Experiment set29IT061 for Pseudomonas putida KT2440

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D-Glucuronic acid gamma lactone carbon source

200 most detrimental genes:

  gene name fitness t score description  
PP_4373 +1.7 13.1 Transcriptional regulator FleQ compare
PP_1623 +1.5 10.2 RNA polymerase, sigma S (sigma 38) factor compare
PP_1055 +1.5 1.8 Type II secretion pathway protein GspN compare
PP_1113 +1.4 9.6 Pyridoxal-phosphate dependent enzyme family protein compare
PP_3916 +1.4 5.7 conserved protein of unknown function compare
PP_0168 +1.2 10.9 putative surface adhesion protein compare
PP_0167 +1.2 10.2 Toxin secretion ATP-binding protein compare
PP_4171 +1.2 9.4 conserved exported protein of unknown function compare
PP_0166 +1.1 9.6 HlyD family secretion protein compare
PP_0165 +1.1 9.0 GGDEF domain protein compare
PP_5053 +1.1 6.5 Protein-export protein SecB compare
PP_0874 +1.1 3.5 conserved protein of unknown function compare
PP_3603 +1.0 6.2 Transcriptional regulator, GntR family compare
PP_0848 +1.0 2.2 donor of Fe2+ and regulator of cysteine desulfurase activity compare
PP_5232 +1.0 2.4 conserved protein of unknown function compare
PP_2459 +0.9 1.6 ribose pyranase compare
PP_4519 +0.9 7.4 Agglutination protein compare
PP_0355 +0.9 2.5 Response regulator compare
PP_2907 +0.9 2.2 DNA-binding response regulator compare
PP_1568 +0.9 1.3 conserved protein of unknown function compare
PP_5546 +0.9 1.8 conserved protein of unknown function compare
PP_3037 +0.9 2.6 C4-type zinc finger protein, DksA/TraR family compare
PP_2889 +0.9 5.1 putative Transmembrane regulator PrtR compare
PP_4227 +0.9 1.8 conserved protein of unknown function compare
PP_3541 +0.9 1.9 Transporter, MgtC family compare
PP_4172 +0.9 3.4 conserved exported protein of unknown function compare
PP_0274 +0.9 0.6 putative transcriptional regulator containing HTH domain compare
PP_2387 +0.8 2.1 conserved protein of unknown function compare
PP_2107 +0.8 2.1 conserved protein of unknown function compare
PP_2725 +0.8 1.6 Protease PfpI compare
PP_2330 +0.8 3.6 conserved protein of unknown function compare
PP_1553 +0.8 1.9 conserved protein of unknown function compare
PP_5201 +0.8 2.4 conserved protein of unknown function, UPF0149 family compare
PP_2186 +0.7 2.4 putative Formate dehydrogenase, delta subunit compare
PP_2898 +0.7 1.7 conserved exported protein of unknown function compare
PP_5598 +0.7 2.8 conserved protein of unknown function compare
PP_5483 +0.7 1.2 conserved protein of unknown function compare
PP_1729 +0.7 1.2 conserved protein of unknown function compare
PP_4388 +0.7 5.2 Flagellar hook protein FlgE compare
PP_2718 +0.7 2.9 arsenic resistance transcriptional regulator compare
PP_0574 +0.7 6.0 DNA-binding response regulator, LuxR family compare
PP_3384 +0.7 2.1 gluconate 2-dehydrogenase gamma subunit compare
PP_0959 +0.7 2.0 phospholipid ABC transporter compare
PP_4710 +0.7 5.2 tRNA pseudouridine 55 synthase compare
PP_3398 +0.7 1.4 putative Curli fiber surface-exposed nucleator CsgB compare
PP_4386 +0.7 3.3 flagellar basal-body rod protein FlgF compare
PP_1112 +0.7 5.1 conserved membrane protein of unknown function compare
PP_3803 +0.7 2.9 putative Cation ABC transporter, permease protein compare
