| | gene | name | fitness | t score | description | |
|---|
| b2020 | hisD | -4.9 | -6.7 | histidinol dehydrogenase (NCBI) | compare |
| b0523 | purE | -4.6 | -3.2 | phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI) | compare |
| b1281 | pyrF | -4.6 | -3.2 | orotidine 5'-phosphate decarboxylase (NCBI) | compare |
| b2023 | hisH | -4.6 | -4.5 | imidazole glycerol phosphate synthase subunit HisH (NCBI) | compare |
| b2838 | lysA | -4.5 | -5.3 | diaminopimelate decarboxylase, PLP-binding (NCBI) | compare |
| b2022 | hisB | -4.4 | -6.0 | imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS) | compare |
| b0907 | serC | -4.4 | -7.3 | phosphoserine aminotransferase (NCBI) | compare |
| b1261 | trpB | -4.3 | -4.2 | tryptophan synthase subunit beta (NCBI) | compare |
| b0450 | glnK | -4.2 | -2.9 | nitrogen assimilation regulatory protein for GlnL, GlnE, and AmtB (NCBI) | compare |
| b1693 | aroD | -4.0 | -6.6 | 3-dehydroquinate dehydratase (NCBI) | compare |
| b4006 | purH | -4.0 | -9.3 | bifunctionalphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI) | compare |
| b3770 | ilvE | -4.0 | -9.6 | branched-chain amino acid aminotransferase (NCBI) | compare |
| b1192 | ldcA | -3.8 | -4.5 | L,D-carboxypeptidase A (NCBI) | compare |
| b1130 | phoP | -3.8 | -5.2 | DNA-binding response regulator in two-component regulatory system with PhoQ (NCBI) | compare |
| b3941 | metF | -3.8 | -9.8 | 5,10-methylenetetrahydrofolate reductase (NCBI) | compare |
| b2312 | purF | -3.8 | -6.3 | amidophosphoribosyltransferase (NCBI) | compare |
| b1260 | trpA | -3.8 | -5.7 | tryptophan synthase subunit alpha (NCBI) | compare |
| b3642 | pyrE | -3.7 | -2.6 | orotate phosphoribosyltransferase (NCBI) | compare |
| b3829 | metE | -3.7 | -12.7 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (NCBI) | compare |
| b4005 | purD | -3.7 | -7.1 | phosphoribosylamine--glycine ligase (NCBI) | compare |
| b1748 | astC | -3.7 | -6.1 | succinylornithine transaminase, PLP-dependent (NCBI) | conserved |
| b0386 | proC | -3.7 | -5.0 | pyrroline-5-carboxylate reductase (NCBI) | compare |
| b2499 | purM | -3.7 | -4.3 | phosphoribosylaminoimidazole synthetase (NCBI) | compare |
| b2024 | hisA | -3.6 | -3.3 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-imidazolecarboxamide isomerase (VIMSS) | compare |
| b4388 | serB | -3.6 | -5.5 | 3-phosphoserine phosphatase (NCBI) | compare |
| b0088 | murD | -3.6 | -3.5 | UDP-N-acetylmuramoyl-L-alanyl-D-glutamatesynthetase (NCBI) | compare |
| b0522 | purK | -3.6 | -6.8 | phosphoribosylaminoimidazole carboxylase (NCBI) | compare |
| b2025 | hisF | -3.5 | -5.3 | imidazole glycerol phosphate synthase subunit HisF (NCBI) | compare |
| b2021 | hisC | -3.5 | -5.3 | histidinol-phosphate aminotransferase (NCBI) | compare |
| b3828 | metR | -3.5 | -10.0 | DNA-binding transcriptional activator, homocysteine-binding (NCBI) | compare |
| b2188 | yejM | -3.4 | -8.3 | predicted hydrolase, inner membrane (NCBI) | compare |
| b1745 | astB | -3.4 | -6.4 | succinylarginine dihydrolase (NCBI) | conserved |
| b0004 | thrC | -3.4 | -7.2 | threonine synthase (NCBI) | compare |
| b1747 | astA | -3.4 | -7.3 | arginine succinyltransferase (NCBI) | conserved |
| b1129 | phoQ | -3.4 | -7.2 | sensory histidine kinase in two-compoent regulatory system with PhoP (NCBI) | compare |
| b3281 | aroE | -3.4 | -13.2 | dehydroshikimate reductase, NAD(P)-binding (NCBI) | compare |
| b0908 | aroA | -3.4 | -8.4 | 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) | compare |
