| | gene | name | fitness | t score | description | |
|---|
| b2476 | purC | -8.7 | -6.0 | phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI) | compare |
| b1260 | trpA | -7.0 | -7.8 | tryptophan synthase subunit alpha (NCBI) | compare |
| b1281 | pyrF | -6.8 | -6.6 | orotidine 5'-phosphate decarboxylase (NCBI) | compare |
| b0523 | purE | -6.2 | -7.4 | phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI) | compare |
| b2557 | purL | -6.2 | -13.9 | phosphoribosylformylglycinamidine synthase (NCBI) | compare |
| b4006 | purH | -6.1 | -20.6 | bifunctionalphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI) | compare |
| b4005 | purD | -6.1 | -15.3 | phosphoribosylamine--glycine ligase (NCBI) | compare |
| b0033 | carB | -6.0 | -23.4 | carbamoyl-phosphate synthase large subunit (NCBI) | compare |
| b2499 | purM | -6.0 | -8.2 | phosphoribosylaminoimidazole synthetase (NCBI) | compare |
| b0004 | thrC | -5.9 | -14.3 | threonine synthase (NCBI) | compare |
| b2312 | purF | -5.9 | -11.3 | amidophosphoribosyltransferase (NCBI) | compare |
| b1062 | pyrC | -5.5 | -13.8 | dihydroorotase (NCBI) | compare |
| b0945 | pyrD | -5.5 | -12.7 | dihydroorotate dehydrogenase (NCBI) | compare |
| b3389 | aroB | -5.5 | -18.7 | 3-dehydroquinate synthase (NCBI) | compare |
| b4388 | serB | -5.5 | -12.7 | 3-phosphoserine phosphatase (NCBI) | compare |
| b2913 | serA | -5.3 | -14.6 | D-3-phosphoglycerate dehydrogenase (NCBI) | compare |
| b1192 | ldcA | -5.3 | -10.1 | L,D-carboxypeptidase A (NCBI) | compare |
| b0032 | carA | -5.3 | -8.7 | carbamoyl-phosphate synthase small subunit (NCBI) | compare |
| b3281 | aroE | -5.2 | -27.3 | dehydroshikimate reductase, NAD(P)-binding (NCBI) | compare |
| b0907 | serC | -5.2 | -10.7 | phosphoserine aminotransferase (NCBI) | compare |
| b3642 | pyrE | -5.2 | -8.6 | orotate phosphoribosyltransferase (NCBI) | compare |
| b3956 | ppc | -5.1 | -25.1 | phosphoenolpyruvate carboxylase (NCBI) | compare |
| b0522 | purK | -5.0 | -15.2 | phosphoribosylaminoimidazole carboxylase (NCBI) | compare |
| b4245 | pyrB | -5.0 | -15.7 | aspartate carbamoyltransferase catalytic subunit (NCBI) | compare |
| b0908 | aroA | -4.9 | -12.7 | 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) | compare |
| b2329 | aroC | -4.7 | -9.4 | chorismate synthase (NCBI) | compare |
| b0003 | thrB | -4.6 | -9.2 | homoserine kinase (NCBI) | compare |
| b1693 | aroD | -4.6 | -9.8 | 3-dehydroquinate dehydratase (NCBI) | compare |
| b2762 | cysH | -4.3 | -14.0 | phosphoadenosine phosphosulfate reductase (NCBI) | compare |
| b0002 | thrA | -4.3 | -18.4 | bifunctional aspartokinase I/homeserine dehydrogenase I (NCBI) | compare |
| b1261 | trpB | -4.2 | -3.1 | tryptophan synthase subunit beta (NCBI) | compare |
| b2479 | gcvR | -4.0 | -8.9 | transcriptional regulation of gcv operon (VIMSS) | compare |
| b0149 | mrcB | -4.0 | -24.4 | penicillin-binding protein 1b (NCBI) | compare |
