Experiment set1IT070 for Escherichia coli BW25113

Compare to:

D-Glucose carbon source MOPS

200 most important genes:

  gene name fitness t score description  
b0004 thrC -6.0 -4.2 threonine synthase (NCBI) compare
b0907 serC -5.5 -7.6 phosphoserine aminotransferase (NCBI) compare
b2320 pdxB -5.4 -8.3 erythronate-4-phosphate dehydrogenase (NCBI) compare
b0052 pdxA -4.8 -9.8 4-hydroxythreonine-4-phosphate dehydrogenase (NCBI) compare
b0002 thrA -4.4 -16.1 bifunctional aspartokinase I/homeserine dehydrogenase I (NCBI) compare
b1130 phoP -4.0 -7.6 DNA-binding response regulator in two-component regulatory system with PhoQ (NCBI) compare
b1129 phoQ -3.8 -8.5 sensory histidine kinase in two-compoent regulatory system with PhoP (NCBI) compare
b0003 thrB -3.4 -6.7 homoserine kinase (NCBI) compare
b2564 pdxJ -3.4 -4.6 pyridoxal phosphate biosynthetic protein (NCBI) compare
b0775 bioB -3.3 -6.2 biotin synthase (NCBI) compare
b3916 pfkA -3.0 -4.5 6-phosphofructokinase (NCBI) compare
b4208 cycA -2.8 -12.2 D-alanine/D-serine/glycine transporter (NCBI) compare
b2297 pta -2.6 -2.5 phosphate acetyltransferase (NCBI) compare
b2567 rnc -2.6 -1.8 ribonuclease III (NCBI) compare
b0118 acnB -2.5 -3.7 aconitate hydratase (NCBI) compare
b2531 iscR -2.4 -2.3 DNA-binding transcriptional repressor (NCBI) compare
b0500 ybbD -2.4 -2.3 hypothetical protein (RefSeq) compare
b0750 nadA -2.4 -5.7 quinolinate synthetase (NCBI) compare
b3764 yifE -2.3 -6.7 hypothetical protein (NCBI) compare
b2518 ndk -2.3 -3.7 nucleoside diphosphate kinase (NCBI) compare
b4163 glyV -2.2 -2.0 tRNA-Gly (NCBI) compare
b0401 brnQ -2.2 -9.4 predicted branched chain amino acid transporter (LIV-II) (NCBI) compare
b4172 hfq -2.2 -2.1 RNA-binding protein Hfq (NCBI) compare
b0109 nadC -2.1 -8.0 nicotinate-nucleotide pyrophosphorylase (NCBI) compare
b2479 gcvR -2.1 -5.3 transcriptional regulation of gcv operon (VIMSS) compare
b0778 bioD -2.1 -4.9 dethiobiotin synthetase (NCBI) compare
b0658 ybeX -2.0 -8.2 predicteed ion transport (NCBI) compare
b0767 ybhE -2.0 -4.6 6-phosphogluconolactonase (NCBI) compare
b1865 nudB -2.0 -2.1 dATP pyrophosphohydrolase (NCBI) compare
b0114 aceE -1.9 -3.4 pyruvate dehydrogenase subunit E1 (NCBI) compare
b3021 ygiT -1.9 -4.4 predicted DNA-binding transcriptional regulator (NCBI) compare
b3121 yhaC -1.8 -2.4 hypothetical protein (NCBI) compare
b3412 bioH -1.8 -7.6 carboxylesterase of pimeloyl-CoA synthesis (NCBI) compare
b3977 tyrU -1.8 -1.7 tRNA-Tyr (NCBI) compare
b0774 bioA -1.8 -5.0 adenosylmethionine--8-amino-7-oxononanoate transaminase (NCBI) conserved
b2498 upp -1.8 -3.8 uracil phosphoribosyltransferase (VIMSS) compare
b4242 mgtA -1.7 -12.7 magnesium transporter (NCBI) compare
b0777 bioC -1.7 -4.5 predicted methltransferase, enzyme of biotin synthesis (NCBI) compare
b3728 pstS -1.7 -5.7 phosphate transporter subunit (NCBI) compare
