| | gene | name | fitness | t score | description | |
|---|
| b2476 | purC | -7.1 | -4.9 | phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI) | compare |
| b1261 | trpB | -6.7 | -4.6 | tryptophan synthase subunit beta (NCBI) | compare |
| b2025 | hisF | -6.0 | -5.8 | imidazole glycerol phosphate synthase subunit HisF (NCBI) | compare |
| b1105 | ycfM | -5.9 | -4.0 | predicted outer membrane lipoprotein (NCBI) | compare |
| b0907 | serC | -5.8 | -8.0 | phosphoserine aminotransferase (NCBI) | compare |
| b1192 | ldcA | -5.8 | -4.0 | L,D-carboxypeptidase A (NCBI) | compare |
| b2023 | hisH | -5.8 | -5.6 | imidazole glycerol phosphate synthase subunit HisH (NCBI) | compare |
| b3774 | ilvC | -5.5 | -12.3 | ketol-acid reductoisomerase (NCBI) | compare |
| b2022 | hisB | -5.4 | -7.4 | imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS) | compare |
| b2020 | hisD | -5.4 | -10.4 | histidinol dehydrogenase (NCBI) | compare |
| b4245 | pyrB | -5.3 | -11.9 | aspartate carbamoyltransferase catalytic subunit (NCBI) | compare |
| b0072 | leuC | -5.3 | -12.3 | isopropylmalate isomerase large subunit (NCBI) | compare |
| b0242 | proB | -5.2 | -7.2 | gamma-glutamyl kinase (NCBI) | compare |
| b2501 | ppk | -5.2 | -8.7 | polyphosphate kinase (NCBI) | compare |
| b3281 | aroE | -5.2 | -15.2 | dehydroshikimate reductase, NAD(P)-binding (NCBI) | compare |
| b4388 | serB | -5.1 | -6.1 | 3-phosphoserine phosphatase (NCBI) | compare |
| b0523 | purE | -5.1 | -4.9 | phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI) | compare |
| b1130 | phoP | -5.0 | -6.9 | DNA-binding response regulator in two-component regulatory system with PhoQ (NCBI) | compare |
| b0078 | ilvH | -5.0 | -11.7 | acetolactate synthase small subunit (NCBI) | compare |
| b2499 | purM | -5.0 | -5.9 | phosphoribosylaminoimidazole synthetase (NCBI) | compare |
| b0073 | leuB | -5.0 | -10.6 | 3-isopropylmalate dehydrogenase (VIMSS) | compare |
| b0071 | leuD | -4.9 | -7.5 | isopropylmalate isomerase small subunit (NCBI) | compare |
| b0033 | carB | -4.9 | -15.5 | carbamoyl-phosphate synthase large subunit (NCBI) | compare |
| b3770 | ilvE | -4.9 | -12.3 | branched-chain amino acid aminotransferase (NCBI) | compare |
| b0032 | carA | -4.9 | -9.3 | carbamoyl-phosphate synthase small subunit (NCBI) | compare |
| b0074 | leuA | -4.9 | -10.4 | 2-isopropylmalate synthase (NCBI) | compare |
| b0908 | aroA | -4.8 | -9.7 | 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) | compare |
| b3771 | ilvD | -4.8 | -13.5 | dihydroxy-acid dehydratase (NCBI) | compare |
| b1129 | phoQ | -4.7 | -9.1 | sensory histidine kinase in two-compoent regulatory system with PhoP (NCBI) | compare |
| b0149 | mrcB | -4.7 | -10.1 | penicillin-binding protein 1b (NCBI) | compare |
| b0052 | pdxA | -4.7 | -9.6 | 4-hydroxythreonine-4-phosphate dehydrogenase (NCBI) | compare |
| b3389 | aroB | -4.7 | -12.9 | 3-dehydroquinate synthase (NCBI) | compare |