| b3941 | metF | -4.0 | -18.4 | 5,10-methylenetetrahydrofolate reductase (NCBI) | compare |
| b3172 | argG | -4.0 | -19.4 | argininosuccinate synthase (NCBI) | compare |
| b0242 | proB | -3.9 | -11.1 | gamma-glutamyl kinase (NCBI) | compare |
| b3960 | argH | -3.9 | -18.1 | argininosuccinate lyase (NCBI) | compare |
| b2750 | cysC | -3.9 | -8.6 | adenylylsulfate kinase (NCBI) | compare |
| b2839 | lysR | -3.9 | -6.9 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b2838 | lysA | -3.9 | -16.9 | diaminopimelate decarboxylase, PLP-binding (NCBI) | compare |
| b3870 | glnA | -3.8 | -3.7 | glutamine synthetase (NCBI) | compare |
| b0243 | proA | -3.7 | -13.3 | gamma-glutamyl phosphate reductase (NCBI) | compare |
| b3957 | argE | -3.7 | -21.2 | acetylornithine deacetylase (NCBI) | compare |
| b0740 | tolB | -3.6 | -10.0 | translocation protein TolB precursor (NCBI) | compare |
| b0386 | proC | -3.6 | -9.4 | pyrroline-5-carboxylate reductase (NCBI) | compare |
| b2414 | cysK | -3.6 | -16.4 | cysteine synthase A, O-acetylserine sulfhydrolase A subunit (NCBI) | compare |
| b4214 | cysQ | -3.6 | -18.5 | PAPS (adenosine 3'-phosphate 5'-phosphosulfate) 3'(2'),5'-bisphosphate nucleotidase (NCBI) | compare |
| b3958 | argC | -3.6 | -19.7 | N-acetyl-gamma-glutamyl-phosphate reductase (NCBI) | compare |
| b0145 | dksA | -3.5 | -7.0 | DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) | compare |
| b0720 | gltA | -3.5 | -12.4 | citrate synthase (NCBI) | compare |
| b3771 | ilvD | -3.5 | -21.6 | dihydroxy-acid dehydratase (NCBI) | compare |
| b3959 | argB | -3.4 | -16.5 | acetylglutamate kinase (RefSeq) | compare |
| b3770 | ilvE | -3.4 | -19.5 | branched-chain amino acid aminotransferase (NCBI) | compare |
| b2818 | argA | -3.4 | -14.9 | N-acetylglutamate synthase (NCBI) | compare |
| b2025 | hisF | -3.4 | -7.6 | imidazole glycerol phosphate synthase subunit HisF (NCBI) | compare |
| b3774 | ilvC | -3.3 | -22.4 | ketol-acid reductoisomerase (NCBI) | compare |
| b1865 | nudB | -3.2 | -4.3 | dATP pyrophosphohydrolase (NCBI) | compare |
| b3390 | aroK | -3.1 | -5.0 | shikimate kinase I (NCBI) | compare |
| b2024 | hisA | -3.1 | -5.4 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-imidazolecarboxamide isomerase (VIMSS) | compare |
| b1850 | eda | -3.0 | -5.6 | keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) | compare |
| b2763 | cysI | -3.0 | -14.0 | sulfite reductase, beta subunit, NAD(P)-binding, heme-binding (NCBI) | compare |
| b2764 | cysJ | -2.9 | -14.7 | sulfite reductase, alpha subunit, flavoprotein (NCBI) | compare |
| b2022 | hisB | -2.8 | -9.8 | imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS) | compare |
| b3939 | metB | -2.8 | -16.9 | cystathionine gamma-synthase (NCBI) | compare |
| b0726 | sucA | -2.8 | -6.1 | alpha-ketoglutarate decarboxylase (NCBI) | compare |
| b2023 | hisH | -2.8 | -10.2 | imidazole glycerol phosphate synthase subunit HisH (NCBI) | compare |
