| | gene | name | fitness | t score | description | |
|---|
| b2476 | purC | -6.7 | -4.4 | phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI) | compare |
| b1260 | trpA | -6.0 | -4.9 | tryptophan synthase subunit alpha (NCBI) | compare |
| b2025 | hisF | -5.5 | -5.4 | imidazole glycerol phosphate synthase subunit HisF (NCBI) | compare |
| b2424 | cysU | -5.5 | -3.8 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b1192 | ldcA | -5.4 | -3.7 | L,D-carboxypeptidase A (NCBI) | compare |
| b2019 | hisG | -5.3 | -6.3 | ATP phosphoribosyltransferase (NCBI) | compare |
| b0071 | leuD | -5.1 | -7.0 | isopropylmalate isomerase small subunit (NCBI) | compare |
| b4214 | cysQ | -5.1 | -11.0 | PAPS (adenosine 3'-phosphate 5'-phosphosulfate) 3'(2'),5'-bisphosphate nucleotidase (NCBI) | compare |
| b0243 | proA | -5.1 | -9.2 | gamma-glutamyl phosphate reductase (NCBI) | compare |
| b0072 | leuC | -5.1 | -11.4 | isopropylmalate isomerase large subunit (NCBI) | compare |
| b2838 | lysA | -5.1 | -8.5 | diaminopimelate decarboxylase, PLP-binding (NCBI) | compare |
| b3774 | ilvC | -5.1 | -14.6 | ketol-acid reductoisomerase (NCBI) | compare |
| b4232 | fbp | -5.0 | -11.6 | fructose-1,6-bisphosphatase (NCBI) | compare |
| b2312 | purF | -5.0 | -6.8 | amidophosphoribosyltransferase (NCBI) | compare |
| b1235 | rssB | -4.9 | -7.5 | response regulator of RpoS (NCBI) | compare |
| b4013 | metA | -4.9 | -6.7 | homoserine O-succinyltransferase (NCBI) | compare |
| b0074 | leuA | -4.9 | -9.3 | 2-isopropylmalate synthase (NCBI) | compare |
| b0721 | sdhC | -4.9 | -5.8 | succinate dehydrogenase cytochrome b556 large membrane subunit (NCBI) | compare |
| b3844 | fre | -4.8 | -4.7 | NAD(P)H-flavin reductase (NCBI) | compare |
| b3941 | metF | -4.8 | -11.6 | 5,10-methylenetetrahydrofolate reductase (NCBI) | compare |
| b3008 | metC | -4.8 | -10.7 | cystathionine beta-lyase (NCBI) | compare |
| b3281 | aroE | -4.8 | -15.6 | dehydroshikimate reductase, NAD(P)-binding (NCBI) | compare |
| b4006 | purH | -4.7 | -11.4 | bifunctionalphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI) | compare |
| b3770 | ilvE | -4.7 | -12.2 | branched-chain amino acid aminotransferase (NCBI) | compare |
| b3939 | metB | -4.7 | -10.9 | cystathionine gamma-synthase (NCBI) | compare |
| b3172 | argG | -4.6 | -9.9 | argininosuccinate synthase (NCBI) | compare |
| b0004 | thrC | -4.6 | -8.9 | threonine synthase (NCBI) | compare |
| b1062 | pyrC | -4.6 | -8.3 | dihydroorotase (NCBI) | compare |
| b1865 | nudB | -4.6 | -3.1 | dATP pyrophosphohydrolase (NCBI) | compare |
| b2020 | hisD | -4.6 | -9.7 | histidinol dehydrogenase (NCBI) | compare |
| b4245 | pyrB | -4.6 | -12.1 | aspartate carbamoyltransferase catalytic subunit (NCBI) | compare |
| b0033 | carB | -4.5 | -15.1 | carbamoyl-phosphate synthase large subunit (NCBI) | compare |
| b0242 | proB | -4.5 | -6.9 | gamma-glutamyl kinase (NCBI) | compare |
| b0386 | proC | -4.5 | -6.9 | pyrroline-5-carboxylate reductase (NCBI) | compare |
