| | gene | name | fitness | t score | description | |
|---|
| GFF215 | | -4.0 | -15.6 | 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13), C-terminal domain | compare |
| GFF3336 | | -3.8 | -2.6 | Aerobic cobaltochelatase CobT subunit (EC 6.6.1.2) | compare |
| GFF79 | | -3.8 | -10.3 | Amidophosphoribosyltransferase (EC 2.4.2.14) | compare |
| GFF3305 | | -3.7 | -8.7 | Histidinol-phosphatase [alternative form] (EC 3.1.3.15) | compare |
| GFF2789 | | -3.7 | -9.8 | N-acetylglutamate kinase (EC 2.7.2.8) | compare |
| GFF3440 | | -3.7 | -8.5 | Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit (EC 6.3.5.3) | compare |
| GFF4190 | | -3.6 | -2.5 | [Protein-PII] uridylyltransferase (EC 2.7.7.59) / [Protein-PII]-UMP uridylyl-removing enzyme | compare |
| GFF1299 | | -3.6 | -4.2 | N5-carboxyaminoimidazole ribonucleotide mutase (EC 5.4.99.18) | compare |
| GFF3277 | | -3.6 | -13.3 | IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) | compare |
| GFF216 | | -3.5 | -9.6 | 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13), N-terminal domain | compare |
| GFF4764 | | -3.5 | -13.8 | Threonine synthase (EC 4.2.3.1) | compare |
| GFF2468 | | -3.5 | -8.6 | Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) | compare |
| GFF2481 | | -3.4 | -8.3 | Prephenate dehydratase (EC 4.2.1.51) | compare |
| GFF1678 | | -3.4 | -3.3 | Ferredoxin, 2Fe-2S | compare |
| GFF825 | | -3.4 | -5.6 | L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) | compare |
| GFF818 | | -3.4 | -7.5 | Phosphoserine aminotransferase (EC 2.6.1.52) | compare |
| GFF824 | | -3.4 | -4.6 | Adenosylcobinamide-phosphate synthase (EC 6.3.1.10) | compare |
| GFF3818 | | -3.4 | -5.1 | Phosphocarrier protein, nitrogen regulation associated | compare |
| GFF1909 | | -3.4 | -9.0 | Chorismate mutase I (EC 5.4.99.5) | compare |
| GFF763 | | -3.4 | -11.8 | Glutamate synthase [NADPH] small chain (EC 1.4.1.13) | compare |
| GFF877 | | -3.4 | -5.1 | Cob(I)alamin adenosyltransferase (EC 2.5.1.17) @ Cob(I)alamin adenosyltransferase (EC 2.5.1.17), clustered with cobalamin synthesis | compare |
| GFF2491 | | -3.4 | -6.4 | Pyrroline-5-carboxylate reductase (EC 1.5.1.2) | compare |
| GFF776 | | -3.3 | -17.1 | RNA polymerase sigma-54 factor RpoN | compare |
| GFF1592 | | -3.3 | -6.3 | Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) | compare |
| GFF3538 | | -3.3 | -14.6 | Indole-3-glycerol phosphate synthase (EC 4.1.1.48) | compare |
| GFF1583 | | -3.3 | -2.3 | 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type | compare |
| GFF1149 | | -3.3 | -11.7 | Nitrogen regulation protein NtrB (EC 2.7.13.3) | compare |
| GFF1627 | | -3.2 | -6.8 | Tryptophan synthase alpha chain (EC 4.2.1.20) | compare |
| GFF3434 | | -3.2 | -3.1 | Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6) | compare |
| GFF1424 | | -3.2 | -15.4 | Dihydroxy-acid dehydratase (EC 4.2.1.9) | compare |
