| | gene | name | fitness | t score | description | |
|---|
| b2020 | hisD | -7.1 | -4.9 | histidinol dehydrogenase (NCBI) | compare |
| b1261 | trpB | -6.9 | -4.8 | tryptophan synthase subunit beta (NCBI) | compare |
| b2025 | hisF | -6.7 | -4.7 | imidazole glycerol phosphate synthase subunit HisF (NCBI) | compare |
| b1260 | trpA | -6.6 | -6.0 | tryptophan synthase subunit alpha (NCBI) | compare |
| b0912 | ihfB | -6.6 | -4.5 | integration host factor subunit beta (NCBI) | compare |
| b4232 | fbp | -6.5 | -6.3 | fructose-1,6-bisphosphatase (NCBI) | compare |
| b0907 | serC | -6.3 | -7.5 | phosphoserine aminotransferase (NCBI) | compare |
| b2600 | tyrA | -6.2 | -6.0 | fused chorismate mutase T/prephenate dehydrogenase (NCBI) | compare |
| b0523 | purE | -6.0 | -4.2 | phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI) | compare |
| b3771 | ilvD | -5.9 | -9.0 | dihydroxy-acid dehydratase (NCBI) | compare |
| b3828 | metR | -5.8 | -9.7 | DNA-binding transcriptional activator, homocysteine-binding (NCBI) | compare |
| b3389 | aroB | -5.8 | -8.9 | 3-dehydroquinate synthase (NCBI) | compare |
| b1712 | ihfA | -5.8 | -4.0 | integration host factor subunit alpha (NCBI) | compare |
| b3960 | argH | -5.8 | -9.7 | argininosuccinate lyase (NCBI) | compare |
| b1693 | aroD | -5.7 | -7.9 | 3-dehydroquinate dehydratase (NCBI) | compare |
| b3774 | ilvC | -5.7 | -12.2 | ketol-acid reductoisomerase (NCBI) | compare |
| b0049 | apaH | -5.7 | -3.9 | diadenosinetetraphosphatase (NCBI) | compare |
| b2838 | lysA | -5.7 | -7.8 | diaminopimelate decarboxylase, PLP-binding (NCBI) | compare |
| b0437 | clpP | -5.7 | -6.7 | ATP-dependent Clp protease proteolytic subunit (NCBI) | compare |
| b2022 | hisB | -5.6 | -7.7 | imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS) | compare |
| b2414 | cysK | -5.6 | -10.8 | cysteine synthase A, O-acetylserine sulfhydrolase A subunit (NCBI) | compare |
| b3941 | metF | -5.6 | -10.7 | 5,10-methylenetetrahydrofolate reductase (NCBI) | compare |
| b1192 | ldcA | -5.6 | -5.4 | L,D-carboxypeptidase A (NCBI) | compare |
| b2021 | hisC | -5.5 | -6.6 | histidinol-phosphate aminotransferase (NCBI) | compare |
| b0386 | proC | -5.5 | -5.4 | pyrroline-5-carboxylate reductase (NCBI) | compare |
| b4388 | serB | -5.5 | -5.3 | 3-phosphoserine phosphatase (NCBI) | compare |
| b0522 | purK | -5.5 | -7.5 | phosphoribosylaminoimidazole carboxylase (NCBI) | compare |
| b0074 | leuA | -5.4 | -9.1 | 2-isopropylmalate synthase (NCBI) | compare |
| b3281 | aroE | -5.4 | -14.8 | dehydroshikimate reductase, NAD(P)-binding (NCBI) | compare |
| b0072 | leuC | -5.4 | -12.1 | isopropylmalate isomerase large subunit (NCBI) | compare |
| b0004 | thrC | -5.4 | -8.2 | threonine synthase (NCBI) | compare |
| b0243 | proA | -5.4 | -9.7 | gamma-glutamyl phosphate reductase (NCBI) | compare |
| b3770 | ilvE | -5.4 | -10.9 | branched-chain amino acid aminotransferase (NCBI) | compare |
