Experiment set2IT053 for Escherichia coli BW25113

Compare to:

LB with Dimethyl Sulfoxide 7.5 vol%

200 most important genes:

  gene name fitness t score description  
b3792 wzxE -3.6 -4.9 O-antigen translocase (NCBI) compare
b4201 priB -3.3 -3.2 primosomal replication protein N (NCBI) compare
b3021 ygiT -3.3 -4.4 predicted DNA-binding transcriptional regulator (NCBI) compare
b1231 tyrT -3.3 -2.1 tRNA-Tyr (NCBI) compare
b2567 rnc -3.0 -2.8 ribonuclease III (NCBI) compare
b2576 srmB -2.6 -3.1 ATP-dependent RNA helicase (NCBI) compare
b3390 aroK -2.5 -2.3 shikimate kinase I (NCBI) compare
b3341 rpsG -2.4 -1.6 30S ribosomal protein S7 (NCBI) compare
b0920 ycbC -2.1 -4.5 conserved inner membrane protein (NCBI) compare
b3229 sspA -2.1 -4.2 stringent starvation protein A (NCBI) compare
b3205 yhbJ -2.1 -3.6 hypothetical protein (NCBI) compare
b0630 lipB -2.1 -2.4 protein of lipoate biosynthesis (VIMSS) compare
b0232 yafN -2.0 -1.3 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b3962 udhA -1.9 -8.5 putative oxidoreductase (VIMSS) compare
b1567 intK -1.9 -2.4 Qin prophage; predicted protein (RefSeq) compare
b2498 upp -1.8 -3.3 uracil phosphoribosyltransferase (VIMSS) compare
b2699 recA -1.8 -2.0 recombinase A (NCBI) compare
b0118 acnB -1.8 -3.2 aconitate hydratase (NCBI) compare
b3121 yhaC -1.7 -2.6 hypothetical protein (NCBI) compare
b4585 sroB -1.7 -1.4 Novel sRNA, function unknown (RefSeq) compare
b0114 aceE -1.7 -1.1 pyruvate dehydrogenase subunit E1 (NCBI) compare
b2528 iscA -1.6 -1.8 iron-sulfur cluster assembly protein (NCBI) compare
b1358 ydaT -1.6 -2.0 Rac prophage; predicted protein (NCBI) compare
b0049 apaH -1.6 -4.7 diadenosinetetraphosphatase (NCBI) compare
b3082 ygjM -1.5 -2.3 predicted DNA-binding transcriptional regulator (NCBI) compare
b3725 pstB -1.5 -2.4 phosphate transporter subunit (NCBI) compare
b1863 ruvC -1.5 -3.3 Holliday junction resolvase (NCBI) compare
b3398 yrfF -1.5 -3.2 predicted inner membrane protein (NCBI) compare
b0560 nohB -1.5 -2.0 DLP12 prophage; DNA packaging protein (NCBI) compare
b1252 tonB -1.5 -2.5 membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) compare
b2894 xerD -1.4 -1.6 site-specific tyrosine recombinase XerD (NCBI) compare
b4699 fnrS -1.4 -1.4 FNR-activated anaerobic sRNA antisense regulator down regulates cydDC, metE, sodA, sodB, Hfq-dependent; mediates negative FNR regulation (RefSeq) compare
b4202 rpsR -1.4 -2.0 30S ribosomal protein S18 (NCBI) compare
b3871 bipA -1.4 -7.5 GTP-binding protein (NCBI) compare
b2569 lepA -1.3 -3.5 GTP-binding protein LepA (NCBI) compare
b2297 pta -1.3 -1.8 phosphate acetyltransferase (NCBI) compare
b3290 trkA -1.3 -2.7 potassium transporter peripheral membrane component (NCBI) compare
b0082 mraW -1.3 -3.0 S-adenosyl-methyltransferase (NCBI) compare
b3183 obgE -1.3 -1.6 GTPase involved in cell partioning and DNA repair (NCBI) compare