| GFF1625 | | -3.2 | -12.5 | Phosphoribosylanthranilate isomerase (EC 5.3.1.24) | compare |
| GFF879 | | -3.2 | -7.3 | CobW GTPase involved in cobalt insertion for B12 biosynthesis | compare |
| GFF2056 | | -3.2 | -11.5 | Acetolactate synthase small subunit (EC 2.2.1.6) | compare |
| GFF1452 | | -3.2 | -2.2 | Sulfite reductase [NADPH] hemoprotein beta-component (EC 1.8.1.2) | compare |
| GFF3058 | | -3.1 | -11.1 | Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) | compare |
| GFF952 | | -3.1 | -10.7 | Gamma-glutamyl phosphate reductase (EC 1.2.1.41) | compare |
| GFF814 | | -3.1 | -14.2 | Adenylosuccinate synthetase (EC 6.3.4.4) | compare |
| GFF3537 | | -3.1 | -9.6 | Anthranilate phosphoribosyltransferase (EC 2.4.2.18) | compare |
| GFF2270 | | -3.1 | -10.3 | N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38) | compare |
| GFF1148 | | -3.1 | -13.8 | Nitrogen regulation protein NR(I), GlnG (=NtrC) | compare |
| GFF403 | | -3.1 | -11.2 | Aspartate aminotransferase (EC 2.6.1.1) | compare |
| GFF765 | | -3.0 | -20.9 | Glutamate synthase [NADPH] large chain (EC 1.4.1.13) | compare |
| GFF2007 | | -3.0 | -17.7 | Phosphoenolpyruvate-protein phosphotransferase, nitrogen regulation associated | compare |
| GFF1626 | | -3.0 | -3.5 | Tryptophan synthase beta chain (EC 4.2.1.20) | compare |
| GFF1490 | | -3.0 | -13.5 | Threonine dehydratase, catabolic (EC 4.3.1.19) @ L-serine dehydratase, (PLP)-dependent (EC 4.3.1.17) | compare |
| GFF2630 | | -3.0 | -17.9 | 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) | compare |
| GFF826 | | -3.0 | -6.6 | Cobalamin synthase (EC 2.7.8.26) | compare |
| GFF217 | | -3.0 | -9.2 | 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) | compare |
| GFF1454 | | -3.0 | -4.0 | Phosphoadenylyl-sulfate reductase [thioredoxin] (EC 1.8.4.8) | compare |
| GFF5 | | -2.9 | -2.9 | DNA-binding protein | compare |
| GFF2370 | | -2.9 | -13.5 | Anthranilate synthase, aminase component (EC 4.1.3.27) | compare |
| GFF784 | | -2.9 | -5.1 | Nitrogen regulatory protein P-II, GlnK | compare |
| GFF3458 | | -2.9 | -13.3 | 3-isopropylmalate dehydrogenase (EC 1.1.1.85) | compare |
| GFF3697 | | -2.9 | -12.6 | Argininosuccinate synthase (EC 6.3.4.5) | compare |
| GFF3455 | | -2.9 | -11.9 | O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) @ O-succinylhomoserine sulfhydrylase (EC 2.5.1.48) | compare |
| GFF2254 | | -2.9 | -3.9 | DksA family protein PA5536 (no Zn-finger) | compare |
| GFF878 | | -2.9 | -11.1 | Aerobic cobaltochelatase CobN subunit (EC 6.6.1.2) | compare |
| GFF2449 | | -2.9 | -2.0 | Succinyl-CoA ligase [ADP-forming] alpha chain (EC 6.2.1.5) | compare |
| GFF2054 | | -2.9 | -14.2 | Acetolactate synthase large subunit (EC 2.2.1.6) | compare |
| GFF120 | | -2.8 | -12.7 | Glucose-6-phosphate isomerase (EC 5.3.1.9) | compare |
| GFF1958 | | -2.8 | -2.5 | hypothetical protein | compare |
| GFF5413 | | -2.8 | -5.3 | Sulfate adenylyltransferase subunit 2 (EC 2.7.7.4) | compare |
