Experiment set2IT048 for Escherichia coli BW25113

Compare to:

LB with benzoic acid 0.58 mg/ml

200 most important genes:

  gene name fitness t score description  
b3792 wzxE -3.9 -2.7 O-antigen translocase (NCBI) compare
b3390 aroK -2.9 -2.7 shikimate kinase I (NCBI) compare
b0630 lipB -2.8 -2.6 protein of lipoate biosynthesis (VIMSS) compare
b0049 apaH -2.8 -6.5 diadenosinetetraphosphatase (NCBI) compare
b2620 smpB -2.7 -2.5 SsrA-binding protein (NCBI) compare
b1279 yciS -2.7 -2.2 conserved inner membrane protein (NCBI) compare
b1712 ihfA -2.5 -3.3 integration host factor subunit alpha (NCBI) compare
b3493 pitA -2.5 -7.4 phosphate transporter, low-affinity (NCBI) compare
b4375 prfC -2.4 -5.3 peptide chain release factor 3 (NCBI) compare
b2330 yfcB -2.4 -2.7 putative adenine-specific methylase (VIMSS) compare
b1167 ymgC -2.2 -2.8 hypothetical protein (NCBI) compare
b4651 yibW -2.1 -2.3 no description compare
b3725 pstB -2.1 -2.0 phosphate transporter subunit (NCBI) compare
b3290 trkA -2.1 -3.3 potassium transporter peripheral membrane component (NCBI) compare
b2363 yfdT -2.0 -3.6 CPS-53 (KpLE1) prophage; predicted protein (NCBI) compare
b2699 recA -2.0 -1.9 recombinase A (NCBI) compare
b0200 gmhB -1.9 -1.8 hypothetical protein (NCBI) compare
b0118 acnB -1.9 -3.2 aconitate hydratase (NCBI) compare
b2567 rnc -1.9 -2.1 ribonuclease III (NCBI) compare
b1095 fabF -1.9 -6.7 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b2894 xerD -1.9 -1.7 site-specific tyrosine recombinase XerD (NCBI) compare
b0226 dinJ -1.8 -2.8 predicted antitoxin of YafQ-DinJ toxin-antitoxin system (NCBI) compare
b3962 udhA -1.8 -8.4 putative oxidoreductase (VIMSS) compare
b1290 sapF -1.8 -2.3 predicted antimicrobial peptide transporter subunit (NCBI) compare
b1236 galU -1.8 -5.3 glucose-1-phosphate uridylyltransferase (NCBI) compare
b2297 pta -1.8 -1.6 phosphate acetyltransferase (NCBI) compare
b1307 pspD -1.7 -2.1 peripheral inner membrane phage-shock protein (NCBI) compare
b3229 sspA -1.7 -3.8 stringent starvation protein A (NCBI) compare
b0739 tolA -1.6 -4.1 cell envelope integrity inner membrane protein TolA (NCBI) compare
b2820 recB -1.6 -2.3 exonuclease V (RecBCD complex), beta subunit (NCBI) compare
b3791 rffA -1.6 -7.0 TDP-4-oxo-6-deoxy-D-glucose transaminase (NCBI) compare
b0222 lpcA -1.6 -2.9 phosphoheptose isomerase (NCBI) compare
b0912 ihfB -1.6 -3.4 integration host factor subunit beta (NCBI) compare
b3871 bipA -1.6 -8.5 GTP-binding protein (NCBI) compare
b1727 yniC -1.5 -2.6 predicted hydrolase (NCBI) compare
b1252 tonB -1.5 -2.7 membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) compare
b4163 glyV -1.4 -1.3 tRNA-Gly (NCBI) compare
b1103 ycfF -1.4 -1.5 orf, hypothetical protein (VIMSS) compare
b0439 lon -1.4 -4.5 DNA-binding ATP-dependent protease La (NCBI) compare
b3238 yhcN -1.4 -1.9 orf, hypothetical protein (VIMSS) compare
