Experiment set22IT080 for Escherichia coli BW25113

Compare to:

T7_phage 0.0000015625 MOI TC6

200 most important genes:

  gene name fitness t score description  
b3842 rfaH -5.8 -4.0 transcriptional activator RfaH (NCBI) compare
b3630 rfaP -4.1 -8.8 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b3627 rfaI -4.0 -7.3 UDP-D-galactose:(glucosyl)lipopolysaccharide- alpha-1,3-D-galactosyltransferase (NCBI) compare
b1882 cheY -3.8 -1.5 chemotaxis regulator transmitting signal to flagellar motor component (NCBI) compare
b2699 recA -3.2 -2.2 recombinase A (NCBI) compare
b0142 folK -3.2 -1.3 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) compare
b0630 lipB -3.0 -2.1 protein of lipoate biosynthesis (VIMSS) compare
b3977 tyrU -2.6 -1.5 tRNA-Tyr (NCBI) compare
b3628 rfaB -2.6 -11.4 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase (RefSeq) compare
b0200 gmhB -2.5 -1.7 hypothetical protein (NCBI) compare
b2567 rnc -2.4 -1.6 ribonuclease III (NCBI) compare
b2168 fruK -2.4 -2.9 1-phosphofructokinase (NCBI) compare
b1865 nudB -2.3 -1.8 dATP pyrophosphohydrolase (NCBI) compare
b0741 pal -2.2 -5.8 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b3500 gor -2.2 -2.8 glutathione reductase (NCBI) compare
b1292 sapC -2.2 -4.3 predicted antimicrobial peptide transporter subunit (NCBI) compare
b3811 xerC -2.1 -2.0 site-specific tyrosine recombinase XerC (NCBI) compare
b3863 polA -2.1 -1.4 DNA polymerase I (NCBI) compare
b1951 rcsA -2.0 -1.9 DNA-binding transcriptional activator, co-regulator with RcsB (NCBI) compare
b3620 rfaF -2.0 -6.7 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b0053 surA -1.9 -7.0 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b4676 yoaK -1.9 -1.0 expressed protein (RefSeq) compare
b2830 nudH -1.9 -2.5 dinucleoside polyphosphate hydrolase (NCBI) compare
b1150 ymfR -1.9 -1.4 e14 prophage; predicted protein (NCBI) compare
b0439 lon -1.8 -6.6 DNA-binding ATP-dependent protease La (NCBI) compare
b2935 tktA -1.7 -2.0 transketolase 1, thiamin-binding (NCBI) compare
b0738 tolR -1.7 -3.8 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b0222 lpcA -1.7 -3.7 phosphoheptose isomerase (NCBI) compare
b1236 galU -1.7 -6.8 glucose-1-phosphate uridylyltransferase (NCBI) compare
b1291 sapD -1.7 -1.9 predicted antimicrobial peptide transporter subunit (NCBI) compare
b0888 trxB -1.7 -4.6 thioredoxin reductase, FAD/NAD(P)-binding (NCBI) compare
b1290 sapF -1.7 -2.5 predicted antimicrobial peptide transporter subunit (NCBI) compare
b4522 yciX_1 -1.6 -3.8 hypothetical protein (NCBI) compare
b2894 xerD -1.6 -1.5 site-specific tyrosine recombinase XerD (NCBI) compare
b4177 purA -1.6 -1.8 adenylosuccinate synthetase (NCBI) compare
b4503 yafF -1.6 -1.2 no description compare
b4375 prfC -1.5 -5.8 peptide chain release factor 3 (NCBI) compare