| GFF633 | | -2.8 | -12.2 | Homoserine dehydrogenase (EC 1.1.1.3) | compare |
| GFF3062 | | -2.8 | -10.2 | Imidazole glycerol phosphate synthase cyclase subunit | compare |
| GFF2057 | | -2.8 | -9.5 | Ketol-acid reductoisomerase (NADP(+)) (EC 1.1.1.86) | compare |
| GFF500 | | -2.8 | -6.9 | ATP:Cob(I)alamin adenosyltransferase (EC 2.5.1.17) | compare |
| GFF3322 | | -2.8 | -11.9 | Biosynthetic Aromatic amino acid aminotransferase beta (EC 2.6.1.57) @ Histidinol-phosphate aminotransferase (EC 2.6.1.9) | compare |
| GFF4129 | | -2.8 | -1.9 | Chromosome (plasmid) partitioning protein ParB | compare |
| GFF828 | | -2.8 | -4.6 | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) | compare |
| GFF963 | | -2.8 | -12.2 | Branched-chain amino acid aminotransferase (EC 2.6.1.42) | compare |
| GFF4957 | | -2.7 | -2.6 | Adenosylhomocysteinase (EC 3.3.1.1) | compare |
| GFF4169 | | -2.7 | -3.2 | Shikimate 5-dehydrogenase I alpha (EC 1.1.1.25) | compare |
| GFF2404 | | -2.7 | -12.8 | Phosphoribosylformylglycinamidine synthase, synthetase subunit (EC 6.3.5.3) | compare |
| GFF3061 | | -2.6 | -8.8 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16) | compare |
| GFF1972 | | -2.6 | -8.8 | Homoserine kinase (EC 2.7.1.39) | compare |
| GFF1053 | | -2.6 | -10.3 | Phosphoribosylamine--glycine ligase (EC 6.3.4.13) | compare |
| GFF803 | | -2.6 | -6.9 | Chorismate synthase (EC 4.2.3.5) | compare |
| GFF2134 | | -2.6 | -2.7 | hypothetical protein | compare |
| GFF816 | | -2.5 | -10.5 | ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17) | compare |
| GFF3060 | | -2.5 | -7.3 | Imidazole glycerol phosphate synthase amidotransferase subunit HisH | compare |
| GFF1891 | | -2.5 | -11.8 | Glutamate 5-kinase (EC 2.7.2.11) / RNA-binding C-terminal domain PUA | compare |
| GFF66 | | -2.5 | -7.2 | Cobyric acid synthase (EC 6.3.5.10) | compare |
| GFF3746 | | -2.5 | -8.2 | Ornithine carbamoyltransferase (EC 2.1.3.3) | compare |
| GFF233 | | -2.4 | -10.3 | 'Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2) / GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase II' transl_table=11 | compare |
| GFF3793 | | -2.4 | -10.2 | Argininosuccinate lyase (EC 4.3.2.1) | compare |
| GFF1593 | | -2.4 | -5.2 | Phosphogluconate dehydratase (EC 4.2.1.12) | compare |
| GFF2060 | | -2.4 | -12.8 | 2-isopropylmalate synthase (EC 2.3.3.13) | compare |
| GFF1052 | | -2.4 | -2.2 | Exodeoxyribonuclease VII large subunit (EC 3.1.11.6) | compare |
| GFF3334 | | -2.3 | -4.7 | Aerobic cobaltochelatase CobS subunit (EC 6.6.1.2) | compare |
| GFF785 | | -2.3 | -13.7 | Ammonium transporter | compare |
| GFF4055 | | -2.3 | -4.1 | ATP-dependent Clp protease ATP-binding subunit ClpX | compare |
| GFF4103 | | -2.3 | -2.7 | Peptide chain release factor N(5)-glutamine methyltransferase (EC 2.1.1.297) | compare |
| GFF3241 | | -2.3 | -9.9 | Histidinol dehydrogenase (EC 1.1.1.23) | compare |
