Experiment set22IT060 for Escherichia coli BW25113

Compare to:

T7_phage 0.0000015625 MOI TC1

200 most important genes:

  gene name fitness t score description  
b4202 rpsR -3.2 -2.2 30S ribosomal protein S18 (NCBI) compare
b3636 rpmG -2.5 -2.9 50S ribosomal protein L33 (NCBI) compare
b3979 thrT -2.4 -1.0 tRNA-Thr (NCBI) compare
b0738 tolR -2.3 -4.1 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b1332 ynaJ -2.2 -1.3 predicted inner membrane protein (NCBI) compare
b2830 nudH -2.1 -2.4 dinucleoside polyphosphate hydrolase (NCBI) compare
b2699 recA -2.1 -2.4 recombinase A (NCBI) compare
b3863 polA -2.1 -1.4 DNA polymerase I (NCBI) compare
b1346 ydaQ -2.0 -2.6 orf, hypothetical protein (VIMSS) compare
b1493 gadB -2.0 -1.2 glutamate decarboxylase B, PLP-dependent (NCBI) compare
b1085 b1085 -2.0 -3.7 orf, hypothetical protein (VIMSS) compare
b3183 obgE -1.9 -1.7 GTPase involved in cell partioning and DNA repair (NCBI) compare
b0739 tolA -1.9 -4.5 cell envelope integrity inner membrane protein TolA (NCBI) compare
b0630 lipB -1.9 -2.1 protein of lipoate biosynthesis (VIMSS) compare
b0114 aceE -1.8 -1.3 pyruvate dehydrogenase subunit E1 (NCBI) compare
b1291 sapD -1.8 -2.6 predicted antimicrobial peptide transporter subunit (NCBI) compare
b3619 rfaD -1.8 -5.3 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b0890 ftsK -1.8 -4.9 DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) compare
b3426 glpD -1.7 -5.6 sn-glycerol-3-phosphate dehydrogenase, aerobic, FAD/NAD(P)-binding (NCBI) compare
b1290 sapF -1.7 -2.4 predicted antimicrobial peptide transporter subunit (NCBI) compare
b1025 ycdT -1.6 -2.4 predicted diguanylate cyclase (NCBI) compare
b3811 xerC -1.6 -2.2 site-specific tyrosine recombinase XerC (NCBI) compare
b2935 tktA -1.6 -2.1 transketolase 1, thiamin-binding (NCBI) compare
b1613 manA -1.6 -2.2 mannose-6-phosphate isomerase (VIMSS) compare
b1236 galU -1.5 -5.7 glucose-1-phosphate uridylyltransferase (NCBI) compare
b2894 xerD -1.5 -1.4 site-specific tyrosine recombinase XerD (NCBI) compare
b4239 treC -1.5 -3.8 trehalose-6-P hydrolase (NCBI) compare
b2285 nuoE -1.5 -3.3 NADH dehydrogenase subunit E (NCBI) compare
b0357 yaiN -1.5 -1.9 putative alpha helix chain (VIMSS) compare
b2846 yqeH -1.5 -1.0 orf, hypothetical protein (VIMSS) compare
b2528 iscA -1.4 -1.7 iron-sulfur cluster assembly protein (NCBI) compare
b3613 yibP -1.4 -4.7 putative membrane protein (VIMSS) compare
b4155 yjeA -1.4 -1.0 putative lysyl-tRNA synthetase (VIMSS) compare
b0232 yafN -1.4 -0.8 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b3500 gor -1.4 -2.0 glutathione reductase (NCBI) compare
b4177 purA -1.4 -1.9 adenylosuccinate synthetase (NCBI) compare
b0222 lpcA -1.4 -3.5 phosphoheptose isomerase (NCBI) compare
b4042 dgkA -1.4 -2.6 diacylglycerol kinase (NCBI) compare
b2168 fruK -1.4 -1.1 1-phosphofructokinase (NCBI) compare
