| | gene | name | fitness | t score | description | |
|---|
| b2476 | purC | -7.1 | -4.9 | phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI) | compare |
| b0912 | ihfB | -6.5 | -4.5 | integration host factor subunit beta (NCBI) | compare |
| b1260 | trpA | -5.8 | -6.9 | tryptophan synthase subunit alpha (NCBI) | compare |
| b1301 | puuB | -5.5 | -7.5 | gamma-Glu-putrescine oxidase, FAD/NAD(P)-binding (NCBI) | conserved |
| b1300 | puuC | -5.3 | -6.3 | gamma-Glu-gamma-aminobutyraldehyde dehydrogenase, NAD(P)H-dependent (NCBI) | conserved |
| b2320 | pdxB | -5.2 | -9.4 | erythronate-4-phosphate dehydrogenase (NCBI) | compare |
| b2023 | hisH | -5.2 | -7.2 | imidazole glycerol phosphate synthase subunit HisH (NCBI) | compare |
| b2022 | hisB | -5.2 | -8.7 | imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS) | compare |
| b0523 | purE | -5.2 | -5.0 | phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI) | compare |
| b0243 | proA | -5.2 | -11.0 | gamma-glutamyl phosphate reductase (NCBI) | compare |
| b1299 | puuR | -5.2 | -6.1 | DNA-binding transcriptional repressor (NCBI) | compare |
| b2024 | hisA | -5.1 | -3.1 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-imidazolecarboxamide isomerase (VIMSS) | compare |
| b2021 | hisC | -5.1 | -6.9 | histidinol-phosphate aminotransferase (NCBI) | compare |
| b0049 | apaH | -5.1 | -6.0 | diadenosinetetraphosphatase (NCBI) | compare |
| b3772 | ilvA | -5.0 | -12.8 | threonine dehydratase (NCBI) | compare |
| b3389 | aroB | -5.0 | -13.6 | 3-dehydroquinate synthase (NCBI) | compare |
| b0522 | purK | -5.0 | -8.9 | phosphoribosylaminoimidazole carboxylase (NCBI) | compare |
| b2025 | hisF | -4.9 | -6.7 | imidazole glycerol phosphate synthase subunit HisF (NCBI) | compare |
| b3941 | metF | -4.9 | -12.6 | 5,10-methylenetetrahydrofolate reductase (NCBI) | compare |
| b0386 | proC | -4.8 | -7.4 | pyrroline-5-carboxylate reductase (NCBI) | compare |
| b3236 | mdh | -4.8 | -8.6 | malate dehydrogenase (NCBI) | compare |
| b3958 | argC | -4.8 | -15.0 | N-acetyl-gamma-glutamyl-phosphate reductase (NCBI) | compare |
| b2020 | hisD | -4.8 | -10.6 | histidinol dehydrogenase (NCBI) | compare |
| b3771 | ilvD | -4.8 | -13.7 | dihydroxy-acid dehydratase (NCBI) | compare |
| b0674 | asnB | -4.8 | -12.7 | asparagine synthetase B (NCBI) | compare |
| b3008 | metC | -4.8 | -11.9 | cystathionine beta-lyase (NCBI) | compare |
| b2026 | hisI | -4.8 | -10.1 | bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI) | compare |
| b3828 | metR | -4.7 | -11.8 | DNA-binding transcriptional activator, homocysteine-binding (NCBI) | compare |
| b2750 | cysC | -4.7 | -7.9 | adenylylsulfate kinase (NCBI) | compare |
| b3774 | ilvC | -4.7 | -16.1 | ketol-acid reductoisomerase (NCBI) | compare |
| b3868 | glnG | -4.7 | -5.6 | fused DNA-binding response regulator in two-component regulatory system with GlnL: response regulator/sigma54 interaction protein (NCBI) | compare |
