| | gene | name | fitness | t score | description | |
|---|
| b2025 | hisF | -7.6 | -7.4 | imidazole glycerol phosphate synthase subunit HisF (NCBI) | compare |
| b2838 | lysA | -7.0 | -19.2 | diaminopimelate decarboxylase, PLP-binding (NCBI) | compare |
| b3771 | ilvD | -6.3 | -22.3 | dihydroxy-acid dehydratase (NCBI) | compare |
| b3642 | pyrE | -6.2 | -9.9 | orotate phosphoribosyltransferase (NCBI) | compare |
| b0073 | leuB | -6.1 | -16.6 | 3-isopropylmalate dehydrogenase (VIMSS) | compare |
| b0072 | leuC | -6.0 | -18.3 | isopropylmalate isomerase large subunit (NCBI) | compare |
| b0071 | leuD | -5.9 | -13.1 | isopropylmalate isomerase small subunit (NCBI) | compare |
| b0074 | leuA | -5.8 | -16.6 | 2-isopropylmalate synthase (NCBI) | compare |
| b3774 | ilvC | -5.7 | -22.2 | ketol-acid reductoisomerase (NCBI) | compare |
| b1281 | pyrF | -5.7 | -8.1 | orotidine 5'-phosphate decarboxylase (NCBI) | compare |
| b0242 | proB | -5.6 | -12.0 | gamma-glutamyl kinase (NCBI) | compare |
| b3172 | argG | -5.2 | -18.4 | argininosuccinate synthase (NCBI) | compare |
| b2024 | hisA | -5.2 | -4.6 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-imidazolecarboxamide isomerase (VIMSS) | compare |
| b2784 | relA | -5.2 | -20.0 | (p)ppGpp synthetase I/GTP pyrophosphokinase (NCBI) | compare |
| b3960 | argH | -5.2 | -16.2 | argininosuccinate lyase (NCBI) | compare |
| b1062 | pyrC | -5.0 | -17.3 | dihydroorotase (NCBI) | compare |
| b0145 | dksA | -5.0 | -4.9 | DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) | compare |
| b0386 | proC | -5.0 | -12.0 | pyrroline-5-carboxylate reductase (NCBI) | compare |
| b2023 | hisH | -4.9 | -9.0 | imidazole glycerol phosphate synthase subunit HisH (NCBI) | compare |
| b2022 | hisB | -4.9 | -11.1 | imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS) | compare |
| b1260 | trpA | -4.9 | -5.6 | tryptophan synthase subunit alpha (NCBI) | compare |
| b4005 | purD | -4.9 | -17.5 | phosphoribosylamine--glycine ligase (NCBI) | compare |
| b1261 | trpB | -4.8 | -4.0 | tryptophan synthase subunit beta (NCBI) | compare |
| b0523 | purE | -4.7 | -5.7 | phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI) | compare |
| b3389 | aroB | -4.7 | -18.1 | 3-dehydroquinate synthase (NCBI) | compare |
| b0243 | proA | -4.7 | -15.4 | gamma-glutamyl phosphate reductase (NCBI) | compare |
| b0907 | serC | -4.7 | -13.7 | phosphoserine aminotransferase (NCBI) | compare |
| b2021 | hisC | -4.6 | -12.1 | histidinol-phosphate aminotransferase (NCBI) | compare |
| b2414 | cysK | -4.6 | -14.3 | cysteine synthase A, O-acetylserine sulfhydrolase A subunit (NCBI) | compare |
| b3941 | metF | -4.6 | -16.9 | 5,10-methylenetetrahydrofolate reductase (NCBI) | compare |
| b2750 | cysC | -4.6 | -11.6 | adenylylsulfate kinase (NCBI) | compare |
| b3772 | ilvA | -4.5 | -22.8 | threonine dehydratase (NCBI) | compare |
| b2913 | serA | -4.5 | -15.7 | D-3-phosphoglycerate dehydrogenase (NCBI) | compare |
| b0945 | pyrD | -4.5 | -16.3 | dihydroorotate dehydrogenase (NCBI) | compare |
| b4388 | serB | -4.5 | -9.6 | 3-phosphoserine phosphatase (NCBI) | compare |
| b3770 | ilvE | -4.5 | -16.8 | branched-chain amino acid aminotransferase (NCBI) | compare |
| b2020 | hisD | -4.5 | -10.0 | histidinol dehydrogenase (NCBI) | compare |
| b0200 | gmhB | -4.5 | -3.1 | hypothetical protein (NCBI) | compare |
| b2476 | purC | -4.5 | -6.8 | phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI) | compare |
| b1712 | ihfA | -4.4 | -3.0 | integration host factor subunit alpha (NCBI) | compare |
