Experiment set29IT063 for Pseudomonas putida KT2440

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Mucic acid carbon source

200 most detrimental genes:

  gene name fitness t score description  
PP_3603 +1.4 8.7 Transcriptional regulator, GntR family compare
PP_5486 +1.3 1.3 conserved protein of unknown function compare
PP_0274 +1.3 1.2 putative transcriptional regulator containing HTH domain compare
PP_5232 +1.3 1.5 conserved protein of unknown function compare
PP_4099 +1.3 11.3 two-componenent system BarA/UvrY - regulatory subunit compare
PP_1650 +1.1 10.4 Sensor protein GacS compare
PP_4814 +1.0 2.1 ATP-dependent protease La domain protein compare
PP_1774 +1.0 2.2 conserved exported protein of unknown function compare
PP_1568 +1.0 1.5 conserved protein of unknown function compare
PP_2773 +0.9 0.8 conserved protein of unknown function compare
PP_1938 +0.9 2.3 conserved protein of unknown function compare
PP_0959 +0.8 3.4 phospholipid ABC transporter compare
PP_1362 +0.8 3.0 pyruvate kinase II compare
PP_2646 +0.8 4.3 conserved protein of unknown function compare
PP_1655 +0.8 2.9 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD compare
PP_4989 +0.8 2.4 Protein PilJ compare
PP_4406 +0.8 2.5 conserved protein of unknown function compare
PP_1366 +0.8 0.6 Transcriptional regulator MvaT, P16 subunit compare
PP_4981 +0.8 1.2 polyisoprene-binding protein, acidic stress response factor compare
PP_1113 +0.8 5.5 Pyridoxal-phosphate dependent enzyme family protein compare
PP_1004 +0.7 1.7 conserved protein of unknown function compare
PP_2291 +0.7 2.0 conserved protein of unknown function compare
PP_3625 +0.7 3.1 Transporter, LysE family compare
PP_0643 +0.7 1.3 protein of unknown function compare
PP_1623 +0.7 4.8 RNA polymerase, sigma S (sigma 38) factor compare
PP_3035 +0.7 1.2 conserved protein of unknown function compare
PP_2655 +0.7 2.7 conserved protein of unknown function compare
PP_0979 +0.7 2.1 DNA polymerase III subunit chi compare
PP_2105 +0.7 2.7 conserved protein of unknown function compare
PP_3312 +0.7 1.3 putative Heat shock protein compare
PP_4373 +0.7 5.4 Transcriptional regulator FleQ compare
PP_2403 +0.7 1.7 Chemotaxis protein CheY compare
PP_2330 +0.7 2.9 conserved protein of unknown function compare
PP_2645 +0.6 4.5 magnesium transporter, ATP-dependent compare
PP_3880 +0.6 0.9 conserved exported protein of unknown function compare
PP_0127 +0.6 3.8 Thiol:disulfide interchange protein compare
PP_0377 +0.6 1.3 coenzyme PQQ synthesis protein D compare
PP_2253 +0.6 0.9 Transcriptional regulator, GntR family compare
PP_3415 +0.6 3.6 Transcriptional regulator, LacI family compare
PP_0874 +0.6 1.2 conserved protein of unknown function compare
PP_4254 +0.6 1.4 conserved protein of unknown function compare
PP_4828 +0.6 0.9 Precorrin-8X methylmutase compare
PP_5053 +0.6 3.1 Protein-export protein SecB compare
PP_1410 +0.6 0.9 conserved protein of unknown function compare
PP_5598 +0.6 1.4 conserved protein of unknown function compare
PP_0905 +0.6 0.7 conserved exported protein of unknown function compare
PP_2525 +0.6 2.4 conserved protein of unknown function compare
PP_5008 +0.6 0.7 Poly granule-associated protein compare
PP_3481 +0.6 1.0 conserved exported protein of unknown function compare