b3405 ompR -1.3 -5.0 osmolarity response regulator (NCBI) compare
b3778 rep -1.3 -5.9 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b0200 gmhB -1.3 -1.9 hypothetical protein (NCBI) compare
b4041 plsB -1.3 -2.2 glycerol-3-phosphate acyltransferase (VIMSS) compare
b4179 vacB -1.3 -6.6 putative enzyme (VIMSS) compare
b3261 fis -1.3 -2.4 DNA-binding protein Fis (NCBI) compare
b2820 recB -1.3 -1.7 exonuclease V (RecBCD complex), beta subunit (NCBI) compare
b0053 surA -1.3 -5.7 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b1506 yneL -1.3 -1.6 predicted transcriptional regulator (NCBI) compare
b1361 ydaW -1.3 -0.7 orf, hypothetical protein (VIMSS) compare
b4651 yibW -1.3 -0.8 no description compare
b4647 mokA -1.2 -0.8 no description compare
b3839 tatC -1.2 -5.5 TatABCE protein translocation system subunit (NCBI) compare
b3290 trkA -1.2 -2.7 potassium transporter peripheral membrane component (NCBI) compare
b3728 pstS -1.2 -3.1 phosphate transporter subunit (NCBI) compare
b4048 yjbM -1.2 -1.7 hypothetical protein (NCBI) compare
b4596 yciZ -1.1 -1.8 hypothetical protein (RefSeq) compare
b2498 upp -1.1 -2.6 uracil phosphoribosyltransferase (VIMSS) compare
b4375 prfC -1.1 -4.6 peptide chain release factor 3 (NCBI) compare
b4201 priB -1.1 -2.1 primosomal replication protein N (NCBI) compare
b3621 rfaC -1.1 -3.8 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b2284 nuoF -1.1 -3.8 NADH:ubiquinone oxidoreductase, chain F (NCBI) compare
b2318 truA -1.1 -2.7 tRNA pseudouridine synthase A (NCBI) compare
b0888 trxB -1.1 -3.5 thioredoxin reductase, FAD/NAD(P)-binding (NCBI) compare
b2934 cmtB -1.1 -0.7 predicted mannitol-specific enzyme IIA component of PTS (NCBI) compare
b1850 eda -1.1 -1.4 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) compare
b0658 ybeX -1.1 -1.2 predicteed ion transport (NCBI) compare
b1176 minC -1.1 -2.2 septum formation inhibitor (NCBI) compare
b0051 ksgA -1.1 -4.1 dimethyladenosine transferase (NCBI) compare
b0767 ybhE -1.1 -2.8 6-phosphogluconolactonase (NCBI) compare
b1351 racC -1.1 -0.7 Rac prophage; predicted protein (NCBI) compare
b1690 ydiM -1.1 -2.2 predicted transporter (NCBI) compare
b1165 ymgA -1.1 -0.7 hypothetical protein (NCBI) compare
b1129 phoQ -1.0 -1.2 sensory histidine kinase in two-compoent regulatory system with PhoP (NCBI) compare
b3162 deaD -1.0 -4.2 inducible ATP-independent RNA helicase (VIMSS) compare
b1363 trkG -1.0 -0.7 Rac prophage; potassium transporter subunit (NCBI) compare
b1865 nudB -1.0 -1.2 dATP pyrophosphohydrolase (NCBI) compare
b1497 b1497 -1.0 -0.6 putative enzyme (VIMSS) compare
b3741 gidA -1.0 -3.9 glucose-inhibited division protein A (NCBI) compare
b4345 mcrC -1.0 -0.7 5-methylcytosine-specific restriction enzyme McrBC, subunit McrC (NCBI) compare
b1258 yciF -1.0 -0.9 hypothetical protein (NCBI) compare