b1347 ydaC -1.7 -2.2 Rac prophage; predicted protein (NCBI) compare
b2330 yfcB -1.7 -2.9 putative adenine-specific methylase (VIMSS) compare
b2574 nadB -1.7 -9.1 L-aspartate oxidase (NCBI) compare
b1850 eda -1.7 -2.2 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) compare
b4480 hdfR -1.6 -6.0 transcriptional regulator HdfR (NCBI) compare
b4179 vacB -1.6 -7.6 putative enzyme (VIMSS) compare
b2784 relA -1.6 -9.5 (p)ppGpp synthetase I/GTP pyrophosphokinase (NCBI) compare
b1942 fliJ -1.6 -1.8 flagellar biosynthesis chaperone (NCBI) compare
b3082 ygjM -1.6 -3.4 predicted DNA-binding transcriptional regulator (NCBI) compare
b3870 glnA -1.5 -3.2 glutamine synthetase (NCBI) compare
b0776 bioF -1.5 -5.6 8-amino-7-oxononanoate synthase (NCBI) compare
b1726 yniB -1.5 -3.2 predicted inner membrane protein (NCBI) compare
b3164 pnp -1.5 -4.0 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b2055 wcaE -1.5 -3.5 predicted glycosyl transferase (NCBI) compare
b1545 pinQ -1.5 -1.6 Qin prophage; predicted site-specific recombinase (NCBI) compare
b4202 rpsR -1.5 -2.5 30S ribosomal protein S18 (NCBI) compare
b4243 yjgF -1.5 -5.5 orf, hypothetical protein (VIMSS) compare
b4146 yjeK -1.4 -3.8 predicted lysine aminomutase (NCBI) compare
b3636 rpmG -1.3 -1.6 50S ribosomal protein L33 (NCBI) compare
b2699 recA -1.3 -2.2 recombinase A (NCBI) compare
b1671 ydhX -1.3 -2.1 predicted 4Fe-4S ferridoxin-type protein (RefSeq) compare
b2894 xerD -1.3 -1.7 site-specific tyrosine recombinase XerD (NCBI) compare
b3442 yhhZ -1.2 -2.9 hypothetical protein (NCBI) compare
b3261 fis -1.2 -3.3 DNA-binding protein Fis (NCBI) compare
b2830 nudH -1.2 -2.0 dinucleoside polyphosphate hydrolase (NCBI) compare
b1295 ymjA -1.2 -1.7 hypothetical protein (NCBI) compare
b1058 yceO -1.2 -1.0 hypothetical protein (NCBI) compare
b2620 smpB -1.2 -2.3 SsrA-binding protein (NCBI) compare
b1286 rnb -1.2 -2.8 exoribonuclease II (NCBI) compare
b1351 racC -1.2 -1.6 Rac prophage; predicted protein (NCBI) compare
b2528 iscA -1.1 -1.7 iron-sulfur cluster assembly protein (NCBI) compare
b4171 miaA -1.1 -5.0 tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) compare
b3962 udhA -1.1 -6.6 putative oxidoreductase (VIMSS) compare
b0630 lipB -1.1 -1.7 protein of lipoate biosynthesis (VIMSS) compare
b2209 eco -1.1 -2.4 ecotin precursor (NCBI) compare
b1257 yciE -1.1 -2.0 hypothetical protein (NCBI) compare
b4603 rseX -1.1 -1.1 sRNA regulating ompA and ompC translation, with Hfq (RefSeq) compare
b1269 rluB -1.0 -2.6 23S rRNA pseudouridylate synthase (NCBI) compare
b4279 yjhB -1.0 -3.6 putative transport protein (VIMSS) compare
b4375 prfC -1.0 -5.5 peptide chain release factor 3 (NCBI) compare
b2938 speA -1.0 -6.5 arginine decarboxylase (NCBI) compare
b0145 dksA -1.0 -3.0 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b2318 truA -1.0 -3.3 tRNA pseudouridine synthase A (NCBI) compare