b2279 nuoK -1.4 -2.2 NADH dehydrogenase subunit K (NCBI) compare
b1658 purR -1.4 -5.2 DNA-binding transcriptional repressor, hypoxanthine-binding (NCBI) compare
b0149 mrcB -1.4 -8.7 penicillin-binding protein 1b (NCBI) compare
b0890 ftsK -1.3 -5.6 DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) compare
b1882 cheY -1.3 -1.6 chemotaxis regulator transmitting signal to flagellar motor component (NCBI) compare
b0949 uup -1.3 -5.7 fused predicted transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b1576 ydfD -1.3 -2.6 Qin prophage; predicted protein (NCBI) compare
b1257 yciE -1.3 -1.7 hypothetical protein (NCBI) compare
b0705 ybfL -1.3 -3.4 putative receptor protein (VIMSS) compare
b0738 tolR -1.3 -2.9 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b3052 rfaE -1.3 -4.1 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare
b1426 ydcH -1.3 -1.3 orf, hypothetical protein (VIMSS) compare
b0737 tolQ -1.3 -2.7 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b2352 yfdI -1.2 -2.9 CPS-53 (KpLE1) prophage; predicted inner membrane protein (NCBI) compare
b3766 ilvL -1.2 -2.5 ilvG operon leader peptide (NCBI) compare
b0053 surA -1.2 -3.8 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b2576 srmB -1.2 -3.0 ATP-dependent RNA helicase (NCBI) compare
b3405 ompR -1.2 -4.0 osmolarity response regulator (NCBI) compare
b0500 ybbD -1.2 -1.3 hypothetical protein (RefSeq) compare
b4551 yheV -1.2 -1.5 hypothetical protein (NCBI) compare
b0726 sucA -1.2 -2.7 alpha-ketoglutarate decarboxylase (NCBI) compare
b3162 deaD -1.2 -3.7 inducible ATP-independent RNA helicase (VIMSS) compare
b3842 rfaH -1.2 -3.6 transcriptional activator RfaH (NCBI) compare
b1984 asnW -1.2 -1.2 tRNA-Asn (NCBI) compare
b1185 dsbB -1.2 -2.1 reoxidizes DsbA protein following formation of disulfide bond in P-ring of flagella. (VIMSS) compare
b0603 ybdO -1.1 -2.9 predicted DNA-binding transcriptional regulator (NCBI) compare
b1860 ruvB -1.1 -1.6 Holliday junction DNA helicase B (NCBI) compare
b2518 ndk -1.1 -2.1 nucleoside diphosphate kinase (NCBI) compare
b3169 nusA -1.1 -2.0 transcription elongation factor NusA (NCBI) compare
b1499 ydeO -1.1 -1.8 predicted DNA-binding transcriptional acfivator (NCBI) compare
b3621 rfaC -1.1 -3.8 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b3619 rfaD -1.1 -2.8 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b3811 xerC -1.1 -1.8 site-specific tyrosine recombinase XerC (NCBI) compare
b3884 yihW -1.1 -4.3 putative DEOR-type transcriptional regulator (VIMSS) compare
b4177 purA -1.1 -2.4 adenylosuccinate synthetase (NCBI) compare
b0018 mokC -1.1 -0.8 regulatory protein for HokC, overlaps CDS of hokC (NCBI) compare
b3348 slyX -1.1 -2.5 hypothetical protein (NCBI) compare
b1818 manY -1.1 -2.1 mannose-specific enzyme IIC component of PTS (NCBI) compare
b1205 ychH -1.0 -1.6 predicted inner membrane protein (NCBI) compare
b3442 yhhZ -1.0 -2.2 hypothetical protein (NCBI) compare
