Experiment set2IT019 for Escherichia coli BW25113

Compare to:

LB with Sodium Chlorite 1.25 mM

200 most important genes:

  gene name fitness t score description  
b0912 ihfB -3.7 -2.5 integration host factor subunit beta (NCBI) compare
b0471 ybaB -3.7 -2.5 hypothetical protein (NCBI) compare
b2016 yeeZ -3.3 -4.5 predicted epimerase, with NAD(P)-binding Rossmann-fold domain (NCBI) compare
b3742 mioC -3.2 -3.7 flavodoxin (NCBI) compare
b2688 gshA -2.8 -3.8 glutamate--cysteine ligase (NCBI) compare
b2168 fruK -2.6 -2.4 1-phosphofructokinase (NCBI) compare
b3961 oxyR -2.6 -9.0 DNA-binding transcriptional dual regulator (NCBI) compare
b1863 ruvC -2.5 -2.4 Holliday junction resolvase (NCBI) compare
b0683 fur -2.4 -1.6 ferric uptake regulator (NCBI) compare
b2392 mntH -2.4 -5.3 manganese transport protein MntH (NCBI) compare
b3366 nirD -2.4 -3.4 nitrite reductase small subunit (NCBI) compare
b2617 smpA -2.3 -2.6 small membrane protein A (VIMSS) compare
b2058 wcaB -2.3 -1.5 predicted acyl transferase (NCBI) compare
b1727 yniC -2.3 -3.2 predicted hydrolase (NCBI) compare
b1187 fadR -2.3 -4.9 fatty acid metabolism regulator (NCBI) compare
b0080 fruR -2.2 -1.5 DNA-binding transcriptional dual regulator (NCBI) compare
b0001 thrL -2.2 -2.3 thr operon leader peptide (NCBI) compare
b4402 yjjY -2.2 -1.5 hypothetical protein (NCBI) compare
b2553 glnB -2.2 -4.3 regulatory protein P-II for glutamine synthetase (NCBI) compare
b1241 adhE -2.1 -6.1 fused acetaldehyde-CoA dehydrogenase/iron-dependent alcohol dehydrogenase/pyruvate-formate lyase deactivase (NCBI) compare
b0641 rlpB -2.1 -2.1 minor lipoprotein (NCBI) compare
b1095 fabF -2.0 -5.4 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b2906 visC -2.0 -2.0 hypothetical protein (NCBI) compare
b1324 tpx -2.0 -3.0 thiol peroxidase (NCBI) compare
b4515 ybgT -2.0 -1.3 hypothetical protein (NCBI) compare
b0145 dksA -2.0 -1.9 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b0460 hha -2.0 -5.4 modulator of gene expression, with H-NS (NCBI) compare
b1961 dcm -2.0 -1.8 DNA cytosine methylase (NCBI) compare
b3844 fre -1.9 -2.5 NAD(P)H-flavin reductase (NCBI) compare
b1658 purR -1.9 -3.9 DNA-binding transcriptional repressor, hypoxanthine-binding (NCBI) compare
b4598 yncL -1.9 -1.5 hypothetical protein (RefSeq) compare
b1778 yeaA -1.9 -2.2 methionine sulfoxide reductase B (NCBI) compare
b4529 ydbJ -1.8 -1.2 hypothetical protein (NCBI) compare
b0388 aroL -1.8 -3.7 shikimate kinase II (NCBI) compare
b1130 phoP -1.8 -5.1 DNA-binding response regulator in two-component regulatory system with PhoQ (NCBI) compare
b4585 sroB -1.7 -0.8 Novel sRNA, function unknown (RefSeq) compare
b1739 osmE -1.7 -3.1 DNA-binding transcriptional activator (NCBI) compare
b4151 frdD -1.7 -2.0 fumarate reductase subunit D (NCBI) compare
b3652 recG -1.7 -4.5 ATP-dependent DNA helicase (NCBI) compare