| b0071 | leuD | -4.7 | -9.0 | isopropylmalate isomerase small subunit (NCBI) | compare |
| b3642 | pyrE | -4.7 | -4.5 | orotate phosphoribosyltransferase (NCBI) | compare |
| b3212 | gltB | -4.7 | -20.9 | glutamate synthase, large subunit (NCBI) | compare |
| b0073 | leuB | -4.7 | -11.3 | 3-isopropylmalate dehydrogenase (VIMSS) | compare |
| b4245 | pyrB | -4.7 | -12.7 | aspartate carbamoyltransferase catalytic subunit (NCBI) | compare |
| b1693 | aroD | -4.7 | -9.4 | 3-dehydroquinate dehydratase (NCBI) | compare |
| b2312 | purF | -4.7 | -8.9 | amidophosphoribosyltransferase (NCBI) | compare |
| b2600 | tyrA | -4.6 | -8.8 | fused chorismate mutase T/prephenate dehydrogenase (NCBI) | compare |
| b1290 | sapF | -4.6 | -3.2 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b1062 | pyrC | -4.6 | -9.8 | dihydroorotase (NCBI) | compare |
| b1297 | b1297 | -4.6 | -10.7 | putative glutamine synthetase (EC 6.3.1.2) (VIMSS) | conserved |
| b2501 | ppk | -4.6 | -12.5 | polyphosphate kinase (NCBI) | compare |
| b0002 | thrA | -4.6 | -16.4 | bifunctional aspartokinase I/homeserine dehydrogenase I (NCBI) | compare |
| b0145 | dksA | -4.6 | -3.1 | DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) | compare |
| b1084 | rne | -4.6 | -5.4 | fused ribonucleaseE: endoribonuclease/RNA-binding protein/RNA degradosome binding protein (NCBI) | compare |
| b3939 | metB | -4.6 | -12.5 | cystathionine gamma-synthase (NCBI) | compare |
| b4006 | purH | -4.5 | -13.9 | bifunctionalphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI) | compare |
| b3957 | argE | -4.5 | -16.0 | acetylornithine deacetylase (NCBI) | compare |
| b2019 | hisG | -4.5 | -7.5 | ATP phosphoribosyltransferase (NCBI) | compare |
| b0003 | thrB | -4.5 | -11.6 | homoserine kinase (NCBI) | compare |
| b0032 | carA | -4.5 | -9.1 | carbamoyl-phosphate synthase small subunit (NCBI) | compare |
| b2557 | purL | -4.5 | -11.2 | phosphoribosylformylglycinamidine synthase (NCBI) | compare |
| b0033 | carB | -4.5 | -16.3 | carbamoyl-phosphate synthase large subunit (NCBI) | compare |
| b0945 | pyrD | -4.5 | -13.5 | dihydroorotate dehydrogenase (NCBI) | compare |
| b2499 | purM | -4.5 | -6.1 | phosphoribosylaminoimidazole synthetase (NCBI) | compare |
| b4005 | purD | -4.4 | -9.9 | phosphoribosylamine--glycine ligase (NCBI) | compare |
| b2784 | relA | -4.4 | -12.5 | (p)ppGpp synthetase I/GTP pyrophosphokinase (NCBI) | compare |
| b4242 | mgtA | -4.4 | -20.9 | magnesium transporter (NCBI) | compare |
| b0242 | proB | -4.4 | -7.9 | gamma-glutamyl kinase (NCBI) | compare |
| b3172 | argG | -4.4 | -12.4 | argininosuccinate synthase (NCBI) | compare |
| b0004 | thrC | -4.4 | -10.2 | threonine synthase (NCBI) | compare |
| b3281 | aroE | -4.4 | -18.4 | dehydroshikimate reductase, NAD(P)-binding (NCBI) | compare |
| b1261 | trpB | -4.3 | -3.9 | tryptophan synthase subunit beta (NCBI) | compare |
| b0437 | clpP | -4.3 | -10.7 | ATP-dependent Clp protease proteolytic subunit (NCBI) | compare |