| GFF646 | | -2.3 | -9.1 | Aspartate aminotransferase (EC 2.6.1.1) | compare |
| GFF4238 | | -2.2 | -2.1 | Capsular polysaccharide export system inner membrane protein KpsE | compare |
| GFF3534 | | -2.2 | -8.6 | Anthranilate synthase, amidotransferase component (EC 4.1.3.27) @ Para-aminobenzoate synthase, amidotransferase component (EC 2.6.1.85) | compare |
| GFF3795 | | -2.2 | -8.5 | Diaminopimelate decarboxylase (EC 4.1.1.20) | compare |
| GFF5249 | | -2.2 | -2.7 | hypothetical protein | compare |
| GFF3059 | | -2.2 | -5.8 | hypothetical protein | compare |
| GFF4947 | | -2.2 | -11.8 | Glutamate N-acetyltransferase (EC 2.3.1.35) @ N-acetylglutamate synthase (EC 2.3.1.1) | compare |
| GFF4052 | | -2.2 | -2.0 | RfbJ protein | compare |
| GFF1668 | | -2.1 | -5.6 | Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) | compare |
| GFF226 | | -2.1 | -2.9 | hypothetical protein | compare |
| GFF2000 | | -2.1 | -2.4 | 'Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) / CBS domain' transl_table=11 | compare |
| GFF2628 | | -2.0 | -7.8 | 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) | compare |
| GFF823 | | -2.0 | -5.5 | Adenosylcobinamide kinase (EC 2.7.1.156) / Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) | compare |
| GFF2974 | | -2.0 | -1.9 | Probable transcription regulator protein of MDR efflux pump cluster | compare |
| GFF4218 | | -2.0 | -2.1 | hypothetical protein | compare |
| GFF4404 | | -2.0 | -1.8 | hypothetical protein | compare |
| GFF1521 | | -2.0 | -1.2 | hypothetical protein | compare |
| GFF3242 | | -2.0 | -5.6 | ATP phosphoribosyltransferase (EC 2.4.2.17) => HisGs | compare |
| GFF5252 | | -1.9 | -2.8 | Prevent host death protein, Phd antitoxin | compare |
| GFF575 | | -1.9 | -2.8 | oligopeptide transporter | compare |
| GFF2890 | | -1.8 | -2.5 | PKHD-type hydroxylase YbiX | compare |
| GFF2269 | | -1.8 | -6.1 | NLP/P60 family lipoprotein | compare |
| GFF1584 | | -1.8 | -1.4 | hypothetical protein | compare |
| GFF1451 | | -1.7 | -1.5 | Conserved hypothetical protein probably involved in sulfate reduction | compare |
| GFF2034 | | -1.7 | -7.6 | Glycogen synthase, ADP-glucose transglucosylase (EC 2.4.1.21) | compare |
| GFF3439 | | -1.7 | -3.1 | Phosphoribosylformylglycinamidine synthase, PurS subunit (EC 6.3.5.3) | compare |
| GFF2079 | | -1.7 | -4.2 | Enolase (EC 4.2.1.11) | compare |
| GFF5251 | | -1.7 | -3.9 | Death on curing protein, Doc toxin | compare |
| GFF5250 | | -1.7 | -3.7 | Replication protein | compare |
| GFF4800 | | -1.7 | -1.7 | Phosphoenolpyruvate carboxylase (EC 4.1.1.31) | compare |
| GFF4076 | | -1.7 | -5.1 | Two-component transcriptional response regulator, LuxR family | compare |
| GFF1973 | | -1.7 | -2.5 | Ribonuclease HI (EC 3.1.26.4) | compare |
| GFF1300 | | -1.6 | -5.3 | Phosphoglycerate mutase (EC 5.4.2.11) | compare |
| GFF3770 | | -1.6 | -2.8 | 2-keto-3-deoxy-D-arabino-heptulosonate-7- phosphate synthase II (EC 2.5.1.54) | compare |
| GFF2286 | | -1.6 | -7.1 | ATP-dependent Clp protease ATP-binding subunit ClpA | compare |
| GFF5248 | | -1.6 | -3.8 | hypothetical protein | compare |
| GFF1918 | | -1.5 | -2.1 | FIG00687856: Predicted nucleotidyltransferases | compare |
| GFF147 | | -1.5 | -4.8 | ATP-dependent hsl protease ATP-binding subunit HslU | compare |
| GFF3291 | | -1.5 | -4.5 | Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) | compare |
| GFF1075 | | -1.5 | -2.4 | Holliday junction ATP-dependent DNA helicase RuvB (EC 3.6.4.12) | compare |
| GFF1855 | | -1.5 | -6.3 | Precorrin-6Y C(5,15)-methyltransferase [decarboxylating] (EC 2.1.1.132) | compare |
| GFF2311 | | -1.5 | -1.9 | Transcriptional regulator, GntR family | compare |
| GFF3485 | | -1.5 | -2.1 | tRNA-Glu-CTC | compare |
| GFF3819 | | -1.5 | -2.9 | PTS system permease (IIAMan), nitrogen regulatory IIA protein | compare |
| GFF3929 | | -1.5 | -2.3 | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex (EC 2.3.1.12) | compare |
| GFF3783 | | -1.5 | -7.0 | L-aspartate oxidase (EC 1.4.3.16) | compare |
| GFF9 | | -1.5 | -1.2 | hypothetical protein | compare |
| GFF4760 | | -1.4 | -1.7 | tRNA-modifying protein YgfZ | compare |
| GFF1961 | | -1.4 | -2.9 | Entericidin A/B family protein | compare |
| GFF5255 | | -1.4 | -5.6 | Mobilization protein MobA @ Conjugal transfer protein TraA | compare |
| GFF2219 | | -1.4 | -2.0 | Organic hydroperoxide resistance transcriptional regulator | compare |
| GFF5253 | | -1.4 | -6.6 | hypothetical protein | compare |
| GFF2076 | | -1.4 | -2.5 | Pyruvate dehydrogenase E1 component beta subunit (EC 1.2.4.1) | compare |
| GFF2369 | | -1.3 | -6.0 | hypothetical protein | compare |
| GFF142 | | -1.3 | -10.0 | Polyhydroxyalkanoic acid synthase | compare |
| GFF953 | | -1.3 | -1.1 | hypothetical protein | compare |
| GFF1682 | | -1.3 | -1.8 | hypothetical protein | compare |
| GFF1883 | | -1.3 | -1.4 | hypothetical protein | compare |
| GFF5247 | | -1.3 | -8.2 | hypothetical protein | compare |
| GFF267 | | -1.3 | -1.7 | hypothetical protein | compare |
| GFF1453 | | -1.3 | -1.6 | Oxidoreductase probably involved in sulfite reduction | compare |
| GFF1251 | | -1.3 | -1.0 | hypothetical protein | compare |
| GFF4953 | | -1.3 | -2.3 | FIG006611: nucleotidyltransferase | compare |
| GFF2593 | | -1.3 | -6.3 | hypothetical protein | compare |
| GFF4211 | | -1.3 | -2.8 | UDP-glucose 6-dehydrogenase (EC 1.1.1.22) | compare |
| GFF4200 | | -1.3 | -1.7 | Integration host factor alpha subunit | compare |
| GFF2077 | | -1.2 | -1.9 | Pyruvate dehydrogenase E1 component alpha subunit (EC 1.2.4.1) | compare |
| GFF243 | | -1.2 | -5.3 | Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19) | compare |
| GFF2052 | | -1.2 | -3.4 | Phosphoserine phosphatase (EC 3.1.3.3) | compare |
| GFF1698 | | -1.2 | -1.9 | hypothetical protein | compare |