| b2913 | serA | -5.3 | -7.3 | D-3-phosphoglycerate dehydrogenase (NCBI) | compare |
| b4005 | purD | -5.3 | -7.3 | phosphoribosylamine--glycine ligase (NCBI) | compare |
| b3172 | argG | -5.3 | -10.2 | argininosuccinate synthase (NCBI) | compare |
| b0242 | proB | -5.3 | -7.2 | gamma-glutamyl kinase (NCBI) | compare |
| b0073 | leuB | -5.3 | -10.1 | 3-isopropylmalate dehydrogenase (VIMSS) | compare |
| b4006 | purH | -5.2 | -12.2 | bifunctionalphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI) | compare |
| b0908 | aroA | -5.2 | -9.4 | 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) | compare |
| b3772 | ilvA | -5.2 | -12.1 | threonine dehydratase (NCBI) | compare |
| b4214 | cysQ | -5.1 | -13.7 | PAPS (adenosine 3'-phosphate 5'-phosphosulfate) 3'(2'),5'-bisphosphate nucleotidase (NCBI) | compare |
| b2499 | purM | -5.1 | -6.1 | phosphoribosylaminoimidazole synthetase (NCBI) | compare |
| b2557 | purL | -5.1 | -8.5 | phosphoribosylformylglycinamidine synthase (NCBI) | compare |
| b2188 | yejM | -5.1 | -10.8 | predicted hydrolase, inner membrane (NCBI) | compare |
| b0071 | leuD | -5.0 | -8.4 | isopropylmalate isomerase small subunit (NCBI) | compare |
| b3956 | ppc | -5.0 | -17.2 | phosphoenolpyruvate carboxylase (NCBI) | compare |
| b2476 | purC | -5.0 | -4.0 | phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI) | compare |
| b0002 | thrA | -4.9 | -15.8 | bifunctional aspartokinase I/homeserine dehydrogenase I (NCBI) | compare |
| b3236 | mdh | -4.8 | -8.7 | malate dehydrogenase (NCBI) | compare |
| b3829 | metE | -4.8 | -18.3 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (NCBI) | compare |
| b0080 | fruR | -4.8 | -6.5 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b3390 | aroK | -4.8 | -3.3 | shikimate kinase I (NCBI) | compare |
| b0720 | gltA | -4.7 | -6.4 | citrate synthase (NCBI) | compare |
| b0438 | clpX | -4.7 | -8.4 | ATP-dependent protease ATP-binding subunit (NCBI) | compare |
| b2023 | hisH | -4.7 | -7.1 | imidazole glycerol phosphate synthase subunit HisH (NCBI) | compare |
| b2312 | purF | -4.7 | -8.3 | amidophosphoribosyltransferase (NCBI) | compare |
| b2500 | purN | -4.7 | -7.1 | phosphoribosylglycinamide formyltransferase (NCBI) | compare |
| b0145 | dksA | -4.6 | -3.2 | DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) | compare |
| b1281 | pyrF | -4.6 | -5.5 | orotidine 5'-phosphate decarboxylase (NCBI) | compare |
| b2750 | cysC | -4.6 | -8.8 | adenylylsulfate kinase (NCBI) | compare |
| b2329 | aroC | -4.6 | -6.2 | chorismate synthase (NCBI) | compare |
| b1129 | phoQ | -4.6 | -10.1 | sensory histidine kinase in two-compoent regulatory system with PhoP (NCBI) | compare |
| b2019 | hisG | -4.6 | -5.8 | ATP phosphoribosyltransferase (NCBI) | compare |
| b1084 | rne | -4.5 | -6.2 | fused ribonucleaseE: endoribonuclease/RNA-binding protein/RNA degradosome binding protein (NCBI) | compare |
| b0003 | thrB | -4.5 | -8.1 | homoserine kinase (NCBI) | compare |