b4702 mgtL -1.0 -2.7 regulatory leader peptide for mgtA (NCBI) compare
b3644 yicC -1.0 -4.5 hypothetical protein (NCBI) compare
b2569 lepA -1.0 -3.1 GTP-binding protein LepA (NCBI) compare
b1144 ymfJ -1.0 -2.1 orf, hypothetical protein (VIMSS) compare
b0603 ybdO -1.0 -2.0 predicted DNA-binding transcriptional regulator (NCBI) compare
b1307 pspD -0.9 -1.7 peripheral inner membrane phage-shock protein (NCBI) compare
b1550 b1550 -0.9 -1.1 orf, hypothetical protein (VIMSS) compare
b4582 yoeA -0.9 -1.8 no description compare
b0049 apaH -0.9 -2.9 diadenosinetetraphosphatase (NCBI) compare
b0849 grxA -0.9 -2.3 glutaredoxin 1, redox coenzyme for ribonucleotide reductase (RNR1a) (NCBI) compare
b1084 rne -0.9 -3.6 fused ribonucleaseE: endoribonuclease/RNA-binding protein/RNA degradosome binding protein (NCBI) compare
b1085 b1085 -0.9 -1.3 orf, hypothetical protein (VIMSS) compare
b2625 yfjI -0.9 -4.0 CP4-57 prophage; predicted protein (NCBI) compare
b4042 dgkA -0.9 -2.5 diacylglycerol kinase (NCBI) compare
b0001 thrL -0.9 -0.9 thr operon leader peptide (NCBI) compare
b0623 cspE -0.9 -2.1 cold shock protein E (NCBI) compare
b4436 ryeC -0.9 -1.2 Novel sRNA, function unknown; paralogous to the other QUAD sRNA genes unknown (RefSeq) compare
b1831 proQ -0.9 -2.1 putative solute/DNA competence effector (NCBI) compare
b1581 rspA -0.9 -2.0 predicted dehydratase (NCBI) compare
b2937 speB -0.9 -4.7 agmatinase (NCBI) compare
b2293 yfbT -0.9 -2.1 putative phosphatase (VIMSS) compare
b4025 pgi -0.9 -5.2 glucose-6-phosphate isomerase (NCBI) compare
b2125 yehT -0.9 -3.8 orf, hypothetical protein (VIMSS) compare
b0238 gpt -0.8 -2.7 xanthine phosphoribosyltransferase (NCBI) compare
b1400 paaY -0.8 -1.5 predicted hexapeptide repeat acetyltransferase (NCBI) compare
b1814 sdaA -0.8 -2.5 L-serine deaminase I (NCBI) compare
b1497 b1497 -0.8 -2.5 putative enzyme (VIMSS) compare
b2853 ygeI -0.8 -2.4 hypothetical protein (NCBI) compare
b2579 yfiD -0.8 -1.9 pyruvate formate lyase subunit (NCBI) compare
b0685 ybfE -0.8 -1.6 orf, hypothetical protein (VIMSS) compare
b1160 elbA -0.8 -1.9 hypothetical protein (NCBI) compare
b1418 cybB -0.8 -1.7 cytochrome b(561) (VIMSS) compare
b0705 ybfL -0.8 -2.2 putative receptor protein (VIMSS) compare
b3386 rpe -0.8 -1.4 ribulose-phosphate 3-epimerase (NCBI) compare
b0142 folK -0.8 -1.0 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) compare
b4438 cyaR -0.8 -1.3 sRNA effector of ompX mRNA instability, cAMP-induced; hfq-dependent (RefSeq) compare
b3500 gor -0.8 -1.2 glutathione reductase (NCBI) compare
b3778 rep -0.8 -4.6 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b3726 pstA -0.8 -3.3 phosphate transporter subunit (NCBI) compare
b3068 ygjF -0.7 -2.1 G/U mismatch-specific DNA glycosylase (NCBI) compare
b1409 ynbB -0.7 -3.0 predicted CDP-diglyceride synthase (NCBI) compare
b4062 soxS -0.7 -2.0 DNA-binding transcriptional dual regulator (NCBI) compare
