Experiment set22IT060 for Escherichia coli BW25113

Compare to:

T7_phage 0.0000015625 MOI TC1

200 most detrimental genes:

  gene name fitness t score description  
b1936 intG +1.5 2.3 predicted defective phage integrase (pseudogene) (RefSeq) compare
b0564 appY +1.4 2.1 DLP12 prophage; DNA-binding transcriptional activator (NCBI) compare
b4458 oxyS +1.3 3.3 global regulatory RNA (NCBI) compare
b1476 fdnI +1.2 1.5 formate dehydrogenase-N, cytochrome B556 (gamma) subunit, nitrate-inducible (NCBI) compare
b4699 fnrS +1.1 1.3 FNR-activated anaerobic sRNA antisense regulator down regulates cydDC, metE, sodA, sodB, Hfq-dependent; mediates negative FNR regulation (RefSeq) compare
b1550 b1550 +1.1 1.8 orf, hypothetical protein (VIMSS) compare
b4701 sokX +1.1 0.9 sok-related sRNA, function unknown (RefSeq) compare
b1942 fliJ +1.0 2.1 flagellar biosynthesis chaperone (NCBI) compare
b1765 ydjA +1.0 1.0 predicted oxidoreductase (NCBI) compare
b1647 ydhF +0.9 4.1 predicted oxidoreductase (NCBI) compare
b1161 ycgX +0.9 1.3 hypothetical protein (NCBI) compare
b4451 ryhB +0.9 0.9 Regulatory sRNA mediating positive Fur regulon response; requires Hfq for function; global iron regulator; degraded by RNase E when bound to target (RefSeq) compare
b1642 slyA +0.8 1.6 transcriptional regulator for cryptic hemolysin (VIMSS) compare
b3341 rpsG +0.8 1.0 30S ribosomal protein S7 (NCBI) compare
b1261 trpB +0.8 2.2 tryptophan synthase subunit beta (NCBI) compare
b1335 ogt +0.8 2.3 O-6-alkylguanine-DNA:cysteine-protein methyltransferase (NCBI) compare
b3890 yiiF +0.8 3.0 orf, hypothetical protein (VIMSS) compare
b4408 csrB +0.8 3.5 CsrA-binding sRNA, antagonizing CsrA regulation (NCBI) compare
b1739 osmE +0.7 1.9 DNA-binding transcriptional activator (NCBI) compare
b4418 sraB +0.7 1.0 unknown RNA (NCBI) compare
b4595 yciY +0.7 1.2 hypothetical protein (RefSeq) compare
b2450 yffS +0.7 2.3 CPZ-55 prophage; predicted protein (RefSeq) compare
b1818 manY +0.7 1.4 mannose-specific enzyme IIC component of PTS (NCBI) compare
b0974 hyaC +0.7 2.5 hydrogenase 1, b-type cytochrome subunit (NCBI) compare
b1984 asnW +0.7 1.0 tRNA-Asn (NCBI) compare
b1566 flxA +0.7 1.6 Qin prophage; predicted protein (NCBI) compare
b4533 ynfO +0.7 1.2 Qin prophage; predicted protein (NCBI) compare
b1220 ychO +0.7 2.5 predicted invasin (RefSeq) compare
b1507 hipA +0.6 2.4 regulator with hipB (NCBI) compare
b1874 cutC +0.6 1.3 copper homeostasis protein (NCBI) compare
b1853 yebK +0.6 1.7 predicted DNA-binding transcriptional regulator (NCBI) compare
b1824 yobF +0.6 1.8 hypothetical protein (NCBI) compare
b4630 ykgP +0.6 2.3 no description compare
b1171 b1171 +0.6 1.6 orf, hypothetical protein (VIMSS) compare
b1758 b1758 +0.6 1.0 putative cytochrome oxidase (VIMSS) compare
b1482 osmC +0.6 0.7 osmotically inducible, stress-inducible membrane protein (NCBI) compare
b1448 yncA +0.6 1.0 predicted acyltransferase with acyl-CoA N-acyltransferase domain (NCBI) compare
