Experiment set22IT068 for Escherichia coli BW25113

Compare to:

T7_phage 0.0000015625 MOI TC3

200 most important genes:

  gene name fitness t score description  
b2168 fruK -4.1 -2.8 1-phosphofructokinase (NCBI) compare
b2830 nudH -3.2 -2.2 dinucleoside polyphosphate hydrolase (NCBI) compare
b0142 folK -3.2 -1.4 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) compare
b2894 xerD -2.6 -1.7 site-specific tyrosine recombinase XerD (NCBI) compare
b0630 lipB -2.4 -2.3 protein of lipoate biosynthesis (VIMSS) compare
b2567 rnc -2.4 -1.6 ribonuclease III (NCBI) compare
b2699 recA -2.2 -2.9 recombinase A (NCBI) compare
b0739 tolA -2.1 -5.2 cell envelope integrity inner membrane protein TolA (NCBI) compare
b4699 fnrS -2.1 -1.3 FNR-activated anaerobic sRNA antisense regulator down regulates cydDC, metE, sodA, sodB, Hfq-dependent; mediates negative FNR regulation (RefSeq) compare
b4676 yoaK -1.8 -1.1 expressed protein (RefSeq) compare
b1600 mdtJ -1.7 -2.5 multidrug efflux system transporter (NCBI) compare
b1607 ydgC -1.7 -1.6 conserved inner membrane protein associated with alginate biosynthesis (NCBI) compare
b4202 rpsR -1.7 -2.3 30S ribosomal protein S18 (NCBI) compare
b2935 tktA -1.7 -2.2 transketolase 1, thiamin-binding (NCBI) compare
b1182 hlyE -1.7 -1.1 hemolysin E (VIMSS) compare
b1551 b1551 -1.6 -1.0 orf, hypothetical protein (VIMSS) compare
b4048 yjbM -1.6 -2.1 hypothetical protein (NCBI) compare
b0683 fur -1.6 -1.9 ferric uptake regulator (NCBI) compare
b4503 yafF -1.6 -1.3 no description compare
b4177 purA -1.5 -2.1 adenylosuccinate synthetase (NCBI) compare
b0740 tolB -1.5 -5.1 translocation protein TolB precursor (NCBI) compare
b2820 recB -1.5 -2.0 exonuclease V (RecBCD complex), beta subunit (NCBI) compare
b1286 rnb -1.5 -3.5 exoribonuclease II (NCBI) compare
b3811 xerC -1.4 -2.1 site-specific tyrosine recombinase XerC (NCBI) compare
b2504 yfgG -1.4 -2.1 Negative regulator of nickel and cobalt uptake (YfgG) (from data) compare
b3916 pfkA -1.4 -3.4 6-phosphofructokinase (NCBI) compare
b0738 tolR -1.4 -3.5 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b3636 rpmG -1.4 -1.5 50S ribosomal protein L33 (NCBI) compare
b1332 ynaJ -1.3 -1.0 predicted inner membrane protein (NCBI) compare
b2528 iscA -1.3 -1.6 iron-sulfur cluster assembly protein (NCBI) compare
b4651 yibW -1.3 -0.8 no description compare
b3290 trkA -1.3 -2.8 potassium transporter peripheral membrane component (NCBI) compare
b1176 minC -1.3 -2.2 septum formation inhibitor (NCBI) compare
b4375 prfC -1.3 -5.2 peptide chain release factor 3 (NCBI) compare
b1951 rcsA -1.3 -2.1 DNA-binding transcriptional activator, co-regulator with RcsB (NCBI) compare
b0053 surA -1.2 -5.2 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b1865 nudB -1.2 -1.7 dATP pyrophosphohydrolase (NCBI) compare
b1730 ydjO -1.2 -1.1 predicted protein (RefSeq) compare
