Experiment set1S426 for Escherichia coli ECOR38

Compare to:

TP7

200 most detrimental genes:

  gene name fitness t score description  
HEPCGN_01560 galT +6.5 44.9 galactose-1-phosphate uridylyltransferase compare
HEPCGN_12895 rfaH +6.2 20.9 transcription/translation regulatory transformer protein RfaH compare
HEPCGN_14525 +6.0 20.0 beta1,3-glucosyltransferase compare
HEPCGN_14490 waaO +5.9 21.6 lipopolysaccharide 3-alpha-galactosyltransferase compare
HEPCGN_23285 ompA +5.9 38.2 outer membrane protein A compare
HEPCGN_14495 rfaJ +5.8 18.3 lipopolysaccharide 1,2-glucosyltransferase compare
HEPCGN_14520 rfaJ +5.7 13.7 UDP-galactose--(galactosyl) LPS alpha1,2-galactosyltransferase compare
HEPCGN_14480 rfaG +5.6 29.0 Lipopolysaccharide core biosynthesis protein RfaG compare
HEPCGN_25050 galU +5.4 18.3 UTP--glucose-1-phosphate uridylyltransferase GalU compare
HEPCGN_14485 rfaP +5.2 26.9 lipopolysaccharide core heptose(I) kinase RfaP compare
HEPCGN_08295 dksA +5.2 20.9 RNA polymerase-binding protein DksA compare
HEPCGN_06830 tomB +5.1 16.9 Hha toxicity modulator TomB compare
HEPCGN_16800 rapZ +4.4 31.9 RNase adapter RapZ compare
HEPCGN_05770 purR +4.3 14.0 HTH-type transcriptional repressor PurR compare
HEPCGN_05950 ydgT +3.8 7.4 transcription modulator YdgT compare
HEPCGN_06825 tomB +3.5 6.3 Hha toxicity modulator TomB compare
HEPCGN_16805 ptsN +3.5 12.1 PTS IIA-like nitrogen regulatory protein PtsN compare
HEPCGN_14475 rfaQ +3.4 4.8 lipopolysaccharide core heptosyltransferase RfaQ compare
HEPCGN_17030 deaD +3.4 8.1 ATP-dependent RNA helicase DeaD compare
HEPCGN_06955 tig +3.3 13.6 trigger factor compare
HEPCGN_23925 yceG +2.9 18.3 cell division protein YceG compare
HEPCGN_23860 rne +2.7 2.8 ribonuclease E compare
HEPCGN_17075 yhbO +2.7 1.6 protein/nucleic acid deglycase compare
HEPCGN_16810 +2.6 4.8 Ribosome hibernation promoting factor compare
HEPCGN_13305 trxA +2.4 7.1 thioredoxin TrxA compare
HEPCGN_13680 +2.4 4.7 tRNA modification GTPase MnmE compare
HEPCGN_21505 nupC +2.3 12.7 nucleoside permease NupC compare
HEPCGN_08305 pcnB +2.3 11.7 polynucleotide adenylyltransferase PcnB compare
HEPCGN_20505 srmB +2.3 13.7 ATP-dependent RNA helicase SrmB compare
HEPCGN_07210 rdgC +2.3 7.5 recombination-associated protein RdgC compare
HEPCGN_22450 rcsB +2.2 9.0 transcriptional regulator RcsB compare
HEPCGN_09220 deoD +2.1 9.5 purine-nucleoside phosphorylase compare
HEPCGN_18750 argP +2.1 8.7 DNA-binding transcriptional regulator ArgP compare
HEPCGN_17105 lpoA +2.0 15.6 penicillin-binding protein activator LpoA compare
HEPCGN_11210 pmrB +2.0 13.4 two-component system sensor histidine kinase PmrB compare
HEPCGN_15355 pitA +2.0 10.9 inorganic phosphate transporter PitA compare
HEPCGN_04715 mepM +2.0 10.7 murein DD-endopeptidase MepM compare
HEPCGN_11205 basR +2.0 11.3 two-component system response regulator BasR compare