b3778 rep -1.5 -7.4 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b3169 nusA -1.5 -3.2 transcription elongation factor NusA (NCBI) compare
b0740 tolB -1.5 -4.8 translocation protein TolB precursor (NCBI) compare
b3613 yibP -1.5 -4.7 putative membrane protein (VIMSS) compare
b2038 rfbC -1.5 -6.0 dTDP-4-deoxyrhamnose-3,5-epimerase (NCBI) compare
b2297 pta -1.5 -1.0 phosphate acetyltransferase (NCBI) compare
b2846 yqeH -1.5 -0.9 orf, hypothetical protein (VIMSS) compare
b4699 fnrS -1.4 -0.9 FNR-activated anaerobic sRNA antisense regulator down regulates cydDC, metE, sodA, sodB, Hfq-dependent; mediates negative FNR regulation (RefSeq) compare
b4048 yjbM -1.4 -1.7 hypothetical protein (NCBI) compare
b1855 lpxM -1.4 -6.1 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase (NCBI) compare
b4202 rpsR -1.4 -2.0 30S ribosomal protein S18 (NCBI) compare
b2040 rfbD -1.4 -8.9 dTDP-4-dehydrorhamnose reductase subunit, NAD(P)-binding, of dTDP-L-rhamnose synthase (NCBI) compare
b2318 truA -1.4 -2.9 tRNA pseudouridine synthase A (NCBI) compare
b3290 trkA -1.3 -2.8 potassium transporter peripheral membrane component (NCBI) compare
b2820 recB -1.3 -1.7 exonuclease V (RecBCD complex), beta subunit (NCBI) compare
b3619 rfaD -1.3 -4.5 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b0658 ybeX -1.3 -0.9 predicteed ion transport (NCBI) compare
b4171 miaA -1.3 -3.3 tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) compare
b0114 aceE -1.3 -1.5 pyruvate dehydrogenase subunit E1 (NCBI) compare
b3052 rfaE -1.3 -5.7 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare
b3839 tatC -1.3 -5.5 TatABCE protein translocation system subunit (NCBI) compare
b0737 tolQ -1.3 -2.8 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b3629 rfaS -1.3 -3.4 lipopolysaccharide core biosynthesis protein (NCBI) compare
b4515 ybgT -1.2 -1.9 hypothetical protein (NCBI) compare
b1351 racC -1.2 -0.8 Rac prophage; predicted protein (NCBI) compare
b3741 gidA -1.2 -4.5 glucose-inhibited division protein A (NCBI) compare
b0767 ybhE -1.2 -4.6 6-phosphogluconolactonase (NCBI) compare
b1497 b1497 -1.2 -0.8 putative enzyme (VIMSS) compare
b4535 yniD -1.2 -1.7 predicted protein (RefSeq) compare
b0088 murD -1.2 -2.0 UDP-N-acetylmuramoyl-L-alanyl-D-glutamatesynthetase (NCBI) compare
b1165 ymgA -1.2 -0.8 hypothetical protein (NCBI) compare
b0739 tolA -1.2 -2.8 cell envelope integrity inner membrane protein TolA (NCBI) compare
b2620 smpB -1.2 -1.7 SsrA-binding protein (NCBI) compare
b4042 dgkA -1.2 -2.3 diacylglycerol kinase (NCBI) compare
b1040 csgD -1.2 -1.5 DNA-binding transcriptional activator in two-component regulatory system (NCBI) compare
b1690 ydiM -1.1 -2.6 predicted transporter (NCBI) compare
b2330 yfcB -1.1 -1.9 putative adenine-specific methylase (VIMSS) compare
b3162 deaD -1.1 -4.5 inducible ATP-independent RNA helicase (VIMSS) compare
b0049 apaH -1.1 -2.8 diadenosinetetraphosphatase (NCBI) compare