PP_4814 +0.7 1.6 ATP-dependent protease La domain protein compare
PP_3761 +0.7 5.7 Sensor histidine kinase/response regulator compare
PP_5583 +0.7 0.7 conserved protein of unknown function compare
PP_5528 +0.7 0.6 conserved protein of unknown function compare
PP_3938 +0.7 1.4 conserved protein of unknown function compare
PP_5248 +0.7 0.9 putative hydrolase compare
PP_1943 +0.7 3.5 formyltetrahydrofolate deformylase compare
PP_0276 +0.7 1.1 Transcriptional regulator, Cro/CI family compare
PP_2229 +0.7 1.5 putative K(+)/H(+) antiporter subunit C compare
PP_2003 +0.7 2.1 conserved protein of unknown function compare
PP_3840 +0.7 0.9 conserved protein of unknown function compare
PP_1328 +0.6 1.5 Protein MraZ compare
PP_5610 +0.6 1.5 protein of unknown function compare
PP_0804 +0.6 3.8 Protein secretion ABC efflux system, permease and ATP-binding protein compare
PP_2717 +0.6 3.3 arsenite/antimonite transporter compare
PP_0135 +0.6 2.3 conserved exported protein of unknown function compare
PP_0258 +0.6 2.2 regulator of murein cross-linking compare
PP_0241 +0.6 1.5 Transporter compare
PP_0398 +0.6 2.0 Thiosulfate sulfurtransferase GlpE compare
PP_5486 +0.6 0.9 conserved protein of unknown function compare
PP_4792 +0.6 1.3 conserved exported protein of unknown function compare
PP_4622 +0.6 2.0 Hmg transcriptional repressor compare
PP_2101 +0.6 2.6 DNA-binding response regulator in two-component regulatory system with EvgS compare
PP_2716 +0.6 1.9 arsenate reductase compare
PP_0962 +0.6 1.3 toluene-tolerance protein compare
PP_5143 +0.6 1.3 conserved membrane protein of unknown function compare
PP_1528 +0.6 1.3 conserved protein of unknown function compare
PP_5058 +0.6 3.3 Carboxy-terminal-processing protease compare
PP_5580 +0.6 1.1 protein of unknown function compare
PP_4207 +0.6 2.1 conserved protein of unknown function compare
PP_2103 +0.6 2.5 conserved protein of unknown function compare
PP_5621 +0.6 1.6 protein of unknown function compare
PP_1415 +0.6 1.3 putative membrane associated enzyme subunit compare
PP_3117 +0.6 1.8 putative protein involved in error-prone processing of DNA lesions compare
PP_4391 +0.6 3.3 flagellar basal-body rod protein FlgB compare
PP_1643 +0.6 2.4 conserved membrane protein of unknown function compare
PP_1410 +0.6 0.8 conserved protein of unknown function compare
PP_0643 +0.6 1.5 protein of unknown function compare
PP_2645 +0.6 4.2 magnesium transporter, ATP-dependent compare
PP_2773 +0.6 1.0 conserved protein of unknown function compare
PP_2147 +0.6 2.4 conserved exported protein of unknown function compare
PP_5717 +0.6 1.2 conserved protein of unknown function compare
PP_4361 +0.6 3.0 Flagellar hook-length control protein FliK compare
PP_1004 +0.6 1.1 conserved protein of unknown function compare
PP_5548 +0.6 1.2 protein of unknown function compare
PP_5422 +0.5 1.7 hypothetical protein compare
PP_1795 +0.5 3.9 conserved protein of unknown function compare
PP_1554 +0.5 1.3 conserved protein of unknown function compare
PP_4365 +0.5 2.7 Flagellar protein FliJ compare
PP_4942 +0.5 0.8 conserved protein of unknown function compare
PP_5238 +0.5 1.5 conserved protein of unknown function compare
PP_5471 +0.5 0.7 putative response regulator receiver protein compare