b4685 yrbN -1.0 -2.1 expressed protein (RefSeq) compare
b1861 ruvA -1.0 -1.7 Holliday junction DNA helicase motor protein (NCBI) compare
b2642 yfjW -1.0 -2.2 CP4-57 prophage; predicted inner membrane protein (NCBI) compare
b4042 dgkA -1.0 -2.3 diacylglycerol kinase (NCBI) compare
b1361 ydaW -1.0 -1.0 orf, hypothetical protein (VIMSS) compare
b3620 rfaF -1.0 -3.2 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b3613 yibP -1.0 -3.9 putative membrane protein (VIMSS) compare
b0051 ksgA -1.0 -3.7 dimethyladenosine transferase (NCBI) compare
b1058 yceO -1.0 -1.1 hypothetical protein (NCBI) compare
b3630 rfaP -1.0 -6.2 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b1187 fadR -1.0 -3.3 fatty acid metabolism regulator (NCBI) compare
b3611 yibN -0.9 -3.0 predicted rhodanese-related sulfurtransferase (NCBI) compare
b0722 sdhD -0.9 -2.7 succinate dehydrogenase cytochrome b556 small membrane subunit (NCBI) compare
b3839 tatC -0.9 -5.4 TatABCE protein translocation system subunit (NCBI) compare
b0741 pal -0.9 -3.0 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b0723 sdhA -0.9 -5.4 succinate dehydrogenase flavoprotein subunit (NCBI) compare
b2498 upp -0.9 -2.2 uracil phosphoribosyltransferase (VIMSS) compare
b1819 manZ -0.9 -2.1 mannose-specific enzyme IID component of PTS (NCBI) compare
b3121 yhaC -0.9 -1.7 hypothetical protein (NCBI) compare
b0406 tgt -0.9 -4.3 queuine tRNA-ribosyltransferase (NCBI) compare
b2650 ypjC -0.9 -1.7 hypothetical protein (RefSeq) compare
b2287 nuoB -0.9 -2.6 NADH dehydrogenase subunit B (NCBI) compare
b3631 rfaG -0.9 -7.2 glucosyltransferase I (NCBI) compare
b3794 rffM -0.9 -4.1 putative UDP-N-acetyl-D-mannosaminuronic acid transferase (NCBI) compare
b3463 ftsE -0.9 -2.9 predicted transporter subunit: ATP-binding component of ABC superfamily (NCBI) compare
b4481 rffT -0.9 -3.9 4-alpha-L-fucosyltransferase (NCBI) compare
b4441 glmY -0.9 -1.3 sRNA activator of glmS mRNA (RefSeq) compare
b1363 trkG -0.9 -3.2 Rac prophage; potassium transporter subunit (NCBI) compare
b4279 yjhB -0.9 -1.5 putative transport protein (VIMSS) compare
b4589 ylcI -0.9 -2.2 hypothetical protein (RefSeq) compare
b1269 rluB -0.9 -2.4 23S rRNA pseudouridylate synthase (NCBI) compare
b3741 gidA -0.9 -4.2 glucose-inhibited division protein A (NCBI) compare
b4509 ylcG -0.9 -2.3 DLP12 prophage; predicted protein (NCBI) compare
b2277 nuoM -0.9 -3.4 NADH dehydrogenase subunit M (NCBI) compare
b2625 yfjI -0.9 -3.7 CP4-57 prophage; predicted protein (NCBI) compare
b0113 pdhR -0.9 -2.7 transcriptional regulator of pyruvate dehydrogenase complex (NCBI) compare
b4172 hfq -0.8 -1.3 RNA-binding protein Hfq (NCBI) compare
b1161 ycgX -0.8 -1.5 hypothetical protein (NCBI) compare
b1863 ruvC -0.8 -2.2 Holliday junction resolvase (NCBI) compare
b3860 dsbA -0.8 -4.6 periplasmic protein disulfide isomerase I (NCBI) compare
