Experiment set2IT039 for Escherichia coli BW25113

Compare to:

LB with copper (II) chloride dihydrate 2 mM

200 most important genes:

  gene name fitness t score description  
b3792 wzxE -3.9 -3.8 O-antigen translocase (NCBI) compare
b2215 ompC -3.8 -10.5 outer membrane porin protein C (NCBI) compare
b2567 rnc -3.7 -2.5 ribonuclease III (NCBI) compare
b0741 pal -3.6 -3.5 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b3472 b3472 -3.3 -8.1 orf, hypothetical protein (VIMSS) compare
b0738 tolR -3.3 -2.2 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b0088 murD -3.2 -3.0 UDP-N-acetylmuramoyl-L-alanyl-D-glutamatesynthetase (NCBI) compare
b3404 envZ -3.1 -11.9 osmolarity sensor protein (NCBI) compare
b3839 tatC -3.1 -9.1 TatABCE protein translocation system subunit (NCBI) compare
b2330 yfcB -3.0 -2.9 putative adenine-specific methylase (VIMSS) compare
b1856 yebA -3.0 -8.2 orf, hypothetical protein (VIMSS) compare
b4042 dgkA -2.9 -2.8 diacylglycerol kinase (NCBI) compare
b2175 spr -2.9 -4.6 predicted peptidase, outer membrane lipoprotein (NCBI) compare
b0149 mrcB -2.9 -11.8 penicillin-binding protein 1b (NCBI) compare
b1236 galU -2.9 -5.9 glucose-1-phosphate uridylyltransferase (NCBI) compare
b0740 tolB -2.7 -3.2 translocation protein TolB precursor (NCBI) compare
b3169 nusA -2.7 -2.6 transcription elongation factor NusA (NCBI) compare
b0632 dacA -2.7 -7.6 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5) (NCBI) compare
b0484 copA -2.7 -11.6 copper transporter (NCBI) conserved
b0737 tolQ -2.7 -3.1 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b0739 tolA -2.6 -4.2 cell envelope integrity inner membrane protein TolA (NCBI) compare
b3405 ompR -2.6 -4.3 osmolarity response regulator (NCBI) compare
b1252 tonB -2.6 -3.3 membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) compare
b3035 tolC -2.5 -8.6 outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) compare
b1111 ycfQ -2.4 -4.0 orf, hypothetical protein (VIMSS) compare
b4685 yrbN -2.3 -3.1 expressed protein (RefSeq) compare
b2699 recA -2.3 -1.6 recombinase A (NCBI) compare
b1291 sapD -2.3 -2.5 predicted antimicrobial peptide transporter subunit (NCBI) compare
b0726 sucA -2.2 -3.5 alpha-ketoglutarate decarboxylase (NCBI) compare
b1279 yciS -2.2 -2.2 conserved inner membrane protein (NCBI) compare
b1863 ruvC -2.1 -4.2 Holliday junction resolvase (NCBI) compare
b2947 gshB -2.1 -4.7 glutathione synthetase (NCBI) compare
b2830 nudH -2.1 -1.9 dinucleoside polyphosphate hydrolase (NCBI) compare
b0436 tig -2.0 -8.2 trigger factor (NCBI) compare
b3871 bipA -2.0 -9.9 GTP-binding protein (NCBI) compare
b0407 yajC -2.0 -3.6 preprotein translocase subunit YajC (NCBI) compare
b3613 yibP -2.0 -4.9 putative membrane protein (VIMSS) compare
b2279 nuoK -2.0 -2.2 NADH dehydrogenase subunit K (NCBI) compare
b2021 hisC -1.9 -5.7 histidinol-phosphate aminotransferase (NCBI) compare
b3609 secB -1.9 -4.0 export protein SecB (NCBI) compare
b0500 ybbD -1.9 -1.9 hypothetical protein (RefSeq) compare
b1861 ruvA -1.9 -2.9 Holliday junction DNA helicase motor protein (NCBI) compare
b0630 lipB -1.8 -2.6 protein of lipoate biosynthesis (VIMSS) compare
b3838 tatB -1.8 -7.0 sec-independent translocase (NCBI) compare
b2894 xerD -1.8 -1.7 site-specific tyrosine recombinase XerD (NCBI) compare
b1860 ruvB -1.8 -2.2 Holliday junction DNA helicase B (NCBI) compare
b3390 aroK -1.7 -2.2 shikimate kinase I (NCBI) compare
b2820 recB -1.7 -2.3 exonuclease V (RecBCD complex), beta subunit (NCBI) compare
b3483 yhhH -1.7 -2.2 orf, hypothetical protein (VIMSS) compare