b1270 btuR +0.6 1.6 cob(I)yrinic acid a,c-diamide adenosyltransferase (NCBI) compare
b3107 yhaL +0.6 1.1 orf, hypothetical protein (VIMSS) compare
b4702 mgtL +0.6 1.3 regulatory leader peptide for mgtA (NCBI) compare
b0263 afuB +0.6 1.2 CP4-6 prophage; predicted ferric trasnporter subunit (RefSeq) compare
b1120 cobB +0.6 2.8 deacetylase of acs and cheY, regulates chemotaxis (NCBI) compare
b1567 intK +0.6 1.8 Qin prophage; predicted protein (RefSeq) compare
b1217 chaB +0.6 1.0 cation transport regulator (NCBI) compare
b2058 wcaB +0.6 1.0 predicted acyl transferase (NCBI) compare
b1742 b1742 +0.5 1.8 orf, hypothetical protein (VIMSS) compare
b1343 dbpA +0.5 2.2 ATP-dependent RNA helicase, specific for 23S rRNA (NCBI) compare
b2197 ccmE +0.5 2.8 periplasmic heme chaperone (NCBI) compare
b2782 chpA +0.5 2.1 toxin of the ChpA-ChpR toxin-antitoxin system, endoribonuclease (NCBI) compare
b1608 rstA +0.5 2.0 DNA-binding response regulator in two-component regulatory system with RstB (RefSeq) compare
b0878 b0878 +0.5 2.2 putative membrane protein (VIMSS) compare
b1731 cedA +0.5 1.4 cell division modulator (RefSeq) compare
b2448 yffQ +0.5 2.5 CPZ-55 prophage; predicted protein (RefSeq) compare
b0730 mngR +0.5 1.1 DNA-binding transcriptional dual regulator, fatty-acyl-binding (NCBI) compare
b2005 yeeV +0.5 2.5 CP4-44 prophage; toxin of the YeeV-YeeU toxin-antitoxin system (NCBI) compare
b4436 ryeC +0.5 1.0 Novel sRNA, function unknown; paralogous to the other QUAD sRNA genes unknown (RefSeq) compare
b1904 yecR +0.5 1.4 hypothetical protein (NCBI) compare
b1070 flgN +0.5 1.0 export chaperone for FlgK and FlgL (NCBI) compare
b1753 ynjA +0.5 1.5 hypothetical protein (NCBI) compare
b1412 azoR +0.5 1.7 acyl carrier protein phosphodiesterase (NCBI) compare
b0817 mntR +0.5 2.2 DNA-binding transcriptional regulator of mntH (NCBI) compare
b2012 yeeD +0.5 2.0 hypothetical protein (NCBI) compare
b1557 cspB +0.5 1.0 Qin prophage; cold shock protein (NCBI) compare
b1429 tehA +0.5 0.9 potassium-tellurite ethidium and proflavin transporter (NCBI) compare
b2061 wzb +0.5 1.4 protein-tyrosine phosphatase (NCBI) compare
b4695 ykgT +0.5 1.3 no description compare
b1583 ynfB +0.5 1.7 hypothetical protein (NCBI) compare
b2410 yfeH +0.5 2.0 predicted inner membrane protein (NCBI) compare
b1192 ldcA +0.5 2.2 L,D-carboxypeptidase A (NCBI) compare
b3882 yihU +0.5 2.7 predicted oxidoreductase with NAD(P)-binding Rossmann-fold domain (NCBI) compare
b4416 rybA +0.5 0.8 unknown RNA (NCBI) compare
b1366 ydaY +0.5 2.2 Rac prophage; predicted protein (RefSeq) compare
b4294 insA-7 +0.5 1.3 KpLE2 phage-like element; IS1 repressor protein InsA (NCBI) compare
b2096 gatY +0.5 2.6 tagatose-bisphosphate aldolase 1 (VIMSS) compare
b0975 hyaD +0.5 2.6 protein involved in processing of HyaA and HyaB proteins (NCBI) compare
b1479 sfcA +0.5 2.0 NAD-linked malate dehydrogenase (malic enzyme) (VIMSS) compare
b4613 dinQ +0.5 1.2 Damage inducible, function unknown (RefSeq) compare