| b2024 | hisA | -4.5 | -3.7 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-imidazolecarboxamide isomerase (VIMSS) | compare |
| b3642 | pyrE | -4.4 | -5.3 | orotate phosphoribosyltransferase (NCBI) | compare |
| b2839 | lysR | -4.4 | -8.0 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b0052 | pdxA | -4.3 | -11.2 | 4-hydroxythreonine-4-phosphate dehydrogenase (NCBI) | compare |
| b2281 | nuoI | -4.2 | -4.1 | NADH dehydrogenase subunit I (NCBI) | compare |
| b2599 | pheA | -4.2 | -11.2 | fused chorismate mutase P/prephenate dehydratase (NCBI) | compare |
| b2564 | pdxJ | -4.2 | -5.7 | pyridoxal phosphate biosynthetic protein (NCBI) | compare |
| b0033 | carB | -4.2 | -16.9 | carbamoyl-phosphate synthase large subunit (NCBI) | compare |
| b0142 | folK | -4.2 | -1.8 | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) | compare |
| b1235 | rssB | -4.2 | -10.3 | response regulator of RpoS (NCBI) | compare |
| b3957 | argE | -4.2 | -15.1 | acetylornithine deacetylase (NCBI) | compare |
| b2287 | nuoB | -4.1 | -2.8 | NADH dehydrogenase subunit B (NCBI) | compare |
| b2762 | cysH | -4.1 | -9.1 | phosphoadenosine phosphosulfate reductase (NCBI) | compare |
| b2279 | nuoK | -4.1 | -2.8 | NADH dehydrogenase subunit K (NCBI) | compare |
| b3405 | ompR | -4.1 | -4.0 | osmolarity response regulator (NCBI) | compare |
| b2288 | nuoA | -4.0 | -4.8 | NADH dehydrogenase I chain A (VIMSS) | compare |
| b1130 | phoP | -4.0 | -9.3 | DNA-binding response regulator in two-component regulatory system with PhoQ (NCBI) | compare |
| b2026 | hisI | -4.0 | -8.0 | bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI) | compare |
| b0439 | lon | -4.0 | -3.9 | DNA-binding ATP-dependent protease La (NCBI) | compare |
| b3169 | nusA | -3.9 | -4.6 | transcription elongation factor NusA (NCBI) | compare |
| b2764 | cysJ | -3.9 | -12.8 | sulfite reductase, alpha subunit, flavoprotein (NCBI) | compare |
| b2283 | nuoG | -3.9 | -8.6 | NADH:ubiquinone oxidoreductase, chain G (RefSeq) | compare |
| b3204 | ptsN | -3.8 | -6.8 | sugar-specific enzyme IIA component of PTS (NCBI) | compare |
| b3958 | argC | -3.8 | -16.1 | N-acetyl-gamma-glutamyl-phosphate reductase (NCBI) | compare |
| b3844 | fre | -3.6 | -7.3 | NAD(P)H-flavin reductase (NCBI) | compare |
| b3959 | argB | -3.6 | -11.4 | acetylglutamate kinase (RefSeq) | compare |
| b2285 | nuoE | -3.6 | -3.5 | NADH dehydrogenase subunit E (NCBI) | compare |
| b2818 | argA | -3.6 | -10.9 | N-acetylglutamate synthase (NCBI) | compare |
| b2282 | nuoH | -3.6 | -3.4 | NADH dehydrogenase subunit H (NCBI) | compare |
| b2320 | pdxB | -3.5 | -9.4 | erythronate-4-phosphate dehydrogenase (NCBI) | compare |
| b1290 | sapF | -3.5 | -4.1 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b2763 | cysI | -3.5 | -10.2 | sulfite reductase, beta subunit, NAD(P)-binding, heme-binding (NCBI) | compare |
| b2276 | nuoN | -3.4 | -7.2 | NADH:ubiquinone oxidoreductase, membrane subunit N (RefSeq) | compare |