| b3941 | metF | -4.7 | -12.0 | 5,10-methylenetetrahydrofolate reductase (NCBI) | compare |
| b0522 | purK | -4.6 | -9.4 | phosphoribosylaminoimidazole carboxylase (NCBI) | compare |
| b2913 | serA | -4.5 | -9.2 | D-3-phosphoglycerate dehydrogenase (NCBI) | compare |
| b0145 | dksA | -4.5 | -3.1 | DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) | compare |
| b0243 | proA | -4.5 | -10.1 | gamma-glutamyl phosphate reductase (NCBI) | compare |
| b2021 | hisC | -4.5 | -6.1 | histidinol-phosphate aminotransferase (NCBI) | compare |
| b2312 | purF | -4.5 | -8.5 | amidophosphoribosyltransferase (NCBI) | compare |
| b2762 | cysH | -4.4 | -8.5 | phosphoadenosine phosphosulfate reductase (NCBI) | compare |
| b3172 | argG | -4.4 | -11.8 | argininosuccinate synthase (NCBI) | compare |
| b1260 | trpA | -4.4 | -5.1 | tryptophan synthase subunit alpha (NCBI) | compare |
| b0077 | ilvI | -4.4 | -12.3 | acetolactate synthase III large subunit (NCBI) | compare |
| b4005 | purD | -4.4 | -10.1 | phosphoribosylamine--glycine ligase (NCBI) | compare |
| b1263 | trpD | -4.4 | -4.2 | bifunctional indole-3-glycerol-phosphate synthase/anthranilate phosphoribosyltransferase (NCBI) | compare |
| b2320 | pdxB | -4.4 | -10.1 | erythronate-4-phosphate dehydrogenase (NCBI) | compare |
| b1712 | ihfA | -4.3 | -5.1 | integration host factor subunit alpha (NCBI) | compare |
| b3960 | argH | -4.3 | -13.1 | argininosuccinate lyase (NCBI) | compare |
| b1693 | aroD | -4.3 | -9.2 | 3-dehydroquinate dehydratase (NCBI) | compare |
| b2329 | aroC | -4.3 | -6.6 | chorismate synthase (NCBI) | compare |
| b2784 | relA | -4.3 | -12.1 | (p)ppGpp synthetase I/GTP pyrophosphokinase (NCBI) | compare |
| b3642 | pyrE | -4.3 | -5.1 | orotate phosphoribosyltransferase (NCBI) | compare |
| b0004 | thrC | -4.3 | -9.9 | threonine synthase (NCBI) | compare |
| b4006 | purH | -4.2 | -13.6 | bifunctionalphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI) | compare |
| b2026 | hisI | -4.2 | -9.4 | bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI) | compare |
| b0003 | thrB | -4.2 | -10.0 | homoserine kinase (NCBI) | compare |
| b2564 | pdxJ | -4.2 | -4.1 | pyridoxal phosphate biosynthetic protein (NCBI) | compare |
| b2188 | yejM | -4.2 | -12.0 | predicted hydrolase, inner membrane (NCBI) | compare |
| b2838 | lysA | -4.1 | -11.3 | diaminopimelate decarboxylase, PLP-binding (NCBI) | compare |
| b0142 | folK | -4.1 | -2.3 | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) | compare |
| b2818 | argA | -4.1 | -10.4 | N-acetylglutamate synthase (NCBI) | compare |
| b3828 | metR | -4.0 | -12.8 | DNA-binding transcriptional activator, homocysteine-binding (NCBI) | compare |
| b0049 | apaH | -4.0 | -6.7 | diadenosinetetraphosphatase (NCBI) | compare |
| b2557 | purL | -4.0 | -11.5 | phosphoribosylformylglycinamidine synthase (NCBI) | compare |
| b0437 | clpP | -4.0 | -10.2 | ATP-dependent Clp protease proteolytic subunit (NCBI) | compare |