HEPCGN_09715 sPS1 +1.9 11.3 serine/threonine protein kinase compare
HEPCGN_14780 yiaL +1.8 3.4 Protein YiaL compare
HEPCGN_22175 pmrD +1.8 8.4 signal transduction protein PmrD compare
HEPCGN_23800 flgN +1.8 2.6 flagella biosynthesis chaperone FlgN compare
HEPCGN_23880 yceD +1.8 4.4 23S rRNA accumulation protein YceD compare
HEPCGN_10020 rraB +1.8 5.3 ribonuclease E inhibitor RraB compare
HEPCGN_22610 yejK +1.7 10.0 nucleoid-associated protein YejK compare
HEPCGN_01625 ybhC +1.7 11.8 putative acyl-CoA thioester hydrolase compare
HEPCGN_26170 opgD +1.7 9.5 glucan biosynthesis protein OpgD compare
HEPCGN_09625 fimE +1.6 2.7 type 1 fimbria switch DNA invertase FimE compare
HEPCGN_10140 mpl +1.6 10.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-me so-diaminopimelate ligase compare
HEPCGN_22930 trxB +1.6 3.6 thioredoxin-disulfide reductase compare
HEPCGN_15900 mrcA +1.6 12.0 peptidoglycan glycosyltransferase/peptidoglycan DD-transpeptidase MrcA compare
HEPCGN_09225 deoB +1.6 7.0 phosphopentomutase compare
HEPCGN_20570 pdxJ +1.6 6.9 pyridoxine 5'-phosphate synthase compare
HEPCGN_24980 narX +1.6 2.4 nitrate/nitrite two-component system sensor histidine kinase NarX compare
HEPCGN_03180 ugd +1.6 9.0 UDP-glucose 6-dehydrogenase compare
HEPCGN_13500 mnmG +1.6 6.8 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG compare
HEPCGN_06455 ybcI +1.5 2.3 Inner membrane protein YbcI compare
HEPCGN_08505 ampD +1.5 6.9 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD compare
HEPCGN_21760 sixA +1.5 3.1 phosphohistidine phosphatase SixA compare
HEPCGN_22900 clpA +1.5 7.0 ATP-dependent Clp protease ATP-binding subunit ClpA compare
HEPCGN_07870 dpaA +1.5 8.9 peptidoglycan meso-diaminopimelic acid protein amidase compare
HEPCGN_21080 gcvR +1.5 5.6 glycine cleavage system transcriptional repressor compare
HEPCGN_04710 znuA +1.4 3.1 zinc ABC transporter substrate-binding protein ZnuA compare
HEPCGN_17695 cpdA +1.4 5.3 3',5'-cyclic-AMP phosphodiesterase compare
HEPCGN_24075 potA +1.4 7.3 spermidine/putrescine ABC transporter ATP-binding protein PotA compare
HEPCGN_22665 mepS +1.4 4.3 bifunctional murein DD-endopeptidase/murein LD-carboxypeptidase compare
HEPCGN_03860 gp18 +1.4 2.9 phage minor tail protein L compare
HEPCGN_18405 +1.4 4.7 Transposase compare
HEPCGN_08835 apaH +1.4 5.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH compare
HEPCGN_14375 spoT +1.4 3.4 bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase compare
HEPCGN_01585 modB +1.4 8.6 molybdate ABC transporter permease subunit compare
HEPCGN_10450 rnr +1.4 9.9 ribonuclease R compare
HEPCGN_10190 ytfP +1.4 5.9 Gamma-glutamylcyclotransferase family protein YtfP compare
HEPCGN_01570 modE +1.4 6.1 molybdenum-dependent transcriptional regulator compare
HEPCGN_08005 rcsF +1.3 6.7 Rcs stress response system protein RcsF compare
HEPCGN_12115 Thr_trna +1.3 2.3 tRNA-Thr(ggt) compare