b1861 ruvA -1.7 -1.5 Holliday junction DNA helicase motor protein (NCBI) compare
b1358 ydaT -1.7 -1.5 Rac prophage; predicted protein (NCBI) compare
b3169 nusA -1.7 -2.6 transcription elongation factor NusA (NCBI) compare
b4648 ysaC -1.7 -2.1 no description compare
b1253 yciA -1.6 -2.2 predicted hydrolase (NCBI) compare
b1531 marA -1.6 -2.8 multiple antibiotic resistance; transcriptional activator of defense systems (VIMSS) compare
b4172 hfq -1.6 -1.1 RNA-binding protein Hfq (NCBI) compare
b1175 minD -1.6 -3.2 membrane ATPase of the MinC-MinD-MinE system (NCBI) compare
b3741 gidA -1.6 -3.2 glucose-inhibited division protein A (NCBI) compare
b3121 yhaC -1.5 -1.7 hypothetical protein (NCBI) compare
b2343 b2343 -1.5 -1.3 orf, hypothetical protein (VIMSS) compare
b1486 ddpB -1.5 -2.6 D-ala-D-ala transporter subunit (NCBI) compare
b3609 secB -1.5 -3.1 export protein SecB (NCBI) compare
b1278 pgpB -1.5 -2.3 phosphatidylglycerophosphatase B (NCBI) compare
b2576 srmB -1.5 -1.0 ATP-dependent RNA helicase (NCBI) compare
b2618 b2618 -1.5 -2.7 orf, hypothetical protein (VIMSS) compare
b4178 yjeB -1.5 -3.3 predicted DNA-binding transcriptional regulator (NCBI) compare
b0059 hepA -1.5 -8.8 ATP-dependent helicase HepA (NCBI) compare
b1817 manX -1.5 -4.6 fused mannose-specific PTS enzymes: IIA component/IIB component (NCBI) compare
b3237 argR -1.5 -2.9 arginine repressor (NCBI) compare
b3042 b3042 -1.5 -2.2 orf, hypothetical protein (VIMSS) compare
b1493 gadB -1.4 -1.4 glutamate decarboxylase B, PLP-dependent (NCBI) compare
b4545 ypdJ -1.4 -2.5 no description compare
b1625 ydgT -1.4 -5.2 predicted regulator (NCBI) compare
b3933 ftsN -1.4 -6.7 essential cell division protein (NCBI) compare
b3858 yihD -1.4 -1.3 hypothetical protein (NCBI) compare
b1129 phoQ -1.4 -4.8 sensory histidine kinase in two-compoent regulatory system with PhoP (NCBI) compare
b0450 glnK -1.4 -2.2 nitrogen assimilation regulatory protein for GlnL, GlnE, and AmtB (NCBI) compare
b3644 yicC -1.4 -3.3 hypothetical protein (NCBI) compare
b2571 rseB -1.4 -4.2 periplasmic negative regulator of sigmaE (NCBI) compare
b4045 yjbJ -1.4 -2.0 predicted stress response protein (NCBI) compare
b0082 mraW -1.3 -2.2 S-adenosyl-methyltransferase (NCBI) compare
b3934 cytR -1.3 -5.8 DNA-binding transcriptional dual regulator (NCBI) compare
b3764 yifE -1.3 -3.0 hypothetical protein (NCBI) compare
b2055 wcaE -1.3 -3.0 predicted glycosyl transferase (NCBI) compare
b3362 yhfG -1.3 -3.1 hypothetical protein (NCBI) compare
b3706 trmE -1.3 -3.8 tRNA modification GTPase (NCBI) compare
b2330 yfcB -1.3 -1.2 putative adenine-specific methylase (VIMSS) compare
b3407 yhgF -1.3 -7.2 orf, hypothetical protein (VIMSS) conserved
b1890 motA -1.3 -2.6 flagellar motor protein MotA (NCBI) compare
b4631 ykgQ -1.3 -1.7 no description compare
b4436 ryeC -1.3 -0.8 Novel sRNA, function unknown; paralogous to the other QUAD sRNA genes unknown (RefSeq) compare