b3386 rpe -1.0 -0.7 ribulose-phosphate 3-epimerase (NCBI) compare
b3916 pfkA -1.0 -2.7 6-phosphofructokinase (NCBI) compare
b1130 phoP -1.0 -1.6 DNA-binding response regulator in two-component regulatory system with PhoQ (NCBI) compare
b4203 rplI -1.0 -4.0 50S ribosomal protein L9 (NCBI) compare
b1882 cheY -1.0 -0.7 chemotaxis regulator transmitting signal to flagellar motor component (NCBI) compare
b2912 ygfA -1.0 -2.4 putative ligase (VIMSS) compare
b3706 trmE -1.0 -3.4 tRNA modification GTPase (NCBI) compare
b2071 yegJ -1.0 -1.6 hypothetical protein (NCBI) compare
b3052 rfaE -1.0 -3.8 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare
b4410 ecnA -1.0 -1.2 entericidin A membrane lipoprotein, antidote entericidin B (NCBI) compare
b4414 tff -0.9 -3.3 unknown RNA (NCBI) compare
b3623 rfaK -0.9 -1.9 lipopolysaccharide core biosynthesis (NCBI) compare
b3210 arcB -0.9 -5.7 hybrid sensory histidine kinase in two-component regulatory system with ArcA (NCBI) compare
b4373 rimI -0.9 -3.1 ribosomal-protein-alanine N-acetyltransferase (NCBI) compare
b3977 tyrU -0.9 -0.9 tRNA-Tyr (NCBI) compare
b3649 rpoZ -0.9 -3.2 DNA-directed RNA polymerase subunit omega (NCBI) compare
b1252 tonB -0.9 -2.1 membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) compare
b0018 mokC -0.9 -1.2 regulatory protein for HokC, overlaps CDS of hokC (NCBI) compare
b1103 ycfF -0.9 -1.6 orf, hypothetical protein (VIMSS) compare
b2904 gcvH -0.9 -2.1 glycine cleavage system protein H (NCBI) compare
b1370 insH-5 -0.9 -2.0 Rac prophage; IS5 transposase and trans-activator (NCBI) compare
b2567 rnc -0.9 -1.0 ribonuclease III (NCBI) compare
b1576 ydfD -0.9 -0.4 Qin prophage; predicted protein (NCBI) compare
b4146 yjeK -0.9 -2.1 predicted lysine aminomutase (NCBI) compare
b1499 ydeO -0.9 -0.4 predicted DNA-binding transcriptional acfivator (NCBI) compare
b0729 sucD -0.9 -2.1 succinyl-CoA synthetase subunit alpha (NCBI) compare
b3204 ptsN -0.9 -3.4 sugar-specific enzyme IIA component of PTS (NCBI) compare
b3609 secB -0.9 -2.7 export protein SecB (NCBI) compare
b1286 rnb -0.9 -1.9 exoribonuclease II (NCBI) compare
b0125 hpt -0.9 -4.1 hypoxanthine phosphoribosyltransferase (VIMSS) compare
b1545 pinQ -0.9 -0.3 Qin prophage; predicted site-specific recombinase (NCBI) compare
b3725 pstB -0.9 -1.1 phosphate transporter subunit (NCBI) compare
b1001 yccE -0.8 -0.5 hypothetical protein (NCBI) compare
b1863 ruvC -0.8 -1.5 Holliday junction resolvase (NCBI) compare
b3026 qseC -0.8 -2.7 sensory histidine kinase in two-component regulatory system with QseB (NCBI) compare
b2698 recX -0.8 -1.6 RecA regulator RecX (NCBI) compare
b0439 lon -0.8 -3.7 DNA-binding ATP-dependent protease La (NCBI) compare
b2822 recC -0.8 -3.4 exonuclease V (RecBCD complex), gamma chain (NCBI) compare
b0705 ybfL -0.8 -0.6 putative receptor protein (VIMSS) compare
b2297 pta -0.8 -0.8 phosphate acetyltransferase (NCBI) compare