| b4006 | purH | -4.4 | -18.7 | bifunctionalphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI) | compare |
| b3281 | aroE | -4.4 | -22.2 | dehydroshikimate reductase, NAD(P)-binding (NCBI) | compare |
| b0908 | aroA | -4.4 | -16.0 | 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) | compare |
| b2499 | purM | -4.4 | -8.1 | phosphoribosylaminoimidazole synthetase (NCBI) | compare |
| b0726 | sucA | -4.3 | -7.8 | alpha-ketoglutarate decarboxylase (NCBI) | compare |
| b2329 | aroC | -4.3 | -13.1 | chorismate synthase (NCBI) | compare |
| b1192 | ldcA | -4.2 | -12.0 | L,D-carboxypeptidase A (NCBI) | compare |
| b0004 | thrC | -4.2 | -12.9 | threonine synthase (NCBI) | compare |
| b0002 | thrA | -4.2 | -20.0 | bifunctional aspartokinase I/homeserine dehydrogenase I (NCBI) | compare |
| b0522 | purK | -4.1 | -12.6 | phosphoribosylaminoimidazole carboxylase (NCBI) | compare |
| b3956 | ppc | -4.1 | -23.3 | phosphoenolpyruvate carboxylase (NCBI) | compare |
| b0437 | clpP | -4.1 | -11.7 | ATP-dependent Clp protease proteolytic subunit (NCBI) | compare |
| b3870 | glnA | -4.1 | -6.3 | glutamine synthetase (NCBI) | compare |
| b1693 | aroD | -4.1 | -10.6 | 3-dehydroquinate dehydratase (NCBI) | compare |
| b4245 | pyrB | -4.1 | -15.5 | aspartate carbamoyltransferase catalytic subunit (NCBI) | compare |
| b2557 | purL | -4.1 | -17.0 | phosphoribosylformylglycinamidine synthase (NCBI) | compare |
| b0033 | carB | -4.1 | -23.6 | carbamoyl-phosphate synthase large subunit (NCBI) | compare |
| b0032 | carA | -4.1 | -11.0 | carbamoyl-phosphate synthase small subunit (NCBI) | compare |
| b2818 | argA | -3.9 | -17.4 | N-acetylglutamate synthase (NCBI) | compare |
| b0003 | thrB | -3.9 | -10.5 | homoserine kinase (NCBI) | compare |
| b1263 | trpD | -3.9 | -4.3 | bifunctional indole-3-glycerol-phosphate synthase/anthranilate phosphoribosyltransferase (NCBI) | compare |
| b2501 | ppk | -3.9 | -16.0 | polyphosphate kinase (NCBI) | compare |
| b2600 | tyrA | -3.7 | -9.2 | fused chorismate mutase T/prephenate dehydrogenase (NCBI) | compare |
| b0889 | lrp | -3.7 | -6.3 | DNA-binding transcriptional dual regulator, leucine-binding (NCBI) | compare |
| b2026 | hisI | -3.6 | -10.1 | bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI) | compare |
| b2019 | hisG | -3.6 | -5.1 | ATP phosphoribosyltransferase (NCBI) | compare |
| b3671 | ilvB | -3.6 | -20.0 | acetolactate synthase large subunit (NCBI) | compare |
| b2312 | purF | -3.6 | -14.3 | amidophosphoribosyltransferase (NCBI) | compare |
| b2763 | cysI | -3.6 | -16.1 | sulfite reductase, beta subunit, NAD(P)-binding, heme-binding (NCBI) | compare |
| b3957 | argE | -3.5 | -20.9 | acetylornithine deacetylase (NCBI) | compare |
| b2762 | cysH | -3.5 | -12.1 | phosphoadenosine phosphosulfate reductase (NCBI) | compare |
| b3390 | aroK | -3.5 | -3.6 | shikimate kinase I (NCBI) | compare |
| b2764 | cysJ | -3.5 | -19.2 | sulfite reductase, alpha subunit, flavoprotein (NCBI) | compare |
| b0077 | ilvI | -3.4 | -16.5 | acetolactate synthase III large subunit (NCBI) | compare |
| b3939 | metB | -3.4 | -16.0 | cystathionine gamma-synthase (NCBI) | compare |
| b3959 | argB | -3.4 | -16.6 | acetylglutamate kinase (RefSeq) | compare |
| b3958 | argC | -3.4 | -20.2 | N-acetyl-gamma-glutamyl-phosphate reductase (NCBI) | compare |
| b4013 | metA | -3.4 | -9.7 | homoserine O-succinyltransferase (NCBI) | compare |
| b0078 | ilvH | -3.4 | -13.1 | acetolactate synthase small subunit (NCBI) | compare |