b1729 ydjN -1.3 -2.3 predicted transporter (NCBI) compare
b1088 yceD -1.3 -2.7 hypothetical protein (NCBI) compare
b4544 yfbW -1.3 -2.6 hypothetical protein (NCBI) compare
b4406 yaeP -1.3 -1.2 hypothetical protein (NCBI) compare
b1263 trpD -1.3 -1.8 bifunctional indole-3-glycerol-phosphate synthase/anthranilate phosphoribosyltransferase (NCBI) compare
b3100 yqjK -1.3 -2.4 hypothetical protein (NCBI) compare
b3163 nlpI -1.3 -2.8 hypothetical protein (NCBI) compare
b2784 relA -1.3 -5.0 (p)ppGpp synthetase I/GTP pyrophosphokinase (NCBI) compare
b3397 nudE -1.2 -5.4 ADP-ribose diphosphatase (NCBI) compare
b2421 cysM -1.2 -1.8 cysteine synthase B (O-acetylserine sulfhydrolase B) (NCBI) compare
b3803 hemX -1.2 -5.7 predicted uroporphyrinogen III methylase (NCBI) compare
b4477 dgoA -1.2 -2.9 2-dehydro-3-deoxy-6-phosphogalactonate aldolase (NCBI) compare
b1831 proQ -1.2 -2.9 putative solute/DNA competence effector (NCBI) compare
b2517 yfgB -1.2 -4.1 predicted enzyme (NCBI) compare
b3258 panF -1.2 -5.4 sodium/pantothenate symporter (VIMSS) compare
b3766 ilvL -1.2 -1.6 ilvG operon leader peptide (NCBI) compare
b0890 ftsK -1.2 -3.3 DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) compare
b0735 ybgE -1.2 -2.2 conserved inner membrane protein (NCBI) compare
b1176 minC -1.2 -1.8 septum formation inhibitor (NCBI) compare
b2434 b2434 -1.2 -2.3 orf, hypothetical protein (VIMSS) compare
b3239 yhcO -1.2 -1.8 predicted barnase inhibitor (NCBI) compare
b1728 ydjM -1.2 -1.5 predicted inner membrane protein regulated by LexA (RefSeq) compare
b0212 gloB -1.2 -1.8 predicted hydroxyacylglutathione hydrolase (NCBI) compare
b4480 hdfR -1.2 -2.7 transcriptional regulator HdfR (NCBI) compare
b4589 ylcI -1.2 -2.0 hypothetical protein (RefSeq) compare
b2080 b2080 -1.2 -1.2 orf, hypothetical protein (VIMSS) compare
b2830 nudH -1.2 -0.8 dinucleoside polyphosphate hydrolase (NCBI) compare
b2953 yggU -1.1 -1.3 orf, hypothetical protein (VIMSS) compare
b1628 rsxB -1.1 -1.8 electron transport complex protein RnfB (NCBI) compare
b4451 ryhB -1.1 -1.0 Regulatory sRNA mediating positive Fur regulon response; requires Hfq for function; global iron regulator; degraded by RNase E when bound to target (RefSeq) compare
b1001 yccE -1.1 -1.3 hypothetical protein (NCBI) compare
b3206 npr -1.1 -3.1 phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) (NCBI) compare
b3157 yhbT -1.1 -2.6 predicted lipid carrier protein (NCBI) compare
b1064 grxB -1.1 -3.1 glutaredoxin 2 (Grx2) (NCBI) compare
b1272 sohB -1.1 -4.1 predicted inner membrane peptidase (NCBI) compare
b2829 ptsP -1.1 -5.3 fused PTS enzyme: PEP-protein phosphotransferase (enzyme I)/GAF domain containing protein (NCBI) compare
b1306 pspC -1.1 -1.5 DNA-binding transcriptional activator (NCBI) compare
b3468 yhhN -1.1 -5.5 conserved inner membrane protein (NCBI) compare