b2569 lepA -0.8 -2.6 GTP-binding protein LepA (NCBI) compare
b1347 ydaC -0.8 -0.4 Rac prophage; predicted protein (NCBI) compare
b3875 ompL -0.8 -2.2 predicted outer membrane porin L (NCBI) compare
b0145 dksA -0.8 -2.5 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b1058 yceO -0.8 -0.4 hypothetical protein (NCBI) compare
b2288 nuoA -0.8 -2.3 NADH dehydrogenase I chain A (VIMSS) compare
b0740 tolB -0.8 -2.7 translocation protein TolB precursor (NCBI) compare
b1773 ydjI -0.8 -1.9 predicted aldolase (NCBI) compare
b4545 ypdJ -0.8 -1.1 no description compare
b3761 trpT -0.8 -1.3 tRNA-Trp (NCBI) compare
b2276 nuoN -0.8 -3.2 NADH:ubiquinone oxidoreductase, membrane subunit N (RefSeq) compare
b2259 pmrD -0.8 -1.0 polymyxin resistance protein B (VIMSS) compare
b4590 ybfK -0.8 -0.5 hypothetical protein (RefSeq) compare
b2055 wcaE -0.8 -0.5 predicted glycosyl transferase (NCBI) compare
b1182 hlyE -0.8 -0.7 hemolysin E (VIMSS) compare
b1579 intQ -0.8 -2.6 Qin prophage; predicted defective integrase (RefSeq) compare
b4520 ymgF -0.8 -1.4 hypothetical protein (NCBI) compare
b3631 rfaG -0.8 -6.0 glucosyltransferase I (NCBI) compare
b2377 yfdY -0.8 -1.3 predicted inner membrane protein (NCBI) compare
b1712 ihfA -0.8 -1.4 integration host factor subunit alpha (NCBI) compare
b3781 trxA -0.8 -2.5 thioredoxin 1 (VIMSS) compare
b1855 lpxM -0.8 -3.8 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase (NCBI) compare
b0722 sdhD -0.8 -3.3 succinate dehydrogenase cytochrome b556 small membrane subunit (NCBI) compare
b1109 ndh -0.8 -1.8 respiratory NADH dehydrogenase 2/cupric reductase (NCBI) compare
b2642 yfjW -0.8 -0.5 CP4-57 prophage; predicted inner membrane protein (NCBI) compare
b2446 yffO -0.8 -2.0 CPZ-55 prophage; predicted protein (NCBI) compare
b1292 sapC -0.8 -1.4 predicted antimicrobial peptide transporter subunit (NCBI) compare
b0310 ykgH -0.7 -0.9 predicted inner membrane protein (NCBI) compare
b0726 sucA -0.7 -2.7 alpha-ketoglutarate decarboxylase (NCBI) compare
b1257 yciE -0.7 -0.4 hypothetical protein (NCBI) compare
b3198 kdsC -0.7 -1.7 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (NCBI) compare
b3027 ygiZ -0.7 -0.5 conserved inner membrane protein (NCBI) compare
b1837 yebW -0.7 -1.7 orf, hypothetical protein (VIMSS) compare
b0706 ybfD -0.7 -1.5 hypothetical protein (NCBI) compare
b2278 nuoL -0.7 -4.3 NADH dehydrogenase subunit L (NCBI) compare
b2504 yfgG -0.7 -1.0 Negative regulator of nickel and cobalt uptake (YfgG) (from data) compare
b3630 rfaP -0.7 -5.0 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b2280 nuoJ -0.7 -2.9 NADH dehydrogenase subunit J (NCBI) compare
b4435 isrC -0.7 -1.4 unknown RNA (NCBI) compare
b2620 smpB -0.7 -0.8 SsrA-binding protein (NCBI) compare
b2283 nuoG -0.7 -3.8 NADH:ubiquinone oxidoreductase, chain G (RefSeq) compare
b2330 yfcB -0.7 -1.2 putative adenine-specific methylase (VIMSS) compare