b2297 pta -1.2 -1.1 phosphate acetyltransferase (NCBI) compare
b1847 yebF -1.2 -2.0 predicted protein (RefSeq) compare
b3261 fis -1.2 -2.5 DNA-binding protein Fis (NCBI) compare
b4407 thiS -1.2 -2.5 sulfur carrier protein ThiS (NCBI) compare
b3500 gor -1.2 -1.7 glutathione reductase (NCBI) compare
b4179 vacB -1.2 -5.5 putative enzyme (VIMSS) compare
b1351 racC -1.2 -0.7 Rac prophage; predicted protein (NCBI) compare
b3026 qseC -1.2 -4.2 sensory histidine kinase in two-component regulatory system with QseB (NCBI) compare
b1363 trkG -1.2 -0.8 Rac prophage; potassium transporter subunit (NCBI) compare
b1762 b1762 -1.1 -2.1 orf, hypothetical protein (VIMSS) compare
b1409 ynbB -1.1 -1.2 predicted CDP-diglyceride synthase (NCBI) compare
b0890 ftsK -1.1 -4.3 DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) compare
b1497 b1497 -1.1 -0.7 putative enzyme (VIMSS) compare
b1936 intG -1.1 -1.0 predicted defective phage integrase (pseudogene) (RefSeq) compare
b2934 cmtB -1.1 -0.7 predicted mannitol-specific enzyme IIA component of PTS (NCBI) compare
b3052 rfaE -1.1 -4.2 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare
b1690 ydiM -1.1 -2.3 predicted transporter (NCBI) compare
b3162 deaD -1.1 -3.7 inducible ATP-independent RNA helicase (VIMSS) compare
b0706 ybfD -1.1 -2.7 hypothetical protein (NCBI) compare
b3977 tyrU -1.1 -1.1 tRNA-Tyr (NCBI) compare
b4402 yjjY -1.1 -1.3 hypothetical protein (NCBI) compare
b0535 fimZ -1.1 -3.6 predicted DNA-binding transcriptional regulator (NCBI) compare
b3621 rfaC -1.1 -4.0 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b1292 sapC -1.0 -2.7 predicted antimicrobial peptide transporter subunit (NCBI) compare
b4345 mcrC -1.0 -0.7 5-methylcytosine-specific restriction enzyme McrBC, subunit McrC (NCBI) compare
b1961 dcm -1.0 -2.1 DNA cytosine methylase (NCBI) compare
b1950 fliR -1.0 -2.7 flagellar biosynthesis protein R (NCBI) compare
b4239 treC -1.0 -2.8 trehalose-6-P hydrolase (NCBI) compare
b4146 yjeK -1.0 -2.6 predicted lysine aminomutase (NCBI) compare
b1293 sapB -1.0 -1.9 predicted antimicrobial peptide transporter subunit (NCBI) compare
b3619 rfaD -1.0 -3.5 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b1130 phoP -1.0 -1.7 DNA-binding response regulator in two-component regulatory system with PhoQ (NCBI) compare
b2352 yfdI -1.0 -0.7 CPS-53 (KpLE1) prophage; predicted inner membrane protein (NCBI) compare
b3426 glpD -1.0 -3.7 sn-glycerol-3-phosphate dehydrogenase, aerobic, FAD/NAD(P)-binding (NCBI) compare
b1499 ydeO -1.0 -0.5 predicted DNA-binding transcriptional acfivator (NCBI) compare
b1758 b1758 -1.0 -1.3 putative cytochrome oxidase (VIMSS) compare
b1576 ydfD -0.9 -0.5 Qin prophage; predicted protein (NCBI) compare
b0088 murD -0.9 -1.7 UDP-N-acetylmuramoyl-L-alanyl-D-glutamatesynthetase (NCBI) compare
b0114 aceE -0.9 -1.5 pyruvate dehydrogenase subunit E1 (NCBI) compare
