L13_1289 +0.9 2.2 Transcriptional regulator, AraC family compare
PfGW456L13_332 +0.9 0.9 Phosphonate ABC transporter phosphate-binding periplasmic component (TC 3.A.1.9.1) compare
PfGW456L13_2305 +0.9 2.1 ABC transporter in pyoverdin gene cluster, ATP-binding component compare
PfGW456L13_1140 +0.9 0.9 Glycine cleavage system transcriptional antiactivator GcvR compare
PfGW456L13_1353 +0.9 1.5 hypothetical protein compare
PfGW456L13_4244 +0.9 2.1 FIG00961250: hypothetical protein compare
PfGW456L13_1936 +0.9 1.8 RNA polymerase sigma-70 factor, ECF subfamily compare
PfGW456L13_2780 +0.9 1.4 hypothetical protein compare
PfGW456L13_279 +0.9 2.5 Type IV pilus biogenesis protein PilO compare
PfGW456L13_4487 +0.9 1.2 FIG00954793: hypothetical protein compare
PfGW456L13_770 +0.9 0.9 Superfamily II DNA and RNA helicases compare
PfGW456L13_1584 +0.9 1.8 Molybdopterin biosynthesis protein MoeB compare
PfGW456L13_2592 +0.9 0.7 hypothetical protein compare
PfGW456L13_5120 +0.9 2.6 hypothetical protein compare
PfGW456L13_483 +0.9 1.2 Sulfate and thiosulfate import ATP-binding protein CysA (EC 3.6.3.25) compare
PfGW456L13_1400 +0.9 1.2 Urea carboxylase-related ABC transporter, permease protein compare
PfGW456L13_2410 +0.9 2.9 Membrane fusion component of tripartite multidrug resistance system compare
PfGW456L13_4059 +0.9 2.0 Cytochrome c oxidase subunit CcoP (EC 1.9.3.1) compare
PfGW456L13_3727 +0.9 1.4 FIG00956189: hypothetical protein compare
PfGW456L13_3568 +0.9 2.6 DNA topoisomerase III (EC 5.99.1.2) compare
PfGW456L13_3005 +0.9 1.3 FIG00960186: hypothetical protein compare
PfGW456L13_1106 +0.8 1.8 Electron transfer flavoprotein, beta subunit compare
PfGW456L13_3442 +0.8 1.6 hypothetical protein compare
PfGW456L13_890 +0.8 2.7 FIG006231: RNA-binding protein compare
PfGW456L13_4917 +0.8 2.0 Osmosensitive K+ channel histidine kinase KdpD (EC 2.7.3.-) compare
PfGW456L13_1618 +0.8 2.2 L-lysine permease compare
PfGW456L13_2776 +0.8 0.7 Phage protein compare
PfGW456L13_787 +0.8 3.1 Exodeoxyribonuclease III (EC 3.1.11.2) compare
PfGW456L13_1498 +0.8 0.7 FIG060329: MOSC domain protein compare
PfGW456L13_1391 +0.8 1.0 Transcriptional regulator, AsnC family compare
PfGW456L13_3824 +0.8 1.1 Muconate cycloisomerase (EC 5.5.1.1) compare
PfGW456L13_3182 +0.8 1.9 Organic hydroperoxide resistance protein compare
PfGW456L13_4337 +0.8 0.6 Flagellar biosynthesis protein FliR compare
PfGW456L13_1947 +0.8 2.6 CTP synthase (EC 6.3.4.2) compare
PfGW456L13_236 +0.8 1.0 Acyl carrier protein (ACP1) compare
PfGW456L13_7 +0.8 1.7 ABC transporter ATP-binding protein compare
PfGW456L13_3011 +0.8 1.4 hypothetical protein compare
PfGW456L13_1526 +0.8 2.6 FIG00954153: hypothetical protein compare
PfGW456L13_2114 +0.8 2.6 Molybdenum cofactor biosynthesis protein MoaA compare
PfGW456L13_4443 +0.8 2.5 Permease of the drug/metabolite transporter (DMT) superfamily compare
PfGW456L13_513 +0.8 1.2 Putative stomatin/prohibitin-family membrane protease subunit aq_911 compare
PfGW456L13_4491 +0.8 3.0 FIG00954807: hypothetical protein compare
PfGW456L13_1138 +0.8 0.7 response regulator compare
PfGW456L13_1008 +0.8 1.1 COG1872 compare
PfGW456L13_4535 +0.8 3.1 Ribosomal small subunit pseudouridine synthase A (EC 4.2.1.70) compare