| b2026 | hisI | -2.7 | -11.5 | bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI) | compare |
| b2020 | hisD | -2.7 | -12.7 | histidinol dehydrogenase (NCBI) | compare |
| b0071 | leuD | -2.7 | -11.5 | isopropylmalate isomerase small subunit (NCBI) | compare |
| b2600 | tyrA | -2.7 | -5.5 | fused chorismate mutase T/prephenate dehydrogenase (NCBI) | compare |
| b1105 | ycfM | -2.6 | -8.4 | predicted outer membrane lipoprotein (NCBI) | compare |
| b4013 | metA | -2.6 | -10.7 | homoserine O-succinyltransferase (NCBI) | compare |
| b2019 | hisG | -2.6 | -6.2 | ATP phosphoribosyltransferase (NCBI) | compare |
| b2021 | hisC | -2.6 | -8.4 | histidinol-phosphate aminotransferase (NCBI) | compare |
| b2500 | purN | -2.6 | -9.4 | phosphoribosylglycinamide formyltransferase (NCBI) | compare |
| b3772 | ilvA | -2.5 | -16.5 | threonine dehydratase (NCBI) | compare |
| b3916 | pfkA | -2.5 | -3.3 | 6-phosphofructokinase (NCBI) | compare |
| b3368 | cysG | -2.5 | -18.4 | fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase (NCBI) | compare |
| b0073 | leuB | -2.4 | -12.9 | 3-isopropylmalate dehydrogenase (VIMSS) | compare |
| b0072 | leuC | -2.4 | -14.3 | isopropylmalate isomerase large subunit (NCBI) | compare |
| b3773 | ilvY | -2.4 | -16.4 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b2830 | nudH | -2.4 | -2.9 | dinucleoside polyphosphate hydrolase (NCBI) | compare |
| b2912 | ygfA | -2.3 | -6.8 | putative ligase (VIMSS) | compare |
| b2313 | cvpA | -2.2 | -3.2 | membrane protein required for colicin V production (NCBI) | compare |
| b0564 | appY | -2.2 | -1.2 | DLP12 prophage; DNA-binding transcriptional activator (NCBI) | compare |
| b0074 | leuA | -2.1 | -13.4 | 2-isopropylmalate synthase (NCBI) | compare |
| b0737 | tolQ | -2.1 | -5.4 | membrane spanning protein in TolA-TolQ-TolR complex (NCBI) | compare |
| b2188 | yejM | -2.1 | -11.6 | predicted hydrolase, inner membrane (NCBI) | compare |
| b3405 | ompR | -2.1 | -7.0 | osmolarity response regulator (NCBI) | compare |
| b0889 | lrp | -2.0 | -6.2 | DNA-binding transcriptional dual regulator, leucine-binding (NCBI) | compare |
| b0739 | tolA | -2.0 | -6.0 | cell envelope integrity inner membrane protein TolA (NCBI) | compare |
| b0741 | pal | -2.0 | -7.2 | peptidoglycan-associated outer membrane lipoprotein (NCBI) | compare |
| b4042 | dgkA | -2.0 | -3.2 | diacylglycerol kinase (NCBI) | compare |
| b3082 | ygjM | -2.0 | -3.6 | predicted DNA-binding transcriptional regulator (NCBI) | compare |
| b3613 | yibP | -1.9 | -7.8 | putative membrane protein (VIMSS) | compare |
| b0049 | apaH | -1.9 | -4.6 | diadenosinetetraphosphatase (NCBI) | compare |
| b1861 | ruvA | -1.9 | -2.4 | Holliday junction DNA helicase motor protein (NCBI) | compare |
| b3940 | metL | -1.9 | -10.3 | bifunctional aspartate kinase II/homoserine dehydrogenase II (NCBI) | compare |
| b4246 | pyrL | -1.8 | -1.7 | pyrBI operon leader peptide (NCBI) | compare |
| b4025 | pgi | -1.8 | -8.8 | glucose-6-phosphate isomerase (NCBI) | compare |