| b0243 | proA | -3.4 | -8.6 | gamma-glutamyl phosphate reductase (NCBI) | compare |
| b0142 | folK | -3.3 | -1.6 | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) | compare |
| b0957 | ompA | -3.3 | -4.9 | outer membrane protein A (3a;II*;G;d) (NCBI) | compare |
| b0003 | thrB | -3.3 | -6.4 | homoserine kinase (NCBI) | compare |
| b3389 | aroB | -3.3 | -10.8 | 3-dehydroquinate synthase (NCBI) | compare |
| b1062 | pyrC | -3.2 | -7.8 | dihydroorotase (NCBI) | compare |
| b3868 | glnG | -3.2 | -4.9 | fused DNA-binding response regulator in two-component regulatory system with GlnL: response regulator/sigma54 interaction protein (NCBI) | compare |
| b0145 | dksA | -3.2 | -2.2 | DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) | compare |
| b2557 | purL | -3.2 | -8.4 | phosphoribosylformylglycinamidine synthase (NCBI) | compare |
| b2762 | cysH | -3.1 | -6.8 | phosphoadenosine phosphosulfate reductase (NCBI) | compare |
| b2913 | serA | -3.0 | -7.7 | D-3-phosphoglycerate dehydrogenase (NCBI) | compare |
| b4702 | mgtL | -2.9 | -2.8 | regulatory leader peptide for mgtA (NCBI) | compare |
| b3650 | spoT | -2.9 | -6.7 | bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase (NCBI) | compare |
| b2839 | lysR | -2.9 | -5.3 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b4242 | mgtA | -2.9 | -13.4 | magnesium transporter (NCBI) | compare |
| b3839 | tatC | -2.8 | -5.7 | TatABCE protein translocation system subunit (NCBI) | compare |
| b3035 | tolC | -2.8 | -8.2 | outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) | compare |
| b2329 | aroC | -2.8 | -5.3 | chorismate synthase (NCBI) | compare |
| b0674 | asnB | -2.8 | -9.8 | asparagine synthetase B (NCBI) | compare |
| b3183 | obgE | -2.7 | -1.9 | GTPase involved in cell partioning and DNA repair (NCBI) | compare |
| b4000 | hupA | -2.7 | -4.4 | HU, DNA-binding transcriptional regulator, alpha subunit (NCBI) | compare |
| b0926 | ycbK | -2.7 | -4.6 | hypothetical protein (NCBI) | compare |
| b0222 | lpcA | -2.7 | -2.6 | phosphoheptose isomerase (NCBI) | compare |
| b3838 | tatB | -2.6 | -7.0 | sec-independent translocase (NCBI) | compare |
| b0739 | tolA | -2.6 | -2.6 | cell envelope integrity inner membrane protein TolA (NCBI) | compare |
| b3405 | ompR | -2.6 | -2.6 | osmolarity response regulator (NCBI) | compare |
| b3213 | gltD | -2.6 | -8.0 | glutamate synthase, 4Fe-4S protein, small subunit (NCBI) | compare |
| b0437 | clpP | -2.6 | -7.4 | ATP-dependent Clp protease proteolytic subunit (NCBI) | compare |
| b3212 | gltB | -2.6 | -13.8 | glutamate synthase, large subunit (NCBI) | compare |
| b2476 | purC | -2.5 | -3.4 | phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI) | compare |
| b1712 | ihfA | -2.5 | -3.4 | integration host factor subunit alpha (NCBI) | compare |
| b2019 | hisG | -2.4 | -4.9 | ATP phosphoribosyltransferase (NCBI) | compare |
| b0945 | pyrD | -2.4 | -10.0 | dihydroorotate dehydrogenase (NCBI) | compare |
| b0438 | clpX | -2.3 | -6.5 | ATP-dependent protease ATP-binding subunit (NCBI) | compare |
| b0740 | tolB | -2.3 | -4.1 | translocation protein TolB precursor (NCBI) | compare |
| b4171 | miaA | -2.3 | -5.3 | tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) | compare |
| b0049 | apaH | -2.3 | -4.8 | diadenosinetetraphosphatase (NCBI) | compare |
| b2343 | b2343 | -2.2 | -1.8 | orf, hypothetical protein (VIMSS) | compare |