PP_4396 +0.6 1.7 conserved protein of unknown function compare
PP_4529 +0.6 2.6 conserved protein of unknown function compare
PP_3798 +0.6 2.9 conserved protein of unknown function compare
PP_0809 +0.6 3.9 disulfide bond formation protein B compare
PP_4470 +0.6 2.3 putative transcriptional regulator (Arc domain-containing) compare
PP_4365 +0.6 2.8 Flagellar protein FliJ compare
PP_5052 +0.6 2.4 tRNA(Leu) mC34,mU34 2'-O-ribose methyltransferase, AdoMet-dependent compare
PP_1550 +0.6 1.6 Transcriptional regulator, Cro/CI family compare
PP_2387 +0.6 2.0 conserved protein of unknown function compare
PP_3610 +0.6 1.9 conserved protein of unknown function compare
PP_1979 +0.5 1.7 putative Hydrolase compare
PP_4368 +0.5 2.9 flagellar motor switch protein compare
PP_3766 +0.5 1.3 Lactoylglutathione lyase compare
PP_4353 +0.5 2.5 Flagellar biosynthetic protein fliR compare
PP_0827 +0.5 1.7 putative phosphonate transport system permease protein PtxC compare
PP_0182 +0.5 2.3 conserved protein of unknown function compare
PP_4265 +0.5 1.5 DNA-binding transcriptional dual regulator compare
PP_5471 +0.5 1.0 putative response regulator receiver protein compare
PP_4386 +0.5 2.6 flagellar basal-body rod protein FlgF compare
PP_4930 +0.5 1.3 putative small multidrug resistance protein compare
PP_4371 +0.5 3.6 two component system AtoC DNA-binding transcriptional activator compare
PP_0614 +0.5 2.5 putative N-carbamoyl-beta-alanine amidohydrolase/allantoine amidohydrolase 1 compare
PP_4238 +0.5 1.7 conserved protein of unknown function compare
PP_0166 +0.5 4.0 HlyD family secretion protein compare
PP_3580 +0.5 1.2 conserved protein of unknown function compare
PP_5428 +0.5 2.3 conserved exported protein of unknown function compare
PP_4384 +0.5 3.6 Flagellar L-ring protein compare
PP_1569 +0.5 1.9 conserved protein of unknown function compare
PP_4835 +0.5 1.2 conserved exported protein of unknown function compare
PP_5161 +0.5 2.0 putative lysophospholipase compare
PP_1087 +0.5 3.4 Outer membrane protein, OmpA family compare
PP_1788 +0.5 0.9 conserved protein of unknown function compare
PP_5519 +0.5 1.2 conserved protein of unknown function of phage origin compare
PP_2147 +0.5 1.9 conserved exported protein of unknown function compare
PP_0007 +0.5 1.3 conserved hypothetical protein compare
PP_2672 +0.5 2.1 Transcriptional activator protein ExaE compare
PP_3341 +0.5 1.8 nickel-responsive regulator compare
PP_5038 +0.5 2.3 conserved lipoprotein of unknown function compare
PP_1349 +0.5 3.0 ATP:cob(I)alamin adenosyltransferase compare
PP_1028 +0.5 2.0 Transcriptional regulator, LysR family compare
PP_4720 +0.5 0.9 putative RNA binding protein compare
PP_2215 +0.5 2.5 acetyl-CoA acetyltransferase compare
PP_2695 +0.5 1.2 Transcriptional regulator, LysR family compare
PP_2107 +0.5 1.2 conserved protein of unknown function compare
PP_0960 +0.5 2.0 phospholipid ABC transporter binding protein compare
PP_0757 +0.5 1.7 conserved protein of unknown function compare
PP_0893 +0.5 1.3 ThiJ/PfpI family protein compare
PP_2163 +0.4 2.9 VacJ lipoprotein compare
PP_5705 +0.4 0.4 protein of unknown function compare
PP_2347 +0.4 1.8 DNA-binding response regulator compare
PP_5337 +0.4 2.1 LysR family transcriptional regulator compare