| b3781 | trxA | -1.8 | -7.6 | thioredoxin 1 (VIMSS) | compare |
| b1262 | trpC | -1.7 | -2.9 | N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase (VIMSS) | compare |
| b0730 | mngR | -1.7 | -2.7 | DNA-binding transcriptional dual regulator, fatty-acyl-binding (NCBI) | compare |
| b2531 | iscR | -1.7 | -3.2 | DNA-binding transcriptional repressor (NCBI) | compare |
| b2599 | pheA | -1.7 | -5.8 | fused chorismate mutase P/prephenate dehydratase (NCBI) | compare |
| b2567 | rnc | -1.7 | -1.5 | ribonuclease III (NCBI) | compare |
| b0738 | tolR | -1.7 | -4.9 | membrane spanning protein in TolA-TolQ-TolR complex (NCBI) | compare |
| b2363 | yfdT | -1.6 | -3.0 | CPS-53 (KpLE1) prophage; predicted protein (NCBI) | compare |
| b3169 | nusA | -1.6 | -3.6 | transcription elongation factor NusA (NCBI) | compare |
| b3204 | ptsN | -1.5 | -5.2 | sugar-specific enzyme IIA component of PTS (NCBI) | compare |
| b0439 | lon | -1.5 | -6.7 | DNA-binding ATP-dependent protease La (NCBI) | compare |
| b0890 | ftsK | -1.4 | -5.2 | DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) | compare |
| b1264 | trpE | -1.4 | -3.5 | anthranilate synthase component I (NCBI) | compare |
| b1361 | ydaW | -1.4 | -0.9 | orf, hypothetical protein (VIMSS) | compare |
| b1860 | ruvB | -1.4 | -1.9 | Holliday junction DNA helicase B (NCBI) | compare |
| b0113 | pdhR | -1.4 | -5.9 | transcriptional regulator of pyruvate dehydrogenase complex (NCBI) | compare |
| b3429 | glgA | -1.4 | -10.9 | glycogen synthase (NCBI) | compare |
| b0767 | ybhE | -1.3 | -3.9 | 6-phosphogluconolactonase (NCBI) | compare |
| b3741 | gidA | -1.3 | -5.5 | glucose-inhibited division protein A (NCBI) | compare |
| b1129 | phoQ | -1.3 | -1.7 | sensory histidine kinase in two-compoent regulatory system with PhoP (NCBI) | compare |
| b2620 | smpB | -1.3 | -1.8 | SsrA-binding protein (NCBI) | compare |
| b2601 | aroF | -1.3 | -6.4 | 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tyrosine-repressible (NCBI) | compare |
| b2330 | yfcB | -1.3 | -2.2 | putative adenine-specific methylase (VIMSS) | compare |
| b2853 | ygeI | -1.3 | -0.8 | hypothetical protein (NCBI) | compare |
| b0912 | ihfB | -1.3 | -4.7 | integration host factor subunit beta (NCBI) | compare |
| b1263 | trpD | -1.3 | -2.7 | bifunctional indole-3-glycerol-phosphate synthase/anthranilate phosphoribosyltransferase (NCBI) | compare |
| b1863 | ruvC | -1.2 | -2.2 | Holliday junction resolvase (NCBI) | compare |
| b1830 | prc | -1.2 | -7.6 | carboxy-terminal protease for penicillin-binding protein 3 (NCBI) | compare |
| b2501 | ppk | -1.2 | -8.8 | polyphosphate kinase (NCBI) | compare |
| b1712 | ihfA | -1.2 | -1.4 | integration host factor subunit alpha (NCBI) | compare |
| b4480 | hdfR | -1.2 | -6.8 | transcriptional regulator HdfR (NCBI) | compare |
| b2934 | cmtB | -1.2 | -1.3 | predicted mannitol-specific enzyme IIA component of PTS (NCBI) | compare |
