| | gene | name | fitness | t score | description | |
|---|
| b0907 | serC | -6.6 | -6.4 | phosphoserine aminotransferase (NCBI) | compare |
| b1192 | ldcA | -5.8 | -4.0 | L,D-carboxypeptidase A (NCBI) | compare |
| b4388 | serB | -5.7 | -4.0 | 3-phosphoserine phosphatase (NCBI) | compare |
| b3389 | aroB | -5.7 | -9.4 | 3-dehydroquinate synthase (NCBI) | compare |
| b1260 | trpA | -5.4 | -4.4 | tryptophan synthase subunit alpha (NCBI) | compare |
| b2019 | hisG | -5.4 | -7.0 | ATP phosphoribosyltransferase (NCBI) | compare |
| b1129 | phoQ | -5.3 | -7.3 | sensory histidine kinase in two-compoent regulatory system with PhoP (NCBI) | compare |
| b1693 | aroD | -5.3 | -8.1 | 3-dehydroquinate dehydratase (NCBI) | compare |
| b0004 | thrC | -5.3 | -8.1 | threonine synthase (NCBI) | compare |
| b2021 | hisC | -5.3 | -6.2 | histidinol-phosphate aminotransferase (NCBI) | compare |
| b0071 | leuD | -5.2 | -8.0 | isopropylmalate isomerase small subunit (NCBI) | compare |
| b2838 | lysA | -5.2 | -9.3 | diaminopimelate decarboxylase, PLP-binding (NCBI) | compare |
| b2025 | hisF | -5.2 | -6.1 | imidazole glycerol phosphate synthase subunit HisF (NCBI) | compare |
| b2023 | hisH | -5.1 | -6.9 | imidazole glycerol phosphate synthase subunit HisH (NCBI) | compare |
| b1130 | phoP | -5.1 | -6.9 | DNA-binding response regulator in two-component regulatory system with PhoQ (NCBI) | compare |
| b2913 | serA | -5.0 | -7.7 | D-3-phosphoglycerate dehydrogenase (NCBI) | compare |
| b3281 | aroE | -5.0 | -15.8 | dehydroshikimate reductase, NAD(P)-binding (NCBI) | compare |
| b2476 | purC | -5.0 | -4.8 | phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI) | compare |
| b0073 | leuB | -4.9 | -10.5 | 3-isopropylmalate dehydrogenase (VIMSS) | compare |
| b0072 | leuC | -4.9 | -12.7 | isopropylmalate isomerase large subunit (NCBI) | compare |
| b2022 | hisB | -4.9 | -8.8 | imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS) | compare |
| b4006 | purH | -4.9 | -12.6 | bifunctionalphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI) | compare |
| b1281 | pyrF | -4.9 | -4.7 | orotidine 5'-phosphate decarboxylase (NCBI) | compare |
| b2020 | hisD | -4.8 | -9.7 | histidinol dehydrogenase (NCBI) | compare |
| b2557 | purL | -4.8 | -9.7 | phosphoribosylformylglycinamidine synthase (NCBI) | compare |
| b0522 | purK | -4.7 | -9.1 | phosphoribosylaminoimidazole carboxylase (NCBI) | compare |
| b3774 | ilvC | -4.7 | -16.0 | ketol-acid reductoisomerase (NCBI) | compare |
| b1261 | trpB | -4.7 | -4.7 | tryptophan synthase subunit beta (NCBI) | compare |
| b3828 | metR | -4.7 | -12.8 | DNA-binding transcriptional activator, homocysteine-binding (NCBI) | compare |
| b3829 | metE | -4.6 | -17.2 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (NCBI) | compare |
| b0243 | proA | -4.6 | -10.7 | gamma-glutamyl phosphate reductase (NCBI) | compare |
| b3771 | ilvD | -4.6 | -13.8 | dihydroxy-acid dehydratase (NCBI) | compare |
