Experiment set2IT044 for Escherichia coli BW25113

Compare to:

LB with Cisplatin 0.1 mg/ml

200 most important genes:

  gene name fitness t score description  
b0472 recR -5.0 -3.5 recombination protein RecR (NCBI) conserved
b1913 uvrC -4.4 -3.0 excinuclease ABC, subunit C; repair of UV damage to DNA (VIMSS) conserved
b4058 uvrA -4.3 -11.7 excinuclease ABC subunit A (NCBI) conserved
b3700 recF -4.0 -7.2 recombination protein F (NCBI) conserved
b2565 recO -4.0 -3.9 DNA repair protein RecO (NCBI) conserved
b1175 minD -3.9 -4.6 membrane ATPase of the MinC-MinD-MinE system (NCBI) compare
b3813 uvrD -3.9 -11.9 DNA-dependent ATPase I and helicase II (NCBI) compare
b3387 dam -3.8 -5.2 DNA adenine methylase (NCBI) compare
b4175 hflC -3.7 -6.7 modulator for HflB protease specific for phage lambda cII repressor (NCBI) compare
b1257 yciE -3.6 -3.0 hypothetical protein (NCBI) compare
b0779 uvrB -3.6 -5.4 excinuclease ABC subunit B (NCBI) conserved
b0605 ahpC -3.5 -6.2 alkyl hydroperoxide reductase, C22 subunit (NCBI) compare
b4174 hflK -3.4 -6.9 modulator for HflB protease specific for phage lambda cII repressor (NCBI) compare
b1184 umuC -3.3 -3.9 DNA polymerase V subunit UmuC (NCBI) conserved
b3961 oxyR -3.3 -10.5 DNA-binding transcriptional dual regulator (NCBI) compare
b1984 asnW -3.3 -1.0 tRNA-Asn (NCBI) compare
b0866 ybjQ -3.3 -1.0 hypothetical protein (NCBI) compare
b4453 ldrD -3.1 -2.1 toxic polypeptide, small (NCBI) compare
b2910 zapA -3.1 -4.6 protein that localizes to the cytokinetic ring (NCBI) compare
b1361 ydaW -3.1 -0.9 orf, hypothetical protein (VIMSS) compare
b1231 tyrT -3.1 -0.9 tRNA-Tyr (NCBI) compare
b2620 smpB -3.1 -1.8 SsrA-binding protein (NCBI) compare
b0849 grxA -3.1 -2.0 glutaredoxin 1, redox coenzyme for ribonucleotide reductase (RNR1a) (NCBI) compare
b2808 gcvA -3.0 -3.6 DNA-binding transcriptional dual regulator (NCBI) compare
b2258 b2258 -3.0 -0.9 putative transport/receptor protein (VIMSS) compare
b3002 yqhA -2.9 -2.1 hypothetical protein (NCBI) compare
b2567 rnc -2.9 -1.9 ribonuclease III (NCBI) compare
b2501 ppk -2.9 -6.7 polyphosphate kinase (NCBI) compare
b1642 slyA -2.9 -1.2 transcriptional regulator for cryptic hemolysin (VIMSS) compare
b1167 ymgC -2.9 -2.0 hypothetical protein (NCBI) compare
b3483 yhhH -2.9 -1.7 orf, hypothetical protein (VIMSS) compare
b2450 yffS -2.8 -1.8 CPZ-55 prophage; predicted protein (RefSeq) compare
b3169 nusA -2.8 -1.9 transcription elongation factor NusA (NCBI) compare
b0500 ybbD -2.8 -2.1 hypothetical protein (RefSeq) compare
b1058 yceO -2.8 -1.1 hypothetical protein (NCBI) compare
b3390 aroK -2.7 -1.9 shikimate kinase I (NCBI) compare
b0407 yajC -2.7 -3.0 preprotein translocase subunit YajC (NCBI) compare
b2083 yegZ -2.6 -1.9 orf, hypothetical protein (VIMSS) compare
