| | gene | name | fitness | t score | description | |
|---|
| b1261 | trpB | -6.8 | -4.7 | tryptophan synthase subunit beta (NCBI) | compare |
| b0242 | proB | -6.8 | -4.7 | gamma-glutamyl kinase (NCBI) | compare |
| b1693 | aroD | -6.2 | -6.1 | 3-dehydroquinate dehydratase (NCBI) | compare |
| b0907 | serC | -6.2 | -7.4 | phosphoserine aminotransferase (NCBI) | compare |
| b3941 | metF | -6.1 | -10.2 | 5,10-methylenetetrahydrofolate reductase (NCBI) | compare |
| b0523 | purE | -6.0 | -4.1 | phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI) | compare |
| b0243 | proA | -6.0 | -7.1 | gamma-glutamyl phosphate reductase (NCBI) | compare |
| b2838 | lysA | -5.9 | -5.8 | diaminopimelate decarboxylase, PLP-binding (NCBI) | compare |
| b0004 | thrC | -5.9 | -5.8 | threonine synthase (NCBI) | compare |
| b3770 | ilvE | -5.9 | -9.0 | branched-chain amino acid aminotransferase (NCBI) | compare |
| b2023 | hisH | -5.9 | -5.7 | imidazole glycerol phosphate synthase subunit HisH (NCBI) | compare |
| b0071 | leuD | -5.8 | -6.9 | isopropylmalate isomerase small subunit (NCBI) | compare |
| b0073 | leuB | -5.8 | -9.7 | 3-isopropylmalate dehydrogenase (VIMSS) | compare |
| b0889 | lrp | -5.7 | -3.9 | DNA-binding transcriptional dual regulator, leucine-binding (NCBI) | compare |
| b1129 | phoQ | -5.7 | -6.7 | sensory histidine kinase in two-compoent regulatory system with PhoP (NCBI) | compare |
| b0678 | nagB | -5.6 | -5.5 | glucosamine-6-phosphate deaminase (NCBI) | compare |
| b3281 | aroE | -5.6 | -14.1 | dehydroshikimate reductase, NAD(P)-binding (NCBI) | compare |
| b4388 | serB | -5.6 | -5.4 | 3-phosphoserine phosphatase (NCBI) | compare |
| b3774 | ilvC | -5.6 | -13.5 | ketol-acid reductoisomerase (NCBI) | compare |
| b2913 | serA | -5.6 | -5.4 | D-3-phosphoglycerate dehydrogenase (NCBI) | compare |
| b0072 | leuC | -5.6 | -11.3 | isopropylmalate isomerase large subunit (NCBI) | compare |
| b0074 | leuA | -5.5 | -9.2 | 2-isopropylmalate synthase (NCBI) | compare |
| b3389 | aroB | -5.5 | -10.5 | 3-dehydroquinate synthase (NCBI) | compare |
| b0522 | purK | -5.5 | -6.5 | phosphoribosylaminoimidazole carboxylase (NCBI) | compare |
| b2025 | hisF | -5.4 | -6.4 | imidazole glycerol phosphate synthase subunit HisF (NCBI) | compare |
| b3771 | ilvD | -5.4 | -12.1 | dihydroxy-acid dehydratase (NCBI) | compare |
| b2320 | pdxB | -5.4 | -9.0 | erythronate-4-phosphate dehydrogenase (NCBI) | compare |
| b4006 | purH | -5.4 | -11.5 | bifunctionalphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI) | compare |
| b3960 | argH | -5.4 | -11.5 | argininosuccinate lyase (NCBI) | compare |
| b2414 | cysK | -5.4 | -12.0 | cysteine synthase A, O-acetylserine sulfhydrolase A subunit (NCBI) | compare |
| b2022 | hisB | -5.3 | -8.1 | imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS) | compare |
| b3828 | metR | -5.3 | -11.9 | DNA-binding transcriptional activator, homocysteine-binding (NCBI) | compare |
| b0908 | aroA | -5.3 | -8.8 | 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) | compare |
| b2312 | purF | -5.3 | -8.0 | amidophosphoribosyltransferase (NCBI) | compare |
| b2026 | hisI | -5.1 | -9.8 | bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI) | compare |
| b1260 | trpA | -5.1 | -4.3 | tryptophan synthase subunit alpha (NCBI) | compare |
| b0386 | proC | -5.1 | -6.1 | pyrroline-5-carboxylate reductase (NCBI) | compare |
| b1130 | phoP | -5.1 | -7.0 | DNA-binding response regulator in two-component regulatory system with PhoQ (NCBI) | compare |