| b3172 | argG | -4.6 | -11.8 | argininosuccinate synthase (NCBI) | compare |
| b0908 | aroA | -4.6 | -10.2 | 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) | compare |
| b0523 | purE | -4.5 | -5.4 | phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI) | compare |
| b2750 | cysC | -4.5 | -8.1 | adenylylsulfate kinase (NCBI) | compare |
| b2312 | purF | -4.5 | -8.5 | amidophosphoribosyltransferase (NCBI) | compare |
| b2329 | aroC | -4.5 | -6.1 | chorismate synthase (NCBI) | compare |
| b4005 | purD | -4.4 | -9.9 | phosphoribosylamine--glycine ligase (NCBI) | compare |
| b0741 | pal | -4.4 | -3.1 | peptidoglycan-associated outer membrane lipoprotein (NCBI) | compare |
| b2499 | purM | -4.4 | -7.3 | phosphoribosylaminoimidazole synthetase (NCBI) | compare |
| b2026 | hisI | -4.4 | -9.0 | bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI) | compare |
| b2188 | yejM | -4.4 | -11.6 | predicted hydrolase, inner membrane (NCBI) | compare |
| b2024 | hisA | -4.4 | -4.2 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-imidazolecarboxamide isomerase (VIMSS) | compare |
| b0074 | leuA | -4.3 | -11.2 | 2-isopropylmalate synthase (NCBI) | compare |
| b3941 | metF | -4.3 | -11.3 | 5,10-methylenetetrahydrofolate reductase (NCBI) | compare |
| b3960 | argH | -4.3 | -13.7 | argininosuccinate lyase (NCBI) | compare |
| b3213 | gltD | -4.2 | -12.1 | glutamate synthase, 4Fe-4S protein, small subunit (NCBI) | compare |
| b2600 | tyrA | -4.2 | -8.0 | fused chorismate mutase T/prephenate dehydrogenase (NCBI) | compare |
| b3642 | pyrE | -4.1 | -4.9 | orotate phosphoribosyltransferase (NCBI) | compare |
| b3212 | gltB | -4.1 | -20.7 | glutamate synthase, large subunit (NCBI) | compare |
| b2762 | cysH | -4.1 | -9.1 | phosphoadenosine phosphosulfate reductase (NCBI) | compare |
| b0386 | proC | -4.1 | -8.7 | pyrroline-5-carboxylate reductase (NCBI) | compare |
| b2414 | cysK | -4.1 | -12.8 | cysteine synthase A, O-acetylserine sulfhydrolase A subunit (NCBI) | compare |
| b0142 | folK | -4.1 | -2.5 | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) | compare |
| b0033 | carB | -4.0 | -16.6 | carbamoyl-phosphate synthase large subunit (NCBI) | compare |
| b0145 | dksA | -4.0 | -3.9 | DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) | compare |
| b3956 | ppc | -3.9 | -18.6 | phosphoenolpyruvate carboxylase (NCBI) | compare |
| b0002 | thrA | -3.9 | -15.5 | bifunctional aspartokinase I/homeserine dehydrogenase I (NCBI) | compare |
| b0737 | tolQ | -3.9 | -3.8 | membrane spanning protein in TolA-TolQ-TolR complex (NCBI) | compare |
| b0242 | proB | -3.9 | -7.9 | gamma-glutamyl kinase (NCBI) | compare |
| b4242 | mgtA | -3.9 | -20.1 | magnesium transporter (NCBI) | compare |
| b0945 | pyrD | -3.8 | -13.8 | dihydroorotate dehydrogenase (NCBI) | compare |
| b0739 | tolA | -3.8 | -4.5 | cell envelope integrity inner membrane protein TolA (NCBI) | compare |
| b0720 | gltA | -3.8 | -7.6 | citrate synthase (NCBI) | compare |