| b1746 | astD | -2.2 | -6.2 | succinylglutamic semialdehyde dehydrogenase (NCBI) | conserved |
| b2414 | cysK | -2.2 | -7.5 | cysteine synthase A, O-acetylserine sulfhydrolase A subunit (NCBI) | compare |
| b3483 | yhhH | -2.1 | -1.8 | orf, hypothetical protein (VIMSS) | compare |
| b3728 | pstS | -2.1 | -2.5 | phosphate transporter subunit (NCBI) | compare |
| b3962 | udhA | -2.1 | -7.2 | putative oxidoreductase (VIMSS) | compare |
| b2830 | nudH | -2.1 | -1.4 | dinucleoside polyphosphate hydrolase (NCBI) | compare |
| b3237 | argR | -2.1 | -4.6 | arginine repressor (NCBI) | compare |
| b2215 | ompC | -2.1 | -8.9 | outer membrane porin protein C (NCBI) | compare |
| b0078 | ilvH | -2.1 | -7.2 | acetolactate synthase small subunit (NCBI) | compare |
| b3052 | rfaE | -1.9 | -4.3 | fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) | compare |
| b2750 | cysC | -1.9 | -3.5 | adenylylsulfate kinase (NCBI) | compare |
| b1576 | ydfD | -1.9 | -2.5 | Qin prophage; predicted protein (NCBI) | compare |
| b0072 | leuC | -1.9 | -8.7 | isopropylmalate isomerase large subunit (NCBI) | compare |
| b2144 | sanA | -1.9 | -11.7 | hypothetical protein (NCBI) | compare |
| b0074 | leuA | -1.9 | -7.7 | 2-isopropylmalate synthase (NCBI) | compare |
| b1084 | rne | -1.9 | -4.7 | fused ribonucleaseE: endoribonuclease/RNA-binding protein/RNA degradosome binding protein (NCBI) | compare |
| b3649 | rpoZ | -1.8 | -2.5 | DNA-directed RNA polymerase subunit omega (NCBI) | compare |
| b3726 | pstA | -1.8 | -5.4 | phosphate transporter subunit (NCBI) | compare |
| b1263 | trpD | -1.8 | -2.7 | bifunctional indole-3-glycerol-phosphate synthase/anthranilate phosphoribosyltransferase (NCBI) | compare |
| b1860 | ruvB | -1.8 | -1.2 | Holliday junction DNA helicase B (NCBI) | compare |
| b0726 | sucA | -1.7 | -1.7 | alpha-ketoglutarate decarboxylase (NCBI) | compare |
| b0033 | carB | -1.7 | -9.3 | carbamoyl-phosphate synthase large subunit (NCBI) | compare |
| b0738 | tolR | -1.7 | -2.3 | membrane spanning protein in TolA-TolQ-TolR complex (NCBI) | compare |
| b3774 | ilvC | -1.7 | -9.6 | ketol-acid reductoisomerase (NCBI) | compare |
| b1841 | yobA | -1.6 | -1.8 | hypothetical protein (NCBI) | compare |
| b2853 | ygeI | -1.6 | -3.2 | hypothetical protein (NCBI) | compare |
| b0741 | pal | -1.6 | -3.4 | peptidoglycan-associated outer membrane lipoprotein (NCBI) | compare |
| b0073 | leuB | -1.6 | -5.6 | 3-isopropylmalate dehydrogenase (VIMSS) | compare |
| b0737 | tolQ | -1.6 | -2.9 | membrane spanning protein in TolA-TolQ-TolR complex (NCBI) | compare |
| b3771 | ilvD | -1.6 | -8.2 | dihydroxy-acid dehydratase (NCBI) | compare |
| b0849 | grxA | -1.5 | -2.0 | glutaredoxin 1, redox coenzyme for ribonucleotide reductase (RNR1a) (NCBI) | compare |
| b3844 | fre | -1.5 | -4.5 | NAD(P)H-flavin reductase (NCBI) | compare |
| b4414 | tff | -1.5 | -1.7 | unknown RNA (NCBI) | compare |
| b0071 | leuD | -1.5 | -5.4 | isopropylmalate isomerase small subunit (NCBI) | compare |
| b0242 | proB | -1.4 | -4.7 | gamma-glutamyl kinase (NCBI) | compare |
| b0890 | ftsK | -1.4 | -4.8 | DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) | compare |
| b4704 | arrS | -1.4 | -1.1 | Antisense sRNA ArrS, function unknown (NCBI) | compare |
| b1524 | yneH | -1.4 | -1.3 | predicted glutaminase (NCBI) | compare |
| b2307 | hisM | -1.4 | -6.9 | histidine/lysine/arginine/ornithine transporter subunit (NCBI) | conserved |
| b2599 | pheA | -1.4 | -4.6 | fused chorismate mutase P/prephenate dehydratase (NCBI) | compare |