b1121 ycfZ -0.9 -1.7 predicted inner membrane protein (NCBI) compare
b1545 pinQ -0.9 -0.3 Qin prophage; predicted site-specific recombinase (NCBI) compare
b3875 ompL -0.9 -2.3 predicted outer membrane porin L (NCBI) compare
b1773 ydjI -0.9 -2.0 predicted aldolase (NCBI) compare
b3164 pnp -0.9 -2.4 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b1347 ydaC -0.9 -0.4 Rac prophage; predicted protein (NCBI) compare
b0888 trxB -0.9 -2.8 thioredoxin reductase, FAD/NAD(P)-binding (NCBI) compare
b0439 lon -0.9 -3.5 DNA-binding ATP-dependent protease La (NCBI) compare
b2569 lepA -0.9 -3.3 GTP-binding protein LepA (NCBI) compare
b1001 yccE -0.9 -0.5 hypothetical protein (NCBI) compare
b2814 metZ -0.9 -1.6 tRNA-Met (NCBI) compare
b1058 yceO -0.9 -0.5 hypothetical protein (NCBI) compare
b1103 ycfF -0.9 -1.7 orf, hypothetical protein (VIMSS) compare
b3238 yhcN -0.9 -2.2 orf, hypothetical protein (VIMSS) compare
b0051 ksgA -0.9 -2.8 dimethyladenosine transferase (NCBI) compare
b2110 yehC -0.9 -0.8 predicted periplasmic pilin chaperone (NCBI) compare
b1691 ydiN -0.9 -3.0 predicted transporter (RefSeq) compare
b4155 yjeA -0.9 -0.8 putative lysyl-tRNA synthetase (VIMSS) compare
b3778 rep -0.8 -4.8 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b4042 dgkA -0.8 -1.7 diacylglycerol kinase (NCBI) compare
b1165 ymgA -0.8 -0.7 hypothetical protein (NCBI) compare
b1861 ruvA -0.8 -1.0 Holliday junction DNA helicase motor protein (NCBI) compare
b1753 ynjA -0.8 -2.3 hypothetical protein (NCBI) compare
b2111 yehD -0.8 -2.1 predicted fimbrial-like adhesin protein (NCBI) compare
b1129 phoQ -0.8 -1.3 sensory histidine kinase in two-compoent regulatory system with PhoP (NCBI) compare
b3386 rpe -0.8 -0.8 ribulose-phosphate 3-epimerase (NCBI) compare
b3210 arcB -0.8 -4.6 hybrid sensory histidine kinase in two-component regulatory system with ArcA (NCBI) compare
b3790 rffC -0.8 -3.2 TDP-fucosamine acetyltransferase (RefSeq) compare
b4585 sroB -0.8 -1.2 Novel sRNA, function unknown (RefSeq) compare
b1480 sra -0.8 -1.5 30S ribosomal subunit protein S22 (NCBI) compare
b1257 yciE -0.8 -0.4 hypothetical protein (NCBI) compare
b2055 wcaE -0.8 -0.5 predicted glycosyl transferase (NCBI) compare
b3725 pstB -0.8 -1.0 phosphate transporter subunit (NCBI) compare
b3781 trxA -0.8 -1.9 thioredoxin 1 (VIMSS) compare
b1579 intQ -0.8 -2.6 Qin prophage; predicted defective integrase (RefSeq) compare
b1236 galU -0.8 -3.5 glucose-1-phosphate uridylyltransferase (NCBI) compare
b0200 gmhB -0.8 -1.2 hypothetical protein (NCBI) compare
b1575 dicB -0.8 -1.1 Qin prophage; cell division inhibition protein (NCBI) compare
b3229 sspA -0.8 -1.9 stringent starvation protein A (NCBI) compare
b1855 lpxM -0.8 -3.7 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase (NCBI) compare
b3620 rfaF -0.8 -3.1 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b3493 pitA -0.8 -4.8 phosphate transporter, low-affinity (NCBI) compare