| b3368 | cysG | -3.3 | -20.7 | fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase (NCBI) | compare |
| b0439 | lon | -3.3 | -11.6 | DNA-binding ATP-dependent protease La (NCBI) | compare |
| b2567 | rnc | -3.3 | -2.2 | ribonuclease III (NCBI) | compare |
| b2830 | nudH | -3.3 | -3.8 | dinucleoside polyphosphate hydrolase (NCBI) | compare |
| b0113 | pdhR | -3.3 | -6.7 | transcriptional regulator of pyruvate dehydrogenase complex (NCBI) | compare |
| b3008 | metC | -3.3 | -17.5 | cystathionine beta-lyase (NCBI) | compare |
| b4214 | cysQ | -3.2 | -17.3 | PAPS (adenosine 3'-phosphate 5'-phosphosulfate) 3'(2'),5'-bisphosphate nucleotidase (NCBI) | compare |
| b0720 | gltA | -3.2 | -10.0 | citrate synthase (NCBI) | compare |
| b0049 | apaH | -3.2 | -7.1 | diadenosinetetraphosphatase (NCBI) | compare |
| b2751 | cysN | -3.2 | -11.6 | sulfate adenylyltransferase subunit 1 (NCBI) | compare |
| b3773 | ilvY | -3.2 | -11.4 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b2752 | cysD | -3.1 | -7.0 | sulfate adenylyltransferase subunit 2 (NCBI) | compare |
| b2188 | yejM | -3.1 | -14.9 | predicted hydrolase, inner membrane (NCBI) | compare |
| b1262 | trpC | -3.1 | -5.6 | N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase (VIMSS) | compare |
| b0142 | folK | -2.9 | -1.0 | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) | compare |
| b2599 | pheA | -2.9 | -8.4 | fused chorismate mutase P/prephenate dehydratase (NCBI) | compare |
| b0740 | tolB | -2.8 | -9.8 | translocation protein TolB precursor (NCBI) | compare |
| b2479 | gcvR | -2.7 | -8.0 | transcriptional regulation of gcv operon (VIMSS) | compare |
| b0741 | pal | -2.6 | -7.5 | peptidoglycan-associated outer membrane lipoprotein (NCBI) | compare |
| b2839 | lysR | -2.6 | -6.7 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b4171 | miaA | -2.6 | -6.2 | tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) | compare |
| b2894 | xerD | -2.6 | -2.4 | site-specific tyrosine recombinase XerD (NCBI) | compare |
| b0739 | tolA | -2.5 | -6.9 | cell envelope integrity inner membrane protein TolA (NCBI) | compare |
| b3916 | pfkA | -2.5 | -6.0 | 6-phosphofructokinase (NCBI) | compare |
| b0928 | aspC | -2.5 | -11.7 | aspartate aminotransferase, PLP-dependent (NCBI) | compare |
| b0912 | ihfB | -2.4 | -7.6 | integration host factor subunit beta (NCBI) | compare |
| b1861 | ruvA | -2.4 | -2.8 | Holliday junction DNA helicase motor protein (NCBI) | compare |
| b2422 | cysA | -2.4 | -13.8 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b3781 | trxA | -2.4 | -5.7 | thioredoxin 1 (VIMSS) | compare |
| b1264 | trpE | -2.3 | -5.3 | anthranilate synthase component I (NCBI) | compare |
| b4177 | purA | -2.3 | -1.6 | adenylosuccinate synthetase (NCBI) | compare |
| b2424 | cysU | -2.3 | -5.6 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b3204 | ptsN | -2.3 | -7.0 | sugar-specific enzyme IIA component of PTS (NCBI) | compare |
| b0738 | tolR | -2.3 | -5.7 | membrane spanning protein in TolA-TolQ-TolR complex (NCBI) | compare |
| b3619 | rfaD | -2.2 | -6.6 | ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) | compare |
| b3026 | qseC | -2.2 | -8.9 | sensory histidine kinase in two-component regulatory system with QseB (NCBI) | compare |
| b0737 | tolQ | -2.2 | -5.3 | membrane spanning protein in TolA-TolQ-TolR complex (NCBI) | compare |
| b3811 | xerC | -2.1 | -2.5 | site-specific tyrosine recombinase XerC (NCBI) | compare |
| b4025 | pgi | -2.1 | -12.3 | glucose-6-phosphate isomerase (NCBI) | compare |