| b2022 | hisB | -4.5 | -8.1 | imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS) | compare |
| b2750 | cysC | -4.5 | -7.5 | adenylylsulfate kinase (NCBI) | compare |
| b0003 | thrB | -4.5 | -10.4 | homoserine kinase (NCBI) | compare |
| b2762 | cysH | -4.5 | -7.5 | phosphoadenosine phosphosulfate reductase (NCBI) | compare |
| b2414 | cysK | -4.4 | -11.4 | cysteine synthase A, O-acetylserine sulfhydrolase A subunit (NCBI) | compare |
| b0073 | leuB | -4.4 | -10.3 | 3-isopropylmalate dehydrogenase (VIMSS) | compare |
| b0052 | pdxA | -4.4 | -9.8 | 4-hydroxythreonine-4-phosphate dehydrogenase (NCBI) | compare |
| b3958 | argC | -4.4 | -14.6 | N-acetyl-gamma-glutamyl-phosphate reductase (NCBI) | compare |
| b3389 | aroB | -4.4 | -13.8 | 3-dehydroquinate synthase (NCBI) | compare |
| b2913 | serA | -4.4 | -9.3 | D-3-phosphoglycerate dehydrogenase (NCBI) | compare |
| b2423 | cysW | -4.4 | -6.0 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b3828 | metR | -4.4 | -11.9 | DNA-binding transcriptional activator, homocysteine-binding (NCBI) | compare |
| b0522 | purK | -4.4 | -8.8 | phosphoribosylaminoimidazole carboxylase (NCBI) | compare |
| b0912 | ihfB | -4.3 | -4.9 | integration host factor subunit beta (NCBI) | compare |
| b0723 | sdhA | -4.3 | -8.7 | succinate dehydrogenase flavoprotein subunit (NCBI) | compare |
| b2026 | hisI | -4.3 | -7.9 | bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI) | compare |
| b2600 | tyrA | -4.3 | -6.8 | fused chorismate mutase T/prephenate dehydrogenase (NCBI) | compare |
| b1693 | aroD | -4.3 | -8.6 | 3-dehydroquinate dehydratase (NCBI) | compare |
| b2285 | nuoE | -4.2 | -2.9 | NADH dehydrogenase subunit E (NCBI) | compare |
| b4388 | serB | -4.2 | -7.6 | 3-phosphoserine phosphatase (NCBI) | compare |
| b2189 | proL | -4.2 | -2.5 | tRNA-Pro (NCBI) | compare |
| b2021 | hisC | -4.2 | -6.4 | histidinol-phosphate aminotransferase (NCBI) | compare |
| b1129 | phoQ | -4.2 | -8.5 | sensory histidine kinase in two-compoent regulatory system with PhoP (NCBI) | compare |
| b2752 | cysD | -4.2 | -7.5 | sulfate adenylyltransferase subunit 2 (NCBI) | compare |
| b0080 | fruR | -4.2 | -7.0 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b0049 | apaH | -4.2 | -6.4 | diadenosinetetraphosphatase (NCBI) | compare |
| b0889 | lrp | -4.2 | -4.0 | DNA-binding transcriptional dual regulator, leucine-binding (NCBI) | compare |
| b3771 | ilvD | -4.2 | -14.0 | dihydroxy-acid dehydratase (NCBI) | compare |
| b2557 | purL | -4.1 | -10.0 | phosphoribosylformylglycinamidine synthase (NCBI) | compare |
| b2839 | lysR | -4.1 | -7.8 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b0907 | serC | -4.1 | -8.9 | phosphoserine aminotransferase (NCBI) | compare |
| b4005 | purD | -4.1 | -9.5 | phosphoribosylamine--glycine ligase (NCBI) | compare |
| b3960 | argH | -4.1 | -12.8 | argininosuccinate lyase (NCBI) | compare |