PP_4642 +0.5 0.8 Cyclic diguanosine monophosphate-binding protein compare
PP_0896 +0.5 2.5 Carbon-nitrogen hydrolase family protein compare
PP_4855 +0.5 2.6 Osmotically-inducible lipoprotein OsmE compare
PP_5589 +0.5 1.9 protein of unknown function containing Rhs repeat-associated core domain compare
PP_5324 +0.5 1.3 Response regulator compare
PP_4925 +0.5 1.7 conserved protein of unknown function compare
PP_4352 +0.5 4.1 flagellin export apparatus, substrate specificity protein compare
PP_2847 +0.5 1.1 Urease accessory protein UreJ compare
PP_2060 +0.5 1.3 DNA-binding transcriptional dual regulator - SoxR-reversible one-electron oxidation of its [2Fe-2S] cluster, NADPH-dependent compare
PP_1498 +0.5 2.5 putative Lipoprotein compare
PP_3019 +0.5 2.6 Carbon-nitrogen hydrolase family protein compare
PP_2142 +0.5 1.3 Cell division inhibitor SulA compare
PP_2745 +0.5 1.3 Universal stress protein family compare
PP_2994 +0.5 2.3 Oxidoreductase, FMN-binding compare
PP_4173 +0.5 3.2 Sensor histidine kinase/response regulator compare
PP_4136 +0.5 0.8 Transcriptional regulator, LuxR family compare
PP_5038 +0.5 1.5 conserved lipoprotein of unknown function compare
PP_4959 +0.5 3.7 diguanylate cyclase compare
PP_1822 +0.5 1.7 conserved protein of unknown function compare
PP_2979 +0.5 2.6 conserved protein of unknown function compare
PP_4366 +0.5 4.1 flagellum-specific ATP synthase compare
PP_0086 +0.5 1.6 conserved protein of unknown function compare
PP_5488 +0.5 2.2 conserved protein of unknown function compare
PP_3903 +0.5 1.2 conserved protein of unknown function compare
PP_5206 +0.5 2.7 putative translation-related protein compare
PP_4341 +0.5 3.1 RNA polymerase sigma 28 (sigma F) factor for class III flagellar operons compare
PP_5682 +0.5 2.1 conserved protein of unknown function compare
PP_1271 +0.5 2.4 putative Multidrug efflux MFS transporter compare
PP_0673 +0.5 0.8 conserved protein of unknown function compare
PP_4390 +0.5 3.4 flagellar basal-body rod protein FlgC compare
PP_0191 +0.5 1.1 Transcriptional regulatory protein AlgQ compare
PP_1786 +0.5 3.9 putative Glycosyl transferase compare
PP_4701 +0.5 0.6 glucose-6-phosphate isomerase compare
PP_5311 +0.5 3.1 putative signal transduction protein compare
PP_5052 +0.5 2.1 tRNA(Leu) mC34,mU34 2'-O-ribose methyltransferase, AdoMet-dependent compare
PP_3284 +0.5 1.8 enoyl-CoA hydratase-isomerase compare
PP_4849 +0.5 2.1 putative DnaK protein compare
PP_4384 +0.5 3.4 Flagellar L-ring protein compare
PP_1555 +0.5 2.0 putative Phage integrase compare
PP_2648 +0.5 1.6 Universal stress protein family compare
PP_4602 +0.5 2.2 Transcriptional regulator, AraC family compare
PP_3128 +0.5 2.7 putative Exopolysaccharide biosynthesis/transport protein compare
PP_3610 +0.5 2.3 conserved protein of unknown function compare
PP_3625 +0.5 1.8 Transporter, LysE family compare
PP_1204 +0.5 2.5 putative Lipoprotein compare
PP_2646 +0.5 2.3 conserved protein of unknown function compare
PP_2269 +0.5 1.4 putative N-acetylmuramoyl-L-alanine amidase compare
PP_0508 +0.5 1.1 conserved exported protein of unknown function compare
PP_2163 +0.5 2.6 VacJ lipoprotein compare
PP_0640 +0.5 1.3 conserved protein of unknown function compare
PP_0803 +0.5 2.5 Protein secretion ABC efflux system, membrane fusion protein compare