| b0720 | gltA | -4.3 | -7.2 | citrate synthase (NCBI) | compare |
| b0072 | leuC | -4.3 | -14.0 | isopropylmalate isomerase large subunit (NCBI) | compare |
| b0052 | pdxA | -4.3 | -11.1 | 4-hydroxythreonine-4-phosphate dehydrogenase (NCBI) | compare |
| b2762 | cysH | -4.3 | -9.1 | phosphoadenosine phosphosulfate reductase (NCBI) | compare |
| b4702 | mgtL | -4.3 | -4.2 | regulatory leader peptide for mgtA (NCBI) | compare |
| b3960 | argH | -4.3 | -13.6 | argininosuccinate lyase (NCBI) | compare |
| b2764 | cysJ | -4.2 | -11.3 | sulfite reductase, alpha subunit, flavoprotein (NCBI) | compare |
| b2414 | cysK | -4.2 | -13.7 | cysteine synthase A, O-acetylserine sulfhydrolase A subunit (NCBI) | compare |
| b3082 | ygjM | -4.2 | -4.1 | predicted DNA-binding transcriptional regulator (NCBI) | compare |
| b3764 | yifE | -4.2 | -7.5 | hypothetical protein (NCBI) | compare |
| b3829 | metE | -4.2 | -17.2 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (NCBI) | compare |
| b2329 | aroC | -4.2 | -6.9 | chorismate synthase (NCBI) | compare |
| b4480 | hdfR | -4.2 | -7.9 | transcriptional regulator HdfR (NCBI) | compare |
| b0908 | aroA | -4.2 | -11.9 | 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) | compare |
| b4214 | cysQ | -4.1 | -14.9 | PAPS (adenosine 3'-phosphate 5'-phosphosulfate) 3'(2'),5'-bisphosphate nucleotidase (NCBI) | compare |
| b2340 | sixA | -4.1 | -6.8 | phosphohistidine phosphatase (NCBI) | compare |
| b1263 | trpD | -4.1 | -4.8 | bifunctional indole-3-glycerol-phosphate synthase/anthranilate phosphoribosyltransferase (NCBI) | compare |
| b0889 | lrp | -4.1 | -4.6 | DNA-binding transcriptional dual regulator, leucine-binding (NCBI) | compare |
| b1296 | ycjJ | -4.1 | -6.2 | putative amino acid/amine transport protein (VIMSS) | conserved |
| b2913 | serA | -4.0 | -10.6 | D-3-phosphoglycerate dehydrogenase (NCBI) | compare |
| b1192 | ldcA | -4.0 | -6.6 | L,D-carboxypeptidase A (NCBI) | compare |
| b3341 | rpsG | -4.0 | -2.7 | 30S ribosomal protein S7 (NCBI) | compare |
| b3959 | argB | -4.0 | -13.1 | acetylglutamate kinase (RefSeq) | compare |
| b4171 | miaA | -3.9 | -7.1 | tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) | compare |
| b4388 | serB | -3.9 | -8.0 | 3-phosphoserine phosphatase (NCBI) | compare |
| b1130 | phoP | -3.9 | -8.3 | DNA-binding response regulator in two-component regulatory system with PhoQ (NCBI) | compare |
| b0907 | serC | -3.9 | -9.4 | phosphoserine aminotransferase (NCBI) | compare |
| b3368 | cysG | -3.9 | -18.3 | fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase (NCBI) | compare |
| b1281 | pyrF | -3.9 | -5.3 | orotidine 5'-phosphate decarboxylase (NCBI) | compare |
| b3706 | trmE | -3.9 | -7.4 | tRNA modification GTPase (NCBI) | compare |
| b2818 | argA | -3.9 | -11.1 | N-acetylglutamate synthase (NCBI) | compare |
| b3844 | fre | -3.9 | -6.9 | NAD(P)H-flavin reductase (NCBI) | compare |