| b4214 | cysQ | -3.8 | -14.8 | PAPS (adenosine 3'-phosphate 5'-phosphosulfate) 3'(2'),5'-bisphosphate nucleotidase (NCBI) | compare |
| b1262 | trpC | -3.8 | -6.3 | N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase (VIMSS) | compare |
| b3958 | argC | -3.7 | -15.4 | N-acetyl-gamma-glutamyl-phosphate reductase (NCBI) | compare |
| b3770 | ilvE | -3.7 | -14.0 | branched-chain amino acid aminotransferase (NCBI) | compare |
| b4245 | pyrB | -3.6 | -12.4 | aspartate carbamoyltransferase catalytic subunit (NCBI) | compare |
| b0437 | clpP | -3.6 | -10.0 | ATP-dependent Clp protease proteolytic subunit (NCBI) | compare |
| b4702 | mgtL | -3.6 | -4.9 | regulatory leader peptide for mgtA (NCBI) | compare |
| b3728 | pstS | -3.6 | -3.5 | phosphate transporter subunit (NCBI) | compare |
| b0003 | thrB | -3.6 | -6.2 | homoserine kinase (NCBI) | compare |
| b0889 | lrp | -3.6 | -4.8 | DNA-binding transcriptional dual regulator, leucine-binding (NCBI) | compare |
| b0738 | tolR | -3.6 | -2.4 | membrane spanning protein in TolA-TolQ-TolR complex (NCBI) | compare |
| b3868 | glnG | -3.6 | -7.5 | fused DNA-binding response regulator in two-component regulatory system with GlnL: response regulator/sigma54 interaction protein (NCBI) | compare |
| b3772 | ilvA | -3.5 | -14.8 | threonine dehydratase (NCBI) | compare |
| b2599 | pheA | -3.5 | -8.1 | fused chorismate mutase P/prephenate dehydratase (NCBI) | compare |
| b3957 | argE | -3.5 | -15.7 | acetylornithine deacetylase (NCBI) | compare |
| b1062 | pyrC | -3.5 | -10.6 | dihydroorotase (NCBI) | compare |
| b0049 | apaH | -3.5 | -6.6 | diadenosinetetraphosphatase (NCBI) | compare |
| b4171 | miaA | -3.5 | -7.7 | tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) | compare |
| b2830 | nudH | -3.5 | -2.4 | dinucleoside polyphosphate hydrolase (NCBI) | compare |
| b0740 | tolB | -3.4 | -6.1 | translocation protein TolB precursor (NCBI) | compare |
| b2564 | pdxJ | -3.4 | -5.6 | pyridoxal phosphate biosynthetic protein (NCBI) | compare |
| b0131 | panD | -3.4 | -3.3 | aspartate 1-decarboxylase precursor (NCBI) | compare |
| b2501 | ppk | -3.4 | -12.4 | polyphosphate kinase (NCBI) | compare |
| b2818 | argA | -3.3 | -8.7 | N-acetylglutamate synthase (NCBI) | compare |
| b0052 | pdxA | -3.3 | -11.3 | 4-hydroxythreonine-4-phosphate dehydrogenase (NCBI) | compare |
| b3962 | udhA | -3.3 | -10.7 | putative oxidoreductase (VIMSS) | compare |
| b3082 | ygjM | -3.3 | -4.4 | predicted DNA-binding transcriptional regulator (NCBI) | compare |
| b3390 | aroK | -3.3 | -3.8 | shikimate kinase I (NCBI) | compare |
| b0032 | carA | -3.3 | -7.8 | carbamoyl-phosphate synthase small subunit (NCBI) | compare |
| b2839 | lysR | -3.3 | -7.8 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b2318 | truA | -3.1 | -5.9 | tRNA pseudouridine synthase A (NCBI) | compare |
| b3959 | argB | -3.1 | -12.6 | acetylglutamate kinase (RefSeq) | compare |
| b2764 | cysJ | -3.0 | -11.4 | sulfite reductase, alpha subunit, flavoprotein (NCBI) | compare |