b1837 yebW -1.1 -1.6 orf, hypothetical protein (VIMSS) compare
b4176 yjeT -1.1 -2.2 conserved inner membrane protein (NCBI) compare
b3082 ygjM -1.1 -1.3 predicted DNA-binding transcriptional regulator (NCBI) compare
b1819 manZ -1.1 -2.4 mannose-specific enzyme IID component of PTS (NCBI) compare
b0623 cspE -1.1 -1.5 cold shock protein E (NCBI) compare
b3649 rpoZ -1.1 -1.5 DNA-directed RNA polymerase subunit omega (NCBI) compare
b1992 cobS -1.1 -1.9 cobalamin synthase (NCBI) compare
b1712 ihfA -1.1 -1.4 integration host factor subunit alpha (NCBI) compare
b0049 apaH -1.0 -3.0 diadenosinetetraphosphatase (NCBI) compare
b2181 yejG -1.0 -3.0 hypothetical protein (NCBI) compare
b0013 yaaI -1.0 -2.9 hypothetical protein (NCBI) compare
b0825 mipB -1.0 -2.2 putative transaldolase (VIMSS) compare
b2947 gshB -1.0 -2.1 glutathione synthetase (NCBI) compare
b1189 dadA -1.0 -3.7 D-amino acid dehydrogenase (quinone) DadA (EC 1.4.5.1) (from data) compare
b1685 ydiH -1.0 -1.0 predicted protein (RefSeq) compare
b3363 ppiA -1.0 -3.9 peptidyl-prolyl cis-trans isomerase A (rotamase A) (NCBI) compare
b2683 ygaH -1.0 -2.6 predicted inner membrane protein (NCBI) compare
b2007 yeeX -1.0 -1.9 conserved protein (RefSeq) compare
b1078 flgG -1.0 -3.5 flagellar component of cell-distal portion of basal-body rod (NCBI) compare
b2909 ygfB -1.0 -3.2 orf, hypothetical protein (VIMSS) compare
b3781 trxA -1.0 -2.1 thioredoxin 1 (VIMSS) compare
b0881 clpS -1.0 -1.4 ATP-dependent Clp protease adaptor protein ClpS (NCBI) compare
b1021 ycdP -1.0 -3.4 predicted inner membrane protein (NCBI) compare
b0340 cynS -1.0 -0.9 cyanate hydratase (NCBI) compare
b1830 prc -1.0 -3.0 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b4426 isrA -1.0 -1.4 unknown RNA (NCBI) compare
b2977 glcG -1.0 -1.8 hypothetical protein (NCBI) compare
b1446 ydcY -1.0 -1.1 hypothetical protein (NCBI) compare
b1347 ydaC -1.0 -1.6 Rac prophage; predicted protein (NCBI) compare
b1448 yncA -1.0 -1.7 predicted acyltransferase with acyl-CoA N-acyltransferase domain (NCBI) compare
b2908 pepP -1.0 -3.8 proline aminopeptidase P II (NCBI) compare
b2614 grpE -1.0 -1.2 heat shock protein (NCBI) compare
b1013 ycdC -0.9 -1.4 predicted DNA-binding transcriptional regulator (NCBI) compare
b1597 asr -0.9 -2.1 acid shock protein (VIMSS) compare
b2910 zapA -0.9 -2.4 protein that localizes to the cytokinetic ring (NCBI) compare
b3728 pstS -0.9 -1.9 phosphate transporter subunit (NCBI) compare
b3834 yigP -0.9 -2.7 hypothetical protein (NCBI) compare
b1623 add -0.9 -2.2 adenosine deaminase (NCBI) compare
b0682 ybfN -0.9 -2.1 predicted lipoprotein (NCBI) compare
b3466 yhhL -0.9 -2.3 conserved inner membrane protein (NCBI) compare
b2419 yfeK -0.9 -1.2 hypothetical protein (NCBI) compare
b2937 speB -0.9 -3.0 agmatinase (NCBI) compare
b4337 yjiO -0.9 -3.2 multidrug efflux system protein (NCBI) compare