| b2500 | purN | -3.8 | -7.3 | phosphoribosylglycinamide formyltransferase (NCBI) | compare |
| b3962 | udhA | -3.8 | -10.2 | putative oxidoreductase (VIMSS) | compare |
| b2838 | lysA | -3.8 | -12.0 | diaminopimelate decarboxylase, PLP-binding (NCBI) | compare |
| b1298 | ycjL | -3.8 | -3.8 | probable amidotransferase subunit (VIMSS) | conserved |
| b1712 | ihfA | -3.8 | -5.2 | integration host factor subunit alpha (NCBI) | compare |
| b2839 | lysR | -3.8 | -6.2 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b3770 | ilvE | -3.8 | -14.5 | branched-chain amino acid aminotransferase (NCBI) | compare |
| b2752 | cysD | -3.7 | -6.0 | sulfate adenylyltransferase subunit 2 (NCBI) | compare |
| b1291 | sapD | -3.7 | -3.5 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b0438 | clpX | -3.6 | -9.8 | ATP-dependent protease ATP-binding subunit (NCBI) | compare |
| b2763 | cysI | -3.6 | -10.5 | sulfite reductase, beta subunit, NAD(P)-binding, heme-binding (NCBI) | compare |
| b3181 | greA | -3.6 | -7.5 | transcription elongation factor: cleaves 3' nucleotide of paused mRNA (VIMSS) | compare |
| b0074 | leuA | -3.5 | -12.6 | 2-isopropylmalate synthase (NCBI) | compare |
| b1129 | phoQ | -3.5 | -9.8 | sensory histidine kinase in two-compoent regulatory system with PhoP (NCBI) | compare |
| b3204 | ptsN | -3.5 | -7.4 | sugar-specific enzyme IIA component of PTS (NCBI) | compare |
| b0658 | ybeX | -3.5 | -11.6 | predicteed ion transport (NCBI) | compare |
| b3849 | trkH | -3.5 | -13.6 | potassium transporter (NCBI) | compare |
| b3728 | pstS | -3.5 | -4.1 | phosphate transporter subunit (NCBI) | compare |
| b2599 | pheA | -3.5 | -8.2 | fused chorismate mutase P/prephenate dehydratase (NCBI) | compare |
| b3741 | gidA | -3.5 | -6.6 | glucose-inhibited division protein A (NCBI) | compare |
| b0439 | lon | -3.4 | -6.5 | DNA-binding ATP-dependent protease La (NCBI) | compare |
| b3213 | gltD | -3.3 | -12.6 | glutamate synthase, 4Fe-4S protein, small subunit (NCBI) | compare |
| b3869 | glnL | -3.3 | -9.3 | sensory histidine kinase in two-component regulatory system with GlnG (NCBI) | compare |
| b4179 | vacB | -3.3 | -11.1 | putative enzyme (VIMSS) | compare |
| b0051 | ksgA | -3.3 | -7.2 | dimethyladenosine transferase (NCBI) | compare |
| b0014 | dnaK | -3.2 | -3.1 | molecular chaperone DnaK (NCBI) | compare |
| b0423 | thiI | -3.2 | -8.3 | thiamine biosynthesis protein ThiI (NCBI) | compare |
| b3671 | ilvB | -3.2 | -16.3 | acetolactate synthase large subunit (NCBI) | compare |
| b0430 | cyoC | -3.2 | -6.3 | cytochrome o ubiquinol oxidase subunit III (NCBI) | compare |
| b3619 | rfaD | -3.2 | -3.7 | ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) | compare |
| b3916 | pfkA | -3.2 | -3.7 | 6-phosphofructokinase (NCBI) | compare |
| b3210 | arcB | -3.2 | -10.5 | hybrid sensory histidine kinase in two-component regulatory system with ArcA (NCBI) | compare |