| b4171 | miaA | -4.0 | -6.6 | tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) | compare |
| b0945 | pyrD | -3.9 | -13.6 | dihydroorotate dehydrogenase (NCBI) | compare |
| b3829 | metE | -3.9 | -17.2 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (NCBI) | compare |
| b0386 | proC | -3.8 | -8.9 | pyrroline-5-carboxylate reductase (NCBI) | compare |
| b3213 | gltD | -3.8 | -12.2 | glutamate synthase, 4Fe-4S protein, small subunit (NCBI) | compare |
| b3956 | ppc | -3.8 | -18.3 | phosphoenolpyruvate carboxylase (NCBI) | compare |
| b3957 | argE | -3.7 | -15.3 | acetylornithine deacetylase (NCBI) | compare |
| b2750 | cysC | -3.7 | -7.6 | adenylylsulfate kinase (NCBI) | compare |
| b0741 | pal | -3.7 | -5.0 | peptidoglycan-associated outer membrane lipoprotein (NCBI) | compare |
| b1281 | pyrF | -3.6 | -4.3 | orotidine 5'-phosphate decarboxylase (NCBI) | compare |
| b1062 | pyrC | -3.6 | -10.4 | dihydroorotase (NCBI) | compare |
| b3958 | argC | -3.6 | -15.2 | N-acetyl-gamma-glutamyl-phosphate reductase (NCBI) | compare |
| b3212 | gltB | -3.6 | -19.8 | glutamate synthase, large subunit (NCBI) | compare |
| b0740 | tolB | -3.6 | -6.0 | translocation protein TolB precursor (NCBI) | compare |
| b2364 | dsdC | -3.6 | -8.9 | DNA-binding transcriptional dual regulator (NCBI) | conserved |
| b3962 | udhA | -3.6 | -10.1 | putative oxidoreductase (VIMSS) | compare |
| b0737 | tolQ | -3.6 | -4.2 | membrane spanning protein in TolA-TolQ-TolR complex (NCBI) | compare |
| b2024 | hisA | -3.5 | -3.1 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-imidazolecarboxamide isomerase (VIMSS) | compare |
| b3728 | pstS | -3.5 | -3.4 | phosphate transporter subunit (NCBI) | compare |
| b0720 | gltA | -3.5 | -7.7 | citrate synthase (NCBI) | compare |
| b2019 | hisG | -3.5 | -4.8 | ATP phosphoribosyltransferase (NCBI) | compare |
| b0889 | lrp | -3.5 | -4.7 | DNA-binding transcriptional dual regulator, leucine-binding (NCBI) | compare |
| b3390 | aroK | -3.5 | -4.0 | shikimate kinase I (NCBI) | compare |
| b0767 | ybhE | -3.4 | -5.7 | 6-phosphogluconolactonase (NCBI) | compare |
| b4214 | cysQ | -3.4 | -13.9 | PAPS (adenosine 3'-phosphate 5'-phosphosulfate) 3'(2'),5'-bisphosphate nucleotidase (NCBI) | compare |
| b2414 | cysK | -3.4 | -12.2 | cysteine synthase A, O-acetylserine sulfhydrolase A subunit (NCBI) | compare |
| b2366 | dsdA | -3.4 | -7.7 | D-serine dehydratase (NCBI) | conserved |
| b1865 | nudB | -3.3 | -3.1 | dATP pyrophosphohydrolase (NCBI) | compare |
| b0738 | tolR | -3.3 | -3.2 | membrane spanning protein in TolA-TolQ-TolR complex (NCBI) | compare |
| b3741 | gidA | -3.3 | -7.3 | glucose-inhibited division protein A (NCBI) | compare |
| b0726 | sucA | -3.2 | -2.2 | alpha-ketoglutarate decarboxylase (NCBI) | compare |
| b2600 | tyrA | -3.2 | -6.1 | fused chorismate mutase T/prephenate dehydrogenase (NCBI) | compare |
| b3959 | argB | -3.2 | -11.7 | acetylglutamate kinase (RefSeq) | compare |