PfGW456L13_2095 +0.8 1.2 Ribonuclease E (EC 3.1.26.12) compare
PfGW456L13_4495 +0.8 1.1 Protein YcgL compare
PfGW456L13_4828 +0.8 1.8 Phosphonate ABC transporter phosphate-binding periplasmic component (TC 3.A.1.9.1) compare
PfGW456L13_2857 +0.8 0.8 ChlD component of cobalt chelatase involved in B12 biosynthesis compare
PfGW456L13_1497 +0.8 2.0 FIG00953980: hypothetical protein compare
PfGW456L13_4925 +0.8 1.6 Probable glutathione S-transferase (EC 2.5.1.18), YfcF homolog compare
PfGW456L13_1370 +0.8 1.2 FIG00957593: hypothetical protein compare
PfGW456L13_1058 +0.8 2.2 Cytochrome c556 compare
PfGW456L13_2942 +0.8 1.7 hypothetical protein compare
PfGW456L13_4922 +0.8 2.0 hypothetical protein compare
PfGW456L13_3294 +0.7 2.1 Mlr0979 protein compare
PfGW456L13_769 +0.7 0.7 DNA-binding protein HU-alpha compare
PfGW456L13_2014 +0.7 0.9 Transcriptional regulator, AraC family compare
PfGW456L13_2093 +0.7 2.8 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family compare
PfGW456L13_2523 +0.7 1.0 Probable phenylacetic acid degradation NADH oxidoreductase paaE (EC 1.-.-.-) compare
PfGW456L13_4936 +0.7 2.8 Cytochrome O ubiquinol oxidase subunit II (EC 1.10.3.-) compare
PfGW456L13_4538 +0.7 2.5 hypothetical protein compare
PfGW456L13_3047 +0.7 0.8 Response regulator compare
PfGW456L13_639 +0.7 1.3 Putative NADH-flavin reductase compare
PfGW456L13_442 +0.7 1.7 hypothetical protein compare
PfGW456L13_848 +0.7 0.8 Frataxin homolog CyaY, facilitates iron supply for heme A synthesis or Fe-S cluster assembly compare
PfGW456L13_201 +0.7 1.3 Hypothetical protein FIG015671 in large core OS assembly cluster compare
PfGW456L13_712 +0.7 2.1 Glutamine synthetase adenylyltransferase compare
PfGW456L13_4972 +0.7 1.1 Hypothetical flavoprotein YqcA (clustered with tRNA pseudouridine synthase C) compare
PfGW456L13_510 +0.7 1.1 FIG00960943: hypothetical protein compare
PfGW456L13_2001 +0.7 1.6 Flagellar basal-body rod protein FlgB compare
PfGW456L13_2487 +0.7 1.9 FIG00961567: hypothetical protein compare
PfGW456L13_3995 +0.7 2.9 UDP-N-acetylglucosamine 2-epimerase (EC 5.1.3.14) compare
PfGW456L13_2527 +0.7 2.3 hypothetical protein compare
PfGW456L13_397 +0.7 2.0 Agmatine deiminase (EC 3.5.3.12) compare
PfGW456L13_261 +0.7 1.4 General secretion pathway protein I compare
PfGW456L13_4540 +0.7 2.1 Trans-aconitate 2-methyltransferase (EC 2.1.1.144) compare
PfGW456L13_4216 +0.7 2.9 DNA recombination-dependent growth factor C compare
PfGW456L13_2888 +0.7 1.8 Mobile element protein compare
PfGW456L13_400 +0.7 2.5 Signal transduction histidine kinase regulating C4-dicarboxylate transport system compare
PfGW456L13_3549 +0.7 2.3 pyridoxal phosphate-dependent deaminase, putative compare
PfGW456L13_4403 +0.7 2.8 Segregation and condensation protein A compare
PfGW456L13_4667 +0.7 1.0 Regulatory protein RecX compare
PfGW456L13_2852 +0.7 1.0 Predicted cobalt transporter CbtA compare
PfGW456L13_3687 +0.7 2.3 Two-component regulator compare
PfGW456L13_3136 +0.7 1.5 putative membrane protein compare
PfGW456L13_1714 +0.7 1.0 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) compare
PfGW456L13_4364 +0.7 2.6 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) compare
PfGW456L13_5022 +0.7 2.4 Fumarate hydratase class II (EC 4.2.1.2) compare