b2050 wcaI +0.5 2.4 predicted glycosyl transferase (NCBI) compare
b0367 tauC +0.5 2.2 taurine transporter subunit (NCBI) compare
b1021 ycdP +0.5 2.1 predicted inner membrane protein (NCBI) compare
b0617 citD +0.5 1.4 citrate lyase, acyl carrier (gamma) subunit (NCBI) compare
b4646 yrdE +0.5 1.6 no description compare
b1830 prc +0.5 2.4 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b1323 tyrR +0.5 2.5 DNA-binding transcriptional dual regulator, tyrosine-binding (NCBI) compare
b1757 b1757 +0.5 2.1 putative thiosulfate sulfur transferase (VIMSS) compare
b1542 ydfI +0.5 1.6 predicted mannonate dehydrogenase (NCBI) compare
b4176 yjeT +0.5 1.8 conserved inner membrane protein (NCBI) compare
b4535 yniD +0.5 0.8 predicted protein (RefSeq) compare
b1944 fliL +0.4 1.7 flagellar basal body-associated protein FliL (NCBI) compare
b1591 b1591 +0.4 1.2 putative oxidoreductase component (VIMSS) compare
b1724 ydiZ +0.4 1.2 hypothetical protein (NCBI) compare
b1620 malI +0.4 1.0 DNA-binding transcriptional repressor (NCBI) compare
b1421 trg +0.4 1.7 methyl-accepting chemotaxis protein III, ribose and galactose sensor receptor (NCBI) compare
b1595 ynfL +0.4 1.0 predicted DNA-binding transcriptional regulator (NCBI) compare
b2080 b2080 +0.4 1.0 orf, hypothetical protein (VIMSS) compare
b4457 csrC +0.4 1.2 regulatory RNA (NCBI) compare
b0556 rzpD +0.4 1.1 DLP12 prophage; predicted murein endopeptidase (NCBI) compare
b4622 ytcA +0.4 2.1 hypothetical protein (RefSeq) compare
b1918 yecS +0.4 1.5 predicted transporter subunit: membrane component of ABC superfamily (NCBI) compare
b0843 ybjH +0.4 1.1 hypothetical protein (NCBI) compare
b2990 hybG +0.4 1.2 hydrogenase 2 accessory protein (NCBI) compare
b1415 aldA +0.4 1.8 Lactaldehyde / glycolaldehyde dehydrogenase aldA (EC 1.2.1.22; EC 1.2.1.21) (from data) compare
b1349 recT +0.4 2.2 Rac prophage; recombination and repair protein (NCBI) compare
b0404 yajB +0.4 1.1 hypothetical protein (NCBI) compare
b4578 insP +0.4 1.2 no description compare
b0210 yafE +0.4 1.6 predicted S-adenosyl-L-methionine-dependent methyltransferase (NCBI) compare
b4614 sokA +0.4 1.7 no description compare
b1651 gloA +0.4 1.5 glyoxalase I, Ni-dependent (NCBI) compare
b1581 rspA +0.4 1.7 predicted dehydratase (NCBI) compare
b0953 rmf +0.4 1.0 ribosome modulation factor (NCBI) compare
b1259 yciG +0.4 0.8 orf, hypothetical protein (VIMSS) compare
b1160 elbA +0.4 0.5 hypothetical protein (NCBI) compare
b2561 yfhH +0.4 2.4 orf, hypothetical protein (VIMSS) compare
b3014 yqhH +0.4 1.3 predicted outer membrane lipoprotein (NCBI) compare
b0987 ymcD +0.4 2.4 orf, hypothetical protein (VIMSS) compare
b2455 eutE +0.4 1.4 predicted aldehyde dehydrogenase, ethanolamine utilization protein (NCBI) compare
b1741 ydjQ +0.4 1.9 endonuclease of nucleotide excision repair (NCBI) compare
b1382 ynbE +0.4 0.8 predicted lipoprotein (NCBI) compare
b1871 yecP +0.4 1.6 predicted S-adenosyl-L-methionine-dependent methyltransferase (NCBI) compare