| b3261 | fis | -3.1 | -3.7 | DNA-binding protein Fis (NCBI) | compare |
| b0739 | tolA | -3.1 | -5.1 | cell envelope integrity inner membrane protein TolA (NCBI) | compare |
| b2564 | pdxJ | -3.1 | -5.8 | pyridoxal phosphate biosynthetic protein (NCBI) | compare |
| b3398 | yrfF | -3.1 | -5.0 | predicted inner membrane protein (NCBI) | compare |
| b3429 | glgA | -3.0 | -13.9 | glycogen synthase (NCBI) | compare |
| b1235 | rssB | -3.0 | -10.4 | response regulator of RpoS (NCBI) | compare |
| b3423 | glpR | -3.0 | -12.4 | DNA-binding transcriptional repressor (NCBI) | compare |
| b2751 | cysN | -3.0 | -7.4 | sulfate adenylyltransferase subunit 1 (NCBI) | compare |
| b2479 | gcvR | -3.0 | -6.5 | transcriptional regulation of gcv operon (VIMSS) | compare |
| b0683 | fur | -3.0 | -2.0 | ferric uptake regulator (NCBI) | compare |
| b3781 | trxA | -2.9 | -5.2 | thioredoxin 1 (VIMSS) | compare |
| b0928 | aspC | -2.9 | -7.9 | aspartate aminotransferase, PLP-dependent (NCBI) | compare |
| b2518 | ndk | -2.9 | -3.9 | nucleoside diphosphate kinase (NCBI) | compare |
| b3726 | pstA | -2.9 | -8.0 | phosphate transporter subunit (NCBI) | compare |
| b0118 | acnB | -2.9 | -2.8 | aconitate hydratase (NCBI) | compare |
| b0088 | murD | -2.8 | -3.1 | UDP-N-acetylmuramoyl-L-alanyl-D-glutamatesynthetase (NCBI) | compare |
| b3166 | truB | -2.8 | -9.7 | tRNA pseudouridine synthase B (NCBI) | compare |
| b3405 | ompR | -2.8 | -6.4 | osmolarity response regulator (NCBI) | compare |
| b1865 | nudB | -2.8 | -3.2 | dATP pyrophosphohydrolase (NCBI) | compare |
| b2567 | rnc | -2.8 | -1.9 | ribonuclease III (NCBI) | compare |
| b3870 | glnA | -2.8 | -1.9 | glutamine synthetase (NCBI) | compare |
| b0630 | lipB | -2.7 | -2.6 | protein of lipoate biosynthesis (VIMSS) | compare |
| b0848 | ybjM | -2.7 | -8.1 | predicted inner membrane protein (NCBI) | compare |
| b3839 | tatC | -2.7 | -10.7 | TatABCE protein translocation system subunit (NCBI) | compare |
| b3390 | aroK | -2.7 | -3.6 | shikimate kinase I (NCBI) | compare |
| b2188 | yejM | -2.7 | -10.8 | predicted hydrolase, inner membrane (NCBI) | compare |
| b1860 | ruvB | -2.7 | -2.5 | Holliday junction DNA helicase B (NCBI) | compare |
| b0142 | folK | -2.7 | -1.9 | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) | compare |
| b3469 | zntA | -2.7 | -14.5 | zinc, cobalt and lead efflux system (NCBI) | compare |
| b2906 | visC | -2.7 | -8.5 | hypothetical protein (NCBI) | compare |
| b3725 | pstB | -2.7 | -1.8 | phosphate transporter subunit (NCBI) | compare |
| b4146 | yjeK | -2.6 | -4.0 | predicted lysine aminomutase (NCBI) | compare |
| b4013 | metA | -2.6 | -6.3 | homoserine O-succinyltransferase (NCBI) | compare |
| b3035 | tolC | -2.6 | -11.4 | outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) | compare |
| b3792 | wzxE | -2.6 | -11.4 | O-antigen translocase (NCBI) | compare |
| b3780 | rhlB | -2.6 | -14.2 | ATP-dependent RNA helicase (NCBI) | compare |