b3149 yraO -1.3 -4.5 DnaA initiator-associating factor for replication initiation (NCBI) compare
b4177 purA -1.3 -2.2 adenylosuccinate synthetase (NCBI) compare
b0890 ftsK -1.3 -5.3 DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) compare
b0053 surA -1.3 -3.5 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b2784 relA -1.3 -6.2 (p)ppGpp synthetase I/GTP pyrophosphokinase (NCBI) compare
b0051 ksgA -1.2 -4.3 dimethyladenosine transferase (NCBI) compare
b3204 ptsN -1.2 -4.1 sugar-specific enzyme IIA component of PTS (NCBI) compare
b2625 yfjI -1.2 -4.8 CP4-57 prophage; predicted protein (NCBI) compare
b0200 gmhB -1.2 -1.5 hypothetical protein (NCBI) compare
b3198 kdsC -1.2 -2.2 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (NCBI) compare
b4503 yafF -1.2 -1.5 no description compare
b1642 slyA -1.2 -1.6 transcriptional regulator for cryptic hemolysin (VIMSS) compare
b3636 rpmG -1.2 -1.6 50S ribosomal protein L33 (NCBI) compare
b2518 ndk -1.2 -2.0 nucleoside diphosphate kinase (NCBI) compare
b3162 deaD -1.2 -3.5 inducible ATP-independent RNA helicase (VIMSS) compare
b4453 ldrD -1.2 -1.8 toxic polypeptide, small (NCBI) compare
b2282 nuoH -1.2 -2.3 NADH dehydrogenase subunit H (NCBI) compare
b1730 ydjO -1.1 -2.6 predicted protein (RefSeq) compare
b2288 nuoA -1.1 -2.5 NADH dehydrogenase I chain A (VIMSS) compare
b3609 secB -1.1 -3.3 export protein SecB (NCBI) compare
b3442 yhhZ -1.1 -2.2 hypothetical protein (NCBI) compare
b3619 rfaD -1.1 -2.6 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b3463 ftsE -1.1 -3.2 predicted transporter subunit: ATP-binding component of ABC superfamily (NCBI) compare
b1257 yciE -1.1 -2.0 hypothetical protein (NCBI) compare
b2650 ypjC -1.1 -1.9 hypothetical protein (RefSeq) compare
b3649 rpoZ -1.1 -2.2 DNA-directed RNA polymerase subunit omega (NCBI) compare
b4613 dinQ -1.1 -1.5 Damage inducible, function unknown (RefSeq) compare
b1363 trkG -1.1 -3.4 Rac prophage; potassium transporter subunit (NCBI) compare
b2277 nuoM -1.0 -3.9 NADH dehydrogenase subunit M (NCBI) compare
b0953 rmf -1.0 -1.9 ribosome modulation factor (NCBI) compare
b2822 recC -1.0 -3.3 exonuclease V (RecBCD complex), gamma chain (NCBI) compare
b2820 recB -1.0 -2.0 exonuclease V (RecBCD complex), beta subunit (NCBI) compare
b3839 tatC -1.0 -5.7 TatABCE protein translocation system subunit (NCBI) compare
b2110 yehC -1.0 -2.5 predicted periplasmic pilin chaperone (NCBI) compare
b0605 ahpC -1.0 -3.8 alkyl hydroperoxide reductase, C22 subunit (NCBI) compare
b2363 yfdT -1.0 -1.9 CPS-53 (KpLE1) prophage; predicted protein (NCBI) compare
b2948 yqgE -1.0 -2.1 orf, hypothetical protein (VIMSS) compare
b1499 ydeO -1.0 -1.8 predicted DNA-binding transcriptional acfivator (NCBI) compare
b4647 mokA -1.0 -1.2 no description compare
b1013 ycdC -1.0 -1.9 predicted DNA-binding transcriptional regulator (NCBI) compare