b2569 lepA -1.1 -3.8 GTP-binding protein LepA (NCBI) compare
b1293 sapB -1.1 -1.9 predicted antimicrobial peptide transporter subunit (NCBI) compare
b0890 ftsK -1.1 -4.4 DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) compare
b1600 mdtJ -1.1 -1.9 multidrug efflux system transporter (NCBI) compare
b4239 treC -1.1 -3.1 trehalose-6-P hydrolase (NCBI) compare
b1499 ydeO -1.1 -0.5 predicted DNA-binding transcriptional acfivator (NCBI) compare
b1850 eda -1.1 -2.4 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) compare
b1084 rne -1.1 -4.4 fused ribonucleaseE: endoribonuclease/RNA-binding protein/RNA degradosome binding protein (NCBI) compare
b4494 arpB -1.1 -2.3 no description compare
b3398 yrfF -1.1 -2.9 predicted inner membrane protein (NCBI) compare
b3405 ompR -1.1 -4.1 osmolarity response regulator (NCBI) compare
b1576 ydfD -1.1 -0.5 Qin prophage; predicted protein (NCBI) compare
b3426 glpD -1.0 -4.2 sn-glycerol-3-phosphate dehydrogenase, aerobic, FAD/NAD(P)-binding (NCBI) compare
b1545 pinQ -1.0 -0.3 Qin prophage; predicted site-specific recombinase (NCBI) compare
b1363 trkG -1.0 -1.2 Rac prophage; potassium transporter subunit (NCBI) compare
b4520 ymgF -1.0 -1.9 hypothetical protein (NCBI) compare
b1409 ynbB -1.0 -1.4 predicted CDP-diglyceride synthase (NCBI) compare
b1677 lpp -1.0 -2.7 murein lipoprotein (NCBI) compare
b3623 rfaK -1.0 -2.0 lipopolysaccharide core biosynthesis (NCBI) compare
b1347 ydaC -1.0 -0.5 Rac prophage; predicted protein (NCBI) compare
b4146 yjeK -1.0 -2.7 predicted lysine aminomutase (NCBI) compare
b1025 ycdT -1.0 -1.5 predicted diguanylate cyclase (NCBI) compare
b3621 rfaC -1.0 -3.7 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b1058 yceO -1.0 -0.5 hypothetical protein (NCBI) compare
b4179 vacB -1.0 -4.4 putative enzyme (VIMSS) compare
b3916 pfkA -1.0 -2.6 6-phosphofructokinase (NCBI) compare
b4603 rseX -1.0 -0.6 sRNA regulating ompA and ompC translation, with Hfq (RefSeq) compare
b3870 glnA -1.0 -2.6 glutamine synthetase (NCBI) compare
b3026 qseC -1.0 -3.5 sensory histidine kinase in two-component regulatory system with QseB (NCBI) compare
b3806 cyaA -0.9 -4.0 adenylate cyclase (NCBI) compare
b0720 gltA -0.9 -5.0 citrate synthase (NCBI) compare
b3387 dam -0.9 -5.9 DNA adenine methylase (NCBI) compare
b1286 rnb -0.9 -1.9 exoribonuclease II (NCBI) compare
b2248 yfaX -0.9 -2.0 predicted DNA-binding transcriptional regulator (NCBI) compare
b3844 fre -0.9 -3.6 NAD(P)H-flavin reductase (NCBI) compare
b2055 wcaE -0.9 -0.5 predicted glycosyl transferase (NCBI) compare
b3626 rfaJ -0.9 -3.6 UDP-D-glucose:(galactosyl)lipopolysaccharide glucosyltransferase (NCBI) compare
b2175 spr -0.9 -2.5 predicted peptidase, outer membrane lipoprotein (NCBI) compare
b1863 ruvC -0.8 -1.6 Holliday junction resolvase (NCBI) compare
b1361 ydaW -0.8 -0.5 orf, hypothetical protein (VIMSS) compare