| b0032 | carA | -4.1 | -8.9 | carbamoyl-phosphate synthase small subunit (NCBI) | compare |
| b3957 | argE | -4.0 | -15.6 | acetylornithine deacetylase (NCBI) | compare |
| b2188 | yejM | -4.0 | -10.4 | predicted hydrolase, inner membrane (NCBI) | compare |
| b2422 | cysA | -4.0 | -8.5 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b3829 | metE | -4.0 | -17.4 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (NCBI) | compare |
| b0908 | aroA | -4.0 | -10.2 | 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) | compare |
| b0438 | clpX | -4.0 | -8.4 | ATP-dependent protease ATP-binding subunit (NCBI) | compare |
| b0113 | pdhR | -4.0 | -6.0 | transcriptional regulator of pyruvate dehydrogenase complex (NCBI) | compare |
| b0724 | sdhB | -4.0 | -6.0 | succinate dehydrogenase, FeS subunit (NCBI) | compare |
| b0523 | purE | -3.9 | -5.2 | phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI) | compare |
| b0142 | folK | -3.9 | -1.6 | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) | compare |
| b0722 | sdhD | -3.9 | -4.7 | succinate dehydrogenase cytochrome b556 small membrane subunit (NCBI) | compare |
| b0945 | pyrD | -3.9 | -12.5 | dihydroorotate dehydrogenase (NCBI) | compare |
| b0002 | thrA | -3.9 | -14.9 | bifunctional aspartokinase I/homeserine dehydrogenase I (NCBI) | compare |
| b4125 | dcuS | -3.9 | -12.9 | sensory histidine kinase in two-component regulatory system with DcuR, regulator of anaerobic fumarate respiration (NCBI) | compare |
| b2329 | aroC | -3.9 | -5.9 | chorismate synthase (NCBI) | compare |
| b3959 | argB | -3.8 | -11.5 | acetylglutamate kinase (RefSeq) | compare |
| b2763 | cysI | -3.8 | -8.5 | sulfite reductase, beta subunit, NAD(P)-binding, heme-binding (NCBI) | compare |
| b4124 | dcuR | -3.8 | -15.2 | DNA-binding response regulator in two-component regulatory system with DcuS (NCBI) | compare |
| b3528 | dctA | -3.8 | -14.4 | C4 dicarboxylate/orotate:H+ symporter (DctA) (from data) | conserved |
| b0437 | clpP | -3.8 | -8.8 | ATP-dependent Clp protease proteolytic subunit (NCBI) | compare |
| b3962 | udhA | -3.8 | -9.1 | putative oxidoreductase (VIMSS) | compare |
| b3368 | cysG | -3.8 | -17.1 | fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase (NCBI) | compare |
| b3390 | aroK | -3.8 | -3.6 | shikimate kinase I (NCBI) | compare |
| b3642 | pyrE | -3.8 | -5.1 | orotate phosphoribosyltransferase (NCBI) | compare |
| b1291 | sapD | -3.8 | -2.6 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b2286 | nuoC | -3.7 | -5.7 | NADH:ubiquinone oxidoreductase, chain C,D (RefSeq) | compare |
| b2897 | ygfY | -3.7 | -3.6 | hypothetical protein (NCBI) | compare |
| b2818 | argA | -3.7 | -10.1 | N-acetylglutamate synthase (NCBI) | compare |
| b2499 | purM | -3.7 | -6.1 | phosphoribosylaminoimidazole synthetase (NCBI) | compare |
| b2284 | nuoF | -3.7 | -5.0 | NADH:ubiquinone oxidoreductase, chain F (NCBI) | compare |
| b1130 | phoP | -3.6 | -8.4 | DNA-binding response regulator in two-component regulatory system with PhoQ (NCBI) | compare |