| b0888 | trxB | -1.2 | -4.3 | thioredoxin reductase, FAD/NAD(P)-binding (NCBI) | compare |
| b3811 | xerC | -1.2 | -2.3 | site-specific tyrosine recombinase XerC (NCBI) | compare |
| b2318 | truA | -1.2 | -3.6 | tRNA pseudouridine synthase A (NCBI) | compare |
| b3237 | argR | -1.2 | -4.9 | arginine repressor (NCBI) | compare |
| b2699 | recA | -1.2 | -1.6 | recombinase A (NCBI) | compare |
| b2752 | cysD | -1.2 | -6.3 | sulfate adenylyltransferase subunit 2 (NCBI) | compare |
| b3008 | metC | -1.1 | -7.6 | cystathionine beta-lyase (NCBI) | compare |
| b0437 | clpP | -1.1 | -4.8 | ATP-dependent Clp protease proteolytic subunit (NCBI) | compare |
| b0075 | leuL | -1.1 | -4.8 | leu operon leader peptide (NCBI) | compare |
| b0438 | clpX | -1.1 | -6.9 | ATP-dependent protease ATP-binding subunit (NCBI) | compare |
| b3839 | tatC | -1.1 | -6.3 | TatABCE protein translocation system subunit (NCBI) | compare |
| b2751 | cysN | -1.1 | -8.1 | sulfate adenylyltransferase subunit 1 (NCBI) | compare |
| b3764 | yifE | -1.0 | -4.0 | hypothetical protein (NCBI) | compare |
| b3386 | rpe | -1.0 | -1.1 | ribulose-phosphate 3-epimerase (NCBI) | compare |
| b2340 | sixA | -1.0 | -4.6 | phosphohistidine phosphatase (NCBI) | compare |
| b0077 | ilvI | -1.0 | -8.0 | acetolactate synthase III large subunit (NCBI) | compare |
| b3404 | envZ | -1.0 | -7.3 | osmolarity sensor protein (NCBI) | compare |
| b0078 | ilvH | -1.0 | -7.1 | acetolactate synthase small subunit (NCBI) | compare |
| b4234 | yjgA | -1.0 | -5.2 | hypothetical protein (NCBI) | compare |
| b0928 | aspC | -1.0 | -5.0 | aspartate aminotransferase, PLP-dependent (NCBI) | compare |
| b0142 | folK | -1.0 | -0.8 | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) | compare |
| b0114 | aceE | -1.0 | -1.6 | pyruvate dehydrogenase subunit E1 (NCBI) | compare |
| b4481 | rffT | -1.0 | -7.0 | 4-alpha-L-fucosyltransferase (NCBI) | compare |
| b2822 | recC | -1.0 | -4.5 | exonuclease V (RecBCD complex), gamma chain (NCBI) | compare |
| b3790 | rffC | -1.0 | -4.6 | TDP-fucosamine acetyltransferase (RefSeq) | compare |
| b3792 | wzxE | -1.0 | -6.3 | O-antigen translocase (NCBI) | compare |
| b0617 | citD | -1.0 | -3.5 | citrate lyase, acyl carrier (gamma) subunit (NCBI) | compare |
| b0683 | fur | -0.9 | -1.8 | ferric uptake regulator (NCBI) | compare |
| b3784 | rfe | -0.9 | -8.0 | UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase (NCBI) | compare |
| b3816 | corA | -0.9 | -6.9 | magnesium/nickel/cobalt transporter (NCBI) | compare |
| b3728 | pstS | -0.9 | -3.1 | phosphate transporter subunit (NCBI) | compare |
| b3388 | damX | -0.9 | -7.6 | hypothetical protein (NCBI) | compare |
| b3791 | rffA | -0.9 | -5.9 | TDP-4-oxo-6-deoxy-D-glucose transaminase (NCBI) | compare |
| b1232 | purU | -0.9 | -5.5 | formyltetrahydrofolate deformylase (NCBI) | compare |
| b1709 | btuD | -0.9 | -1.4 | vitamin B12-transporter ATPase (NCBI) | compare |