b3120 yhaB +0.4 0.8 orf, hypothetical protein (VIMSS) compare
b2635 ypjK +0.4 1.8 CP4-57 prophage; predicted inner membrane protein (NCBI) compare
b4057 yjbR +0.4 1.8 hypothetical protein (NCBI) compare
b1519 tam +0.4 2.0 trans-aconitate 2-methyltransferase (NCBI) compare
b4505 insX +0.4 0.9 predicted IS protein (RefSeq) compare
b0994 torT +0.4 1.4 periplasmic sensory protein associated with the TorRS two-component regulatory system (NCBI) compare
b4438 cyaR +0.4 0.9 sRNA effector of ompX mRNA instability, cAMP-induced; hfq-dependent (RefSeq) compare
b2381 ypdB +0.4 1.9 predicted response regulator in two-component system withYpdA (NCBI) compare
b1602 pntB +0.4 1.4 pyridine nucleotide transhydrogenase (NCBI) compare
b2291 yfbR +0.4 1.8 hypothetical protein (NCBI) compare
b1045 ymdB +0.4 2.0 hypothetical protein (NCBI) compare
b1756 ynjD +0.4 1.5 predicted transporter subunit: ATP-binding component of ABC superfamily (NCBI) compare
b1067 yceH +0.4 1.8 hypothetical protein (NCBI) compare
b3206 npr +0.4 1.6 phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) (NCBI) compare
b1494 pqqL +0.4 2.4 predicted peptidase (NCBI) compare
b3005 exbD +0.4 2.0 membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) compare
b1222 narX +0.4 1.9 sensory histidine kinase in two-component regulatory system with NarL (NCBI) compare
b3098 yqjD +0.4 1.6 hypothetical protein (NCBI) compare
b1296 ycjJ +0.4 1.3 putative amino acid/amine transport protein (VIMSS) compare
b1046 ymdC +0.4 2.2 putative synthase (VIMSS) compare
b2438 b2438 +0.4 1.5 orf, hypothetical protein (VIMSS) compare
b1399 paaX +0.4 1.3 DNA-binding transcriptional repressor of phenylacetic acid degradation, aryl-CoA responsive (NCBI) compare
b1484 ddpD +0.4 1.8 D-ala-D-ala transporter subunit (NCBI) compare
b3382 yhfY +0.4 1.5 orf, hypothetical protein (VIMSS) compare
b1971 yedY +0.4 1.4 hypothetical protein (NCBI) compare
b1861 ruvA +0.4 0.6 Holliday junction DNA helicase motor protein (NCBI) compare
b0380 b0380 +0.4 1.2 orf, hypothetical protein (VIMSS) compare
b2033 wbbJ +0.4 1.9 predicted acyl transferase (NCBI) compare
b4506 ykgO +0.4 1.5 rpmJ (L36) paralog (NCBI) compare
b0685 ybfE +0.4 0.7 orf, hypothetical protein (VIMSS) compare
b0784 moaD +0.4 0.9 molybdopterin synthase, small subunit (NCBI) compare
b2378 ddg +0.4 1.6 putative heat shock protein (VIMSS) compare
b1013 ycdC +0.4 1.2 predicted DNA-binding transcriptional regulator (NCBI) compare
b2114 metG +0.4 0.7 methionyl-tRNA synthetase (NCBI) compare
b1623 add +0.4 1.1 adenosine deaminase (NCBI) compare
b4585 sroB +0.4 0.7 Novel sRNA, function unknown (RefSeq) compare
b4493 gapC +0.4 0.7 no description compare
b0717 ybgP +0.4 1.4 predicted assembly protein (NCBI) compare
b1696 ydiP +0.4 0.9 predicted DNA-binding transcriptional regulator (NCBI) compare
b1063 yceB +0.4 0.8 predicted lipoprotein (NCBI) compare
b1162 ycgE +0.4 1.8 predicted DNA-binding transcriptional regulator (NCBI) compare