| b0912 | ihfB | -3.1 | -5.8 | integration host factor subunit beta (NCBI) | compare |
| b3706 | trmE | -3.1 | -8.7 | tRNA modification GTPase (NCBI) | compare |
| b3772 | ilvA | -3.0 | -14.1 | threonine dehydratase (NCBI) | compare |
| b3204 | ptsN | -3.0 | -7.1 | sugar-specific enzyme IIA component of PTS (NCBI) | compare |
| b2894 | xerD | -2.9 | -2.0 | site-specific tyrosine recombinase XerD (NCBI) | compare |
| b2830 | nudH | -2.9 | -2.8 | dinucleoside polyphosphate hydrolase (NCBI) | compare |
| b4242 | mgtA | -2.9 | -17.6 | magnesium transporter (NCBI) | compare |
| b0739 | tolA | -2.9 | -5.1 | cell envelope integrity inner membrane protein TolA (NCBI) | compare |
| b3650 | spoT | -2.9 | -9.4 | bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase (NCBI) | compare |
| b2752 | cysD | -2.7 | -6.0 | sulfate adenylyltransferase subunit 2 (NCBI) | compare |
| b2567 | rnc | -2.7 | -1.8 | ribonuclease III (NCBI) | compare |
| b0134 | panB | -2.7 | -6.9 | 3-methyl-2-oxobutanoate hydroxymethyltransferase (NCBI) | compare |
| b0002 | thrA | -2.7 | -13.3 | bifunctional aspartokinase I/homeserine dehydrogenase I (NCBI) | compare |
| b0928 | aspC | -2.6 | -8.3 | aspartate aminotransferase, PLP-dependent (NCBI) | compare |
| b0133 | panC | -2.6 | -9.2 | pantoate--beta-alanine ligase (NCBI) | compare |
| b3870 | glnA | -2.6 | -2.5 | glutamine synthetase (NCBI) | compare |
| b1830 | prc | -2.6 | -8.2 | carboxy-terminal protease for penicillin-binding protein 3 (NCBI) | compare |
| b3916 | pfkA | -2.6 | -4.6 | 6-phosphofructokinase (NCBI) | compare |
| b1702 | pps | -2.5 | -10.4 | phosphoenolpyruvate synthase (NCBI) | compare |
| b2479 | gcvR | -2.5 | -5.8 | transcriptional regulation of gcv operon (VIMSS) | compare |
| b4177 | purA | -2.5 | -1.7 | adenylosuccinate synthetase (NCBI) | compare |
| b0113 | pdhR | -2.5 | -5.5 | transcriptional regulator of pyruvate dehydrogenase complex (NCBI) | compare |
| b0075 | leuL | -2.4 | -5.6 | leu operon leader peptide (NCBI) | compare |
| b3459 | yhhK | -2.4 | -7.1 | hypothetical protein (NCBI) | compare |
| b0131 | panD | -2.3 | -4.6 | aspartate 1-decarboxylase precursor (NCBI) | compare |
| b0118 | acnB | -2.3 | -3.8 | aconitate hydratase (NCBI) | compare |
| b3613 | yibP | -2.3 | -6.5 | putative membrane protein (VIMSS) | compare |
| b3386 | rpe | -2.3 | -1.6 | ribulose-phosphate 3-epimerase (NCBI) | compare |
| b3290 | trkA | -2.3 | -3.1 | potassium transporter peripheral membrane component (NCBI) | compare |
| b1264 | trpE | -2.3 | -4.3 | anthranilate synthase component I (NCBI) | compare |
| b2764 | cysJ | -2.2 | -8.4 | sulfite reductase, alpha subunit, flavoprotein (NCBI) | compare |
| b3781 | trxA | -2.2 | -4.9 | thioredoxin 1 (VIMSS) | compare |
| b1860 | ruvB | -2.2 | -2.5 | Holliday junction DNA helicase B (NCBI) | compare |
| b3939 | metB | -2.2 | -10.9 | cystathionine gamma-synthase (NCBI) | compare |
| b3863 | polA | -2.2 | -1.5 | DNA polymerase I (NCBI) | compare |