HEPCGN_24070 potB +1.3 4.9 spermidine/putrescine ABC transporter permease PotB compare
HEPCGN_16655 argR +1.3 7.1 transcriptional regulator ArgR compare
HEPCGN_24200 phoP +1.3 8.1 two-component system response regulator PhoP compare
HEPCGN_18865 dsbC +1.3 7.6 bifunctional protein-disulfide isomerase/oxidoreductase DsbC compare
HEPCGN_16020 nirD +1.3 1.9 nitrite reductase small subunit NirD compare
HEPCGN_14515 rfaY +1.3 0.8 lipopolysaccharide core heptose(II) kinase RfaY compare
HEPCGN_16345 trkA +1.3 3.8 Trk system potassium transporter TrkA compare
HEPCGN_16375 yrdD +1.3 3.3 Uncharacterized protein YrdD compare
HEPCGN_12395 rraA +1.2 1.7 ribonuclease E activity regulator RraA compare
HEPCGN_01580 modA +1.2 4.8 molybdate ABC transporter substrate-binding protein compare
HEPCGN_24480 gpG +1.2 1.8 phage virion morphogenesis protein compare
HEPCGN_10835 arsR +1.2 2.6 transcriptional regulator compare
HEPCGN_24195 phoQ +1.2 7.2 two-component system sensor histidine kinase PhoQ compare
HEPCGN_13315 gppA +1.1 6.3 guanosine-5'-triphosphate,3'-diphosphate diphosphatase compare
HEPCGN_10675 dsbD +1.1 8.8 protein-disulfide reductase DsbD compare
HEPCGN_20940 yfgG +1.1 2.0 Uncharacterized protein YfgG compare
HEPCGN_22165 menC +1.1 3.4 o-succinylbenzoate synthase compare
HEPCGN_11015 +1.1 3.2 inovirus Gp2 family protein compare
HEPCGN_23780 rimJ +1.1 1.4 ribosomal protein S5-alanine N-acetyltransferase compare
HEPCGN_19430 sdaB +1.1 5.6 L-serine ammonia-lyase II compare
HEPCGN_05960 add +1.1 2.9 adenosine deaminase compare
HEPCGN_06645 +1.1 4.5 hypothetical protein compare
HEPCGN_06785 apt +1.1 2.2 adenine phosphoribosyltransferase compare
HEPCGN_10130 yjgA +1.1 4.6 ribosome-associated protein compare
HEPCGN_26285 mcbR +1.1 1.5 colanic acid/biofilm transcriptional regulator McbR compare
HEPCGN_22030 alaA +1.1 4.6 alanine transaminase AlaA compare
HEPCGN_09040 mokC +1.1 0.9 Regulatory protein MokC compare
HEPCGN_04045 fliL +1.0 1.3 flagellar basal body-associated protein FliL compare
HEPCGN_01590 modC +1.0 4.9 molybdenum ABC transporter ATP-binding protein ModC compare
HEPCGN_10485 hfq +1.0 1.9 RNA chaperone Hfq compare
HEPCGN_21075 bcp +1.0 3.8 thioredoxin-dependent thiol peroxidase compare
HEPCGN_11405 +1.0 2.5 Uncharacterized protein YjcO compare
HEPCGN_13505 rsmG +1.0 5.5 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG compare
HEPCGN_16115 slyD +1.0 3.2 peptidylprolyl isomerase compare
HEPCGN_22515 napD +1.0 2.0 chaperone NapD compare
HEPCGN_03690 +1.0 1.3 Tellurite resistance protein TehB compare
HEPCGN_04385 marR +1.0 1.2 MarR family transcriptional regulator compare
HEPCGN_12485 cpxP +1.0 3.5 cell-envelope stress modulator CpxP compare
HEPCGN_17025 yrbN +1.0 1.1 Uncharacterized protein YrbN compare
HEPCGN_26620 tam +1.0 2.2 trans-aconitate 2-methyltransferase compare
HEPCGN_18850 ygfX +1.0 2.6 Inner membrane protein YgfX compare