b1084 rne -1.0 -3.0 fused ribonucleaseE: endoribonuclease/RNA-binding protein/RNA degradosome binding protein (NCBI) compare
b4685 yrbN -1.0 -1.9 expressed protein (RefSeq) compare
b1286 rnb -1.0 -2.3 exoribonuclease II (NCBI) compare
b1088 yceD -0.9 -2.5 hypothetical protein (NCBI) compare
b2824 ygdB -0.9 -2.6 orf, hypothetical protein (VIMSS) compare
b3250 mreC -0.9 -1.4 cell wall structural complex MreBCD transmembrane component MreC (NCBI) compare
b1493 gadB -0.9 -1.5 glutamate decarboxylase B, PLP-dependent (NCBI) compare
b4505 insX -0.9 -1.1 predicted IS protein (RefSeq) compare
b0028 fkpB -0.9 -2.6 FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase) (NCBI) compare
b1438 ydcQ -0.9 -1.9 predicted DNA-binding transcriptional regulator (RefSeq) compare
b3778 rep -0.9 -4.9 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b2007 yeeX -0.9 -2.1 conserved protein (RefSeq) compare
b1236 galU -0.9 -3.1 glucose-1-phosphate uridylyltransferase (NCBI) compare
b2285 nuoE -0.9 -1.4 NADH dehydrogenase subunit E (NCBI) compare
b4255 yjgD -0.9 -2.7 hypothetical protein (NCBI) compare
b3650 spoT -0.9 -3.9 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase (NCBI) compare
b2456 cchB -0.9 -2.6 predicted carboxysome structural protein, ethanolamine utilization protein (NCBI) compare
b3163 nlpI -0.9 -2.9 hypothetical protein (NCBI) compare
b1623 add -0.9 -2.5 adenosine deaminase (NCBI) compare
b2635 ypjK -0.9 -1.7 CP4-57 prophage; predicted inner membrane protein (NCBI) compare
b2276 nuoN -0.9 -3.0 NADH:ubiquinone oxidoreductase, membrane subunit N (RefSeq) compare
b0957 ompA -0.9 -2.4 outer membrane protein A (3a;II*;G;d) (NCBI) compare
b4128 yjdK -0.9 -3.0 hypothetical protein (NCBI) compare
b3621 rfaC -0.9 -3.1 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b0437 clpP -0.9 -4.0 ATP-dependent Clp protease proteolytic subunit (NCBI) compare
b2340 sixA -0.9 -2.5 phosphohistidine phosphatase (NCBI) compare
b3816 corA -0.9 -4.2 magnesium/nickel/cobalt transporter (NCBI) compare
b0726 sucA -0.9 -2.2 alpha-ketoglutarate decarboxylase (NCBI) compare
b0741 pal -0.9 -2.7 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b1120 cobB -0.9 -2.7 deacetylase of acs and cheY, regulates chemotaxis (NCBI) compare
b1446 ydcY -0.8 -1.1 hypothetical protein (NCBI) compare
b4246 pyrL -0.8 -1.6 pyrBI operon leader peptide (NCBI) compare
b1551 b1551 -0.8 -1.1 orf, hypothetical protein (VIMSS) compare
b3617 kbl -0.8 -3.9 2-amino-3-ketobutyrate coenzyme A ligase (NCBI) compare
b1290 sapF -0.8 -1.3 predicted antimicrobial peptide transporter subunit (NCBI) compare
b3616 tdh -0.8 -3.2 L-threonine 3-dehydrogenase (NCBI) compare
b4172 hfq -0.8 -1.3 RNA-binding protein Hfq (NCBI) compare
b4571 wbbL -0.8 -2.2 no description compare
b2280 nuoJ -0.8 -2.8 NADH dehydrogenase subunit J (NCBI) compare
b0784 moaD -0.8 -1.8 molybdopterin synthase, small subunit (NCBI) compare