| b2024 | hisA | -5.1 | -2.9 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-imidazolecarboxamide isomerase (VIMSS) | compare |
| b4005 | purD | -5.0 | -9.1 | phosphoribosylamine--glycine ligase (NCBI) | compare |
| b2020 | hisD | -5.0 | -10.2 | histidinol dehydrogenase (NCBI) | compare |
| b4214 | cysQ | -5.0 | -14.6 | PAPS (adenosine 3'-phosphate 5'-phosphosulfate) 3'(2'),5'-bisphosphate nucleotidase (NCBI) | compare |
| b0002 | thrA | -5.0 | -16.2 | bifunctional aspartokinase I/homeserine dehydrogenase I (NCBI) | compare |
| b2557 | purL | -4.9 | -9.9 | phosphoribosylformylglycinamidine synthase (NCBI) | compare |
| b3008 | metC | -4.9 | -12.2 | cystathionine beta-lyase (NCBI) | compare |
| b3956 | ppc | -4.8 | -18.4 | phosphoenolpyruvate carboxylase (NCBI) | compare |
| b3642 | pyrE | -4.8 | -4.7 | orotate phosphoribosyltransferase (NCBI) | compare |
| b3772 | ilvA | -4.8 | -13.7 | threonine dehydratase (NCBI) | compare |
| b3829 | metE | -4.7 | -18.7 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (NCBI) | compare |
| b2750 | cysC | -4.7 | -8.4 | adenylylsulfate kinase (NCBI) | compare |
| b2501 | ppk | -4.7 | -10.9 | polyphosphate kinase (NCBI) | compare |
| b2329 | aroC | -4.7 | -5.5 | chorismate synthase (NCBI) | compare |
| b2763 | cysI | -4.7 | -8.4 | sulfite reductase, beta subunit, NAD(P)-binding, heme-binding (NCBI) | compare |
| b1281 | pyrF | -4.6 | -4.9 | orotidine 5'-phosphate decarboxylase (NCBI) | compare |
| b0033 | carB | -4.5 | -16.9 | carbamoyl-phosphate synthase large subunit (NCBI) | compare |
| b3957 | argE | -4.5 | -14.5 | acetylornithine deacetylase (NCBI) | compare |
| b2499 | purM | -4.5 | -6.8 | phosphoribosylaminoimidazole synthetase (NCBI) | compare |
| b0003 | thrB | -4.5 | -7.5 | homoserine kinase (NCBI) | compare |
| b0113 | pdhR | -4.5 | -6.3 | transcriptional regulator of pyruvate dehydrogenase complex (NCBI) | compare |
| b2762 | cysH | -4.4 | -9.0 | phosphoadenosine phosphosulfate reductase (NCBI) | compare |
| b0945 | pyrD | -4.4 | -13.9 | dihydroorotate dehydrogenase (NCBI) | compare |
| b3671 | ilvB | -4.4 | -16.2 | acetolactate synthase large subunit (NCBI) | compare |
| b3958 | argC | -4.4 | -15.7 | N-acetyl-gamma-glutamyl-phosphate reductase (NCBI) | compare |
| b0145 | dksA | -4.4 | -4.2 | DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) | compare |
| b0052 | pdxA | -4.3 | -11.1 | 4-hydroxythreonine-4-phosphate dehydrogenase (NCBI) | compare |
| b3368 | cysG | -4.3 | -18.4 | fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase (NCBI) | compare |
| b3172 | argG | -4.3 | -12.6 | argininosuccinate synthase (NCBI) | compare |
| b2752 | cysD | -4.2 | -6.0 | sulfate adenylyltransferase subunit 2 (NCBI) | compare |
| b0142 | folK | -4.2 | -1.9 | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) | compare |
| b1819 | manZ | -4.1 | -6.8 | mannose-specific enzyme IID component of PTS (NCBI) | conserved |
| b1062 | pyrC | -4.1 | -10.6 | dihydroorotase (NCBI) | compare |
| b3959 | argB | -4.1 | -13.2 | acetylglutamate kinase (RefSeq) | compare |
| b1263 | trpD | -4.1 | -4.8 | bifunctional indole-3-glycerol-phosphate synthase/anthranilate phosphoribosyltransferase (NCBI) | compare |
| b2599 | pheA | -4.1 | -10.5 | fused chorismate mutase P/prephenate dehydratase (NCBI) | compare |
| b2476 | purC | -4.0 | -2.8 | phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI) | compare |
| b3237 | argR | -4.0 | -6.6 | arginine repressor (NCBI) | compare |