b3781 trxA -0.8 -2.5 thioredoxin 1 (VIMSS) compare
b1862 yebB -0.8 -3.0 orf, hypothetical protein (VIMSS) compare
b4702 mgtL -0.8 -1.5 regulatory leader peptide for mgtA (NCBI) compare
b1594 dgsA -0.8 -2.9 DNA-binding transcriptional repressor (NCBI) compare
b1048 mdoG -0.8 -3.7 glucan biosynthesis protein, periplasmic (NCBI) compare
b1536 ydeI -0.8 -1.0 hypothetical protein (NCBI) compare
b4155 yjeA -0.8 -0.8 putative lysyl-tRNA synthetase (VIMSS) compare
b4513 kdpF -0.8 -1.9 potassium ion accessory transporter subunit (NCBI) compare
b0858 ybjO -0.8 -1.9 predicted inner membrane protein (NCBI) compare
b2947 gshB -0.8 -2.7 glutathione synthetase (NCBI) compare
b1167 ymgC -0.8 -0.4 hypothetical protein (NCBI) compare
b1551 b1551 -0.8 -0.7 orf, hypothetical protein (VIMSS) compare
b2285 nuoE -0.8 -1.7 NADH dehydrogenase subunit E (NCBI) compare
b3414 gntY -0.8 -2.9 predicted gluconate transport associated protein (NCBI) compare
b2276 nuoN -0.8 -3.3 NADH:ubiquinone oxidoreductase, membrane subunit N (RefSeq) compare
b3725 pstB -0.8 -1.0 phosphate transporter subunit (NCBI) compare
b0814 ompX -0.8 -2.1 outer membrane protein X (NCBI) compare
b2528 iscA -0.8 -1.1 iron-sulfur cluster assembly protein (NCBI) compare
b2352 yfdI -0.8 -0.7 CPS-53 (KpLE1) prophage; predicted inner membrane protein (NCBI) compare
b1762 b1762 -0.8 -1.9 orf, hypothetical protein (VIMSS) compare
b2446 yffO -0.8 -1.2 CPZ-55 prophage; predicted protein (NCBI) compare
b1192 ldcA -0.8 -3.0 L,D-carboxypeptidase A (NCBI) compare
b0018 mokC -0.8 -1.0 regulatory protein for HokC, overlaps CDS of hokC (NCBI) compare
b2288 nuoA -0.8 -2.3 NADH dehydrogenase I chain A (VIMSS) compare
b2912 ygfA -0.8 -1.7 putative ligase (VIMSS) compare
b3386 rpe -0.8 -0.7 ribulose-phosphate 3-epimerase (NCBI) compare
b3068 ygjF -0.7 -2.3 G/U mismatch-specific DNA glycosylase (NCBI) compare
b0438 clpX -0.7 -3.5 ATP-dependent protease ATP-binding subunit (NCBI) compare
b1691 ydiN -0.7 -2.7 predicted transporter (RefSeq) compare
b0549 ybcO -0.7 -2.0 DLP12 prophage; predicted protein (NCBI) compare
b2822 recC -0.7 -3.3 exonuclease V (RecBCD complex), gamma chain (NCBI) compare
b1556 b1556 -0.7 -1.9 orf, hypothetical protein (VIMSS) compare
b0676 nagC -0.7 -3.5 DNA-binding transcriptional dual regulator, repressor of N-acetylglucosamine (NCBI) compare
b1931 yedK -0.7 -2.3 hypothetical protein (NCBI) compare
b3807 cyaY -0.7 -3.1 frataxin-like protein (NCBI) compare
b3794 rffM -0.7 -3.7 putative UDP-N-acetyl-D-mannosaminuronic acid transferase (NCBI) compare
b2279 nuoK -0.7 -1.6 NADH dehydrogenase subunit K (NCBI) compare
b3838 tatB -0.7 -3.6 sec-independent translocase (NCBI) compare
b3973 birA -0.7 -1.8 biotin--protein ligase (NCBI) compare
b2188 yejM -0.7 -4.6 predicted hydrolase, inner membrane (NCBI) compare
b2071 yegJ -0.7 -1.2 hypothetical protein (NCBI) compare