b1709 btuD -0.8 -0.8 vitamin B12-transporter ATPase (NCBI) compare
b2279 nuoK -0.8 -1.4 NADH dehydrogenase subunit K (NCBI) compare
b1361 ydaW -0.8 -0.9 orf, hypothetical protein (VIMSS) compare
b0850 ybjC -0.8 -2.0 predicted inner membrane protein (NCBI) compare
b2330 yfcB -0.8 -1.4 putative adenine-specific methylase (VIMSS) compare
b1390 paaC -0.8 -2.0 predicted multicomponent oxygenase/reductase subunit for phenylacetic acid degradation (NCBI) compare
b1434 ydcN -0.8 -1.1 predicted DNA-binding transcriptional regulator (NCBI) compare
b0149 mrcB -0.8 -5.3 penicillin-binding protein 1b (NCBI) compare
b2143 cdd -0.8 -2.5 cytidine deaminase (NCBI) compare
b4497 yeeL -0.8 -3.2 no description compare
b2479 gcvR -0.8 -2.3 transcriptional regulation of gcv operon (VIMSS) compare
b3726 pstA -0.8 -3.3 phosphate transporter subunit (NCBI) compare
b0226 dinJ -0.8 -1.8 predicted antitoxin of YafQ-DinJ toxin-antitoxin system (NCBI) compare
b0222 lpcA -0.8 -1.8 phosphoheptose isomerase (NCBI) compare
b3613 yibP -0.8 -3.0 putative membrane protein (VIMSS) compare
b0617 citD -0.8 -1.3 citrate lyase, acyl carrier (gamma) subunit (NCBI) compare
b3493 pitA -0.8 -4.0 phosphate transporter, low-affinity (NCBI) compare
b4383 deoB -0.7 -3.8 phosphopentomutase (NCBI) compare
b3935 priA -0.7 -1.4 primosome assembly protein PriA (NCBI) compare
b2287 nuoB -0.7 -2.0 NADH dehydrogenase subunit B (NCBI) compare
b0843 ybjH -0.7 -1.3 hypothetical protein (NCBI) compare
b1085 b1085 -0.7 -1.2 orf, hypothetical protein (VIMSS) compare
b0001 thrL -0.7 -1.4 thr operon leader peptide (NCBI) compare
b3483 yhhH -0.7 -1.3 orf, hypothetical protein (VIMSS) compare
b1060 yceP -0.7 -2.6 orf, hypothetical protein (VIMSS) compare
b1058 yceO -0.7 -1.1 hypothetical protein (NCBI) compare
b0990 cspG -0.7 -1.7 DNA-binding transcriptional regulator (NCBI) compare
b3811 xerC -0.7 -1.5 site-specific tyrosine recombinase XerC (NCBI) compare
b0145 dksA -0.7 -1.9 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b2352 yfdI -0.7 -2.0 CPS-53 (KpLE1) prophage; predicted inner membrane protein (NCBI) compare
b1394 paaG -0.7 -1.3 enoyl-CoA hydratase (NCBI) compare
b3239 yhcO -0.7 -1.6 predicted barnase inhibitor (NCBI) compare
b0696 kdpC -0.7 -1.4 potassium-transporting ATPase subunit C (NCBI) compare
b2055 wcaE -0.7 -1.5 predicted glycosyl transferase (NCBI) compare
b3620 rfaF -0.7 -2.5 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b3052 rfaE -0.7 -2.6 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare
b4493 gapC -0.7 -1.1 no description compare
b1355 b1355 -0.7 -2.1 orf, hypothetical protein (VIMSS) compare
b0603 ybdO -0.7 -1.8 predicted DNA-binding transcriptional regulator (NCBI) compare
b4239 treC -0.7 -2.5 trehalose-6-P hydrolase (NCBI) compare
b2743 pcm -0.7 -1.6 protein-L-isoaspartate O-methyltransferase (NCBI) compare