| b3650 | spoT | -2.1 | -8.6 | bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase (NCBI) | compare |
| b1860 | ruvB | -2.1 | -1.9 | Holliday junction DNA helicase B (NCBI) | compare |
| b1859 | znuB | -2.0 | -13.9 | high-affinity zinc transporter membrane component (NCBI) | compare |
| b2340 | sixA | -2.0 | -8.1 | phosphohistidine phosphatase (NCBI) | compare |
| b2423 | cysW | -2.0 | -6.1 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b2820 | recB | -2.0 | -2.6 | exonuclease V (RecBCD complex), beta subunit (NCBI) | compare |
| b1857 | yebL | -2.0 | -10.2 | putative adhesin (VIMSS) | compare |
| b3290 | trkA | -1.9 | -5.4 | potassium transporter peripheral membrane component (NCBI) | compare |
| b1858 | znuC | -1.9 | -8.7 | high-affinity zinc transporter ATPase (NCBI) | compare |
| b0585 | fes | -1.9 | -9.3 | enterobactin/ferric enterobactin esterase (NCBI) | compare |
| b3672 | ivbL | -1.9 | -3.0 | ilvB operon leader peptide (NCBI) | compare |
| b0114 | aceE | -1.9 | -1.3 | pyruvate dehydrogenase subunit E1 (NCBI) | compare |
| b0590 | fepD | -1.8 | -11.3 | iron-enterobactin transporter subunit (NCBI) | compare |
| b3828 | metR | -1.8 | -11.3 | DNA-binding transcriptional activator, homocysteine-binding (NCBI) | compare |
| b3670 | ilvN | -1.8 | -10.6 | acetolactate synthase small subunit (NCBI) | compare |
| b3247 | cafA | -1.8 | -12.9 | bundles of cytoplasmic filaments (VIMSS) | compare |
| b3236 | mdh | -1.7 | -10.0 | malate dehydrogenase (NCBI) | compare |
| b2935 | tktA | -1.7 | -4.0 | transketolase 1, thiamin-binding (NCBI) | compare |
| b0075 | leuL | -1.7 | -4.2 | leu operon leader peptide (NCBI) | compare |
| b3741 | gidA | -1.7 | -7.7 | glucose-inhibited division protein A (NCBI) | compare |
| b3053 | glnE | -1.7 | -7.2 | fused deadenylyltransferase/adenylyltransferase for glutamine synthetase (NCBI) | compare |
| b0438 | clpX | -1.7 | -9.6 | ATP-dependent protease ATP-binding subunit (NCBI) | compare |
| b3613 | yibP | -1.7 | -6.6 | putative membrane protein (VIMSS) | compare |
| b0589 | fepG | -1.6 | -11.5 | iron-enterobactin transporter subunit (NCBI) | compare |
| b2528 | iscA | -1.6 | -3.9 | iron-sulfur cluster assembly protein (NCBI) | compare |
| b3169 | nusA | -1.6 | -3.1 | transcription elongation factor NusA (NCBI) | compare |
| b0592 | fepB | -1.6 | -12.1 | iron-enterobactin transporter subunit (NCBI) | compare |
| b2853 | ygeI | -1.6 | -0.9 | hypothetical protein (NCBI) | compare |
| b0588 | fepC | -1.5 | -8.4 | iron-enterobactin transporter subunit (NCBI) | compare |
| b1677 | lpp | -1.5 | -4.7 | murein lipoprotein (NCBI) | compare |
| b0890 | ftsK | -1.5 | -7.4 | DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) | compare |
| b1290 | sapF | -1.5 | -2.9 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b2318 | truA | -1.5 | -4.5 | tRNA pseudouridine synthase A (NCBI) | compare |
| b0630 | lipB | -1.5 | -2.4 | protein of lipoate biosynthesis (VIMSS) | compare |
| b3839 | tatC | -1.5 | -8.2 | TatABCE protein translocation system subunit (NCBI) | compare |
| b1160 | elbA | -1.5 | -2.1 | hypothetical protein (NCBI) | compare |
| b3398 | yrfF | -1.5 | -5.6 | predicted inner membrane protein (NCBI) | compare |
| b3405 | ompR | -1.5 | -7.4 | osmolarity response regulator (NCBI) | compare |
| b1084 | rne | -1.5 | -5.0 | fused ribonucleaseE: endoribonuclease/RNA-binding protein/RNA degradosome binding protein (NCBI) | compare |
| b3706 | trmE | -1.5 | -5.9 | tRNA modification GTPase (NCBI) | compare |
| b2846 | yqeH | -1.4 | -1.1 | orf, hypothetical protein (VIMSS) | compare |