b0407 yajC -0.7 -2.2 preprotein translocase subunit YajC (NCBI) compare
b2620 smpB -0.7 -1.4 SsrA-binding protein (NCBI) compare
b1882 cheY -0.7 -0.6 chemotaxis regulator transmitting signal to flagellar motor component (NCBI) compare
b4593 ymgI -0.7 -0.6 hypothetical protein (RefSeq) compare
b1686 ydiI -0.7 -1.9 hypothetical protein (NCBI) compare
b3613 yibP -0.7 -2.7 putative membrane protein (VIMSS) compare
b0167 glnD -0.7 -2.8 PII uridylyl-transferase (NCBI) compare
b3741 gidA -0.7 -3.1 glucose-inhibited division protein A (NCBI) compare
b1167 ymgC -0.7 -0.3 hypothetical protein (NCBI) compare
b4068 yjcH -0.7 -2.0 required for glycolate transport, with actP (from data) compare
b1407 ydbD -0.7 -3.6 orf, hypothetical protein (VIMSS) compare
b0658 ybeX -0.7 -0.7 predicteed ion transport (NCBI) compare
b3027 ygiZ -0.7 -0.5 conserved inner membrane protein (NCBI) compare
b2688 gshA -0.7 -3.6 glutamate--cysteine ligase (NCBI) compare
b0688 pgm -0.7 -2.3 phosphoglucomutase (NCBI) compare
b1290 sapF -0.7 -1.3 predicted antimicrobial peptide transporter subunit (NCBI) compare
b3414 gntY -0.7 -3.8 predicted gluconate transport associated protein (NCBI) compare
b4215 ytfI -0.7 -1.2 hypothetical protein (NCBI) compare
b2518 ndk -0.7 -1.1 nucleoside diphosphate kinase (NCBI) compare
b3609 secB -0.7 -2.6 export protein SecB (NCBI) compare
b4577 sgrS -0.7 -1.4 small antisense RNA (NCBI) compare
b1827 kdgR -0.7 -1.8 predicted DNA-binding transcriptional regulator (NCBI) compare
b2582 trxC -0.6 -1.6 thioredoxin 2 (NCBI) compare
b1105 ycfM -0.6 -1.8 predicted outer membrane lipoprotein (NCBI) compare
b3858 yihD -0.6 -2.1 hypothetical protein (NCBI) compare
b3728 pstS -0.6 -2.0 phosphate transporter subunit (NCBI) compare
b4497 yeeL -0.6 -1.0 no description compare
b1536 ydeI -0.6 -0.8 hypothetical protein (NCBI) compare
b1684 sufA -0.6 -2.1 iron-sulfur cluster assembly scaffold protein (NCBI) compare
b1040 csgD -0.6 -1.3 DNA-binding transcriptional activator in two-component regulatory system (NCBI) compare
b1505 ydeT -0.6 -1.0 hypothetical protein (RefSeq) compare
b1151 ymfO -0.6 -2.1 e14 prophage; conserved protein (RefSeq) compare
b1482 osmC -0.6 -1.3 osmotically inducible, stress-inducible membrane protein (NCBI) compare
b0125 hpt -0.6 -3.2 hypoxanthine phosphoribosyltransferase (VIMSS) compare
b3169 nusA -0.6 -1.4 transcription elongation factor NusA (NCBI) compare
b0858 ybjO -0.6 -1.7 predicted inner membrane protein (NCBI) compare
b3390 aroK -0.6 -1.6 shikimate kinase I (NCBI) compare
b1877 yecT -0.6 -1.6 orf, hypothetical protein (VIMSS) compare
b2198 ccmD -0.6 -2.1 cytochrome c biogenesis protein (NCBI) compare
b1503 ydeR -0.6 -1.9 predicted fimbrial-like adhesin protein (NCBI) compare
b0741 pal -0.6 -2.2 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b2477 nlpB -0.6 -2.6 lipoprotein-34 (VIMSS) compare