HEPCGN_24860 dhaL +1.0 1.7 dihydroxyacetone kinase subunit DhaL compare
HEPCGN_26340 yddH +1.0 2.0 Uncharacterized protein YddH compare
HEPCGN_16350 rsmB +1.0 3.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB compare
HEPCGN_17330 mzrA +1.0 3.6 EnvZ/OmpR regulon moderator MzrA compare
HEPCGN_05340 chbR +1.0 1.4 transcriptional regulator ChbR compare
HEPCGN_03445 +1.0 2.2 transcriptional regulator compare
HEPCGN_20755 iscR +1.0 1.3 Fe-S cluster assembly transcriptional regulator IscR compare
HEPCGN_07935 yafD +0.9 5.8 endonuclease/exonuclease/phosphatase family protein compare
HEPCGN_06310 +0.9 2.8 antitermination protein compare
HEPCGN_18815 gcvH +0.9 3.6 glycine cleavage system protein GcvH compare
HEPCGN_14610 lldD +0.9 6.1 quinone-dependent L-lactate dehydrogenase compare
HEPCGN_19285 ygdB +0.9 1.3 DUF2509 domain-containing protein compare
HEPCGN_02455 +0.9 1.2 DUF826 domain-containing protein compare
HEPCGN_24065 potC +0.9 2.3 spermidine/putrescine ABC transporter permease PotC compare
HEPCGN_24285 +0.9 1.9 cell division protein ZapA compare
HEPCGN_09980 pepA +0.9 2.9 leucyl aminopeptidase compare
HEPCGN_20980 upp +0.9 3.2 uracil phosphoribosyltransferase compare
HEPCGN_05680 fumD +0.9 2.0 fumarate hydratase FumD compare
HEPCGN_00850 pagP +0.9 2.9 lipid IV(A) palmitoyltransferase PagP compare
HEPCGN_17175 agaR +0.9 3.2 aga operon transcriptional regulator AgaR compare
HEPCGN_18945 mocA +0.9 1.8 molybdenum cofactor cytidylyltransferase compare
HEPCGN_01150 +0.9 2.5 hypothetical protein compare
HEPCGN_05155 rbsK +0.9 1.8 sugar kinase compare
HEPCGN_16120 slyX +0.9 2.1 Protein SlyX compare
HEPCGN_16615 yhdP +0.9 7.3 AsmA2 domain-containing protein YhdP compare
HEPCGN_02625 +0.9 1.3 damage-inducible protein DinI compare
HEPCGN_06130 +0.9 0.9 Putative voltage-gated ClC-type chloride channel ClcB compare
HEPCGN_04740 zwf +0.9 3.9 glucose-6-phosphate dehydrogenase compare
HEPCGN_06640 ybbJ +0.9 1.1 Inner membrane protein YbbJ compare
HEPCGN_06880 glnK +0.9 1.7 P-II family nitrogen regulator compare
HEPCGN_01200 ybgI +0.9 1.2 radiation resistance protein YbgI compare
HEPCGN_20075 +0.9 2.7 baseplate assembly protein compare
HEPCGN_18430 +0.9 1.9 integrase compare
HEPCGN_08000 metQ +0.9 3.8 methionine ABC transporter substrate-binding lipoprotein MetQ compare
HEPCGN_14815 bax +0.9 5.5 protein bax compare
HEPCGN_10580 +0.9 0.6 Fumarate reductase subunit C compare
HEPCGN_16045 fic +0.9 1.8 putative adenosine monophosphate-protein transferase Fic compare
HEPCGN_25925 fnr +0.9 2.2 fumarate/nitrate reduction transcriptional regulator Fnr compare
HEPCGN_27170 +0.8 1.6 hypothetical protein compare
HEPCGN_20945 +0.8 2.1 hypothetical protein compare
HEPCGN_08790 rapA +0.8 6.2 RNA polymerase-associated protein RapA compare
HEPCGN_26485 +0.8 1.1 Heme-regulated cyclic AMP phosphodiesterase (Direct oxygen sensor protein) compare