| b1281 | pyrF | -3.6 | -4.9 | orotidine 5'-phosphate decarboxylase (NCBI) | compare |
| b4171 | miaA | -3.6 | -6.9 | tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) | compare |
| b2279 | nuoK | -3.6 | -2.4 | NADH dehydrogenase subunit K (NCBI) | compare |
| b3169 | nusA | -3.6 | -4.2 | transcription elongation factor NusA (NCBI) | compare |
| b3772 | ilvA | -3.6 | -14.0 | threonine dehydratase (NCBI) | compare |
| b2281 | nuoI | -3.6 | -3.4 | NADH dehydrogenase subunit I (NCBI) | compare |
| b2023 | hisH | -3.6 | -6.3 | imidazole glycerol phosphate synthase subunit HisH (NCBI) | compare |
| b1261 | trpB | -3.5 | -2.2 | tryptophan synthase subunit beta (NCBI) | compare |
| b2283 | nuoG | -3.5 | -6.7 | NADH:ubiquinone oxidoreductase, chain G (RefSeq) | compare |
| b2024 | hisA | -3.5 | -1.9 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-imidazolecarboxamide isomerase (VIMSS) | compare |
| b0683 | fur | -3.5 | -2.3 | ferric uptake regulator (NCBI) | compare |
| b2947 | gshB | -3.5 | -6.2 | glutathione synthetase (NCBI) | compare |
| b0589 | fepG | -3.5 | -8.9 | iron-enterobactin transporter subunit (NCBI) | compare |
| b0439 | lon | -3.5 | -4.1 | DNA-binding ATP-dependent protease La (NCBI) | compare |
| b0737 | tolQ | -3.5 | -3.3 | membrane spanning protein in TolA-TolQ-TolR complex (NCBI) | compare |
| b1084 | rne | -3.4 | -6.1 | fused ribonucleaseE: endoribonuclease/RNA-binding protein/RNA degradosome binding protein (NCBI) | compare |
| b0739 | tolA | -3.4 | -3.3 | cell envelope integrity inner membrane protein TolA (NCBI) | compare |
| b1290 | sapF | -3.4 | -3.3 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b0740 | tolB | -3.4 | -5.7 | translocation protein TolB precursor (NCBI) | compare |
| b3405 | ompR | -3.4 | -4.6 | osmolarity response regulator (NCBI) | compare |
| b3842 | rfaH | -3.4 | -5.6 | transcriptional activator RfaH (NCBI) | compare |
| b2764 | cysJ | -3.4 | -11.0 | sulfite reductase, alpha subunit, flavoprotein (NCBI) | compare |
| b3726 | pstA | -3.4 | -7.5 | phosphate transporter subunit (NCBI) | compare |
| b0390 | aroM | -3.3 | -11.2 | hypothetical protein (NCBI) | compare |
| b3052 | rfaE | -3.3 | -5.5 | fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) | compare |
| b2587 | kgtP | -3.3 | -8.4 | alpha-ketoglutarate transporter (NCBI) | compare |
| b4018 | iclR | -3.3 | -9.5 | repressor of aceBA operon (VIMSS) | compare |
| b0222 | lpcA | -3.3 | -3.9 | phosphoheptose isomerase (NCBI) | compare |
| b1293 | sapB | -3.3 | -2.8 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b3204 | ptsN | -3.3 | -6.6 | sugar-specific enzyme IIA component of PTS (NCBI) | compare |
| b0720 | gltA | -3.2 | -6.9 | citrate synthase (NCBI) | compare |
| b3806 | cyaA | -3.2 | -3.8 | adenylate cyclase (NCBI) | compare |
| b3619 | rfaD | -3.2 | -2.2 | ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) | compare |