| b0222 | lpcA | -3.4 | -4.6 | phosphoheptose isomerase (NCBI) | compare |
| b2286 | nuoC | -3.4 | -7.5 | NADH:ubiquinone oxidoreductase, chain C,D (RefSeq) | compare |
| b2278 | nuoL | -3.4 | -10.1 | NADH dehydrogenase subunit L (NCBI) | compare |
| b3603 | lldP | -3.4 | -17.8 | (R)-lactate / (S)-lactate / glycolate:H+ symporter LldP (from data) | conserved |
| b4171 | miaA | -3.4 | -7.7 | tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) | compare |
| b0032 | carA | -3.3 | -9.6 | carbamoyl-phosphate synthase small subunit (NCBI) | compare |
| b2340 | sixA | -3.3 | -6.9 | phosphohistidine phosphatase (NCBI) | compare |
| b0688 | pgm | -3.3 | -5.4 | phosphoglucomutase (NCBI) | compare |
| b2284 | nuoF | -3.2 | -6.5 | NADH:ubiquinone oxidoreductase, chain F (NCBI) | compare |
| b0683 | fur | -3.2 | -3.1 | ferric uptake regulator (NCBI) | compare |
| b3849 | trkH | -3.2 | -14.1 | potassium transporter (NCBI) | compare |
| b1062 | pyrC | -3.2 | -10.6 | dihydroorotase (NCBI) | compare |
| b2277 | nuoM | -3.2 | -7.8 | NADH dehydrogenase subunit M (NCBI) | compare |
| b0630 | lipB | -3.2 | -2.2 | protein of lipoate biosynthesis (VIMSS) | compare |
| b3008 | metC | -3.1 | -10.8 | cystathionine beta-lyase (NCBI) | compare |
| b0114 | aceE | -3.1 | -2.1 | pyruvate dehydrogenase subunit E1 (NCBI) | compare |
| b3052 | rfaE | -3.0 | -6.7 | fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) | compare |
| b3839 | tatC | -3.0 | -10.9 | TatABCE protein translocation system subunit (NCBI) | compare |
| b0726 | sucA | -3.0 | -3.6 | alpha-ketoglutarate decarboxylase (NCBI) | compare |
| b0078 | ilvH | -3.0 | -12.7 | acetolactate synthase small subunit (NCBI) | compare |
| b0723 | sdhA | -3.0 | -12.5 | succinate dehydrogenase flavoprotein subunit (NCBI) | compare |
| b2479 | gcvR | -2.9 | -6.2 | transcriptional regulation of gcv operon (VIMSS) | compare |
| b0118 | acnB | -2.9 | -2.8 | aconitate hydratase (NCBI) | compare |
| b3761 | trpT | -2.9 | -2.1 | tRNA-Trp (NCBI) | compare |
| b3741 | gidA | -2.9 | -9.3 | glucose-inhibited division protein A (NCBI) | compare |
| b3650 | spoT | -2.9 | -9.3 | bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase (NCBI) | compare |
| b2830 | nudH | -2.9 | -2.7 | dinucleoside polyphosphate hydrolase (NCBI) | compare |
| b2297 | pta | -2.8 | -2.7 | phosphate acetyltransferase (NCBI) | compare |
| b0588 | fepC | -2.8 | -8.2 | iron-enterobactin transporter subunit (NCBI) | compare |
| b0077 | ilvI | -2.8 | -13.0 | acetolactate synthase III large subunit (NCBI) | compare |
| b1702 | pps | -2.8 | -11.6 | phosphoenolpyruvate synthase (NCBI) | conserved |
| b3368 | cysG | -2.8 | -16.9 | fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase (NCBI) | compare |
| b0945 | pyrD | -2.8 | -13.7 | dihydroorotate dehydrogenase (NCBI) | compare |
| b3870 | glnA | -2.8 | -2.7 | glutamine synthetase (NCBI) | compare |