b4443 gcvB -0.7 -1.1 GcvB sRNA gene divergent from gcvA (RefSeq) compare
b4546 ypeB -0.7 -1.0 hypothetical protein (NCBI) compare
b1159 mcrA -0.7 -2.7 e14 prophage; 5-methylcytosine-specific restriction endonuclease B (NCBI) compare
b2934 cmtB -0.7 -1.5 predicted mannitol-specific enzyme IIA component of PTS (NCBI) compare
b1293 sapB -0.7 -1.2 predicted antimicrobial peptide transporter subunit (NCBI) compare
b1346 ydaQ -0.7 -1.8 orf, hypothetical protein (VIMSS) compare
b2029 gnd -0.7 -3.8 6-phosphogluconate dehydrogenase (NCBI) compare
b3727 pstC -0.7 -3.0 phosphate transporter subunit (NCBI) compare
b0249 ykfF -0.7 -1.8 CP4-6 prophage; predicted protein (NCBI) compare
b1179 ycgL -0.7 -1.8 conserved protein (NCBI) compare
b0696 kdpC -0.7 -1.5 potassium-transporting ATPase subunit C (NCBI) compare
b0881 clpS -0.7 -1.6 ATP-dependent Clp protease adaptor protein ClpS (NCBI) compare
b0438 clpX -0.7 -3.7 ATP-dependent protease ATP-binding subunit (NCBI) compare
b1753 ynjA -0.7 -1.6 hypothetical protein (NCBI) compare
b3483 yhhH -0.7 -0.9 orf, hypothetical protein (VIMSS) compare
b1167 ymgC -0.7 -1.1 hypothetical protein (NCBI) compare
b1476 fdnI -0.7 -1.0 formate dehydrogenase-N, cytochrome B556 (gamma) subunit, nitrate-inducible (NCBI) compare
b1109 ndh -0.7 -2.6 respiratory NADH dehydrogenase 2/cupric reductase (NCBI) compare
b2289 lrhA -0.6 -4.3 DNA-binding transcriptional repressor of flagellar, motility and chemotaxis genes (NCBI) compare
b4497 yeeL -0.6 -2.5 no description compare
b4590 ybfK -0.6 -2.8 hypothetical protein (RefSeq) compare
b4515 ybgT -0.6 -1.1 hypothetical protein (NCBI) compare
b4370 leuQ -0.6 -1.8 tRNA-Leu (NCBI) compare
b1007 b1007 -0.6 -1.1 orf, hypothetical protein (VIMSS) compare
b2847 yqeI -0.6 -3.5 predicted transcriptional regulator (NCBI) compare
b3504 yhiS -0.6 -1.7 hypothetical protein (RefSeq) compare
b0450 glnK -0.6 -1.6 nitrogen assimilation regulatory protein for GlnL, GlnE, and AmtB (NCBI) compare
b3725 pstB -0.6 -1.5 phosphate transporter subunit (NCBI) compare
b1259 yciG -0.6 -0.8 orf, hypothetical protein (VIMSS) compare
b1576 ydfD -0.6 -1.3 Qin prophage; predicted protein (NCBI) compare
b3493 pitA -0.6 -4.1 phosphate transporter, low-affinity (NCBI) compare
b1480 sra -0.6 -1.1 30S ribosomal subunit protein S22 (NCBI) compare
b3204 ptsN -0.6 -2.4 sugar-specific enzyme IIA component of PTS (NCBI) compare
b0481 ybaK -0.6 -2.1 hypothetical protein (NCBI) compare
b1278 pgpB -0.6 -1.4 phosphatidylglycerophosphatase B (NCBI) compare
b0999 cbpM -0.6 -1.8 modulator of CbpA co-chaperone (NCBI) compare
b1575 dicB -0.6 -2.1 Qin prophage; cell division inhibition protein (NCBI) compare
b4041 plsB -0.6 -1.4 glycerol-3-phosphate acyltransferase (VIMSS) compare
b1659 ydhB -0.6 -1.5 predicted DNA-binding transcriptional regulator (NCBI) compare
b3741 gidA -0.6 -3.7 glucose-inhibited division protein A (NCBI) compare