| GFF645 | | -1.2 | -9.2 | Polyhydroxyalkanoic acid synthase | compare |
| GFF2652 | | -1.2 | -3.6 | Phosphate ABC transporter, substrate-binding protein PstS (TC 3.A.1.7.1) | compare |
| GFF4438 | | -1.2 | -5.6 | Plasmid replication protein RepA | compare |
| GFF3120 | | -1.2 | -1.9 | RecA protein | compare |
| GFF5409 | | -1.2 | -1.1 | hypothetical protein | compare |
| GFF2131 | | -1.2 | -6.2 | Phosphoglycerate kinase (EC 2.7.2.3) | compare |
| GFF4530 | | -1.2 | -2.1 | hypothetical protein | compare |
| GFF3790 | | -1.2 | -0.9 | hypothetical protein | compare |
| GFF276 | | -1.2 | -3.3 | hypothetical protein | compare |
| GFF1859 | | -1.2 | -3.4 | Precorrin-8X methylmutase (EC 5.4.99.61) | compare |
| GFF148 | | -1.2 | -3.2 | ATP-dependent protease subunit HslV (EC 3.4.25.2) | compare |
| GFF2132 | | -1.2 | -5.9 | NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12) | compare |
| GFF3610 | | -1.2 | -1.7 | hypothetical protein | compare |
| GFF132 | | -1.2 | -2.8 | Methylmalonyl-CoA mutase (EC 5.4.99.2) / B12 binding domain of Methylmalonyl-CoA mutase (EC 5.4.99.2) | compare |
| GFF951 | | -1.2 | -4.2 | 2-Keto-3-deoxy-D-manno-octulosonate-8-phosphate synthase (EC 2.5.1.55) | compare |
| GFF2900 | | -1.2 | -2.0 | HflK protein | compare |
| GFF131 | | -1.1 | -3.0 | Methylmalonyl-CoA epimerase (EC 5.1.99.1) @ Ethylmalonyl-CoA epimerase | compare |
| GFF668 | | -1.1 | -3.5 | Rrf2 family transcriptional regulator | compare |
| GFF3188 | | -1.1 | -1.6 | hypothetical protein | compare |
| GFF3569 | | -1.1 | -2.5 | hypothetical protein | compare |
| GFF1589 | | -1.1 | -1.8 | hypothetical protein | compare |
| GFF1747 | | -1.1 | -3.4 | hypothetical protein | compare |
| GFF4171 | | -1.0 | -3.6 | Phosphoenolpyruvate synthase regulatory protein | compare |
| GFF50 | | -1.0 | -1.3 | Phosphoglucomutase (EC 5.4.2.2) | compare |
| GFF1248 | | -1.0 | -3.2 | hypothetical protein | compare |
| GFF1764 | | -1.0 | -1.9 | Outer membrane protein A precursor | compare |
| GFF2542 | | -1.0 | -1.7 | Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase | compare |
| GFF2787 | | -1.0 | -2.7 | Cell division integral membrane protein, YggT and half-length relatives | compare |
| GFF4024 | | -1.0 | -0.9 | hypothetical protein | compare |
| GFF1956 | | -1.0 | -0.9 | Transcriptional regulator MraZ | compare |
| GFF1921 | | -1.0 | -5.7 | Glycine dehydrogenase [decarboxylating] (glycine cleavage system P1 protein) (EC 1.4.4.2) | compare |
| GFF1566 | | -1.0 | -1.8 | hypothetical protein | compare |
| GFF4565 | | -1.0 | -1.5 | hypothetical protein | compare |
| GFF1860 | | -1.0 | -4.2 | Precorrin-3B synthase | compare |
| GFF582 | | -1.0 | -1.7 | NADPH-dependent 7-cyano-7-deazaguanine reductase (EC 1.7.1.13) | compare |
| GFF1944 | | -1.0 | -2.6 | hypothetical protein | compare |
| GFF2893 | | -0.9 | -5.3 | Acetoacetyl-CoA reductase (EC 1.1.1.36) | compare |