PP_0125 +0.5 1.3 putative cytochrome c-type protein compare
PP_5711 +0.5 1.6 protein of unknown function compare
PP_4593 +0.5 1.0 conserved protein of unknown function compare
PP_1441 +0.5 1.6 tRNA (cmo5U34)-methyltransferase compare
PP_4818 +0.5 1.8 ribosomal protein L11 methyltransferase compare
PP_2793 +0.5 0.9 Acyl-CoA dehydrogenase family protein compare
PP_0926 +0.5 3.7 putative Membrane protein compare
PP_4669 +0.5 1.7 OmpA family protein compare
PP_1049 +0.5 1.8 putative protein secretion protein for export compare
PP_0806 +0.5 4.2 putative Surface adhesion protein compare
PP_4215 +0.5 2.3 pyoverdine biosynthesis related protein compare
PP_3443 +0.5 3.0 putative glyceraldehyde-3-phosphate dehydrogenase compare
PP_5485 +0.5 2.5 putative N-acetyltransferase, GNAT domain compare
PP_5204 +0.5 1.5 conserved protein of unknown function compare
PP_4382 +0.5 3.0 Peptidoglycan hydrolase FlgJ compare
PP_2274 +0.5 1.2 conserved protein of unknown function compare
PP_2550 +0.5 1.5 putative transcriptional regulatory protein compare
PP_4632 +0.5 1.9 dihydrofolate reductase / dihydromonapterin reductase compare
PP_0114 +0.5 2.2 methionine ABC transporter ATP-binding protein compare
PP_3527 +0.4 3.1 Transcriptional regulator, TetR family compare
PP_5712 +0.4 1.8 conserved protein of unknown function compare
PP_5745 +0.4 2.5 paraquat-inducible protein A compare
PP_0495 +0.4 2.0 type 1 L-asparaginase compare
PP_2950 +0.4 1.6 conserved protein of unknown function compare
PP_3487 +0.4 1.2 conserved exported protein of unknown function compare
PP_5051 +0.4 1.4 conserved protein of unknown function compare
PP_5502 +0.4 1.6 ribosome modulation factor compare
PP_5240 +0.4 1.8 Response regulator compare
PP_5063 +0.4 2.0 betaine aldehyde dehydrogenase, NAD-dependent compare
PP_2712 +0.4 1.5 conserved exported protein of unknown function compare
PP_0775 +0.4 1.1 conserved protein of unknown function compare
PP_2122 +0.4 1.8 molybdenum cofactor biosynthesis protein B compare
PP_1087 +0.4 2.7 Outer membrane protein, OmpA family compare
PP_3549 +0.4 1.6 multidrug efflux transport system - membrane fusion protein compare
PP_1550 +0.4 1.1 Transcriptional regulator, Cro/CI family compare
PP_0960 +0.4 2.4 phospholipid ABC transporter binding protein compare
PP_4400 +0.4 2.6 Bkd operon transcriptional regulator compare
PP_2016 +0.4 1.7 conserved protein of unknown function compare
PP_2764 +0.4 2.4 FMN reductase (NADPH) compare
PP_1609 +0.4 1.0 conserved protein of unknown function compare
PP_4835 +0.4 1.3 conserved exported protein of unknown function compare
PP_0868 +0.4 1.9 ABC transporter ATP-binding subunit compare
PP_5609 +0.4 1.4 conserved protein of unknown function compare
PP_2160 +0.4 1.7 NADPH-dependent 7-cyano-7-deazaguanine reductase compare
PP_5359 +0.4 0.8 CobW/P47K family protein compare
PP_3902 +0.4 1.0 conserved protein of unknown function compare
PP_4419 +0.4 0.8 transposase compare
PP_5617 +0.4 1.5 conserved protein of unknown function compare
PP_1388 +0.4 2.6 Drug resistance transporter, EmrB/QacA family compare


Specific Phenotypes

For 10 genes in this experiment

For carbon source D-Glucuronic acid gamma lactone in Pseudomonas putida KT2440

For carbon source D-Glucuronic acid gamma lactone across organisms