| b1262 | trpC | -2.1 | -3.6 | N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase (VIMSS) | compare |
| b2763 | cysI | -2.1 | -8.6 | sulfite reductase, beta subunit, NAD(P)-binding, heme-binding (NCBI) | compare |
| b3008 | metC | -2.1 | -10.5 | cystathionine beta-lyase (NCBI) | compare |
| b0114 | aceE | -2.1 | -3.6 | pyruvate dehydrogenase subunit E1 (NCBI) | compare |
| b0888 | trxB | -2.1 | -4.2 | thioredoxin reductase, FAD/NAD(P)-binding (NCBI) | compare |
| b1290 | sapF | -2.0 | -3.3 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b0200 | gmhB | -2.0 | -2.3 | hypothetical protein (NCBI) | compare |
| b3868 | glnG | -2.0 | -6.6 | fused DNA-binding response regulator in two-component regulatory system with GlnL: response regulator/sigma54 interaction protein (NCBI) | compare |
| b2340 | sixA | -2.0 | -5.7 | phosphohistidine phosphatase (NCBI) | compare |
| b2935 | tktA | -2.0 | -4.0 | transketolase 1, thiamin-binding (NCBI) | compare |
| b3992 | thiF | -2.0 | -9.5 | thiamin biosynthesis, thiazole moiety (VIMSS) | compare |
| b3725 | pstB | -2.0 | -2.6 | phosphate transporter subunit (NCBI) | compare |
| b1942 | fliJ | -2.0 | -2.2 | flagellar biosynthesis chaperone (NCBI) | compare |
| b3368 | cysG | -1.9 | -13.4 | fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase (NCBI) | compare |
| b3169 | nusA | -1.9 | -3.6 | transcription elongation factor NusA (NCBI) | compare |
| b2599 | pheA | -1.9 | -3.9 | fused chorismate mutase P/prephenate dehydratase (NCBI) | compare |
| b0890 | ftsK | -1.9 | -7.9 | DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) | compare |
| b1292 | sapC | -1.8 | -3.4 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b3121 | yhaC | -1.8 | -2.4 | hypothetical protein (NCBI) | compare |
| b2839 | lysR | -1.8 | -6.3 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b3764 | yifE | -1.8 | -4.4 | hypothetical protein (NCBI) | compare |
| b2103 | thiD | -1.8 | -5.8 | phosphomethylpyrimidine kinase (NCBI) | compare |
| b3849 | trkH | -1.7 | -10.3 | potassium transporter (NCBI) | compare |
| b0580 | ybdJ | -1.7 | -2.3 | predicted inner membrane protein (NCBI) | compare |
| b3993 | thiE | -1.7 | -6.4 | thiamine-phosphate pyrophosphorylase (NCBI) | compare |
| b3469 | zntA | -1.6 | -10.6 | zinc, cobalt and lead efflux system (NCBI) | compare |
| b4013 | metA | -1.6 | -4.0 | homoserine O-succinyltransferase (NCBI) | compare |
| b3994 | thiC | -1.6 | -10.8 | thiamine biosynthesis protein ThiC (NCBI) | compare |
| b3726 | pstA | -1.6 | -4.9 | phosphate transporter subunit (NCBI) | compare |
| b0438 | clpX | -1.6 | -7.5 | ATP-dependent protease ATP-binding subunit (NCBI) | compare |
| b3811 | xerC | -1.6 | -3.1 | site-specific tyrosine recombinase XerC (NCBI) | compare |
| b2318 | truA | -1.6 | -4.5 | tRNA pseudouridine synthase A (NCBI) | compare |
| b1827 | kdgR | -1.6 | -3.0 | predicted DNA-binding transcriptional regulator (NCBI) | compare |