| b4375 | prfC | -2.6 | -9.6 | peptide chain release factor 3 (NCBI) | compare |
| b4390 | nadR | -2.6 | -12.2 | probable nadAB transcriptional regulator (VIMSS) | compare |
| b0738 | tolR | -2.6 | -4.5 | membrane spanning protein in TolA-TolQ-TolR complex (NCBI) | compare |
| b3290 | trkA | -2.6 | -3.0 | potassium transporter peripheral membrane component (NCBI) | compare |
| b3621 | rfaC | -2.5 | -6.6 | ADP-heptose:LPS heptosyl transferase I (NCBI) | compare |
| b0114 | aceE | -2.5 | -3.4 | pyruvate dehydrogenase subunit E1 (NCBI) | compare |
| b0431 | cyoB | -2.5 | -12.9 | cytochrome o ubiquinol oxidase subunit I (NCBI) | compare |
| b4481 | rffT | -2.5 | -9.6 | 4-alpha-L-fucosyltransferase (NCBI) | compare |
| b2830 | nudH | -2.5 | -2.9 | dinucleoside polyphosphate hydrolase (NCBI) | compare |
| b0750 | nadA | -2.5 | -7.4 | quinolinate synthetase (NCBI) | compare |
| b3773 | ilvY | -2.5 | -10.3 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b2894 | xerD | -2.5 | -2.3 | site-specific tyrosine recombinase XerD (NCBI) | compare |
| b0890 | ftsK | -2.4 | -8.8 | DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) | compare |
| b0113 | pdhR | -2.4 | -5.4 | transcriptional regulator of pyruvate dehydrogenase complex (NCBI) | compare |
| b3670 | ilvN | -2.4 | -7.2 | acetolactate synthase small subunit (NCBI) | compare |
| b2297 | pta | -2.4 | -3.2 | phosphate acetyltransferase (NCBI) | compare |
| b0428 | cyoE | -2.4 | -8.4 | protoheme IX farnesyltransferase (NCBI) | compare |
| b4239 | treC | -2.4 | -5.0 | trehalose-6-P hydrolase (NCBI) | compare |
| b2517 | yfgB | -2.4 | -9.0 | predicted enzyme (NCBI) | compare |
| b4172 | hfq | -2.4 | -2.2 | RNA-binding protein Hfq (NCBI) | compare |
| b2017 | yefM | -2.3 | -3.1 | orf, hypothetical protein (VIMSS) | compare |
| b0222 | lpcA | -2.3 | -4.3 | phosphoheptose isomerase (NCBI) | compare |
| b1109 | ndh | -2.3 | -5.7 | respiratory NADH dehydrogenase 2/cupric reductase (NCBI) | compare |
| b0432 | cyoA | -2.3 | -11.6 | cytochrome o ubiquinol oxidase subunit II (NCBI) | compare |
| b1273 | yciN | -2.3 | -3.3 | hypothetical protein (NCBI) | compare |
| b0200 | gmhB | -2.3 | -2.6 | hypothetical protein (NCBI) | compare |
| b2935 | tktA | -2.2 | -3.9 | transketolase 1, thiamin-binding (NCBI) | compare |
| b0740 | tolB | -2.2 | -6.5 | translocation protein TolB precursor (NCBI) | compare |
| b1262 | trpC | -2.2 | -3.6 | N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase (VIMSS) | compare |
| b0588 | fepC | -2.2 | -9.7 | iron-enterobactin transporter subunit (NCBI) | compare |
| b3386 | rpe | -2.2 | -2.1 | ribulose-phosphate 3-epimerase (NCBI) | compare |
| b3911 | cpxA | -2.2 | -12.2 | two-component sensor protein (NCBI) | compare |
| b4246 | pyrL | -2.2 | -1.8 | pyrBI operon leader peptide (NCBI) | compare |
| b3838 | tatB | -2.2 | -9.5 | sec-independent translocase (NCBI) | compare |
| b1292 | sapC | -2.2 | -3.5 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |