Experiment set1IT059 for Escherichia coli BW25113

Compare to:

casamino acids carbon source

200 most important genes:

  gene name fitness t score description  
b2312 purF -5.6 -6.7 amidophosphoribosyltransferase (NCBI) compare
b4232 fbp -5.5 -11.6 fructose-1,6-bisphosphatase (NCBI) compare
b1261 trpB -5.3 -4.2 tryptophan synthase subunit beta (NCBI) compare
b2476 purC -4.9 -4.5 phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI) compare
b2499 purM -4.9 -5.8 phosphoribosylaminoimidazole synthetase (NCBI) compare
b4006 purH -4.9 -13.4 bifunctionalphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI) compare
b1260 trpA -4.8 -6.7 tryptophan synthase subunit alpha (NCBI) compare
b2188 yejM -4.8 -10.8 predicted hydrolase, inner membrane (NCBI) compare
b2285 nuoE -4.7 -3.2 NADH dehydrogenase subunit E (NCBI) compare
b0522 purK -4.7 -10.0 phosphoribosylaminoimidazole carboxylase (NCBI) compare
b0728 sucC -4.6 -8.3 succinyl-CoA synthetase subunit beta (NCBI) compare
b0729 sucD -4.6 -4.5 succinyl-CoA synthetase subunit alpha (NCBI) compare
b1281 pyrF -4.5 -5.4 orotidine 5'-phosphate decarboxylase (NCBI) compare
b1062 pyrC -4.5 -10.0 dihydroorotase (NCBI) compare
b4005 purD -4.5 -10.4 phosphoribosylamine--glycine ligase (NCBI) compare
b0945 pyrD -4.4 -13.9 dihydroorotate dehydrogenase (NCBI) compare
b3642 pyrE -4.4 -5.2 orotate phosphoribosyltransferase (NCBI) compare
b4245 pyrB -4.4 -12.1 aspartate carbamoyltransferase catalytic subunit (NCBI) compare
b2500 purN -4.4 -5.7 phosphoribosylglycinamide formyltransferase (NCBI) compare
b0523 purE -4.3 -5.1 phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI) compare
b2557 purL -4.2 -11.9 phosphoribosylformylglycinamidine synthase (NCBI) compare
b0032 carA -4.1 -8.9 carbamoyl-phosphate synthase small subunit (NCBI) compare
b3844 fre -4.0 -7.1 NAD(P)H-flavin reductase (NCBI) compare
b2276 nuoN -4.0 -7.1 NADH:ubiquinone oxidoreductase, membrane subunit N (RefSeq) compare
b0033 carB -3.9 -17.0 carbamoyl-phosphate synthase large subunit (NCBI) compare
b2286 nuoC -3.9 -6.9 NADH:ubiquinone oxidoreductase, chain C,D (RefSeq) compare
b4139 aspA -3.8 -12.4 aspartate ammonia-lyase (aspartase) (VIMSS) compare
b3281 aroE -3.8 -19.0 dehydroshikimate reductase, NAD(P)-binding (NCBI) compare
b2281 nuoI -3.7 -4.4 NADH dehydrogenase subunit I (NCBI) compare
b2501 ppk -3.7 -13.1 polyphosphate kinase (NCBI) compare
b2277 nuoM -3.6 -6.8 NADH dehydrogenase subunit M (NCBI) compare
b1264 trpE -3.6 -6.1 anthranilate synthase component I (NCBI) compare
b1290 sapF -3.6 -4.1 predicted antimicrobial peptide transporter subunit (NCBI) compare
b1693 aroD -3.5 -9.3 3-dehydroquinate dehydratase (NCBI) compare
b2320 pdxB -3.5 -9.2 erythronate-4-phosphate dehydrogenase (NCBI) compare
b2278 nuoL -3.5 -10.3 NADH dehydrogenase subunit L (NCBI) compare
b2830 nudH -3.5 -2.4 dinucleoside polyphosphate hydrolase (NCBI) compare
b2280 nuoJ -3.5 -7.3 NADH dehydrogenase subunit J (NCBI) compare