b2822 recC -0.8 -3.0 exonuclease V (RecBCD complex), gamma chain (NCBI) compare
b0542 renD -0.8 -1.6 orf, hypothetical protein (VIMSS) compare
b3164 pnp -0.8 -1.7 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b2286 nuoC -0.8 -3.2 NADH:ubiquinone oxidoreductase, chain C,D (RefSeq) compare
b2512 yfgL -0.8 -2.7 protein assembly complex, lipoprotein component (NCBI) compare
b3035 tolC -0.8 -4.4 outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) compare
b2948 yqgE -0.8 -1.8 orf, hypothetical protein (VIMSS) compare
b0617 citD -0.8 -1.2 citrate lyase, acyl carrier (gamma) subunit (NCBI) compare
b4076 nrfG -0.8 -3.2 heme lyase (NrfEFG) for insertion of heme into c552, subunit NrfG (NCBI) compare
b2288 nuoA -0.8 -1.9 NADH dehydrogenase I chain A (VIMSS) compare
b1347 ydaC -0.8 -1.3 Rac prophage; predicted protein (NCBI) compare
b3398 yrfF -0.8 -2.1 predicted inner membrane protein (NCBI) compare
b1919 yedO -0.8 -2.1 putative 1-aminocyclopropane-1-carboxylate deaminase (VIMSS) compare
b1304 pspA -0.8 -2.5 regulatory protein for phage-shock-protein operon (NCBI) compare
b2283 nuoG -0.8 -3.5 NADH:ubiquinone oxidoreductase, chain G (RefSeq) compare
b3806 cyaA -0.8 -3.1 adenylate cyclase (NCBI) compare
b3483 yhhH -0.8 -1.4 orf, hypothetical protein (VIMSS) compare
b1126 potA -0.8 -3.2 putrescine/spermidine ABC transporter ATPase protein (NCBI) compare
b1358 ydaT -0.8 -1.1 Rac prophage; predicted protein (NCBI) compare
b3790 rffC -0.8 -3.1 TDP-fucosamine acetyltransferase (RefSeq) compare
b0432 cyoA -0.8 -4.6 cytochrome o ubiquinol oxidase subunit II (NCBI) compare
b1651 gloA -0.8 -1.8 glyoxalase I, Ni-dependent (NCBI) compare
b1123 potD -0.8 -3.0 spermidine/putrescine ABC transporter periplasmic substrate-binding protein (NCBI) compare
b3870 glnA -0.8 -1.7 glutamine synthetase (NCBI) compare
b0407 yajC -0.8 -1.4 preprotein translocase subunit YajC (NCBI) compare
b2859 ygeO -0.8 -1.6 hypothetical protein (RefSeq) compare
b0220 ivy -0.8 -3.0 inhibitor of vertebrate C-lysozyme (NCBI) compare
b3082 ygjM -0.8 -1.3 predicted DNA-binding transcriptional regulator (NCBI) compare
b4426 isrA -0.7 -1.6 unknown RNA (NCBI) compare
b4552 yrhC -0.7 -1.3 no description compare
b0605 ahpC -0.7 -2.3 alkyl hydroperoxide reductase, C22 subunit (NCBI) compare
b1291 sapD -0.7 -1.3 predicted antimicrobial peptide transporter subunit (NCBI) compare
b2569 lepA -0.7 -2.4 GTP-binding protein LepA (NCBI) compare
b1306 pspC -0.7 -1.9 DNA-binding transcriptional activator (NCBI) compare
b0471 ybaB -0.7 -2.0 hypothetical protein (NCBI) compare
b1231 tyrT -0.7 -0.8 tRNA-Tyr (NCBI) compare
b2652 ileY -0.7 -2.3 tRNA-Ile (NCBI) compare
b1433 b1433 -0.7 -2.2 putative membrane transport protein (VIMSS) compare
b0866 ybjQ -0.7 -0.8 hypothetical protein (NCBI) compare
b1390 paaC -0.7 -1.6 predicted multicomponent oxygenase/reductase subunit for phenylacetic acid degradation (NCBI) compare