| b3631 | rfaG | -3.2 | -18.1 | glucosyltransferase I (NCBI) | compare |
| b0430 | cyoC | -3.2 | -5.3 | cytochrome o ubiquinol oxidase subunit III (NCBI) | compare |
| b0585 | fes | -3.2 | -7.6 | enterobactin/ferric enterobactin esterase (NCBI) | compare |
| b1479 | sfcA | -3.2 | -5.9 | NAD-linked malate dehydrogenase (malic enzyme) (VIMSS) | compare |
| b3839 | tatC | -3.2 | -9.9 | TatABCE protein translocation system subunit (NCBI) | compare |
| b0775 | bioB | -3.2 | -6.3 | biotin synthase (NCBI) | compare |
| b2564 | pdxJ | -3.1 | -5.2 | pyridoxal phosphate biosynthetic protein (NCBI) | compare |
| b2751 | cysN | -3.1 | -8.9 | sulfate adenylyltransferase subunit 1 (NCBI) | compare |
| b0588 | fepC | -3.1 | -9.7 | iron-enterobactin transporter subunit (NCBI) | compare |
| b2287 | nuoB | -3.1 | -3.7 | NADH dehydrogenase subunit B (NCBI) | compare |
| b1185 | dsbB | -3.1 | -3.6 | reoxidizes DsbA protein following formation of disulfide bond in P-ring of flagella. (VIMSS) | compare |
| b3791 | rffA | -3.1 | -9.7 | TDP-4-oxo-6-deoxy-D-glucose transaminase (NCBI) | compare |
| b1712 | ihfA | -3.1 | -3.8 | integration host factor subunit alpha (NCBI) | compare |
| b0741 | pal | -3.1 | -4.7 | peptidoglycan-associated outer membrane lipoprotein (NCBI) | compare |
| b0688 | pgm | -3.1 | -4.2 | phosphoglucomutase (NCBI) | compare |
| b3630 | rfaP | -3.1 | -12.8 | kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) | compare |
| b2784 | relA | -3.1 | -11.7 | (p)ppGpp synthetase I/GTP pyrophosphokinase (NCBI) | compare |
| b0145 | dksA | -3.0 | -4.1 | DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) | compare |
| b3979 | thrT | -3.0 | -1.2 | tRNA-Thr (NCBI) | compare |
| b3621 | rfaC | -3.0 | -5.0 | ADP-heptose:LPS heptosyl transferase I (NCBI) | compare |
| b0432 | cyoA | -3.0 | -11.9 | cytochrome o ubiquinol oxidase subunit II (NCBI) | compare |
| b1292 | sapC | -3.0 | -3.5 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b0590 | fepD | -3.0 | -7.9 | iron-enterobactin transporter subunit (NCBI) | compare |
| b2278 | nuoL | -2.9 | -8.6 | NADH dehydrogenase subunit L (NCBI) | compare |
| b3860 | dsbA | -2.9 | -11.1 | periplasmic protein disulfide isomerase I (NCBI) | compare |
| b3792 | wzxE | -2.9 | -11.0 | O-antigen translocase (NCBI) | compare |
| b3773 | ilvY | -2.9 | -9.7 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b2280 | nuoJ | -2.9 | -6.4 | NADH dehydrogenase subunit J (NCBI) | compare |
| b1545 | pinQ | -2.9 | -1.7 | Qin prophage; predicted site-specific recombinase (NCBI) | compare |
| b3849 | trkH | -2.9 | -12.5 | potassium transporter (NCBI) | compare |
| b2501 | ppk | -2.9 | -11.5 | polyphosphate kinase (NCBI) | compare |
| b3232 | yhcM | -2.9 | -11.4 | conserved protein with nucleoside triphosphate hydrolase domain (NCBI) | compare |
| b2479 | gcvR | -2.9 | -5.1 | transcriptional regulation of gcv operon (VIMSS) | compare |
| b2320 | pdxB | -2.9 | -9.2 | erythronate-4-phosphate dehydrogenase (NCBI) | compare |