| b2019 | hisG | -4.0 | -5.9 | ATP phosphoribosyltransferase (NCBI) | compare |
| b2564 | pdxJ | -4.0 | -4.7 | pyridoxal phosphate biosynthetic protein (NCBI) | compare |
| b1817 | manX | -3.9 | -9.7 | fused mannose-specific PTS enzymes: IIA component/IIB component (NCBI) | conserved |
| b2764 | cysJ | -3.9 | -12.0 | sulfite reductase, alpha subunit, flavoprotein (NCBI) | compare |
| b2818 | argA | -3.9 | -10.8 | N-acetylglutamate synthase (NCBI) | compare |
| b4018 | iclR | -3.8 | -10.7 | repressor of aceBA operon (VIMSS) | compare |
| b2021 | hisC | -3.8 | -6.8 | histidinol-phosphate aminotransferase (NCBI) | compare |
| b1818 | manY | -3.8 | -4.5 | mannose-specific enzyme IIC component of PTS (NCBI) | compare |
| b3405 | ompR | -3.8 | -4.5 | osmolarity response regulator (NCBI) | compare |
| b0720 | gltA | -3.8 | -8.4 | citrate synthase (NCBI) | compare |
| b0049 | apaH | -3.8 | -7.2 | diadenosinetetraphosphatase (NCBI) | compare |
| b1192 | ldcA | -3.8 | -7.1 | L,D-carboxypeptidase A (NCBI) | compare |
| b4245 | pyrB | -3.7 | -12.1 | aspartate carbamoyltransferase catalytic subunit (NCBI) | compare |
| b0032 | carA | -3.7 | -7.8 | carbamoyl-phosphate synthase small subunit (NCBI) | compare |
| b3939 | metB | -3.7 | -13.5 | cystathionine gamma-synthase (NCBI) | compare |
| b4013 | metA | -3.7 | -6.7 | homoserine O-succinyltransferase (NCBI) | compare |
| b2600 | tyrA | -3.7 | -6.8 | fused chorismate mutase T/prephenate dehydrogenase (NCBI) | compare |
| b2479 | gcvR | -3.6 | -4.9 | transcriptional regulation of gcv operon (VIMSS) | compare |
| b3916 | pfkA | -3.6 | -2.5 | 6-phosphofructokinase (NCBI) | compare |
| b2424 | cysU | -3.5 | -3.6 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b2830 | nudH | -3.5 | -2.4 | dinucleoside polyphosphate hydrolase (NCBI) | compare |
| b2751 | cysN | -3.5 | -8.4 | sulfate adenylyltransferase subunit 1 (NCBI) | compare |
| b2422 | cysA | -3.5 | -9.5 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b2188 | yejM | -3.5 | -12.0 | predicted hydrolase, inner membrane (NCBI) | compare |
| b1727 | yniC | -3.4 | -3.9 | predicted hydrolase (NCBI) | compare |
| b2423 | cysW | -3.4 | -7.8 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b2839 | lysR | -3.4 | -5.8 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b3204 | ptsN | -3.3 | -7.7 | sugar-specific enzyme IIA component of PTS (NCBI) | compare |
| b0014 | dnaK | -3.3 | -3.1 | molecular chaperone DnaK (NCBI) | compare |
| b0118 | acnB | -3.2 | -2.2 | aconitate hydratase (NCBI) | compare |
| b0114 | aceE | -3.1 | -2.1 | pyruvate dehydrogenase subunit E1 (NCBI) | compare |
| b3621 | rfaC | -3.0 | -6.3 | ADP-heptose:LPS heptosyl transferase I (NCBI) | compare |
| b3741 | gidA | -3.0 | -9.0 | glucose-inhibited division protein A (NCBI) | compare |
| b3870 | glnA | -2.9 | -2.0 | glutamine synthetase (NCBI) | compare |
| b1262 | trpC | -2.9 | -4.6 | N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase (VIMSS) | compare |
| b0200 | gmhB | -2.9 | -2.0 | hypothetical protein (NCBI) | compare |
| b3728 | pstS | -2.9 | -5.8 | phosphate transporter subunit (NCBI) | compare |
| b3650 | spoT | -2.9 | -9.5 | bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase (NCBI) | compare |
| b3052 | rfaE | -2.8 | -6.9 | fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) | compare |
| b3961 | oxyR | -2.8 | -13.6 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b3390 | aroK | -2.8 | -3.5 | shikimate kinase I (NCBI) | compare |