| b1101 | ptsG | -0.9 | -7.0 | fused glucose-specific PTS enzymes: IIB component/IIC component (NCBI) | compare |
| b3205 | yhbJ | -0.9 | -3.6 | hypothetical protein (NCBI) | compare |
| b1049 | mdoH | -0.9 | -6.1 | glucosyltransferase MdoH (NCBI) | compare |
| b2518 | ndk | -0.9 | -2.7 | nucleoside diphosphate kinase (NCBI) | compare |
| b3794 | rffM | -0.9 | -6.4 | putative UDP-N-acetyl-D-mannosaminuronic acid transferase (NCBI) | compare |
| b0222 | lpcA | -0.9 | -2.4 | phosphoheptose isomerase (NCBI) | compare |
| b2894 | xerD | -0.9 | -1.0 | site-specific tyrosine recombinase XerD (NCBI) | compare |
| b3787 | rffD | -0.9 | -6.9 | UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase (NCBI) | compare |
| b1765 | ydjA | -0.9 | -1.1 | predicted oxidoreductase (NCBI) | compare |
| b0161 | degP | -0.8 | -4.7 | serine endoprotease (protease Do), membrane-associated (NCBI) | compare |
| b3828 | metR | -0.8 | -6.0 | DNA-binding transcriptional activator, homocysteine-binding (NCBI) | compare |
| b3052 | rfaE | -0.8 | -4.1 | fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) | compare |
| b4585 | sroB | -0.8 | -1.6 | Novel sRNA, function unknown (RefSeq) | compare |
| b3838 | tatB | -0.8 | -4.8 | sec-independent translocase (NCBI) | compare |
| b3021 | ygiT | -0.8 | -2.8 | predicted DNA-binding transcriptional regulator (NCBI) | compare |
| b4375 | prfC | -0.8 | -3.4 | peptide chain release factor 3 (NCBI) | compare |
| b3163 | nlpI | -0.8 | -4.5 | hypothetical protein (NCBI) | compare |
| b3863 | polA | -0.7 | -1.2 | DNA polymerase I (NCBI) | compare |
| b3621 | rfaC | -0.7 | -3.7 | ADP-heptose:LPS heptosyl transferase I (NCBI) | compare |
| b3026 | qseC | -0.7 | -3.5 | sensory histidine kinase in two-component regulatory system with QseB (NCBI) | compare |
| b1540 | ydfH | -0.7 | -1.7 | predicted DNA-binding transcriptional regulator (NCBI) | compare |
| b4545 | ypdJ | -0.7 | -1.5 | no description | compare |
| b3786 | rffE | -0.7 | -6.0 | UDP-N-acetyl glucosamine-2-epimerase (NCBI) | compare |
| b1048 | mdoG | -0.7 | -3.7 | glucan biosynthesis protein, periplasmic (NCBI) | compare |
| b0722 | sdhD | -0.7 | -3.3 | succinate dehydrogenase cytochrome b556 small membrane subunit (NCBI) | compare |
| b3002 | yqhA | -0.7 | -1.4 | hypothetical protein (NCBI) | compare |
| b1476 | fdnI | -0.7 | -1.0 | formate dehydrogenase-N, cytochrome B556 (gamma) subunit, nitrate-inducible (NCBI) | compare |
| b3609 | secB | -0.7 | -2.7 | export protein SecB (NCBI) | compare |
| b0920 | ycbC | -0.7 | -4.4 | conserved inner membrane protein (NCBI) | compare |
| b1348 | lar | -0.7 | -2.0 | Rac prophage; restriction alleviation protein (NCBI) | compare |
| b4215 | ytfI | -0.7 | -1.5 | hypothetical protein (NCBI) | compare |
| b3359 | argD | -0.7 | -6.0 | bifunctional acetylornithine aminotransferase/ succinyldiaminopimelate aminotransferase (NCBI) | compare |
| b2553 | glnB | -0.7 | -2.7 | regulatory protein P-II for glutamine synthetase (NCBI) | compare |