b0505 allA -0.6 -1.5 ureidoglycolate hydrolase (NCBI) compare
b2101 yegW -0.6 -2.1 predicted DNA-binding transcriptional regulator (NCBI) compare
b1926 fliT -0.6 -1.0 predicted chaperone (NCBI) compare
b1292 sapC -0.6 -1.3 predicted antimicrobial peptide transporter subunit (NCBI) compare
b3162 deaD -0.6 -2.9 inducible ATP-independent RNA helicase (VIMSS) compare
b1712 ihfA -0.6 -1.7 integration host factor subunit alpha (NCBI) compare
b0143 pcnB -0.6 -3.4 poly(A) polymerase I (VIMSS) compare
b2248 yfaX -0.6 -1.3 predicted DNA-binding transcriptional regulator (NCBI) compare
b0888 trxB -0.6 -1.7 thioredoxin reductase, FAD/NAD(P)-binding (NCBI) compare
b2207 napD -0.6 -2.3 assembly protein for periplasmic nitrate reductase (NCBI) compare
b4570 lomR -0.6 -1.1 no description compare
b1448 yncA -0.6 -0.6 predicted acyltransferase with acyl-CoA N-acyltransferase domain (NCBI) compare
b2082 ogrK -0.6 -1.8 DNA-binding transcriptional regulator prophage P2 remnant (NCBI) compare
b0082 mraW -0.6 -2.2 S-adenosyl-methyltransferase (NCBI) compare
b3469 zntA -0.6 -4.5 zinc, cobalt and lead efflux system (NCBI) compare
b0018 mokC -0.6 -0.8 regulatory protein for HokC, overlaps CDS of hokC (NCBI) compare
b3206 npr -0.6 -2.8 phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) (NCBI) compare
b2017 yefM -0.6 -1.5 orf, hypothetical protein (VIMSS) compare
b1539 ydfG -0.6 -1.9 L-allo-threonine dehydrogenase, NAD(P)-binding (NCBI) compare
b4393 trpR -0.6 -3.2 Trp operon repressor (NCBI) compare
b1859 znuB -0.6 -3.0 high-affinity zinc transporter membrane component (NCBI) compare
b4699 fnrS -0.6 -0.7 FNR-activated anaerobic sRNA antisense regulator down regulates cydDC, metE, sodA, sodB, Hfq-dependent; mediates negative FNR regulation (RefSeq) compare
b0051 ksgA -0.6 -2.7 dimethyladenosine transferase (NCBI) compare
b4558 yifL -0.6 -2.4 predicted lipoprotein (NCBI) compare
b1487 ddpA -0.6 -1.8 D-ala-D-a la transporter subunit (NCBI) compare
b4630 ykgP -0.5 -0.9 no description compare
b2205 napG -0.5 -2.7 quinol dehydrogenase periplasmic component (NCBI) compare
b4445 omrB -0.5 -1.9 sRNA down regulates OM proteins; positively regulated by OmpR/EnvZ; binds Hfq (RefSeq) compare
b4416 rybA -0.5 -0.8 unknown RNA (NCBI) compare
b3811 xerC -0.5 -1.5 site-specific tyrosine recombinase XerC (NCBI) compare
b2582 trxC -0.5 -0.9 thioredoxin 2 (NCBI) compare
b1618 uidR -0.5 -1.7 DNA-binding transcriptional repressor (NCBI) compare
b2309 hisJ -0.5 -2.2 histidine/lysine/arginine/ornithine transporter subunit (NCBI) compare
b2340 sixA -0.5 -2.0 phosphohistidine phosphatase (NCBI) compare
b2009 sbmC -0.5 -1.8 DNA gyrase inhibitor (NCBI) compare
b1383 ydbL -0.5 -1.2 orf, hypothetical protein (VIMSS) compare


Specific Phenotypes

For 6 genes in this experiment

For carbon source D-Glucose in Escherichia coli BW25113

For carbon source D-Glucose across organisms