| b3621 | rfaC | -2.7 | -6.8 | ADP-heptose:LPS heptosyl transferase I (NCBI) | compare |
| b0590 | fepD | -2.7 | -8.6 | iron-enterobactin transporter subunit (NCBI) | compare |
| b3706 | trmE | -2.7 | -6.6 | tRNA modification GTPase (NCBI) | compare |
| b2424 | cysU | -2.7 | -3.2 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b2280 | nuoJ | -2.7 | -6.0 | NADH dehydrogenase subunit J (NCBI) | compare |
| b2168 | fruK | -2.7 | -2.1 | 1-phosphofructokinase (NCBI) | compare |
| b1257 | yciE | -2.7 | -4.8 | hypothetical protein (NCBI) | compare |
| b0721 | sdhC | -2.7 | -4.0 | succinate dehydrogenase cytochrome b556 large membrane subunit (NCBI) | compare |
| b4177 | purA | -2.7 | -1.8 | adenylosuccinate synthetase (NCBI) | compare |
| b0589 | fepG | -2.7 | -9.9 | iron-enterobactin transporter subunit (NCBI) | compare |
| b3806 | cyaA | -2.7 | -7.0 | adenylate cyclase (NCBI) | compare |
| b1291 | sapD | -2.7 | -3.5 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b3939 | metB | -2.7 | -11.7 | cystathionine gamma-synthase (NCBI) | compare |
| b0739 | tolA | -2.6 | -5.3 | cell envelope integrity inner membrane protein TolA (NCBI) | compare |
| b1545 | pinQ | -2.6 | -1.9 | Qin prophage; predicted site-specific recombinase (NCBI) | compare |
| b2601 | aroF | -2.6 | -5.4 | 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tyrosine-repressible (NCBI) | compare |
| b0724 | sdhB | -2.5 | -7.6 | succinate dehydrogenase, FeS subunit (NCBI) | compare |
| b3755 | yieP | -2.5 | -7.6 | predicted transcriptional regulator (NCBI) | compare |
| b3290 | trkA | -2.5 | -2.9 | potassium transporter peripheral membrane component (NCBI) | compare |
| b0738 | tolR | -2.4 | -4.6 | membrane spanning protein in TolA-TolQ-TolR complex (NCBI) | compare |
| b0200 | gmhB | -2.4 | -2.3 | hypothetical protein (NCBI) | compare |
| b3386 | rpe | -2.4 | -1.7 | ribulose-phosphate 3-epimerase (NCBI) | compare |
| b3082 | ygjM | -2.4 | -2.9 | predicted DNA-binding transcriptional regulator (NCBI) | compare |
| b1292 | sapC | -2.4 | -3.9 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b3781 | trxA | -2.4 | -5.2 | thioredoxin 1 (VIMSS) | compare |
| b0592 | fepB | -2.4 | -10.9 | iron-enterobactin transporter subunit (NCBI) | compare |
| b2518 | ndk | -2.3 | -3.4 | nucleoside diphosphate kinase (NCBI) | compare |
| b2422 | cysA | -2.3 | -8.1 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b3728 | pstS | -2.3 | -6.2 | phosphate transporter subunit (NCBI) | compare |
| b3993 | thiE | -2.3 | -8.0 | thiamine-phosphate pyrophosphorylase (NCBI) | compare |
| b3619 | rfaD | -2.3 | -4.8 | ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) | compare |
| b1863 | ruvC | -2.3 | -5.1 | Holliday junction resolvase (NCBI) | compare |
| b0889 | lrp | -2.3 | -4.1 | DNA-binding transcriptional dual regulator, leucine-binding (NCBI) | compare |
| b0722 | sdhD | -2.3 | -5.5 | succinate dehydrogenase cytochrome b556 small membrane subunit (NCBI) | compare |