b4171 miaA -1.7 -5.3 tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) compare
b1192 ldcA -1.7 -4.6 L,D-carboxypeptidase A (NCBI) compare
b0890 ftsK -1.7 -6.6 DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) compare
b3791 rffA -1.7 -7.2 TDP-4-oxo-6-deoxy-D-glucose transaminase (NCBI) compare
b3725 pstB -1.6 -2.4 phosphate transporter subunit (NCBI) compare
b3741 gidA -1.6 -6.2 glucose-inhibited division protein A (NCBI) compare
b3863 polA -1.6 -1.1 DNA polymerase I (NCBI) compare
b1497 b1497 -1.6 -3.6 putative enzyme (VIMSS) compare
b3398 yrfF -1.6 -3.3 predicted inner membrane protein (NCBI) compare
b1167 ymgC -1.5 -2.2 hypothetical protein (NCBI) compare
b3199 yrbK -1.5 -2.5 hypothetical protein (NCBI) compare
b4375 prfC -1.5 -6.0 peptide chain release factor 3 (NCBI) compare
b1286 rnb -1.5 -3.5 exoribonuclease II (NCBI) compare
b3121 yhaC -1.5 -2.2 hypothetical protein (NCBI) compare
b3621 rfaC -1.5 -4.6 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b1161 ycgX -1.5 -1.7 hypothetical protein (NCBI) compare
b3250 mreC -1.5 -1.6 cell wall structural complex MreBCD transmembrane component MreC (NCBI) compare
b2318 truA -1.4 -3.7 tRNA pseudouridine synthase A (NCBI) compare
b3463 ftsE -1.4 -3.9 predicted transporter subunit: ATP-binding component of ABC superfamily (NCBI) compare
b1084 rne -1.4 -4.3 fused ribonucleaseE: endoribonuclease/RNA-binding protein/RNA degradosome binding protein (NCBI) compare
b1176 minC -1.4 -3.6 septum formation inhibitor (NCBI) compare
b0145 dksA -1.4 -3.0 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b0191 yaeJ -1.4 -3.2 hypothetical protein (NCBI) compare
b2498 upp -1.4 -2.9 uracil phosphoribosyltransferase (VIMSS) compare
b2937 speB -1.4 -5.8 agmatinase (NCBI) compare
b4172 hfq -1.4 -2.1 RNA-binding protein Hfq (NCBI) compare
b2020 hisD -1.4 -5.6 histidinol dehydrogenase (NCBI) compare
b1085 b1085 -1.4 -2.4 orf, hypothetical protein (VIMSS) compare
b2893 dsbC -1.3 -4.7 protein disulfide isomerase II (NCBI) compare
b3290 trkA -1.3 -3.1 potassium transporter peripheral membrane component (NCBI) compare
b2019 hisG -1.3 -4.0 ATP phosphoribosyltransferase (NCBI) compare
b3052 rfaE -1.3 -4.0 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare
b3790 rffC -1.3 -4.4 TDP-fucosamine acetyltransferase (RefSeq) compare
b3611 yibN -1.3 -3.7 predicted rhodanese-related sulfurtransferase (NCBI) compare
b1918 yecS -1.3 -2.5 predicted transporter subunit: membrane component of ABC superfamily (NCBI) compare
b0439 lon -1.3 -4.2 DNA-binding ATP-dependent protease La (NCBI) compare
b0222 lpcA -1.3 -2.6 phosphoheptose isomerase (NCBI) compare
b1677 lpp -1.3 -2.6 murein lipoprotein (NCBI) compare
b3977 tyrU -1.2 -1.2 tRNA-Tyr (NCBI) compare
b3500 gor -1.2 -1.1 glutathione reductase (NCBI) compare
b3786 rffE -1.2 -8.1 UDP-N-acetyl glucosamine-2-epimerase (NCBI) compare
b3631 rfaG -1.2 -9.4 glucosyltransferase I (NCBI) compare
b1290 sapF -1.2 -2.0 predicted antimicrobial peptide transporter subunit (NCBI) compare
b0603 ybdO -1.2 -2.9 predicted DNA-binding transcriptional regulator (NCBI) compare
b3787 rffD -1.2 -7.2 UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase (NCBI) compare
b0705 ybfL -1.2 -3.1 putative receptor protein (VIMSS) compare
b0053 surA -1.2 -3.7 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b2168 fruK -1.2 -1.7 1-phosphofructokinase (NCBI) compare
b2912 ygfA -1.2 -2.0 putative ligase (VIMSS) compare
b3005 exbD -1.2 -3.7 membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) compare