| b3706 | trmE | -2.8 | -6.7 | tRNA modification GTPase (NCBI) | compare |
| b3773 | ilvY | -2.8 | -9.2 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b0726 | sucA | -2.7 | -3.6 | alpha-ketoglutarate decarboxylase (NCBI) | compare |
| b0439 | lon | -2.6 | -7.3 | DNA-binding ATP-dependent protease La (NCBI) | compare |
| b4177 | purA | -2.6 | -2.5 | adenylosuccinate synthetase (NCBI) | compare |
| b0222 | lpcA | -2.6 | -4.2 | phosphoheptose isomerase (NCBI) | compare |
| b3619 | rfaD | -2.6 | -5.1 | ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) | compare |
| b4171 | miaA | -2.5 | -7.9 | tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) | compare |
| b4242 | mgtA | -2.5 | -17.0 | magnesium transporter (NCBI) | compare |
| b3386 | rpe | -2.4 | -1.7 | ribulose-phosphate 3-epimerase (NCBI) | compare |
| b4702 | mgtL | -2.4 | -4.5 | regulatory leader peptide for mgtA (NCBI) | compare |
| b2935 | tktA | -2.4 | -4.2 | transketolase 1, thiamin-binding (NCBI) | compare |
| b4480 | hdfR | -2.4 | -7.5 | transcriptional regulator HdfR (NCBI) | compare |
| b0683 | fur | -2.3 | -3.1 | ferric uptake regulator (NCBI) | compare |
| b0737 | tolQ | -2.3 | -5.0 | membrane spanning protein in TolA-TolQ-TolR complex (NCBI) | compare |
| b1712 | ihfA | -2.3 | -3.9 | integration host factor subunit alpha (NCBI) | compare |
| b3811 | xerC | -2.2 | -3.6 | site-specific tyrosine recombinase XerC (NCBI) | compare |
| b2330 | yfcB | -2.2 | -3.8 | putative adenine-specific methylase (VIMSS) | compare |
| b3860 | dsbA | -2.2 | -11.4 | periplasmic protein disulfide isomerase I (NCBI) | compare |
| b0738 | tolR | -2.2 | -4.3 | membrane spanning protein in TolA-TolQ-TolR complex (NCBI) | compare |
| b1273 | yciN | -2.2 | -2.3 | hypothetical protein (NCBI) | compare |
| b3781 | trxA | -2.2 | -5.1 | thioredoxin 1 (VIMSS) | compare |
| b1291 | sapD | -2.2 | -3.2 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b0605 | ahpC | -2.2 | -7.8 | alkyl hydroperoxide reductase, C22 subunit (NCBI) | compare |
| b1290 | sapF | -2.2 | -3.4 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b3993 | thiE | -2.2 | -7.3 | thiamine-phosphate pyrophosphorylase (NCBI) | compare |
| b3725 | pstB | -2.1 | -2.8 | phosphate transporter subunit (NCBI) | compare |
| b1857 | yebL | -2.1 | -5.5 | putative adhesin (VIMSS) | compare |
| b2340 | sixA | -2.1 | -5.2 | phosphohistidine phosphatase (NCBI) | compare |
| b0606 | ahpF | -2.1 | -8.4 | alkyl hydroperoxide reductase, F52a subunit; detoxification of hydroperoxides (VIMSS) | compare |
| b1859 | znuB | -2.1 | -7.6 | high-affinity zinc transporter membrane component (NCBI) | compare |
| b2894 | xerD | -2.0 | -2.3 | site-specific tyrosine recombinase XerD (NCBI) | compare |
| b0630 | lipB | -2.0 | -2.3 | protein of lipoate biosynthesis (VIMSS) | compare |
| b3672 | ivbL | -2.0 | -2.7 | ilvB operon leader peptide (NCBI) | compare |
| b2820 | recB | -2.0 | -3.4 | exonuclease V (RecBCD complex), beta subunit (NCBI) | compare |
| b3398 | yrfF | -2.0 | -4.5 | predicted inner membrane protein (NCBI) | compare |
| b1858 | znuC | -2.0 | -6.8 | high-affinity zinc transporter ATPase (NCBI) | compare |
| b3764 | yifE | -1.9 | -6.3 | hypothetical protein (NCBI) | compare |
| b2297 | pta | -1.9 | -2.8 | phosphate acetyltransferase (NCBI) | compare |
| b3630 | rfaP | -1.9 | -11.9 | kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) | compare |
| b0739 | tolA | -1.9 | -5.1 | cell envelope integrity inner membrane protein TolA (NCBI) | compare |