| b2308 | hisQ | -1.4 | -5.9 | histidine/lysine/arginine/ornithine transporter subunit (NCBI) | conserved |
| b4042 | dgkA | -1.4 | -2.2 | diacylglycerol kinase (NCBI) | compare |
| b0077 | ilvI | -1.4 | -6.5 | acetolactate synthase III large subunit (NCBI) | compare |
| b3869 | glnL | -1.4 | -5.2 | sensory histidine kinase in two-component regulatory system with GlnG (NCBI) | compare |
| b3398 | yrfF | -1.3 | -2.7 | predicted inner membrane protein (NCBI) | compare |
| b1861 | ruvA | -1.3 | -2.2 | Holliday junction DNA helicase motor protein (NCBI) | compare |
| b2600 | tyrA | -1.3 | -3.1 | fused chorismate mutase T/prephenate dehydrogenase (NCBI) | compare |
| b3621 | rfaC | -1.3 | -3.5 | ADP-heptose:LPS heptosyl transferase I (NCBI) | compare |
| b3870 | glnA | -1.3 | -1.3 | glutamine synthetase (NCBI) | compare |
| b1262 | trpC | -1.3 | -4.1 | N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase (VIMSS) | compare |
| b1179 | ycgL | -1.3 | -1.8 | conserved protein (NCBI) | compare |
| b2518 | ndk | -1.3 | -2.1 | nucleoside diphosphate kinase (NCBI) | compare |
| b1936 | intG | -1.3 | -1.9 | predicted defective phage integrase (pseudogene) (RefSeq) | compare |
| b3390 | aroK | -1.3 | -1.8 | shikimate kinase I (NCBI) | compare |
| b0696 | kdpC | -1.3 | -2.4 | potassium-transporting ATPase subunit C (NCBI) | compare |
| b1863 | ruvC | -1.3 | -2.9 | Holliday junction resolvase (NCBI) | compare |
| b2698 | recX | -1.3 | -2.2 | RecA regulator RecX (NCBI) | compare |
| b1545 | pinQ | -1.3 | -1.2 | Qin prophage; predicted site-specific recombinase (NCBI) | compare |
| b4578 | insP | -1.3 | -2.0 | no description | compare |
| b3781 | trxA | -1.3 | -2.7 | thioredoxin 1 (VIMSS) | compare |
| b0167 | glnD | -1.2 | -2.8 | PII uridylyl-transferase (NCBI) | compare |
| b1290 | sapF | -1.2 | -2.0 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b2501 | ppk | -1.2 | -6.1 | polyphosphate kinase (NCBI) | compare |
| b1426 | ydcH | -1.2 | -1.3 | orf, hypothetical protein (VIMSS) | compare |
| b3619 | rfaD | -1.2 | -2.3 | ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) | compare |
| b4245 | pyrB | -1.2 | -5.2 | aspartate carbamoyltransferase catalytic subunit (NCBI) | compare |
| b1380 | ldhA | -1.2 | -1.9 | D-lactate dehydrogenase (NCBI) | compare |
| b1804 | rnd | -1.2 | -3.2 | ribonuclease D (NCBI) | compare |
| b0632 | dacA | -1.1 | -5.1 | D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5) (NCBI) | compare |
| b0802 | ybiJ | -1.1 | -2.2 | hypothetical protein (NCBI) | compare |
| b0134 | panB | -1.1 | -4.6 | 3-methyl-2-oxobutanoate hydroxymethyltransferase (NCBI) | compare |
| b4375 | prfC | -1.1 | -4.2 | peptide chain release factor 3 (NCBI) | compare |
| b0200 | gmhB | -1.1 | -1.0 | hypothetical protein (NCBI) | compare |
| b0002 | thrA | -1.1 | -5.0 | bifunctional aspartokinase I/homeserine dehydrogenase I (NCBI) | compare |
| b1999 | yeeP | -1.1 | -3.3 | putative histone (VIMSS) | compare |
| b4613 | dinQ | -1.1 | -1.5 | Damage inducible, function unknown (RefSeq) | compare |
| b3387 | dam | -1.1 | -6.5 | DNA adenine methylase (NCBI) | compare |
| b4546 | ypeB | -1.1 | -1.0 | hypothetical protein (NCBI) | compare |
| b0588 | fepC | -1.1 | -4.3 | iron-enterobactin transporter subunit (NCBI) | compare |
| b2320 | pdxB | -1.1 | -4.6 | erythronate-4-phosphate dehydrogenase (NCBI) | compare |
| b2682 | ygaZ | -1.1 | -3.1 | predicted transporter (NCBI) | compare |
| b0720 | gltA | -1.0 | -3.2 | citrate synthase (NCBI) | compare |