b0218 yafU -0.7 -2.0 predicted inner membrane protein (RefSeq) compare
b1062 pyrC -0.7 -3.4 dihydroorotase (NCBI) compare
b4497 yeeL -0.7 -1.1 no description compare
b3631 rfaG -0.7 -5.7 glucosyltransferase I (NCBI) compare
b3790 rffC -0.7 -2.9 TDP-fucosamine acetyltransferase (RefSeq) compare
b4481 rffT -0.7 -3.3 4-alpha-L-fucosyltransferase (NCBI) compare
b3849 trkH -0.7 -4.8 potassium transporter (NCBI) compare
b3979 thrT -0.7 -0.4 tRNA-Thr (NCBI) compare
b2372 yfdV -0.7 -3.0 predicted transporter (NCBI) compare
b3027 ygiZ -0.7 -0.4 conserved inner membrane protein (NCBI) compare
b1049 mdoH -0.7 -4.4 glucosyltransferase MdoH (NCBI) compare
b4594 ymgJ -0.7 -1.8 hypothetical protein (RefSeq) compare
b0364 yaiS -0.7 -2.2 orf, hypothetical protein (VIMSS) compare
b1121 ycfZ -0.7 -1.5 predicted inner membrane protein (NCBI) compare
b1612 fumA -0.7 -2.6 fumarate hydratase (fumarase A), aerobic Class I (NCBI) compare
b3205 yhbJ -0.7 -2.4 hypothetical protein (NCBI) compare
b3071 yqjI -0.7 -2.2 predicted transcriptional regulator (NCBI) compare
b2564 pdxJ -0.7 -2.0 pyridoxal phosphate biosynthetic protein (NCBI) compare
b2209 eco -0.7 -1.7 ecotin precursor (NCBI) compare
b0249 ykfF -0.7 -1.3 CP4-6 prophage; predicted protein (NCBI) compare
b0723 sdhA -0.7 -4.5 succinate dehydrogenase flavoprotein subunit (NCBI) compare
b1074 flgC -0.6 -1.2 flagellar basal-body rod protein C (NCBI) compare
b2498 upp -0.6 -1.7 uracil phosphoribosyltransferase (VIMSS) compare
b3098 yqjD -0.6 -2.3 hypothetical protein (NCBI) compare
b1579 intQ -0.6 -2.4 Qin prophage; predicted defective integrase (RefSeq) compare
b1999 yeeP -0.6 -3.0 putative histone (VIMSS) compare
b1182 hlyE -0.6 -0.6 hemolysin E (VIMSS) compare
b1176 minC -0.6 -1.5 septum formation inhibitor (NCBI) compare
b0928 aspC -0.6 -3.8 aspartate aminotransferase, PLP-dependent (NCBI) compare
b1104 ycfL -0.6 -1.4 hypothetical protein (NCBI) compare
b1827 kdgR -0.6 -1.6 predicted DNA-binding transcriptional regulator (NCBI) compare
b2512 yfgL -0.6 -3.6 protein assembly complex, lipoprotein component (NCBI) compare
b1235 rssB -0.6 -2.9 response regulator of RpoS (NCBI) compare
b1685 ydiH -0.6 -0.9 predicted protein (RefSeq) compare
b1921 fliZ -0.6 -2.1 orf, hypothetical protein (VIMSS) compare
b3042 b3042 -0.6 -2.0 orf, hypothetical protein (VIMSS) compare
b2906 visC -0.6 -3.4 hypothetical protein (NCBI) compare
b3935 priA -0.6 -1.2 primosome assembly protein PriA (NCBI) compare
b1505 ydeT -0.6 -1.0 hypothetical protein (RefSeq) compare
b2215 ompC -0.6 -3.6 outer membrane porin protein C (NCBI) compare
b0991 ymcE -0.6 -2.3 cold shock gene (NCBI) compare
b1673 ydhV -0.6 -2.8 predicted oxidoreductase (NCBI) compare
b3609 secB -0.6 -2.8 export protein SecB (NCBI) compare


Specific Phenotypes

For 2 genes in this experiment

For phage T7_phage in Escherichia coli BW25113

For phage T7_phage across organisms