| b3725 | pstB | -2.2 | -2.6 | phosphate transporter subunit (NCBI) | compare |
| b1859 | znuB | -2.2 | -7.0 | high-affinity zinc transporter membrane component (NCBI) | compare |
| b1476 | fdnI | -2.2 | -2.0 | formate dehydrogenase-N, cytochrome B556 (gamma) subunit, nitrate-inducible (NCBI) | compare |
| b1262 | trpC | -2.2 | -3.7 | N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase (VIMSS) | compare |
| b1263 | trpD | -2.2 | -3.7 | bifunctional indole-3-glycerol-phosphate synthase/anthranilate phosphoribosyltransferase (NCBI) | compare |
| b0737 | tolQ | -2.2 | -5.0 | membrane spanning protein in TolA-TolQ-TolR complex (NCBI) | compare |
| b4407 | thiS | -2.1 | -2.3 | sulfur carrier protein ThiS (NCBI) | compare |
| b3237 | argR | -2.1 | -5.6 | arginine repressor (NCBI) | compare |
| b4013 | metA | -2.1 | -6.9 | homoserine O-succinyltransferase (NCBI) | compare |
| b1857 | yebL | -2.1 | -5.5 | putative adhesin (VIMSS) | compare |
| b4245 | pyrB | -2.1 | -10.7 | aspartate carbamoyltransferase catalytic subunit (NCBI) | compare |
| b2103 | thiD | -2.1 | -8.2 | phosphomethylpyrimidine kinase (NCBI) | compare |
| b0390 | aroM | -2.1 | -7.9 | hypothetical protein (NCBI) | compare |
| b3992 | thiF | -2.1 | -7.7 | thiamin biosynthesis, thiazole moiety (VIMSS) | compare |
| b0890 | ftsK | -2.1 | -8.7 | DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) | compare |
| b4480 | hdfR | -2.0 | -7.2 | transcriptional regulator HdfR (NCBI) | compare |
| b3387 | dam | -2.0 | -13.3 | DNA adenine methylase (NCBI) | compare |
| b2752 | cysD | -2.0 | -5.5 | sulfate adenylyltransferase subunit 2 (NCBI) | compare |
| b0334 | prpD | -2.0 | -6.8 | 2-methylcitrate dehydratase (NCBI) | compare |
| b3620 | rfaF | -2.0 | -5.6 | ADP-heptose:LPS heptosyltransferase II (NCBI) | compare |
| b0585 | fes | -2.0 | -6.4 | enterobactin/ferric enterobactin esterase (NCBI) | compare |
| b3990 | thiH | -2.0 | -9.5 | thiamine biosynthesis protein ThiH (NCBI) | compare |
| b0564 | appY | -2.0 | -1.8 | DLP12 prophage; DNA-binding transcriptional activator (NCBI) | compare |
| b4410 | ecnA | -2.0 | -1.4 | entericidin A membrane lipoprotein, antidote entericidin B (NCBI) | compare |
| b0741 | pal | -1.9 | -5.4 | peptidoglycan-associated outer membrane lipoprotein (NCBI) | compare |
| b3398 | yrfF | -1.9 | -4.6 | predicted inner membrane protein (NCBI) | compare |
| b2751 | cysN | -1.9 | -5.1 | sulfate adenylyltransferase subunit 1 (NCBI) | compare |
| b2567 | rnc | -1.9 | -2.1 | ribonuclease III (NCBI) | compare |
| b2215 | ompC | -1.8 | -9.1 | outer membrane porin protein C (NCBI) | compare |
| b1264 | trpE | -1.8 | -3.1 | anthranilate synthase component I (NCBI) | compare |
| b0113 | pdhR | -1.8 | -3.2 | transcriptional regulator of pyruvate dehydrogenase complex (NCBI) | compare |
| b0729 | sucD | -1.8 | -3.9 | succinyl-CoA synthetase subunit alpha (NCBI) | compare |
| b2189 | proL | -1.8 | -2.4 | tRNA-Pro (NCBI) | compare |