| b4375 | prfC | -1.9 | -8.6 | peptide chain release factor 3 (NCBI) | compare |
| b3213 | gltD | -1.9 | -9.5 | glutamate synthase, 4Fe-4S protein, small subunit (NCBI) | compare |
| b3212 | gltB | -1.8 | -13.1 | glutamate synthase, large subunit (NCBI) | compare |
| b0890 | ftsK | -1.8 | -8.3 | DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) | compare |
| b1185 | dsbB | -1.8 | -3.9 | reoxidizes DsbA protein following formation of disulfide bond in P-ring of flagella. (VIMSS) | compare |
| b1264 | trpE | -1.8 | -3.7 | anthranilate synthase component I (NCBI) | compare |
| b2567 | rnc | -1.8 | -2.0 | ribonuclease III (NCBI) | compare |
| b3290 | trkA | -1.8 | -3.4 | potassium transporter peripheral membrane component (NCBI) | compare |
| b2189 | proL | -1.8 | -2.6 | tRNA-Pro (NCBI) | compare |
| b0688 | pgm | -1.8 | -5.0 | phosphoglucomutase (NCBI) | compare |
| b0912 | ihfB | -1.8 | -3.7 | integration host factor subunit beta (NCBI) | compare |
| b3620 | rfaF | -1.8 | -5.1 | ADP-heptose:LPS heptosyltransferase II (NCBI) | compare |
| b1684 | sufA | -1.7 | -3.5 | iron-sulfur cluster assembly scaffold protein (NCBI) | compare |
| b0750 | nadA | -1.7 | -5.5 | quinolinate synthetase (NCBI) | compare |
| b3469 | zntA | -1.7 | -11.1 | zinc, cobalt and lead efflux system (NCBI) | compare |
| b1084 | rne | -1.7 | -6.1 | fused ribonucleaseE: endoribonuclease/RNA-binding protein/RNA degradosome binding protein (NCBI) | compare |
| b3849 | trkH | -1.7 | -10.4 | potassium transporter (NCBI) | compare |
| b1187 | fadR | -1.7 | -6.6 | fatty acid metabolism regulator (NCBI) | compare |
| b4585 | sroB | -1.6 | -1.4 | Novel sRNA, function unknown (RefSeq) | compare |
| b2500 | purN | -1.6 | -5.8 | phosphoribosylglycinamide formyltransferase (NCBI) | compare |
| b3842 | rfaH | -1.6 | -5.4 | transcriptional activator RfaH (NCBI) | compare |
| b0101 | yacG | -1.6 | -2.7 | zinc-binding protein (NCBI) | compare |
| b2103 | thiD | -1.6 | -6.7 | phosphomethylpyrimidine kinase (NCBI) | compare |
| b0741 | pal | -1.6 | -4.9 | peptidoglycan-associated outer membrane lipoprotein (NCBI) | compare |
| b3992 | thiF | -1.6 | -7.7 | thiamin biosynthesis, thiazole moiety (VIMSS) | compare |
| b3236 | mdh | -1.5 | -7.4 | malate dehydrogenase (NCBI) | compare |
| b1724 | ydiZ | -1.5 | -2.8 | hypothetical protein (NCBI) | compare |
| b0740 | tolB | -1.5 | -5.6 | translocation protein TolB precursor (NCBI) | compare |
| b3991 | thiG | -1.5 | -7.5 | thiamin biosynthesis, thiazole moiety (VIMSS) | compare |
| b3806 | cyaA | -1.5 | -5.9 | adenylate cyclase (NCBI) | compare |
| b3790 | rffC | -1.5 | -5.3 | TDP-fucosamine acetyltransferase (RefSeq) | compare |
| b2853 | ygeI | -1.5 | -2.8 | hypothetical protein (NCBI) | compare |
| b0767 | ybhE | -1.5 | -4.5 | 6-phosphogluconolactonase (NCBI) | compare |
| b3994 | thiC | -1.4 | -10.2 | thiamine biosynthesis protein ThiC (NCBI) | compare |
| b3675 | yidG | -1.4 | -6.7 | predicted inner membrane protein (NCBI) | compare |
| b0623 | cspE | -1.4 | -2.1 | cold shock protein E (NCBI) | compare |
| b2215 | ompC | -1.4 | -8.3 | outer membrane porin protein C (NCBI) | compare |
| b3404 | envZ | -1.4 | -7.0 | osmolarity sensor protein (NCBI) | compare |
| b0075 | leuL | -1.4 | -2.9 | leu operon leader peptide (NCBI) | compare |
| b3791 | rffA | -1.4 | -7.3 | TDP-4-oxo-6-deoxy-D-glucose transaminase (NCBI) | compare |
| b3792 | wzxE | -1.4 | -7.6 | O-antigen translocase (NCBI) | compare |
| b3631 | rfaG | -1.4 | -11.0 | glucosyltransferase I (NCBI) | compare |