| b3811 | xerC | -1.0 | -1.4 | site-specific tyrosine recombinase XerC (NCBI) | compare |
| b2187 | yejL | -1.0 | -2.4 | hypothetical protein (NCBI) | compare |
| b1686 | ydiI | -1.0 | -2.0 | hypothetical protein (NCBI) | compare |
| b3725 | pstB | -1.0 | -1.0 | phosphate transporter subunit (NCBI) | compare |
| b0251 | yafY | -1.0 | -2.3 | CP4-6 prophage; predicted DNA-binding transcriptional regulator (RefSeq) | compare |
| b3429 | glgA | -1.0 | -5.5 | glycogen synthase (NCBI) | compare |
| b0032 | carA | -1.0 | -2.7 | carbamoyl-phosphate synthase small subunit (NCBI) | compare |
| b0439 | lon | -1.0 | -3.2 | DNA-binding ATP-dependent protease La (NCBI) | compare |
| b2620 | smpB | -1.0 | -1.3 | SsrA-binding protein (NCBI) | compare |
| b1103 | ycfF | -1.0 | -1.2 | orf, hypothetical protein (VIMSS) | compare |
| b0440 | hupB | -1.0 | -3.5 | HU, DNA-binding transcriptional regulator, beta subunit (NCBI) | compare |
| b4239 | treC | -1.0 | -2.3 | trehalose-6-P hydrolase (NCBI) | compare |
| b3121 | yhaC | -1.0 | -1.1 | hypothetical protein (NCBI) | compare |
| b1837 | yebW | -1.0 | -1.1 | orf, hypothetical protein (VIMSS) | compare |
| b2820 | recB | -1.0 | -1.1 | exonuclease V (RecBCD complex), beta subunit (NCBI) | compare |
| b1235 | rssB | -1.0 | -4.5 | response regulator of RpoS (NCBI) | compare |
| b4177 | purA | -1.0 | -1.1 | adenylosuccinate synthetase (NCBI) | compare |
| b0990 | cspG | -1.0 | -1.9 | DNA-binding transcriptional regulator (NCBI) | compare |
| b1733 | chbG | -1.0 | -2.7 | hypothetical protein (NCBI) | compare |
| b0630 | lipB | -1.0 | -1.1 | protein of lipoate biosynthesis (VIMSS) | compare |
| b3727 | pstC | -1.0 | -3.9 | phosphate transporter subunit (NCBI) | compare |
| b3236 | mdh | -1.0 | -3.9 | malate dehydrogenase (NCBI) | compare |
| b3442 | yhhZ | -0.9 | -1.9 | hypothetical protein (NCBI) | compare |
| b2650 | ypjC | -0.9 | -1.2 | hypothetical protein (RefSeq) | compare |
| b1363 | trkG | -0.9 | -2.9 | Rac prophage; potassium transporter subunit (NCBI) | compare |
| b2306 | hisP | -0.9 | -3.2 | histidine/lysine/arginine/ornithine transporter subunit (NCBI) | conserved |
| b1497 | b1497 | -0.9 | -2.0 | putative enzyme (VIMSS) | compare |
| b3204 | ptsN | -0.9 | -3.0 | sugar-specific enzyme IIA component of PTS (NCBI) | compare |
| b0791 | ybhQ | -0.9 | -2.5 | predicted inner membrane protein (NCBI) | compare |
| b1361 | ydaW | -0.9 | -0.7 | orf, hypothetical protein (VIMSS) | compare |
| b1236 | galU | -0.9 | -2.9 | glucose-1-phosphate uridylyltransferase (NCBI) | compare |
| b1257 | yciE | -0.9 | -1.9 | hypothetical protein (NCBI) | compare |
| b1708 | nlpC | -0.9 | -2.6 | predicted lipoprotein (NCBI) | compare |
| b3772 | ilvA | -0.9 | -5.5 | threonine dehydratase (NCBI) | compare |
| b4146 | yjeK | -0.9 | -1.8 | predicted lysine aminomutase (NCBI) | compare |
| b3609 | secB | -0.9 | -2.7 | export protein SecB (NCBI) | compare |
| b1150 | ymfR | -0.9 | -0.8 | e14 prophage; predicted protein (NCBI) | compare |
| b1765 | ydjA | -0.9 | -0.8 | predicted oxidoreductase (NCBI) | compare |
| b4503 | yafF | -0.9 | -1.4 | no description | compare |
| b0389 | yaiA | -0.9 | -1.6 | hypothetical protein (NCBI) | compare |
| b4104 | phnE | -0.9 | -2.1 | phosphonate/organophosphate ester transporter subunit (NCBI) | compare |
| b2136 | yohD | -0.9 | -3.3 | orf, hypothetical protein (VIMSS) | compare |
| b0118 | acnB | -0.9 | -1.7 | aconitate hydratase (NCBI) | compare |