PfGW456L13_922 +0.7 1.3 Alkanesulfonates ABC transporter ATP-binding protein / Sulfonate ABC transporter, ATP-binding subunit SsuB compare
PfGW456L13_1322 +0.7 0.5 Permeases of the major facilitator superfamily compare
PfGW456L13_3316 +0.7 0.6 Ketoglutarate semialdehyde dehydrogenase (EC 1.2.1.26) compare
PfGW456L13_4633 +0.7 1.5 Isochorismatase (EC 3.3.2.1) compare
PfGW456L13_727 +0.7 2.2 LysR family transcriptional regulator PA5437 compare
PfGW456L13_1570 +0.7 1.3 hypothetical protein compare
PfGW456L13_2401 +0.7 1.5 Methylglyoxal reductase, acetol producing (EC 1.1.1.-) / 2,5-diketo-D-gluconic acid reductase B (EC 1.1.1.274) compare
PfGW456L13_4485 +0.7 0.9 Cyclic nucleotide-binding protein compare
PfGW456L13_4501 +0.6 2.5 Transcriptional regulator, LysR family compare
PfGW456L13_1637 +0.6 1.7 Stringent starvation protein A compare
PfGW456L13_1100 +0.6 1.2 hypothetical protein compare
PfGW456L13_2686 +0.6 0.8 Glycine cleavage system H protein compare
PfGW456L13_2029 +0.6 4.1 BarA sensory histidine kinase (= VarS = GacS) compare
PfGW456L13_2299 +0.6 1.2 Two-component system response regulator QseB compare
PfGW456L13_4544 +0.6 2.1 Transcriptional regulator, LysR family compare
PfGW456L13_2813 +0.6 1.2 Adenylylsulfate reductase beta-subunit (EC 1.8.99.2) compare
PfGW456L13_813 +0.6 1.2 Translation initiation inhibitor compare
PfGW456L13_533 +0.6 3.8 Type I secretion system, membrane fusion protein LapC compare
PfGW456L13_3901 +0.6 2.2 FIG00953292: hypothetical protein compare
PfGW456L13_3697 +0.6 1.4 Arsenic resistance protein ArsH compare
PfGW456L13_3105 +0.6 0.9 hypothetical protein compare
PfGW456L13_4384 +0.6 1.2 Flagellar P-ring protein FlgI compare
PfGW456L13_3990 +0.6 1.2 Response regulator receiver domain protein (CheY) compare
PfGW456L13_3000 +0.6 0.4 FIG00961385: hypothetical protein compare
PfGW456L13_950 +0.6 1.5 Predicted integral membrane protein compare
PfGW456L13_2526 +0.6 0.9 4-hydroxyphenylacetate 3-monooxygenase, reductase component (EC 1.6.8.-) compare
PfGW456L13_4136 +0.6 1.0 PlcB, ORFX, ORFP, ORFB, ORFA, ldh gene compare
PfGW456L13_3433 +0.6 0.7 3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100) compare
PfGW456L13_4678 +0.6 1.9 5-nucleotidase SurE (EC 3.1.3.5) @ Exopolyphosphatase (EC 3.6.1.11) compare
PfGW456L13_1641 +0.6 1.9 Predicted endonuclease distantly related to archaeal Holliday junction resolvase compare
PfGW456L13_872 +0.6 1.8 FIG139438: lipoprotein B compare
PfGW456L13_3813 +0.6 1.4 hypothetical protein compare
PfGW456L13_4570 +0.6 2.1 FIG00953409: hypothetical protein compare
PfGW456L13_2541 +0.6 0.6 Sodium:dicarboxylate symporter compare
PfGW456L13_1993 +0.6 2.1 glutamine synthetase family protein compare
PfGW456L13_4129 +0.6 1.7 Oxidoreductase, short chain dehydrogenase/reductase family compare
PfGW456L13_2511 +0.6 0.5 short-chain dehydrogenase/reductase SDR compare
PfGW456L13_3749 +0.6 0.7 Nitrogen regulation protein NR(I) compare
PfGW456L13_4670 +0.6 1.6 Holin compare


Specific Phenotypes

For 3 genes in this experiment

For carbon source a-Ketoglutaric acid disodium salt hydrate in Pseudomonas fluorescens GW456-L13

For carbon source a-Ketoglutaric acid disodium salt hydrate across organisms