b1262 trpC -3.4 -6.5 N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase (VIMSS) compare
b2283 nuoG -3.4 -9.3 NADH:ubiquinone oxidoreductase, chain G (RefSeq) compare
b2284 nuoF -3.4 -6.5 NADH:ubiquinone oxidoreductase, chain F (NCBI) compare
b1292 sapC -3.4 -4.0 predicted antimicrobial peptide transporter subunit (NCBI) compare
b0439 lon -3.3 -6.7 DNA-binding ATP-dependent protease La (NCBI) compare
b0052 pdxA -3.3 -11.8 4-hydroxythreonine-4-phosphate dehydrogenase (NCBI) compare
b2564 pdxJ -3.3 -6.2 pyridoxal phosphate biosynthetic protein (NCBI) compare
b3389 aroB -3.3 -14.1 3-dehydroquinate synthase (NCBI) compare
b0437 clpP -3.3 -10.2 ATP-dependent Clp protease proteolytic subunit (NCBI) compare
b0721 sdhC -3.3 -5.8 succinate dehydrogenase cytochrome b556 large membrane subunit (NCBI) compare
b0683 fur -3.2 -3.0 ferric uptake regulator (NCBI) compare
b3390 aroK -3.2 -4.0 shikimate kinase I (NCBI) compare
b2288 nuoA -3.2 -4.3 NADH dehydrogenase I chain A (VIMSS) compare
b3236 mdh -3.1 -9.1 malate dehydrogenase (NCBI) compare
b1263 trpD -3.0 -3.8 bifunctional indole-3-glycerol-phosphate synthase/anthranilate phosphoribosyltransferase (NCBI) compare
b0114 aceE -3.0 -2.1 pyruvate dehydrogenase subunit E1 (NCBI) compare
b0118 acnB -3.0 -2.9 aconitate hydratase (NCBI) compare
b0723 sdhA -3.0 -12.3 succinate dehydrogenase flavoprotein subunit (NCBI) compare
b3082 ygjM -2.9 -4.3 predicted DNA-binding transcriptional regulator (NCBI) compare
b0145 dksA -2.9 -5.1 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b0438 clpX -2.9 -10.0 ATP-dependent protease ATP-binding subunit (NCBI) compare
b2329 aroC -2.9 -6.7 chorismate synthase (NCBI) compare
b3962 udhA -2.9 -11.3 putative oxidoreductase (VIMSS) compare
b3870 glnA -2.9 -2.0 glutamine synthetase (NCBI) compare
b0724 sdhB -2.8 -7.6 succinate dehydrogenase, FeS subunit (NCBI) compare
b0049 apaH -2.8 -6.5 diadenosinetetraphosphatase (NCBI) compare
b0750 nadA -2.8 -9.2 quinolinate synthetase (NCBI) compare
b0428 cyoE -2.8 -8.7 protoheme IX farnesyltransferase (NCBI) compare
b0726 sucA -2.8 -3.8 alpha-ketoglutarate decarboxylase (NCBI) compare
b3806 cyaA -2.7 -6.7 adenylate cyclase (NCBI) compare
b0430 cyoC -2.7 -5.7 cytochrome o ubiquinol oxidase subunit III (NCBI) compare
b3728 pstS -2.7 -5.9 phosphate transporter subunit (NCBI) compare
b0630 lipB -2.7 -2.5 protein of lipoate biosynthesis (VIMSS) compare
b0142 folK -2.7 -1.9 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) compare
b0109 nadC -2.6 -7.1 nicotinate-nucleotide pyrophosphorylase (NCBI) compare
b4177 purA -2.6 -1.8 adenylosuccinate synthetase (NCBI) compare
b0908 aroA -2.6 -10.4 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) compare
b2282 nuoH -2.5 -4.0 NADH dehydrogenase subunit H (NCBI) compare
b2574 nadB -2.5 -10.2 L-aspartate oxidase (NCBI) compare
b2287 nuoB -2.5 -4.9 NADH dehydrogenase subunit B (NCBI) compare