b3162 deaD -0.9 -2.0 inducible ATP-independent RNA helicase (VIMSS) compare
b2895 fldB -0.9 -1.6 flavodoxin 2 (NCBI) compare
b4212 ytfH -0.9 -2.3 orf, hypothetical protein (VIMSS) compare
b2105 yohL -0.9 -2.0 hypothetical protein (NCBI) compare
b2940 yqgC -0.9 -2.4 hypothetical protein (NCBI) compare
b1011 b1011 -0.9 -2.3 putative synthetase (VIMSS) compare
b1426 ydcH -0.9 -0.7 orf, hypothetical protein (VIMSS) compare
b4618 tisB -0.9 -2.0 lexA-regulated toxic peptide (RefSeq) compare
b1818 manY -0.9 -1.1 mannose-specific enzyme IIC component of PTS (NCBI) compare
b3871 bipA -0.9 -4.7 GTP-binding protein (NCBI) compare
b3257 yhdT -0.9 -1.5 conserved inner membrane protein (NCBI) compare
b4202 rpsR -0.9 -0.6 30S ribosomal protein S18 (NCBI) compare
b1164 ycgZ -0.9 -1.5 hypothetical protein (NCBI) compare
b3408 feoA -0.9 -4.8 ferrous iron transport protein A (NCBI) compare
b0178 hlpA -0.9 -1.6 periplasmic chaperone (NCBI) compare
b1183 umuD -0.9 -1.2 DNA polymerase V, subunit D (NCBI) compare
b0226 dinJ -0.9 -1.7 predicted antitoxin of YafQ-DinJ toxin-antitoxin system (NCBI) compare
b3361 fic -0.9 -2.0 stationary-phase protein, cell division (NCBI) compare
b0934 ycbM -0.9 -1.0 putative transport system permease protein (VIMSS) compare
b2894 xerD -0.9 -0.7 site-specific tyrosine recombinase XerD (NCBI) compare
b0346 mhpR -0.9 -2.0 DNA-binding transcriptional activator, 3HPP-binding (RefSeq) compare
b3973 birA -0.9 -0.9 biotin--protein ligase (NCBI) compare
b0113 pdhR -0.8 -2.2 transcriptional regulator of pyruvate dehydrogenase complex (NCBI) compare
b0303 ykgI -0.8 -1.8 orf, hypothetical protein (VIMSS) compare
b1222 narX -0.8 -1.8 sensory histidine kinase in two-component regulatory system with NarL (NCBI) compare
b1259 yciG -0.8 -1.2 orf, hypothetical protein (VIMSS) compare
b2326 yfcM -0.8 -2.7 hypothetical protein (NCBI) compare
b1085 b1085 -0.8 -1.0 orf, hypothetical protein (VIMSS) compare
b4416 rybA -0.8 -1.0 unknown RNA (NCBI) compare
b1954 dsrA -0.8 -1.3 regulatory antisense RNA (NCBI) compare
b1588 ynfF -0.8 -1.9 oxidoreductase subunit (RefSeq) compare
b4454 rdlD -0.8 -2.1 sRNA antisense regulator affects LdrD translation; proposed addiction module in LDR-D repeat, with toxic peptide LdrD (RefSeq) compare
b3465 yhhF -0.8 -2.6 predicted methyltransferase (NCBI) compare
b2570 rseC -0.8 -2.6 RseC protein involved in reduction of the SoxR iron-sulfur cluster (NCBI) compare
b1304 pspA -0.8 -1.5 regulatory protein for phage-shock-protein operon (NCBI) compare
b4060 yjcB -0.8 -2.3 orf, hypothetical protein (VIMSS) compare
b2377 yfdY -0.8 -1.4 predicted inner membrane protein (NCBI) compare
b4148 sugE -0.8 -2.5 suppresses groEL, may be chaperone (VIMSS) compare


Specific Phenotypes

For 23 genes in this experiment

For stress Sodium Chlorite in Escherichia coli BW25113

For stress Sodium Chlorite across organisms