b3620 rfaF -1.2 -3.5 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b2642 yfjW -1.2 -2.1 CP4-57 prophage; predicted inner membrane protein (NCBI) compare
b3183 obgE -1.2 -1.4 GTPase involved in cell partioning and DNA repair (NCBI) compare
b3933 ftsN -1.1 -6.6 essential cell division protein (NCBI) compare
b2518 ndk -1.1 -1.9 nucleoside diphosphate kinase (NCBI) compare
b3006 exbB -1.1 -5.0 membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) compare
b3794 rffM -1.1 -5.1 putative UDP-N-acetyl-D-mannosaminuronic acid transferase (NCBI) compare
b1143 ymfI -1.1 -1.1 orf, hypothetical protein (VIMSS) compare
b3706 trmE -1.1 -4.1 tRNA modification GTPase (NCBI) compare
b4481 rffT -1.1 -4.7 4-alpha-L-fucosyltransferase (NCBI) compare
b2822 recC -1.1 -3.6 exonuclease V (RecBCD complex), gamma chain (NCBI) compare
b3912 cpxR -1.1 -6.0 DNA-binding response regulator in two-component regulatory system with CpxA (NCBI) compare
b2900 yqfB -1.1 -2.7 hypothetical protein (NCBI) compare
b3162 deaD -1.1 -3.5 inducible ATP-independent RNA helicase (VIMSS) compare
b3630 rfaP -1.1 -6.9 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b2423 cysW -1.1 -3.5 sulfate/thiosulfate transporter subunit (NCBI) compare
b2025 hisF -1.1 -3.6 imidazole glycerol phosphate synthase subunit HisF (NCBI) compare
b0014 dnaK -1.1 -1.4 molecular chaperone DnaK (NCBI) compare
b0617 citD -1.1 -1.8 citrate lyase, acyl carrier (gamma) subunit (NCBI) compare
b2569 lepA -1.1 -3.3 GTP-binding protein LepA (NCBI) compare
b2352 yfdI -1.1 -3.4 CPS-53 (KpLE1) prophage; predicted inner membrane protein (NCBI) compare
b3940 metL -1.0 -6.3 bifunctional aspartate kinase II/homoserine dehydrogenase II (NCBI) compare
b1183 umuD -1.0 -1.3 DNA polymerase V, subunit D (NCBI) compare
b3836 b3836 -1.0 -2.1 orf, hypothetical protein (VIMSS) compare
b3469 zntA -1.0 -6.9 zinc, cobalt and lead efflux system (NCBI) compare
b3778 rep -1.0 -5.5 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b2528 iscA -1.0 -1.4 iron-sulfur cluster assembly protein (NCBI) compare
b1874 cutC -1.0 -3.0 copper homeostasis protein (NCBI) compare
b1576 ydfD -1.0 -2.2 Qin prophage; predicted protein (NCBI) compare
b2319 usg -1.0 -3.2 hypothetical protein (NCBI) compare
b2297 pta -1.0 -1.4 phosphate acetyltransferase (NCBI) compare
b2055 wcaE -1.0 -2.0 predicted glycosyl transferase (NCBI) compare
b4046 yjbK -1.0 -4.3 putative regulator (VIMSS) compare
b1730 ydjO -1.0 -2.6 predicted protein (RefSeq) compare
b0118 acnB -1.0 -2.4 aconitate hydratase (NCBI) compare
b2808 gcvA -1.0 -3.4 DNA-binding transcriptional dual regulator (NCBI) compare
b2424 cysU -1.0 -1.8 sulfate/thiosulfate transporter subunit (NCBI) compare
b1727 yniC -1.0 -2.0 predicted hydrolase (NCBI) compare
b4146 yjeK -1.0 -2.3 predicted lysine aminomutase (NCBI) compare
b1409 ynbB -1.0 -3.8 predicted CDP-diglyceride synthase (NCBI) compare
b4646 yrdE -1.0 -2.0 no description compare
b4695 ykgT -1.0 -1.4 no description compare
b4253 yjgL -1.0 -4.5 orf, hypothetical protein (VIMSS) compare
b2620 smpB -1.0 -1.4 SsrA-binding protein (NCBI) compare
b0688 pgm -1.0 -2.5 phosphoglucomutase (NCBI) compare
b1818 manY -1.0 -1.8 mannose-specific enzyme IIC component of PTS (NCBI) compare
b3652 recG -1.0 -5.6 ATP-dependent DNA helicase (NCBI) compare
b3462 ftsX -1.0 -3.8 predicted transporter subunit: membrane component of ABC superfamily (NCBI) compare
b1231 tyrT -0.9 -1.1 tRNA-Tyr (NCBI) compare
b1105 ycfM -0.9 -2.2 predicted outer membrane lipoprotein (NCBI) compare
b0406 tgt -0.9 -4.0 queuine tRNA-ribosyltransferase (NCBI) compare
b0051 ksgA -0.9 -3.6 dimethyladenosine transferase (NCBI) compare