| b2029 | gnd | -1.4 | -10.1 | 6-phosphogluconate dehydrogenase (NCBI) | compare |
| b1058 | yceO | -1.4 | -0.7 | hypothetical protein (NCBI) | compare |
| b2911 | ssrS | -1.4 | -2.8 | 6S regulatory RNA (NCBI) | compare |
| b0755 | gpmA | -1.4 | -9.1 | phosphoglyceromutase (NCBI) | compare |
| b0774 | bioA | -1.4 | -6.8 | adenosylmethionine--8-amino-7-oxononanoate transaminase (NCBI) | compare |
| b1130 | phoP | -1.4 | -3.8 | DNA-binding response regulator in two-component regulatory system with PhoQ (NCBI) | compare |
| b3849 | trkH | -1.4 | -10.3 | potassium transporter (NCBI) | compare |
| b2611 | ypjD | -1.3 | -9.6 | predicted inner membrane protein (RefSeq) | compare |
| b0189 | yaeO | -1.3 | -7.6 | orf, hypothetical protein (VIMSS) | compare |
| b3493 | pitA | -1.3 | -8.4 | phosphate transporter, low-affinity (NCBI) | compare |
| b3844 | fre | -1.3 | -6.4 | NAD(P)H-flavin reductase (NCBI) | compare |
| b0888 | trxB | -1.3 | -4.2 | thioredoxin reductase, FAD/NAD(P)-binding (NCBI) | compare |
| b3035 | tolC | -1.3 | -8.6 | outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) | compare |
| b2425 | cysP | -1.2 | -4.3 | thiosulfate transporter subunit (NCBI) | compare |
| b2500 | purN | -1.2 | -3.2 | phosphoribosylglycinamide formyltransferase (NCBI) | compare |
| b2822 | recC | -1.2 | -5.1 | exonuclease V (RecBCD complex), gamma chain (NCBI) | compare |
| b3979 | thrT | -1.2 | -0.6 | tRNA-Thr (NCBI) | compare |
| b2313 | cvpA | -1.2 | -3.9 | membrane protein required for colicin V production (NCBI) | compare |
| b3935 | priA | -1.2 | -3.2 | primosome assembly protein PriA (NCBI) | compare |
| b3237 | argR | -1.2 | -5.7 | arginine repressor (NCBI) | compare |
| b0957 | ompA | -1.2 | -5.7 | outer membrane protein A (3a;II*;G;d) (NCBI) | compare |
| b4481 | rffT | -1.2 | -6.9 | 4-alpha-L-fucosyltransferase (NCBI) | compare |
| b0564 | appY | -1.2 | -0.4 | DLP12 prophage; DNA-binding transcriptional activator (NCBI) | compare |
| b0776 | bioF | -1.2 | -8.0 | 8-amino-7-oxononanoate synthase (NCBI) | compare |
| b0775 | bioB | -1.1 | -5.6 | biotin synthase (NCBI) | compare |
| b1252 | tonB | -1.1 | -4.0 | membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) | compare |
| b4146 | yjeK | -1.1 | -3.9 | predicted lysine aminomutase (NCBI) | compare |
| b0088 | murD | -1.1 | -1.7 | UDP-N-acetylmuramoyl-L-alanyl-D-glutamatesynthetase (NCBI) | compare |
| b1235 | rssB | -1.1 | -6.8 | response regulator of RpoS (NCBI) | compare |
| b3630 | rfaP | -1.1 | -8.8 | kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) | compare |
| b3027 | ygiZ | -1.1 | -0.7 | conserved inner membrane protein (NCBI) | compare |
| b3860 | dsbA | -1.1 | -8.0 | periplasmic protein disulfide isomerase I (NCBI) | compare |
| b0767 | ybhE | -1.1 | -3.1 | 6-phosphogluconolactonase (NCBI) | compare |
| b0232 | yafN | -1.1 | -0.7 | predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) | compare |
| b1830 | prc | -1.1 | -7.3 | carboxy-terminal protease for penicillin-binding protein 3 (NCBI) | compare |
| b2620 | smpB | -1.1 | -1.7 | SsrA-binding protein (NCBI) | compare |
| b1292 | sapC | -1.1 | -2.9 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b0001 | thrL | -1.1 | -0.9 | thr operon leader peptide (NCBI) | compare |
| b0683 | fur | -1.1 | -1.5 | ferric uptake regulator (NCBI) | compare |
| b0658 | ybeX | -1.0 | -1.5 | predicteed ion transport (NCBI) | compare |
| b3412 | bioH | -1.0 | -6.8 | carboxylesterase of pimeloyl-CoA synthesis (NCBI) | compare |