b0949 uup -2.6 -7.0 fused predicted transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b1176 minC -2.6 -2.5 septum formation inhibitor (NCBI) compare
b4480 hdfR -2.6 -6.1 transcriptional regulator HdfR (NCBI) compare
b3101 yqjF -2.5 -2.3 orf, hypothetical protein (VIMSS) compare
b1518 lsrG -2.5 -1.5 autoinducer-2 (AI-2) modifying protein LsrG (NCBI) compare
b1882 cheY -2.5 -1.0 chemotaxis regulator transmitting signal to flagellar motor component (NCBI) compare
b2435 amiA -2.5 -4.8 N-acetylmuramoyl-l-alanine amidase I (NCBI) compare
b0060 polB -2.5 -11.3 DNA polymerase II (NCBI) conserved
b4505 insX -2.5 -1.0 predicted IS protein (RefSeq) compare
b2080 b2080 -2.5 -1.0 orf, hypothetical protein (VIMSS) compare
b1273 yciN -2.4 -1.4 hypothetical protein (NCBI) compare
b2236 yfaE -2.4 -2.2 predicted 2Fe-2S cluster-containing protein (NCBI) compare
b2616 recN -2.4 -7.7 recombination and repair protein (NCBI) conserved
b0610 rnk -2.4 -2.0 nucleoside diphosphate kinase regulator (NCBI) compare
b1114 mfd -2.4 -5.9 transcription-repair coupling factor (NCBI) conserved
b4246 pyrL -2.4 -2.3 pyrBI operon leader peptide (NCBI) compare
b4294 insA-7 -2.4 -1.2 KpLE2 phage-like element; IS1 repressor protein InsA (NCBI) compare
b4402 yjjY -2.3 -1.0 hypothetical protein (NCBI) compare
b1138 ymfE -2.3 -0.9 e14 prophage; predicted inner membrane protein (NCBI) compare
b4570 lomR -2.3 -1.9 no description compare
b3778 rep -2.3 -7.4 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b4695 ykgT -2.2 -1.6 no description compare
b3728 pstS -2.2 -2.6 phosphate transporter subunit (NCBI) compare
b0263 afuB -2.2 -1.8 CP4-6 prophage; predicted ferric trasnporter subunit (RefSeq) compare
b1476 fdnI -2.2 -0.9 formate dehydrogenase-N, cytochrome B556 (gamma) subunit, nitrate-inducible (NCBI) compare
b1942 fliJ -2.2 -0.9 flagellar biosynthesis chaperone (NCBI) compare
b3121 yhaC -2.2 -2.5 hypothetical protein (NCBI) compare
b0611 rna -2.2 -4.0 ribonuclease I (NCBI) compare
b4407 thiS -2.2 -1.5 sulfur carrier protein ThiS (NCBI) compare
b0606 ahpF -2.2 -3.6 alkyl hydroperoxide reductase, F52a subunit; detoxification of hydroperoxides (VIMSS) compare
b3727 pstC -2.2 -5.0 phosphate transporter subunit (NCBI) compare
b3021 ygiT -2.2 -3.5 predicted DNA-binding transcriptional regulator (NCBI) compare
b1255 yciC -2.1 -2.7 hypothetical protein (NCBI) compare
b2259 pmrD -2.1 -1.1 polymyxin resistance protein B (VIMSS) compare
b3163 nlpI -2.1 -3.5 hypothetical protein (NCBI) compare
b4163 glyV -2.1 -1.2 tRNA-Gly (NCBI) compare
b3652 recG -2.1 -8.5 ATP-dependent DNA helicase (NCBI) compare
b3644 yicC -2.1 -6.0 hypothetical protein (NCBI) compare
b2431 b2431 -2.1 -6.4 orf, hypothetical protein (VIMSS) compare
b2642 yfjW -2.1 -2.4 CP4-57 prophage; predicted inner membrane protein (NCBI) compare
b1182 hlyE -2.1 -2.5 hemolysin E (VIMSS) compare
b2698 recX -2.0 -1.7 RecA regulator RecX (NCBI) compare