| b0118 | acnB | -3.0 | -2.9 | aconitate hydratase (NCBI) | compare |
| b3916 | pfkA | -3.0 | -4.1 | 6-phosphofructokinase (NCBI) | compare |
| b0149 | mrcB | -3.0 | -14.5 | penicillin-binding protein 1b (NCBI) | compare |
| b1861 | ruvA | -2.9 | -3.9 | Holliday junction DNA helicase motor protein (NCBI) | compare |
| b3706 | trmE | -2.9 | -8.6 | tRNA modification GTPase (NCBI) | compare |
| b0438 | clpX | -2.9 | -9.5 | ATP-dependent protease ATP-binding subunit (NCBI) | compare |
| b3741 | gidA | -2.9 | -8.9 | glucose-inhibited division protein A (NCBI) | compare |
| b1273 | yciN | -2.8 | -3.3 | hypothetical protein (NCBI) | compare |
| b3204 | ptsN | -2.8 | -7.3 | sugar-specific enzyme IIA component of PTS (NCBI) | compare |
| b0726 | sucA | -2.7 | -3.7 | alpha-ketoglutarate decarboxylase (NCBI) | compare |
| b1863 | ruvC | -2.7 | -4.8 | Holliday junction resolvase (NCBI) | compare |
| b3459 | yhhK | -2.7 | -7.5 | hypothetical protein (NCBI) | compare |
| b3650 | spoT | -2.7 | -9.6 | bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase (NCBI) | compare |
| b1263 | trpD | -2.7 | -4.0 | bifunctional indole-3-glycerol-phosphate synthase/anthranilate phosphoribosyltransferase (NCBI) | compare |
| b3725 | pstB | -2.7 | -1.9 | phosphate transporter subunit (NCBI) | compare |
| b2763 | cysI | -2.7 | -9.7 | sulfite reductase, beta subunit, NAD(P)-binding, heme-binding (NCBI) | compare |
| b2320 | pdxB | -2.6 | -8.1 | erythronate-4-phosphate dehydrogenase (NCBI) | compare |
| b1264 | trpE | -2.6 | -4.8 | anthranilate synthase component I (NCBI) | compare |
| b3035 | tolC | -2.5 | -11.0 | outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) | compare |
| b0114 | aceE | -2.5 | -3.3 | pyruvate dehydrogenase subunit E1 (NCBI) | compare |
| b4177 | purA | -2.4 | -2.3 | adenylosuccinate synthetase (NCBI) | compare |
| b3764 | yifE | -2.4 | -6.6 | hypothetical protein (NCBI) | compare |
| b0077 | ilvI | -2.4 | -9.6 | acetolactate synthase III large subunit (NCBI) | compare |
| b3869 | glnL | -2.4 | -10.0 | sensory histidine kinase in two-component regulatory system with GlnG (NCBI) | compare |
| b3386 | rpe | -2.3 | -1.6 | ribulose-phosphate 3-epimerase (NCBI) | compare |
| b3368 | cysG | -2.3 | -15.3 | fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase (NCBI) | compare |
| b0200 | gmhB | -2.3 | -2.2 | hypothetical protein (NCBI) | compare |
| b3236 | mdh | -2.3 | -9.0 | malate dehydrogenase (NCBI) | compare |
| b3844 | fre | -2.3 | -7.3 | NAD(P)H-flavin reductase (NCBI) | compare |
| b0451 | amtB | -2.2 | -8.2 | ammonium transporter (NCBI) | conserved |
| b0133 | panC | -2.2 | -8.6 | pantoate--beta-alanine ligase (NCBI) | compare |
| b1712 | ihfA | -2.2 | -4.5 | integration host factor subunit alpha (NCBI) | compare |
| b3405 | ompR | -2.2 | -5.9 | osmolarity response regulator (NCBI) | compare |
| b2820 | recB | -2.2 | -2.9 | exonuclease V (RecBCD complex), beta subunit (NCBI) | compare |