b2726 hypA +0.4 1.8 protein involved in nickel insertion into hydrogenases 3 (NCBI) compare
b0682 ybfN +0.3 1.0 predicted lipoprotein (NCBI) compare
b2492 focB +0.3 2.2 predicted formate transporter (NCBI) compare
b1478 adhP +0.3 1.6 alcohol dehydrogenase (VIMSS) compare
b1679 sufE +0.3 1.2 cysteine desufuration protein SufE (NCBI) compare
b2732 ygbA +0.3 1.9 hypothetical protein (NCBI) compare
b1279 yciS +0.3 0.5 conserved inner membrane protein (NCBI) compare
b4207 fklB +0.3 2.2 FKBP-type 22KD peptidyl-prolyl cis-trans isomerase (rotamase) (VIMSS) compare
b4490 efeU +0.3 2.4 no description compare
b1961 dcm +0.3 0.6 DNA cytosine methylase (NCBI) compare
b3594 yibA +0.3 2.0 lyase containing HEAT-repeat (NCBI) compare
b0872 hcr +0.3 1.9 HCP oxidoreductase, NADH-dependent (NCBI) compare
b4224 chpS +0.3 2.0 suppressor of inhibitory function of ChpB, PemI-like, autoregulated (VIMSS) compare
b0596 entA +0.3 1.9 2,3-dihydroxybenzoate-2,3-dehydrogenase (NCBI) compare
b0088 murD +0.3 0.6 UDP-N-acetylmuramoyl-L-alanyl-D-glutamatesynthetase (NCBI) compare
b0991 ymcE +0.3 1.1 cold shock gene (NCBI) compare
b1513 lsrA +0.3 1.7 fused AI2 transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b1348 lar +0.3 0.6 Rac prophage; restriction alleviation protein (NCBI) compare
b2911 ssrS +0.3 0.4 6S regulatory RNA (NCBI) compare
b1431 ydcL +0.3 1.4 predicted lipoprotein (NCBI) compare
b1248 b1248 +0.3 0.9 orf, hypothetical protein (VIMSS) compare
b1617 uidA +0.3 2.0 beta-D-glucuronidase (NCBI) compare
b1803 yeaX +0.3 1.0 predicted oxidoreductase (NCBI) compare
b4406 yaeP +0.3 1.1 hypothetical protein (NCBI) compare
b0840 deoR +0.3 1.2 DNA-binding transcriptional repressor (NCBI) compare
b4502 yeiW +0.3 1.2 hypothetical protein (NCBI) compare
b0447 ybaO +0.3 1.2 putative LRP-like transcriptional regulator (VIMSS) compare
b0927 ycbL +0.3 1.3 predicted metal-binding enzyme (NCBI) compare
b1197 treA +0.3 2.0 periplasmic trehalase (NCBI) compare
b0261 mmuM +0.3 2.1 homocysteine methyltransferase (NCBI) compare
b2362 yfdS +0.3 1.4 CPS-53 (KpLE1) prophage; predicted protein (NCBI) compare
b0041 fixA +0.3 1.8 probable flavoprotein subunit, carnitine metabolism (VIMSS) compare
b2147 yeiA +0.3 1.8 putative oxidoreductase (VIMSS) compare
b1622 malY +0.3 1.4 bifunctional beta-cystathionase, PLP-dependent/ regulator of maltose regulon (NCBI) compare
b1441 ydcT +0.3 1.1 predicted spermidine/putrescine transporter subunit (NCBI) compare
b2622 intA +0.3 1.7 CP4-57 prophage; integrase (NCBI) compare
b4369 leuP +0.3 0.7 tRNA-Leu (NCBI) compare
b1245 oppC +0.3 1.7 oligopeptide transporter subunit (NCBI) compare
b2352 yfdI +0.3 0.5 CPS-53 (KpLE1) prophage; predicted inner membrane protein (NCBI) compare
b0870 ltaE +0.3 1.5 L-allo-threonine aldolase, PLP-dependent (NCBI) compare


Specific Phenotypes

None in this experiment

For Escherichia coli BW25113 in phage experiments

For phage T7_phage across organisms