b1144 ymfJ -2.0 -1.6 orf, hypothetical protein (VIMSS) compare
b2579 yfiD -2.0 -2.1 pyruvate formate lyase subunit (NCBI) compare
b0946 ycbW -2.0 -4.8 orf, hypothetical protein (VIMSS) conserved
b4416 rybA -2.0 -0.8 unknown RNA (NCBI) compare
b3935 priA -2.0 -2.0 primosome assembly protein PriA (NCBI) compare
b1446 ydcY -2.0 -1.4 hypothetical protein (NCBI) compare
b1185 dsbB -2.0 -1.8 reoxidizes DsbA protein following formation of disulfide bond in P-ring of flagella. (VIMSS) compare
b2796 sdaC -2.0 -10.3 predicted serine transporter (NCBI) compare
b4598 yncL -2.0 -1.1 hypothetical protein (RefSeq) compare
b1293 sapB -2.0 -1.1 predicted antimicrobial peptide transporter subunit (NCBI) compare
b1829 htpX -2.0 -3.4 heat shock protein HtpX (NCBI) compare
b0145 dksA -2.0 -2.6 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b0082 mraW -2.0 -3.5 S-adenosyl-methyltransferase (NCBI) compare
b1863 ruvC -2.0 -3.1 Holliday junction resolvase (NCBI) compare
b3977 tyrU -2.0 -0.8 tRNA-Tyr (NCBI) compare
b0705 ybfL -2.0 -3.2 putative receptor protein (VIMSS) compare
b2859 ygeO -2.0 -3.3 hypothetical protein (RefSeq) compare
b1954 dsrA -2.0 -1.5 regulatory antisense RNA (NCBI) compare
b4414 tff -1.9 -3.2 unknown RNA (NCBI) compare
b3463 ftsE -1.9 -2.9 predicted transporter subunit: ATP-binding component of ABC superfamily (NCBI) compare
b0603 ybdO -1.9 -3.6 predicted DNA-binding transcriptional regulator (NCBI) compare
b1382 ynbE -1.9 -1.1 predicted lipoprotein (NCBI) compare
b0015 dnaJ -1.9 -8.1 chaperone Hsp40, co-chaperone with DnaK (NCBI) compare
b2930 yggF -1.9 -3.5 predicted hexoseP phosphatase (NCBI) compare
b3792 wzxE -1.9 -8.2 O-antigen translocase (NCBI) compare
b1566 flxA -1.9 -2.5 Qin prophage; predicted protein (NCBI) compare
b0014 dnaK -1.9 -1.6 molecular chaperone DnaK (NCBI) compare
b3726 pstA -1.9 -5.4 phosphate transporter subunit (NCBI) compare
b2248 yfaX -1.9 -1.9 predicted DNA-binding transcriptional regulator (NCBI) compare
b4551 yheV -1.9 -1.1 hypothetical protein (NCBI) compare
b4487 yjdP -1.9 -4.8 hypothetical protein (NCBI) compare
b2741 rpoS -1.9 -4.7 RNA polymerase sigma factor (NCBI) compare
b3462 ftsX -1.8 -3.6 predicted transporter subunit: membrane component of ABC superfamily (NCBI) compare
b2938 speA -1.8 -8.3 arginine decarboxylase (NCBI) compare
b4172 hfq -1.8 -1.7 RNA-binding protein Hfq (NCBI) compare
b3611 yibN -1.8 -4.6 predicted rhodanese-related sulfurtransferase (NCBI) compare
b0406 tgt -1.8 -6.2 queuine tRNA-ribosyltransferase (NCBI) compare
b1130 phoP -1.8 -5.9 DNA-binding response regulator in two-component regulatory system with PhoQ (NCBI) compare
b1497 b1497 -1.8 -3.1 putative enzyme (VIMSS) compare
b0802 ybiJ -1.8 -1.8 hypothetical protein (NCBI) compare
b3933 ftsN -1.8 -8.1 essential cell division protein (NCBI) compare