b2894 xerD -2.5 -2.3 site-specific tyrosine recombinase XerD (NCBI) compare
b0431 cyoB -2.5 -12.7 cytochrome o ubiquinol oxidase subunit I (NCBI) compare
b3725 pstB -2.4 -2.3 phosphate transporter subunit (NCBI) compare
b0720 gltA -2.4 -7.3 citrate synthase (NCBI) compare
b0080 fruR -2.4 -8.0 DNA-binding transcriptional dual regulator (NCBI) compare
b0722 sdhD -2.4 -5.4 succinate dehydrogenase cytochrome b556 small membrane subunit (NCBI) compare
b0907 serC -2.4 -7.1 phosphoserine aminotransferase (NCBI) compare
b3414 gntY -2.4 -7.7 predicted gluconate transport associated protein (NCBI) compare
b2297 pta -2.3 -2.7 phosphate acetyltransferase (NCBI) compare
b0928 aspC -2.2 -8.0 aspartate aminotransferase, PLP-dependent (NCBI) compare
b2567 rnc -2.2 -2.1 ribonuclease III (NCBI) compare
b1129 phoQ -2.2 -9.2 sensory histidine kinase in two-compoent regulatory system with PhoP (NCBI) compare
b3849 trkH -2.2 -11.0 potassium transporter (NCBI) compare
b1235 rssB -2.1 -9.2 response regulator of RpoS (NCBI) compare
b3052 rfaE -2.1 -6.7 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare
b0200 gmhB -2.1 -2.4 hypothetical protein (NCBI) compare
b3121 yhaC -2.1 -2.4 hypothetical protein (NCBI) compare
b0222 lpcA -2.1 -3.6 phosphoheptose isomerase (NCBI) compare
b1084 rne -2.1 -5.7 fused ribonucleaseE: endoribonuclease/RNA-binding protein/RNA degradosome binding protein (NCBI) compare
b3619 rfaD -2.1 -4.7 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b1704 aroH -2.1 -5.6 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tryptophan repressible (NCBI) conserved
b0738 tolR -2.1 -4.1 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b4480 hdfR -2.0 -5.6 transcriptional regulator HdfR (NCBI) compare
b3621 rfaC -2.0 -6.7 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b1612 fumA -2.0 -5.7 fumarate hydratase (fumarase A), aerobic Class I (NCBI) compare
b3620 rfaF -2.0 -5.9 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b4042 dgkA -2.0 -4.1 diacylglycerol kinase (NCBI) compare
b2279 nuoK -2.0 -2.1 NADH dehydrogenase subunit K (NCBI) compare
b0564 appY -2.0 -2.1 DLP12 prophage; DNA-binding transcriptional activator (NCBI) compare
b1291 sapD -1.9 -3.1 predicted antimicrobial peptide transporter subunit (NCBI) compare
b3386 rpe -1.9 -2.2 ribulose-phosphate 3-epimerase (NCBI) compare
b0432 cyoA -1.9 -8.4 cytochrome o ubiquinol oxidase subunit II (NCBI) compare
b2318 truA -1.9 -5.4 tRNA pseudouridine synthase A (NCBI) compare
b1863 ruvC -1.8 -4.8 Holliday junction resolvase (NCBI) compare
b3811 xerC -1.8 -3.4 site-specific tyrosine recombinase XerC (NCBI) compare
b2313 cvpA -1.8 -3.4 membrane protein required for colicin V production (NCBI) compare
b2528 iscA -1.8 -2.4 iron-sulfur cluster assembly protein (NCBI) compare
b3204 ptsN -1.8 -5.2 sugar-specific enzyme IIA component of PTS (NCBI) compare
b0740 tolB -1.8 -6.0 translocation protein TolB precursor (NCBI) compare
b0500 ybbD -1.8 -3.1 hypothetical protein (RefSeq) compare