b0888 trxB -0.9 -2.2 thioredoxin reductase, FAD/NAD(P)-binding (NCBI) compare
b1591 b1591 -0.9 -1.5 putative oxidoreductase component (VIMSS) compare
b3150 yraP -0.9 -3.4 hypothetical protein (NCBI) compare
b0200 gmhB -0.9 -1.3 hypothetical protein (NCBI) compare
b2938 speA -0.9 -5.2 arginine decarboxylase (NCBI) compare
b1836 yebV -0.9 -2.1 orf, hypothetical protein (VIMSS) compare
b0957 ompA -0.9 -2.7 outer membrane protein A (3a;II*;G;d) (NCBI) compare
b1063 yceB -0.9 -1.5 predicted lipoprotein (NCBI) compare
b3728 pstS -0.9 -2.8 phosphate transporter subunit (NCBI) compare
b4163 glyV -0.9 -1.2 tRNA-Gly (NCBI) compare
b1358 ydaT -0.9 -1.5 Rac prophage; predicted protein (NCBI) compare
b0232 yafN -0.9 -0.9 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b3636 rpmG -0.9 -1.2 50S ribosomal protein L33 (NCBI) compare
b2506 yfgI -0.9 -1.5 hypothetical protein (NCBI) compare
b4558 yifL -0.9 -1.7 predicted lipoprotein (NCBI) compare
b1049 mdoH -0.8 -4.5 glucosyltransferase MdoH (NCBI) compare
b4552 yrhC -0.8 -1.5 no description compare
b0548 ninE -0.8 -2.3 DLP12 prophage; conserved protein (NCBI) compare
b0523 purE -0.8 -2.2 phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI) compare
b3029 ygiN -0.8 -1.8 quinol monooxygenase (NCBI) compare
b3120 yhaB -0.8 -2.6 orf, hypothetical protein (VIMSS) compare
b3619 rfaD -0.8 -2.4 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b4551 yheV -0.8 -1.9 hypothetical protein (NCBI) compare
b0015 dnaJ -0.8 -4.6 chaperone Hsp40, co-chaperone with DnaK (NCBI) compare
b2022 hisB -0.8 -3.4 imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS) compare
b2652 ileY -0.8 -3.3 tRNA-Ile (NCBI) compare
b3026 qseC -0.8 -2.9 sensory histidine kinase in two-component regulatory system with QseB (NCBI) compare
b1058 yceO -0.8 -1.0 hypothetical protein (NCBI) compare
b2110 yehC -0.8 -2.6 predicted periplasmic pilin chaperone (NCBI) compare
b1658 purR -0.8 -3.5 DNA-binding transcriptional repressor, hypoxanthine-binding (NCBI) compare
b1363 trkG -0.8 -2.7 Rac prophage; potassium transporter subunit (NCBI) compare
b1536 ydeI -0.8 -3.1 hypothetical protein (NCBI) compare
b1499 ydeO -0.8 -1.6 predicted DNA-binding transcriptional acfivator (NCBI) compare
b0990 cspG -0.8 -1.6 DNA-binding transcriptional regulator (NCBI) compare
b2026 hisI -0.8 -3.5 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI) compare
b2422 cysA -0.8 -3.3 sulfate/thiosulfate transporter subunit (NCBI) compare
b2625 yfjI -0.8 -3.5 CP4-57 prophage; predicted protein (NCBI) compare
b0767 ybhE -0.8 -2.3 6-phosphogluconolactonase (NCBI) compare
b1129 phoQ -0.8 -4.0 sensory histidine kinase in two-compoent regulatory system with PhoP (NCBI) compare
b1317 ycjU -0.8 -2.4 predicted beta-phosphoglucomutase (NCBI) compare
b1382 ynbE -0.8 -1.3 predicted lipoprotein (NCBI) compare
b4592 yccB -0.8 -1.0 hypothetical protein (RefSeq) compare
b0934 ycbM -0.8 -2.0 putative transport system permease protein (VIMSS) compare
b3617 kbl -0.8 -3.7 2-amino-3-ketobutyrate coenzyme A ligase (NCBI) compare
b2313 cvpA -0.8 -2.4 membrane protein required for colicin V production (NCBI) compare
b1551 b1551 -0.8 -1.4 orf, hypothetical protein (VIMSS) compare
b3098 yqjD -0.8 -1.9 hypothetical protein (NCBI) compare
b3387 dam -0.8 -5.1 DNA adenine methylase (NCBI) compare
b1850 eda -0.8 -1.5 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) compare


Specific Phenotypes

For 3 genes in this experiment

For stress copper (II) chloride dihydrate in Escherichia coli BW25113

For stress copper (II) chloride dihydrate across organisms