b0623 cspE -0.7 -0.9 cold shock protein E (NCBI) compare
b4655 ythA -0.7 -1.3 expressed protein (RefSeq) compare
b1527 yneK -0.7 -1.8 hypothetical protein (NCBI) compare
b0938 ycbQ -0.7 -3.7 putative fimbrial-like protein (VIMSS) compare
b4529 ydbJ -0.7 -0.7 hypothetical protein (NCBI) compare
b0406 tgt -0.7 -3.1 queuine tRNA-ribosyltransferase (NCBI) compare
b2283 nuoG -0.7 -2.9 NADH:ubiquinone oxidoreductase, chain G (RefSeq) compare
b2236 yfaE -0.7 -1.2 predicted 2Fe-2S cluster-containing protein (NCBI) compare
b0439 lon -0.7 -2.4 DNA-binding ATP-dependent protease La (NCBI) compare
b0895 dmsB -0.7 -2.1 dimethyl sulfoxide reductase, anaerobic, subunit B (NCBI) compare
b1591 b1591 -0.7 -1.1 putative oxidoreductase component (VIMSS) compare
b1841 yobA -0.7 -0.9 hypothetical protein (NCBI) compare
b0092 ddlB -0.6 -2.3 D-alanylalanine synthetase (NCBI) compare
b3741 gidA -0.6 -3.2 glucose-inhibited division protein A (NCBI) compare
b3863 polA -0.6 -0.8 DNA polymerase I (NCBI) compare
b1902 yecI -0.6 -2.4 predicted ferritin-like protein (NCBI) compare
b2259 pmrD -0.6 -1.0 polymyxin resistance protein B (VIMSS) compare
b1861 ruvA -0.6 -1.1 Holliday junction DNA helicase motor protein (NCBI) compare
b0080 fruR -0.6 -2.6 DNA-binding transcriptional dual regulator (NCBI) compare
b0367 tauC -0.6 -1.7 taurine transporter subunit (NCBI) compare
b2278 nuoL -0.6 -3.5 NADH dehydrogenase subunit L (NCBI) compare
b3414 gntY -0.6 -2.7 predicted gluconate transport associated protein (NCBI) compare
b4041 plsB -0.6 -1.2 glycerol-3-phosphate acyltransferase (VIMSS) compare
b2329 aroC -0.6 -2.2 chorismate synthase (NCBI) compare
b4191 ulaR -0.6 -2.1 DNA-binding transcriptional dual regulator (NCBI) compare
b3029 ygiN -0.6 -1.3 quinol monooxygenase (NCBI) compare
b2597 yfiA -0.6 -1.0 cold shock protein associated with 30S ribosomal subunit (NCBI) compare
b0610 rnk -0.6 -1.3 nucleoside diphosphate kinase regulator (NCBI) compare
b1712 ihfA -0.6 -1.4 integration host factor subunit alpha (NCBI) compare
b4375 prfC -0.6 -2.9 peptide chain release factor 3 (NCBI) compare
b1379 hslJ -0.6 -1.7 heat-inducible protein (NCBI) compare
b4253 yjgL -0.6 -2.9 orf, hypothetical protein (VIMSS) compare
b1658 purR -0.6 -2.6 DNA-binding transcriptional repressor, hypoxanthine-binding (NCBI) compare
b3658 selC -0.6 -1.3 tRNA-Sec (NCBI) compare
b3842 rfaH -0.6 -2.1 transcriptional activator RfaH (NCBI) compare
b1823 cspC -0.6 -1.4 stress protein, member of the CspA-family (NCBI) compare
b4551 yheV -0.6 -1.4 hypothetical protein (NCBI) compare
b2698 recX -0.6 -1.0 RecA regulator RecX (NCBI) compare
b3469 zntA -0.6 -4.0 zinc, cobalt and lead efflux system (NCBI) compare
b3728 pstS -0.6 -2.0 phosphate transporter subunit (NCBI) compare


Specific Phenotypes

None in this experiment

For Escherichia coli BW25113 in stress experiments

For stress Dimethyl Sulfoxide across organisms