| b0928 | aspC | -2.2 | -7.7 | aspartate aminotransferase, PLP-dependent (NCBI) | compare |
| b0078 | ilvH | -2.2 | -9.3 | acetolactate synthase small subunit (NCBI) | compare |
| b3781 | trxA | -2.1 | -4.9 | thioredoxin 1 (VIMSS) | compare |
| b3870 | glnA | -2.1 | -3.1 | glutamine synthetase (NCBI) | compare |
| b2751 | cysN | -2.1 | -7.9 | sulfate adenylyltransferase subunit 1 (NCBI) | compare |
| b0439 | lon | -2.1 | -6.8 | DNA-binding ATP-dependent protease La (NCBI) | compare |
| b1850 | eda | -2.1 | -3.4 | keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) | compare |
| b0890 | ftsK | -2.1 | -8.2 | DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) | compare |
| b4025 | pgi | -2.1 | -9.5 | glucose-6-phosphate isomerase (NCBI) | compare |
| b3619 | rfaD | -2.0 | -4.8 | ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) | compare |
| b3671 | ilvB | -2.0 | -11.9 | acetolactate synthase large subunit (NCBI) | compare |
| b0167 | glnD | -2.0 | -5.0 | PII uridylyl-transferase (NCBI) | compare |
| b1189 | dadA | -2.0 | -8.1 | D-amino acid dehydrogenase (quinone) DadA (EC 1.4.5.1) (from data) | conserved |
| b3811 | xerC | -2.0 | -3.2 | site-specific tyrosine recombinase XerC (NCBI) | compare |
| b3398 | yrfF | -2.0 | -4.5 | predicted inner membrane protein (NCBI) | compare |
| b2479 | gcvR | -2.0 | -5.5 | transcriptional regulation of gcv operon (VIMSS) | compare |
| b0222 | lpcA | -1.9 | -3.8 | phosphoheptose isomerase (NCBI) | compare |
| b0134 | panB | -1.9 | -7.1 | 3-methyl-2-oxobutanoate hydroxymethyltransferase (NCBI) | compare |
| b3726 | pstA | -1.9 | -5.9 | phosphate transporter subunit (NCBI) | compare |
| b0450 | glnK | -1.9 | -3.7 | nitrogen assimilation regulatory protein for GlnL, GlnE, and AmtB (NCBI) | compare |
| b2055 | wcaE | -1.9 | -3.2 | predicted glycosyl transferase (NCBI) | compare |
| b2340 | sixA | -1.9 | -4.6 | phosphohistidine phosphatase (NCBI) | compare |
| b0113 | pdhR | -1.9 | -4.9 | transcriptional regulator of pyruvate dehydrogenase complex (NCBI) | compare |
| b3620 | rfaF | -1.9 | -5.6 | ADP-heptose:LPS heptosyltransferase II (NCBI) | compare |
| b1257 | yciE | -1.8 | -3.0 | hypothetical protein (NCBI) | compare |
| b2752 | cysD | -1.8 | -6.3 | sulfate adenylyltransferase subunit 2 (NCBI) | compare |
| b3052 | rfaE | -1.8 | -6.1 | fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) | compare |
| b0053 | surA | -1.8 | -6.1 | peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) | compare |
| b0683 | fur | -1.8 | -2.4 | ferric uptake regulator (NCBI) | compare |
| b2784 | relA | -1.8 | -9.9 | (p)ppGpp synthetase I/GTP pyrophosphokinase (NCBI) | compare |
| b4480 | hdfR | -1.7 | -5.4 | transcriptional regulator HdfR (NCBI) | compare |
| b3621 | rfaC | -1.7 | -6.2 | ADP-heptose:LPS heptosyl transferase I (NCBI) | compare |
| b0500 | ybbD | -1.7 | -2.8 | hypothetical protein (RefSeq) | compare |
| b3008 | metC | -1.7 | -8.6 | cystathionine beta-lyase (NCBI) | compare |