b0014 dnaK -0.7 -1.1 molecular chaperone DnaK (NCBI) compare
b0728 sucC -0.7 -2.5 succinyl-CoA synthetase subunit beta (NCBI) compare
b0724 sdhB -0.7 -2.7 succinate dehydrogenase, FeS subunit (NCBI) compare
b1822 rrmA -0.7 -1.7 23S rRNA m1G745 methyltransferase (NCBI) compare
b4595 yciY -0.7 -0.9 hypothetical protein (RefSeq) compare
b3609 secB -0.7 -2.4 export protein SecB (NCBI) compare
b2910 zapA -0.7 -2.7 protein that localizes to the cytokinetic ring (NCBI) compare
b0279 yagM -0.7 -3.0 CP4-6 prophage; predicted protein (NCBI) compare
b0430 cyoC -0.7 -2.0 cytochrome o ubiquinol oxidase subunit III (NCBI) compare
b2276 nuoN -0.7 -2.6 NADH:ubiquinone oxidoreductase, membrane subunit N (RefSeq) compare
b2143 cdd -0.7 -2.3 cytidine deaminase (NCBI) compare
b0080 fruR -0.7 -2.9 DNA-binding transcriptional dual regulator (NCBI) compare
b0303 ykgI -0.7 -2.4 orf, hypothetical protein (VIMSS) compare
b1685 ydiH -0.7 -0.8 predicted protein (RefSeq) compare
b3242 yhcR -0.7 -2.8 orf, hypothetical protein (VIMSS) compare
b1558 cspF -0.7 -1.5 Qin prophage; cold shock protein (NCBI) compare
b4383 deoB -0.7 -3.7 phosphopentomutase (NCBI) compare
b3426 glpD -0.7 -3.1 sn-glycerol-3-phosphate dehydrogenase, aerobic, FAD/NAD(P)-binding (NCBI) compare
b3834 yigP -0.7 -2.2 hypothetical protein (NCBI) compare
b0756 galM -0.7 -2.6 galactose-1-epimerase (mutarotase) (NCBI) compare
b1595 ynfL -0.7 -1.3 predicted DNA-binding transcriptional regulator (NCBI) compare
b3026 qseC -0.7 -2.5 sensory histidine kinase in two-component regulatory system with QseB (NCBI) compare
b1409 ynbB -0.7 -2.9 predicted CDP-diglyceride synthase (NCBI) compare
b1273 yciN -0.7 -1.2 hypothetical protein (NCBI) compare
b4253 yjgL -0.7 -3.2 orf, hypothetical protein (VIMSS) compare
b4533 ynfO -0.7 -0.9 Qin prophage; predicted protein (NCBI) compare
b3636 rpmG -0.7 -1.0 50S ribosomal protein L33 (NCBI) compare
b4497 yeeL -0.7 -2.6 no description compare
b1383 ydbL -0.7 -1.4 orf, hypothetical protein (VIMSS) compare
b1730 ydjO -0.6 -1.7 predicted protein (RefSeq) compare
b1124 potC -0.6 -2.3 spermidine/putrescine ABC transporter membrane protein (NCBI) compare
b1551 b1551 -0.6 -1.2 orf, hypothetical protein (VIMSS) compare
b2930 yggF -0.6 -1.8 predicted hexoseP phosphatase (NCBI) compare
b1138 ymfE -0.6 -0.8 e14 prophage; predicted inner membrane protein (NCBI) compare
b0429 cyoD -0.6 -1.8 cytochrome o ubiquinol oxidase subunit IV (NCBI) compare
b0431 cyoB -0.6 -3.8 cytochrome o ubiquinol oxidase subunit I (NCBI) compare
b2025 hisF -0.6 -2.2 imidazole glycerol phosphate synthase subunit HisF (NCBI) compare
b1591 b1591 -0.6 -0.9 putative oxidoreductase component (VIMSS) compare
b3836 b3836 -0.6 -1.8 orf, hypothetical protein (VIMSS) compare
b1977 asnT -0.6 -0.9 tRNA-Asn (NCBI) compare


Specific Phenotypes

None in this experiment

For Escherichia coli BW25113 in stress experiments

For stress benzoic acid across organisms