| b1863 | ruvC | -1.6 | -3.7 | Holliday junction resolvase (NCBI) | compare |
| b3292 | zntR | -1.6 | -5.4 | zinc-responsive transcriptional regulator (NCBI) | compare |
| b3483 | yhhH | -1.5 | -2.0 | orf, hypothetical protein (VIMSS) | compare |
| b1273 | yciN | -1.5 | -1.7 | hypothetical protein (NCBI) | compare |
| b4702 | mgtL | -1.5 | -3.5 | regulatory leader peptide for mgtA (NCBI) | compare |
| b4585 | sroB | -1.5 | -1.7 | Novel sRNA, function unknown (RefSeq) | compare |
| b3990 | thiH | -1.5 | -7.8 | thiamine biosynthesis protein ThiH (NCBI) | compare |
| b4246 | pyrL | -1.5 | -2.7 | pyrBI operon leader peptide (NCBI) | compare |
| b4480 | hdfR | -1.5 | -5.0 | transcriptional regulator HdfR (NCBI) | compare |
| b3773 | ilvY | -1.5 | -5.3 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b1101 | ptsG | -1.5 | -8.9 | fused glucose-specific PTS enzymes: IIB component/IIC component (NCBI) | compare |
| b0630 | lipB | -1.4 | -2.1 | protein of lipoate biosynthesis (VIMSS) | compare |
| b4451 | ryhB | -1.4 | -1.9 | Regulatory sRNA mediating positive Fur regulon response; requires Hfq for function; global iron regulator; degraded by RNase E when bound to target (RefSeq) | compare |
| b1861 | ruvA | -1.4 | -2.1 | Holliday junction DNA helicase motor protein (NCBI) | compare |
| b3082 | ygjM | -1.4 | -2.5 | predicted DNA-binding transcriptional regulator (NCBI) | compare |
| b2820 | recB | -1.4 | -2.2 | exonuclease V (RecBCD complex), beta subunit (NCBI) | compare |
| b2751 | cysN | -1.4 | -5.3 | sulfate adenylyltransferase subunit 1 (NCBI) | compare |
| b2330 | yfcB | -1.4 | -2.7 | putative adenine-specific methylase (VIMSS) | compare |
| b3991 | thiG | -1.4 | -6.6 | thiamin biosynthesis, thiazole moiety (VIMSS) | compare |
| b4202 | rpsR | -1.3 | -2.3 | 30S ribosomal protein S18 (NCBI) | compare |
| b3671 | ilvB | -1.3 | -8.9 | acetolactate synthase large subunit (NCBI) | compare |
| b0439 | lon | -1.3 | -5.2 | DNA-binding ATP-dependent protease La (NCBI) | compare |
| b4407 | thiS | -1.3 | -2.1 | sulfur carrier protein ThiS (NCBI) | compare |
| b3247 | cafA | -1.3 | -8.6 | bundles of cytoplasmic filaments (VIMSS) | compare |
| b0092 | ddlB | -1.3 | -4.9 | D-alanylalanine synthetase (NCBI) | compare |
| b1167 | ymgC | -1.3 | -1.8 | hypothetical protein (NCBI) | compare |
| b4025 | pgi | -1.3 | -6.8 | glucose-6-phosphate isomerase (NCBI) | compare |
| b1602 | pntB | -1.2 | -5.9 | pyridine nucleotide transhydrogenase (NCBI) | compare |
| b2029 | gnd | -1.2 | -6.7 | 6-phosphogluconate dehydrogenase (NCBI) | compare |
| b2297 | pta | -1.2 | -2.2 | phosphate acetyltransferase (NCBI) | compare |
| b0423 | thiI | -1.2 | -4.9 | thiamine biosynthesis protein ThiI (NCBI) | compare |
| b1603 | pntA | -1.2 | -4.0 | NAD(P) transhydrogenase subunit alpha (NCBI) | compare |
| b2055 | wcaE | -1.2 | -3.6 | predicted glycosyl transferase (NCBI) | compare |
| b3163 | nlpI | -1.2 | -4.1 | hypothetical protein (NCBI) | compare |