b2340 sixA -1.8 -4.4 phosphohistidine phosphatase (NCBI) compare
b0589 fepG -1.8 -6.7 iron-enterobactin transporter subunit (NCBI) compare
b3405 ompR -1.8 -5.6 osmolarity response regulator (NCBI) compare
b3726 pstA -1.7 -5.7 phosphate transporter subunit (NCBI) compare
b0737 tolQ -1.7 -4.2 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b0585 fes -1.7 -5.9 enterobactin/ferric enterobactin esterase (NCBI) compare
b0890 ftsK -1.7 -7.5 DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) compare
b4630 ykgP -1.6 -3.4 no description compare
b3839 tatC -1.6 -8.3 TatABCE protein translocation system subunit (NCBI) compare
b3993 thiE -1.5 -6.3 thiamine-phosphate pyrophosphorylase (NCBI) compare
b0739 tolA -1.5 -4.6 cell envelope integrity inner membrane protein TolA (NCBI) compare
b1130 phoP -1.5 -6.7 DNA-binding response regulator in two-component regulatory system with PhoQ (NCBI) compare
b2906 visC -1.5 -6.5 hypothetical protein (NCBI) compare
b1347 ydaC -1.5 -2.4 Rac prophage; predicted protein (NCBI) compare
b2114 metG -1.5 -1.9 methionyl-tRNA synthetase (NCBI) compare
b0592 fepB -1.5 -7.2 iron-enterobactin transporter subunit (NCBI) compare
b1551 b1551 -1.5 -3.0 orf, hypothetical protein (VIMSS) compare
b0588 fepC -1.5 -7.7 iron-enterobactin transporter subunit (NCBI) compare
b4179 vacB -1.5 -7.9 putative enzyme (VIMSS) compare
b2055 wcaE -1.4 -3.3 predicted glycosyl transferase (NCBI) compare
b3764 yifE -1.4 -4.4 hypothetical protein (NCBI) compare
b4146 yjeK -1.4 -3.7 predicted lysine aminomutase (NCBI) compare
b3290 trkA -1.4 -3.3 potassium transporter peripheral membrane component (NCBI) compare
b0741 pal -1.4 -4.5 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b0429 cyoD -1.4 -4.2 cytochrome o ubiquinol oxidase subunit IV (NCBI) compare
b2168 fruK -1.4 -2.5 1-phosphofructokinase (NCBI) compare
b4481 rffT -1.4 -6.6 4-alpha-L-fucosyltransferase (NCBI) compare
b3232 yhcM -1.3 -7.3 conserved protein with nucleoside triphosphate hydrolase domain (NCBI) conserved
b0590 fepD -1.3 -5.4 iron-enterobactin transporter subunit (NCBI) compare
b2103 thiD -1.3 -5.4 phosphomethylpyrimidine kinase (NCBI) compare
b1860 ruvB -1.3 -1.5 Holliday junction DNA helicase B (NCBI) compare
b4443 gcvB -1.3 -1.8 GcvB sRNA gene divergent from gcvA (RefSeq) compare
b3991 thiG -1.3 -5.8 thiamin biosynthesis, thiazole moiety (VIMSS) compare
b3601 mtlR -1.2 -4.7 DNA-binding repressor (NCBI) compare
b3994 thiC -1.2 -8.7 thiamine biosynthesis protein ThiC (NCBI) compare
b0134 panB -1.2 -6.2 3-methyl-2-oxobutanoate hydroxymethyltransferase (NCBI) compare
b1167 ymgC -1.2 -2.0 hypothetical protein (NCBI) compare
b4025 pgi -1.2 -6.2 glucose-6-phosphate isomerase (NCBI) compare
b2518 ndk -1.2 -2.3 nucleoside diphosphate kinase (NCBI) compare
b0658 ybeX -1.2 -6.5 predicteed ion transport (NCBI) compare
b3169 nusA -1.2 -2.3 transcription elongation factor NusA (NCBI) compare
b2897 ygfY -1.2 -3.3 hypothetical protein (NCBI) compare