HEPCGN_27405 +0.8 2.0 Uncharacterized endonuclease compare
HEPCGN_20870 +0.8 1.0 zinc-ribbons compare
HEPCGN_17800 dkgA +0.8 2.2 2,5-didehydrogluconate reductase DkgA compare
HEPCGN_26515 gadB +0.8 1.3 glutamate decarboxylase compare
HEPCGN_05815 +0.8 1.6 Lactoylglutathione lyase compare
HEPCGN_04085 yedL +0.8 2.0 Uncharacterized N-acetyltransferase YedL compare
HEPCGN_23730 yceI +0.8 2.7 YceI family protein compare
HEPCGN_23765 yceB +0.8 2.7 lipoprotein compare
HEPCGN_18395 +0.8 1.9 carbohydrate-binding protein compare
HEPCGN_07455 cynR +0.8 2.2 transcriptional regulator CynR compare
HEPCGN_14620 lldP +0.8 4.7 L-lactate permease compare
HEPCGN_04010 rcsA +0.8 1.6 transcriptional regulator RcsA compare
HEPCGN_19675 rpoS +0.8 2.9 RNA polymerase sigma factor RpoS compare
HEPCGN_11380 ytcA +0.8 1.5 Uncharacterized protein YtcA compare
HEPCGN_26655 +0.8 1.7 Transcriptional regulator YneJ compare
HEPCGN_12860 trkH +0.8 3.6 Trk system potassium transporter TrkH compare
HEPCGN_02220 pbpG +0.8 2.7 D-alanyl-D-alanine endopeptidase compare
HEPCGN_19715 ygbA +0.8 1.3 nitrous oxide-stimulated promoter family protein compare
HEPCGN_16515 panF +0.8 4.9 sodium/pantothenate symporter compare
HEPCGN_21195 eutT +0.8 1.2 ethanolamine utilization cob(I)yrinic acid a,c-diamide adenosyltransferase EutT compare
HEPCGN_19360 csdA +0.8 2.5 cysteine desulfurase CsdA compare
HEPCGN_22170 menE +0.8 4.1 o-succinylbenzoate--CoA ligase compare
HEPCGN_12310 metF +0.8 2.2 methylenetetrahydrofolate reductase compare
HEPCGN_25115 oppF +0.8 2.4 murein tripeptide/oligopeptide ABC transporter ATP-binding protein OppF compare
HEPCGN_08660 mraZ +0.8 1.5 division/cell wall cluster transcriptional repressor MraZ compare
HEPCGN_26945 ydfI +0.8 1.6 Uncharacterized oxidoreductase YdfI compare
HEPCGN_11540 alr +0.8 3.9 alanine racemase compare
HEPCGN_27220 +0.8 2.0 CopG family transcriptional regulator compare
HEPCGN_26600 lsrD +0.8 1.5 autoinducer 2 ABC transporter permease LsrD compare
HEPCGN_11075 +0.8 0.8 Phage-related protein compare
HEPCGN_09545 iraD +0.8 1.9 anti-adapter protein IraD compare
HEPCGN_15760 glpR +0.8 2.2 DeoR/GlpR family transcriptional regulator compare
HEPCGN_13310 rhlB +0.8 4.6 ATP-dependent RNA helicase RhlB compare
HEPCGN_01110 ybfE +0.7 3.0 LexA regulated protein compare
HEPCGN_04965 yoaB +0.7 1.0 RutC family protein YoaB compare
HEPCGN_01795 +0.7 2.4 PKHD-type hydroxylase YbiX compare
HEPCGN_15360 yhiN +0.7 3.4 Uncharacterized protein YhiN compare
HEPCGN_27265 traI +0.7 0.9 conjugative transfer relaxase/helicase TraI compare
HEPCGN_23170 ssuC +0.7 2.0 aliphatic sulfonate ABC transporter permease SsuC compare
HEPCGN_00355 +0.7 1.1 head decoration protein compare
HEPCGN_10405 yjfN +0.7 2.0 protease activator YjfN compare


Specific Phenotypes

None in this experiment

For Escherichia coli ECOR38 in phage experiments

For phage MOI 10 across organisms