b2652 ileY -1.7 -4.1 tRNA-Ile (NCBI) compare
b1219 ychN -1.7 -2.6 hypothetical protein (NCBI) compare
b1753 ynjA -1.7 -1.3 hypothetical protein (NCBI) compare
b4561 insM -1.7 -2.4 transposase (RefSeq) compare
b4585 sroB -1.7 -0.7 Novel sRNA, function unknown (RefSeq) compare
b1730 ydjO -1.7 -2.5 predicted protein (RefSeq) compare
b3839 tatC -1.7 -7.9 TatABCE protein translocation system subunit (NCBI) compare
b1259 yciG -1.7 -2.3 orf, hypothetical protein (VIMSS) compare
b3442 yhhZ -1.7 -2.6 hypothetical protein (NCBI) compare
b0799 dinG -1.7 -5.5 ATP-dependent DNA helicase (NCBI) conserved
b2945 endA -1.7 -5.1 DNA-specific endonuclease I (NCBI) conserved
b3613 yibP -1.7 -4.9 putative membrane protein (VIMSS) compare
b3037 ygiB -1.7 -4.2 conserved outer membrane protein (RefSeq) compare
b2819 recD -1.7 -4.1 exonuclease V (RecBCD complex), alpha chain (NCBI) compare
b2058 wcaB -1.7 -0.7 predicted acyl transferase (NCBI) compare
b0957 ompA -1.7 -3.2 outer membrane protein A (3a;II*;G;d) (NCBI) compare
b3651 trmH -1.7 -4.3 tRNA (Guanosine-2'-O-)-methyltransferase (NCBI) compare
b2330 yfcB -1.7 -2.1 putative adenine-specific methylase (VIMSS) compare
b2184 yejH -1.6 -6.2 DNA damage response helicase (yejH or radD) (from data) conserved
b2363 yfdT -1.6 -2.7 CPS-53 (KpLE1) prophage; predicted protein (NCBI) compare
b2110 yehC -1.6 -2.8 predicted periplasmic pilin chaperone (NCBI) compare
b2822 recC -1.6 -2.9 exonuclease V (RecBCD complex), gamma chain (NCBI) compare
b1830 prc -1.6 -4.0 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b4389 radA -1.6 -7.0 predicted repair protein (NCBI) conserved
b0149 mrcB -1.6 -9.0 penicillin-binding protein 1b (NCBI) compare
b0814 ompX -1.6 -4.2 outer membrane protein X (NCBI) compare
b3027 ygiZ -1.6 -2.5 conserved inner membrane protein (NCBI) compare
b2531 iscR -1.6 -1.3 DNA-binding transcriptional repressor (NCBI) compare
b1103 ycfF -1.6 -0.9 orf, hypothetical protein (VIMSS) compare
b1907 tyrP -1.6 -3.3 tyrosine transporter (NCBI) compare
b1304 pspA -1.6 -2.0 regulatory protein for phage-shock-protein operon (NCBI) compare
b2784 relA -1.6 -6.5 (p)ppGpp synthetase I/GTP pyrophosphokinase (NCBI) compare
b1143 ymfI -1.6 -0.9 orf, hypothetical protein (VIMSS) compare
b1861 ruvA -1.6 -1.9 Holliday junction DNA helicase motor protein (NCBI) compare
b0998 torD -1.6 -0.8 chaperone protein TorD (NCBI) compare
b2968 yghD -1.6 -2.9 predicted secretion pathway M-type protein, membrane anchored (NCBI) compare
b3725 pstB -1.6 -1.5 phosphate transporter subunit (NCBI) compare
b0051 ksgA -1.6 -4.9 dimethyladenosine transferase (NCBI) compare
b0948 ycbY -1.6 -5.7 predicted methyltransferase (NCBI) compare
b0460 hha -1.6 -5.2 modulator of gene expression, with H-NS (NCBI) compare
b2366 dsdA -1.5 -4.7 D-serine dehydratase (NCBI) compare