PP_3891 +0.4 1.5 conserved protein of unknown function compare
PP_3376 +0.4 2.2 putative phosphonate dehydrogenase compare
PP_1007 +0.4 2.6 putative Transmembrane sensor compare
PP_5747 +0.4 1.9 pyridine nucleotide transhydrogenase subunit alpha compare
PP_2652 +0.4 2.2 putative Hydratase/decarboxylase compare
PP_5324 +0.4 1.3 Response regulator compare
PP_1417 +0.4 1.8 putative Tricarboxylate transport protein TctB compare
PP_1404 +0.4 1.1 conserved protein of unknown function compare
PP_3019 +0.4 1.6 Carbon-nitrogen hydrolase family protein compare
PP_4223 +0.4 1.5 diaminobutyrate-2-oxoglutarate transaminase compare
PP_1068 +0.4 1.5 glutamate / aspartate ABC transporter - ATP binding subunit compare
PP_2960 +0.4 2.1 transcriptional regulator, AraC family compare
PP_2777 +0.4 2.0 putative Acyl carrier protein compare
PP_4343 +0.4 2.4 Flagellar biosynthesis protein FlhF compare
PP_3634 +0.4 1.9 putative acetyltransferase, GNAT family compare
PP_0574 +0.4 3.3 DNA-binding response regulator, LuxR family compare
PP_4208 +0.4 2.2 RNA polymerase sigma-70 factor, ECF subfamily compare
PP_0384 +0.4 2.6 Transcriptional regulator, AsnC family compare
PP_2976 +0.4 1.0 putative transposase compare
PP_2118 +0.4 0.9 conserved protein of unknown function compare
PP_5244 +0.4 2.1 Transcriptional regulator, AraC family compare
PP_3451 +0.4 2.3 conserved exported protein of unknown function compare
PP_4966 +0.4 1.3 transcriptional regulator of methionine metabolism compare
PP_4771 +0.4 1.9 conserved membrane protein of unknown function compare
PP_5496 +0.4 1.7 conserved exported protein of unknown function compare
PP_t49 +0.4 2.6 tRNA-Met compare
PP_2459 +0.4 1.0 ribose pyranase compare
PP_4382 +0.4 2.9 Peptidoglycan hydrolase FlgJ compare
PP_0642 +0.4 2.2 conserved membrane protein of unknown function compare
PP_5582 +0.4 0.5 conserved protein of unknown function compare
PP_4249 +0.4 1.9 conserved protein of unknown function compare
PP_5243 +0.4 1.6 putative hydrolase compare
PP_0416 +0.4 2.6 Phosphoglycolate phosphatase compare
PP_1077 +0.4 2.6 Cys-tRNAPro deacylase compare
PP_3277 +0.4 0.9 ring 1,2-phenylacetyl-CoA epoxidase regulatory subunit compare
PP_0109 +0.4 2.2 conserved membrane protein of unknown function compare
PP_2712 +0.4 1.8 conserved exported protein of unknown function compare
PP_5359 +0.4 0.6 CobW/P47K family protein compare
PP_0262 +0.4 1.5 conserved protein of unknown function compare
PP_1761 +0.4 2.9 diguanylate cyclase with phosphodiesterase domain compare
PP_4171 +0.4 3.2 conserved exported protein of unknown function compare
PP_2701 +0.4 1.9 Transcriptional regulator, LysR family compare
PP_4388 +0.4 3.2 Flagellar hook protein FlgE compare
PP_1047 +0.4 1.7 putative protein secretion protein for export compare
PP_4361 +0.4 2.2 Flagellar hook-length control protein FliK compare
PP_5167 +0.4 1.1 conserved hypothetical protein compare
PP_4329 +0.4 1.5 FlhB domain protein compare
PP_0167 +0.4 3.2 Toxin secretion ATP-binding protein compare
PP_2040 +0.4 2.2 Major facilitator family transporter compare
PP_3587 +0.4 2.1 lipid hydroperoxide peroxidase compare
PP_4503 +0.4 0.7 DNA-binding response regulator compare
PP_2889 +0.4 1.6 putative Transmembrane regulator PrtR compare