b1488 ddpX -0.6 -2.7 D-ala-D-ala dipeptidase, Zn-dependent (NCBI) compare
b4246 pyrL -0.6 -1.6 pyrBI operon leader peptide (NCBI) compare
b1465 narV -0.6 -1.0 nitrate reductase 2 (NRZ), gamma subunit (NCBI) compare
b1434 ydcN -0.6 -0.9 predicted DNA-binding transcriptional regulator (NCBI) compare
b1949 fliQ -0.6 -1.9 flagellar biosynthesis protein Q (NCBI) compare
b3630 rfaP -0.6 -4.2 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b3726 pstA -0.6 -2.8 phosphate transporter subunit (NCBI) compare
b0310 ykgH -0.6 -0.9 predicted inner membrane protein (NCBI) compare
b1977 asnT -0.6 -1.5 tRNA-Asn (NCBI) compare
b0549 ybcO -0.6 -1.6 DLP12 prophage; predicted protein (NCBI) compare
b1582 ynfA -0.6 -1.3 hypothetical protein (NCBI) compare
b0049 apaH -0.6 -1.4 diadenosinetetraphosphatase (NCBI) compare
b0677 nagA -0.6 -3.0 N-acetylglucosamine-6-phosphate deacetylase (NCBI) compare
b2288 nuoA -0.6 -1.3 NADH dehydrogenase I chain A (VIMSS) compare
b2846 yqeH -0.6 -0.5 orf, hypothetical protein (VIMSS) compare
b4453 ldrD -0.6 -1.1 toxic polypeptide, small (NCBI) compare
b2939 yqgB -0.6 -0.6 predicted protein (RefSeq) compare
b2369 evgA -0.5 -2.0 DNA-binding response regulator in two-component regulatory system with EvgS (NCBI) compare
b2822 recC -0.5 -2.5 exonuclease V (RecBCD complex), gamma chain (NCBI) compare
b1634 tppB -0.5 -2.5 putative tripeptide transporter permease (NCBI) compare
b1850 eda -0.5 -1.4 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) compare
b4144 yjeI -0.5 -1.3 orf, hypothetical protein (VIMSS) compare
b3623 rfaK -0.5 -1.3 lipopolysaccharide core biosynthesis (NCBI) compare
b3842 rfaH -0.5 -2.1 transcriptional activator RfaH (NCBI) compare
b0862 artQ -0.5 -1.6 arginine transporter subunit (NCBI) compare
b1113 ycfS -0.5 -3.2 hypothetical protein (NCBI) compare
b3844 fre -0.5 -2.6 NAD(P)H-flavin reductase (NCBI) compare
b1084 rne -0.5 -2.1 fused ribonucleaseE: endoribonuclease/RNA-binding protein/RNA degradosome binding protein (NCBI) compare
b0082 mraW -0.5 -2.1 S-adenosyl-methyltransferase (NCBI) compare
b1969 yedW -0.5 -2.2 putative 2-component transcriptional regulator (VIMSS) compare
b4255 yjgD -0.5 -2.0 hypothetical protein (NCBI) compare
b1712 ihfA -0.5 -1.1 integration host factor subunit alpha (NCBI) compare
b1572 ydfB -0.5 -1.0 orf, hypothetical protein (VIMSS) compare
b3563 yiaB -0.5 -2.2 orf, hypothetical protein (VIMSS) compare
b0550 rusA -0.5 -1.5 DLP12 prophage; endonuclease RUS (NCBI) compare
b4642 yoeD -0.5 -1.3 no description compare
b1138 ymfE -0.5 -0.9 e14 prophage; predicted inner membrane protein (NCBI) compare
b1380 ldhA -0.5 -1.2 D-lactate dehydrogenase (NCBI) compare
b1025 ycdT -0.5 -0.9 predicted diguanylate cyclase (NCBI) compare


Specific Phenotypes

None in this experiment

For Escherichia coli BW25113 in phage experiments

For phage T7_phage across organisms