b2512 yfgL -1.5 -3.4 protein assembly complex, lipoprotein component (NCBI) compare
b3032 cpdA -1.5 -4.4 cyclic 3',5'-adenosine monophosphate phosphodiesterase (NCBI) compare
b3100 yqjK -1.5 -2.8 hypothetical protein (NCBI) compare
b1252 tonB -1.5 -2.4 membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) compare
b2398 yfeC -1.5 -1.7 orf, hypothetical protein (VIMSS) compare
b2617 smpA -1.5 -2.6 small membrane protein A (VIMSS) compare
b1434 ydcN -1.5 -1.0 predicted DNA-binding transcriptional regulator (NCBI) compare
b2952 yggT -1.5 -4.7 predicted inner membrane protein (NCBI) compare
b4679 yohP -1.5 -3.3 expressed protein (RefSeq) compare
b0542 renD -1.5 -1.9 orf, hypothetical protein (VIMSS) compare
b2625 yfjI -1.5 -4.7 CP4-57 prophage; predicted protein (NCBI) compare
b3206 npr -1.5 -2.8 phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) (NCBI) compare
b3764 yifE -1.5 -4.4 hypothetical protein (NCBI) compare
b4685 yrbN -1.5 -2.2 expressed protein (RefSeq) compare
b3017 sufI -1.5 -8.0 repressor protein for FtsI (NCBI) compare
b2195 ccmG -1.5 -1.3 periplasmic thioredoxin of cytochrome c-type biogenesis (NCBI) compare
b1594 dgsA -1.5 -3.0 DNA-binding transcriptional repressor (NCBI) compare
b1792 yeaO -1.5 -2.0 orf, hypothetical protein (VIMSS) compare
b0520 ylbF -1.5 -3.6 hypothetical protein (NCBI) compare
b1749 xthA -1.5 -2.9 exonuclease III (NCBI) compare
b1868 yecE -1.5 -2.4 hypothetical protein (NCBI) compare
b1811 yoaH -1.5 -1.8 hypothetical protein (NCBI) compare
b2699 recA -1.4 -1.0 recombinase A (NCBI) compare
b1399 paaX -1.4 -1.8 DNA-binding transcriptional repressor of phenylacetic acid degradation, aryl-CoA responsive (NCBI) compare
b0118 acnB -1.4 -2.1 aconitate hydratase (NCBI) compare
b0990 cspG -1.4 -1.6 DNA-binding transcriptional regulator (NCBI) compare
b0471 ybaB -1.4 -1.4 hypothetical protein (NCBI) compare
b2830 nudH -1.4 -1.3 dinucleoside polyphosphate hydrolase (NCBI) compare
b1305 pspB -1.4 -1.7 phage shock protein B (NCBI) compare
b0523 purE -1.4 -2.0 phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI) compare
b1187 fadR -1.4 -2.8 fatty acid metabolism regulator (NCBI) compare
b4450 arcZ -1.4 -1.9 sRNA antisense regulator of tpx and sdaA, Hfq-dependent (RefSeq) compare
b1766 sppA -1.4 -3.0 protease IV (signal peptide peptidase) (NCBI) compare
b1499 ydeO -1.4 -2.0 predicted DNA-binding transcriptional acfivator (NCBI) compare
b4410 ecnA -1.4 -0.7 entericidin A membrane lipoprotein, antidote entericidin B (NCBI) compare
b3466 yhhL -1.4 -3.3 conserved inner membrane protein (NCBI) compare
b3755 yieP -1.4 -4.1 predicted transcriptional regulator (NCBI) compare
b2659 b2659 -1.4 -1.5 orf, hypothetical protein (VIMSS) compare


Specific Phenotypes

For 29 genes in this experiment

For stress Cisplatin in Escherichia coli BW25113

For stress Cisplatin across organisms