b3493 pitA -0.7 -3.8 phosphate transporter, low-affinity (NCBI) compare
b1635 gst -0.7 -2.0 glutathionine S-transferase (NCBI) compare
b0683 fur -0.7 -0.8 ferric uptake regulator (NCBI) compare
b1167 ymgC -0.7 -0.3 hypothetical protein (NCBI) compare
b3264 envR -0.7 -2.5 DNA-binding transcriptional regulator (NCBI) compare
b1921 fliZ -0.7 -1.2 orf, hypothetical protein (VIMSS) compare
b1969 yedW -0.7 -2.5 putative 2-component transcriptional regulator (VIMSS) compare
b1084 rne -0.7 -3.2 fused ribonucleaseE: endoribonuclease/RNA-binding protein/RNA degradosome binding protein (NCBI) compare
b3387 dam -0.7 -4.8 DNA adenine methylase (NCBI) compare
b3962 udhA -0.7 -3.2 putative oxidoreductase (VIMSS) compare
b4593 ymgI -0.6 -0.5 hypothetical protein (RefSeq) compare
b3626 rfaJ -0.6 -2.8 UDP-D-glucose:(galactosyl)lipopolysaccharide glucosyltransferase (NCBI) compare
b1121 ycfZ -0.6 -1.3 predicted inner membrane protein (NCBI) compare
b3138 agaB -0.6 -1.5 N-acetylgalactosamine-specific enzyme IIB component of PTS (NCBI) compare
b3624 rfaZ -0.6 -1.3 lipopolysaccharide core biosynthesis protein (NCBI) compare
b3658 selC -0.6 -1.6 tRNA-Sec (NCBI) compare
b1409 ynbB -0.6 -1.0 predicted CDP-diglyceride synthase (NCBI) compare
b4497 yeeL -0.6 -0.9 no description compare
b4494 arpB -0.6 -1.5 no description compare
b1330 ynaI -0.6 -2.6 conserved inner membrane protein (NCBI) compare
b0429 cyoD -0.6 -2.6 cytochrome o ubiquinol oxidase subunit IV (NCBI) compare
b1194 ycgR -0.6 -2.2 protein involved in flagellar function (NCBI) compare
b4546 ypeB -0.6 -0.8 hypothetical protein (NCBI) compare
b1139 lit -0.6 -2.5 e14 prophage; cell death peptidase, inhibitor of T4 late gene expression (NCBI) compare
b3620 rfaF -0.6 -2.4 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b1548 nohA -0.6 -1.1 Qin prophage; predicted packaging protein (RefSeq) compare
b4592 yccB -0.6 -1.4 hypothetical protein (RefSeq) compare
b0737 tolQ -0.6 -1.1 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b2688 gshA -0.6 -3.9 glutamate--cysteine ligase (NCBI) compare
b0560 nohB -0.6 -1.5 DLP12 prophage; DNA packaging protein (NCBI) compare
b0386 proC -0.6 -1.8 pyrroline-5-carboxylate reductase (NCBI) compare
b1183 umuD -0.6 -0.6 DNA polymerase V, subunit D (NCBI) compare
b0099 mutT -0.6 -2.9 nucleoside triphosphate pyrophosphohydrolase, marked preference for dGTP (NCBI) compare
b0430 cyoC -0.6 -2.8 cytochrome o ubiquinol oxidase subunit III (NCBI) compare
b4012 yjaB -0.6 -1.4 predicted acetyltransferase (NCBI) compare
b3844 fre -0.6 -3.3 NAD(P)H-flavin reductase (NCBI) compare
b2263 yfbB -0.6 -1.2 predicted peptidase (NCBI) compare
b3238 yhcN -0.6 -1.5 orf, hypothetical protein (VIMSS) compare


Specific Phenotypes

None in this experiment

For Escherichia coli BW25113 in phage experiments

For phage T7_phage across organisms