PP_5719 +0.4 2.2 choline-responsive transcriptional repressor BetI compare
PP_3473 +0.4 1.2 curli secretion and assembly outer membrane associated component compare
PP_5211 +0.4 2.1 ChaC-related protein compare
PP_1829 +0.4 1.1 Hydrolase, alpha/beta fold family compare
PP_4375 +0.4 2.5 flagellar chaperone, inhibits premature FliC assembly compare
PP_3902 +0.4 1.0 conserved protein of unknown function compare
PP_0168 +0.4 3.3 putative surface adhesion protein compare
PP_0321 +0.4 1.8 low specificity L-threonine aldolase compare
PP_3189 +0.4 1.9 cytosine deaminase / isoguanine deaminase compare
PP_2970 +0.4 0.8 conserved exported protein of unknown function compare
PP_0957 +0.4 0.7 D-arabinose 5-phosphate isomerase compare
PP_1728 +0.4 2.5 conserved membrane protein of unknown function compare
PP_2432 +0.4 1.7 6,7-dihydropteridine reductase compare
PP_4905 +0.4 2.3 Flagellar motor rotation protein compare
PP_3987 +0.4 2.8 Site-specific recombinase, phage integrase family compare
PP_5721 +0.4 2.0 conserved protein of unknown function compare
PP_0876 +0.4 2.1 Transcriptional regulator, AraC family compare
PP_3438 +0.4 1.6 conserved membrane protein of unknown function compare
PP_5522 +0.4 1.5 protein of unknown function compare
PP_0992 +0.4 2.0 conserved protein of unknown function, UPF0276 family compare
PP_2318 +0.4 1.8 acyl-CoA thioesterase I/protease I/lysophospholipase L1 compare
PP_5631 +0.4 1.9 protein of unknown function compare
PP_4196 +0.4 1.0 conserved exported protein of unknown function compare
PP_3198 +0.4 1.5 Ferredoxin, 2Fe-2S compare
PP_4855 +0.4 1.9 Osmotically-inducible lipoprotein OsmE compare
PP_3563 +0.3 1.3 conserved exported protein of unknown function compare
PP_2585 +0.3 1.8 Alpha-ketoglutaric semialdehyde dehydrogenase compare
PP_4500 +0.3 1.7 TrpH family protein compare
PP_t11 +0.3 1.2 tRNA-Lys compare
PP_3367 +0.3 1.5 conserved protein of unknown function compare
PP_3205 +0.3 1.2 Fumarylacetoacetate hydrolase family protein compare
PP_3512 +0.3 1.7 conserved membrane protein of unknown function compare
PP_1697 +0.3 1.2 transcriptional regulator, GntR family compare
PP_3750 +0.3 1.9 Transcriptional regulator, GntR family compare
PP_1387 +0.3 1.2 Probable HTH-type transcriptional regulator TtgR compare
PP_4366 +0.3 2.7 flagellum-specific ATP synthase compare
PP_0805 +0.3 2.5 Outer membrane efflux protein compare
PP_4054 +0.3 1.3 conserved protein of unknown function compare
PP_5110 +0.3 0.9 cytokinetic ring ABC transporter-like subunit - ATP-binding subunit compare
PP_4519 +0.3 2.5 Agglutination protein compare
PP_2969 +0.3 1.0 putative repressor of copper utilisation proteins compare
PP_3645 +0.3 1.7 putative L-proline amide hydrolase compare
PP_0962 +0.3 1.1 toluene-tolerance protein compare
PP_4904 +0.3 2.1 Flagellar motor rotation protein compare
PP_1575 +0.3 0.7 conserved protein of unknown function compare
PP_5636 +0.3 1.8 protein of unknown function compare
PP_4639 +0.3 2.0 P-loop guanosine triphosphatase-dependent zinc chaperone compare
PP_5475 +0.3 0.4 conserved protein of unknown function compare


Specific Phenotypes

For 7 genes in this experiment

For carbon source Mucic acid in Pseudomonas putida KT2440

For carbon source Mucic acid across organisms