| b3728 | pstS | -2.9 | -4.7 | phosphate transporter subunit (NCBI) | compare |
| b2276 | nuoN | -2.9 | -6.6 | NADH:ubiquinone oxidoreductase, membrane subunit N (RefSeq) | compare |
| b2282 | nuoH | -2.8 | -3.3 | NADH dehydrogenase subunit H (NCBI) | compare |
| b0118 | acnB | -2.8 | -1.9 | aconitate hydratase (NCBI) | compare |
| b1333 | uspE | -2.8 | -4.0 | stress-induced protein (NCBI) | compare |
| b0738 | tolR | -2.7 | -3.2 | membrane spanning protein in TolA-TolQ-TolR complex (NCBI) | compare |
| b4481 | rffT | -2.7 | -9.1 | 4-alpha-L-fucosyltransferase (NCBI) | compare |
| b0592 | fepB | -2.7 | -10.3 | iron-enterobactin transporter subunit (NCBI) | compare |
| b4042 | dgkA | -2.7 | -3.6 | diacylglycerol kinase (NCBI) | compare |
| b0429 | cyoD | -2.7 | -5.1 | cytochrome o ubiquinol oxidase subunit IV (NCBI) | compare |
| b2175 | spr | -2.6 | -5.6 | predicted peptidase, outer membrane lipoprotein (NCBI) | compare |
| b3423 | glpR | -2.6 | -10.9 | DNA-binding transcriptional repressor (NCBI) | compare |
| b3870 | glnA | -2.6 | -1.8 | glutamine synthetase (NCBI) | compare |
| b1855 | lpxM | -2.6 | -6.4 | lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase (NCBI) | compare |
| b1859 | znuB | -2.6 | -8.4 | high-affinity zinc transporter membrane component (NCBI) | compare |
| b4242 | mgtA | -2.5 | -14.5 | magnesium transporter (NCBI) | compare |
| b0431 | cyoB | -2.5 | -11.7 | cytochrome o ubiquinol oxidase subunit I (NCBI) | compare |
| b3237 | argR | -2.5 | -6.2 | arginine repressor (NCBI) | compare |
| b0200 | gmhB | -2.5 | -1.7 | hypothetical protein (NCBI) | compare |
| b0114 | aceE | -2.5 | -2.4 | pyruvate dehydrogenase subunit E1 (NCBI) | compare |
| b2830 | nudH | -2.5 | -2.4 | dinucleoside polyphosphate hydrolase (NCBI) | compare |
| b0677 | nagA | -2.5 | -7.1 | N-acetylglucosamine-6-phosphate deacetylase (NCBI) | compare |
| b2935 | tktA | -2.5 | -3.4 | transketolase 1, thiamin-binding (NCBI) | compare |
| b3403 | pck | -2.5 | -8.4 | phosphoenolpyruvate carboxykinase (NCBI) | conserved |
| b3725 | pstB | -2.4 | -1.7 | phosphate transporter subunit (NCBI) | compare |
| b3290 | trkA | -2.4 | -2.3 | potassium transporter peripheral membrane component (NCBI) | compare |
| b1262 | trpC | -2.4 | -4.4 | N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase (VIMSS) | compare |
| b3414 | gntY | -2.4 | -7.3 | predicted gluconate transport associated protein (NCBI) | compare |
| b3463 | ftsE | -2.3 | -5.1 | predicted transporter subunit: ATP-binding component of ABC superfamily (NCBI) | compare |
| b3412 | bioH | -2.3 | -8.6 | carboxylesterase of pimeloyl-CoA synthesis (NCBI) | compare |
| b1857 | yebL | -2.3 | -6.0 | putative adhesin (VIMSS) | compare |
| b0428 | cyoE | -2.3 | -7.3 | protoheme IX farnesyltransferase (NCBI) | compare |
| b4177 | purA | -2.3 | -1.6 | adenylosuccinate synthetase (NCBI) | compare |
| b3977 | tyrU | -2.3 | -1.3 | tRNA-Tyr (NCBI) | compare |