b3727 pstC -1.2 -4.5 phosphate transporter subunit (NCBI) compare
b3992 thiF -1.2 -6.6 thiamin biosynthesis, thiazole moiety (VIMSS) compare
b3630 rfaP -1.2 -8.0 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b1236 galU -1.1 -4.0 glucose-1-phosphate uridylyltransferase (NCBI) compare
b3528 dctA -1.1 -7.8 C4 dicarboxylate/orotate:H+ symporter (DctA) (from data) compare
b4660 yhiL -1.1 -3.1 no description compare
b4702 mgtL -1.1 -2.2 regulatory leader peptide for mgtA (NCBI) compare
b0427 yajR -1.1 -6.0 putative transport protein (VIMSS) compare
b3237 argR -1.1 -3.8 arginine repressor (NCBI) compare
b0018 mokC -1.1 -1.3 regulatory protein for HokC, overlaps CDS of hokC (NCBI) compare
b4590 ybfK -1.1 -3.6 hypothetical protein (RefSeq) compare
b0121 speE -1.1 -4.7 spermidine synthase (NCBI) compare
b2935 tktA -1.0 -3.1 transketolase 1, thiamin-binding (NCBI) compare
b1434 ydcN -1.0 -2.0 predicted DNA-binding transcriptional regulator (NCBI) compare
b3463 ftsE -1.0 -3.8 predicted transporter subunit: ATP-binding component of ABC superfamily (NCBI) compare
b0688 pgm -1.0 -3.3 phosphoglucomutase (NCBI) compare
b2330 yfcB -1.0 -2.3 putative adenine-specific methylase (VIMSS) compare
b1545 pinQ -1.0 -1.4 Qin prophage; predicted site-specific recombinase (NCBI) compare
b1187 fadR -1.0 -4.6 fatty acid metabolism regulator (NCBI) compare
b3247 cafA -1.0 -7.1 bundles of cytoplasmic filaments (VIMSS) compare
b3631 rfaG -1.0 -8.4 glucosyltransferase I (NCBI) compare
b3465 yhhF -1.0 -3.6 predicted methyltransferase (NCBI) compare
b4453 ldrD -1.0 -2.3 toxic polypeptide, small (NCBI) compare
b0676 nagC -1.0 -5.2 DNA-binding transcriptional dual regulator, repressor of N-acetylglucosamine (NCBI) compare
b3183 obgE -1.0 -1.6 GTPase involved in cell partioning and DNA repair (NCBI) compare
b0685 ybfE -1.0 -2.4 orf, hypothetical protein (VIMSS) compare
b3863 polA -1.0 -1.1 DNA polymerase I (NCBI) compare
b3164 pnp -1.0 -2.5 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b0450 glnK -1.0 -1.8 nitrogen assimilation regulatory protein for GlnL, GlnE, and AmtB (NCBI) compare
b1231 tyrT -1.0 -1.1 tRNA-Tyr (NCBI) compare
b3842 rfaH -0.9 -3.8 transcriptional activator RfaH (NCBI) compare
b1865 nudB -0.9 -1.3 dATP pyrophosphohydrolase (NCBI) compare
b4279 yjhB -0.9 -2.9 putative transport protein (VIMSS) compare
b0167 glnD -0.9 -3.4 PII uridylyl-transferase (NCBI) compare
b3398 yrfF -0.9 -2.7 predicted inner membrane protein (NCBI) compare
b4388 serB -0.9 -3.5 3-phosphoserine phosphatase (NCBI) compare
b4242 mgtA -0.9 -6.9 magnesium transporter (NCBI) compare
b1266 yciV -0.9 -2.9 hypothetical protein (NCBI) compare
b3781 trxA -0.9 -3.0 thioredoxin 1 (VIMSS) compare
b0390 aroM -0.9 -5.5 hypothetical protein (NCBI) compare


Specific Phenotypes

For 6 genes in this experiment

For carbon source casamino acids in Escherichia coli BW25113

For carbon source casamino acids across organisms