| b2567 | rnc | -1.7 | -1.9 | ribonuclease III (NCBI) | compare |
| b2422 | cysA | -1.7 | -6.9 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b3290 | trkA | -1.6 | -3.2 | potassium transporter peripheral membrane component (NCBI) | compare |
| b1138 | ymfE | -1.6 | -2.3 | e14 prophage; predicted inner membrane protein (NCBI) | compare |
| b3483 | yhhH | -1.6 | -2.2 | orf, hypothetical protein (VIMSS) | compare |
| b2620 | smpB | -1.6 | -2.8 | SsrA-binding protein (NCBI) | compare |
| b3469 | zntA | -1.6 | -10.3 | zinc, cobalt and lead efflux system (NCBI) | compare |
| b1105 | ycfM | -1.5 | -3.6 | predicted outer membrane lipoprotein (NCBI) | compare |
| b0767 | ybhE | -1.5 | -4.2 | 6-phosphogluconolactonase (NCBI) | compare |
| b2518 | ndk | -1.5 | -2.0 | nucleoside diphosphate kinase (NCBI) | compare |
| b0075 | leuL | -1.5 | -3.4 | leu operon leader peptide (NCBI) | compare |
| b2935 | tktA | -1.5 | -3.4 | transketolase 1, thiamin-binding (NCBI) | compare |
| b0912 | ihfB | -1.5 | -4.2 | integration host factor subunit beta (NCBI) | compare |
| b1476 | fdnI | -1.5 | -2.2 | formate dehydrogenase-N, cytochrome B556 (gamma) subunit, nitrate-inducible (NCBI) | compare |
| b1830 | prc | -1.5 | -6.1 | carboxy-terminal protease for penicillin-binding protein 3 (NCBI) | compare |
| b1084 | rne | -1.4 | -5.4 | fused ribonucleaseE: endoribonuclease/RNA-binding protein/RNA degradosome binding protein (NCBI) | compare |
| b0592 | fepB | -1.4 | -7.2 | iron-enterobactin transporter subunit (NCBI) | compare |
| b0589 | fepG | -1.4 | -6.8 | iron-enterobactin transporter subunit (NCBI) | compare |
| b0674 | asnB | -1.4 | -8.7 | asparagine synthetase B (NCBI) | compare |
| b3670 | ilvN | -1.4 | -4.9 | acetolactate synthase small subunit (NCBI) | compare |
| b1291 | sapD | -1.4 | -2.3 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b2330 | yfcB | -1.4 | -2.8 | putative adenine-specific methylase (VIMSS) | compare |
| b3121 | yhaC | -1.4 | -2.0 | hypothetical protein (NCBI) | compare |
| b3672 | ivbL | -1.4 | -3.2 | ilvB operon leader peptide (NCBI) | compare |
| b4279 | yjhB | -1.4 | -3.2 | putative transport protein (VIMSS) | compare |
| b3026 | qseC | -1.3 | -5.1 | sensory histidine kinase in two-component regulatory system with QseB (NCBI) | compare |
| b1860 | ruvB | -1.3 | -1.7 | Holliday junction DNA helicase B (NCBI) | compare |
| b1865 | nudB | -1.3 | -2.0 | dATP pyrophosphohydrolase (NCBI) | compare |
| b0588 | fepC | -1.3 | -6.7 | iron-enterobactin transporter subunit (NCBI) | compare |
| b3993 | thiE | -1.3 | -5.5 | thiamine-phosphate pyrophosphorylase (NCBI) | compare |
| b3387 | dam | -1.3 | -9.1 | DNA adenine methylase (NCBI) | compare |
| b3991 | thiG | -1.3 | -6.4 | thiamin biosynthesis, thiazole moiety (VIMSS) | compare |
| b3761 | trpT | -1.3 | -2.1 | tRNA-Trp (NCBI) | compare |
| b3773 | ilvY | -1.3 | -6.9 | DNA-binding transcriptional dual regulator (NCBI) | compare |