Experiment set1IT020 for Escherichia coli BW25113

Compare to:

a-Ketoglutaric acid disodium salt hydrate carbon source

200 most important genes:

  gene name fitness t score description  
b2476 purC -6.7 -4.1 phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI) compare
b1261 trpB -6.5 -4.4 tryptophan synthase subunit beta (NCBI) compare
b0242 proB -6.3 -4.4 gamma-glutamyl kinase (NCBI) compare
b0907 serC -6.0 -7.1 phosphoserine aminotransferase (NCBI) compare
b2414 cysK -6.0 -9.2 cysteine synthase A, O-acetylserine sulfhydrolase A subunit (NCBI) compare
b2020 hisD -5.8 -7.9 histidinol dehydrogenase (NCBI) compare
b3774 ilvC -5.7 -8.7 ketol-acid reductoisomerase (NCBI) compare
b4232 fbp -5.7 -8.6 fructose-1,6-bisphosphatase (NCBI) compare
b1693 aroD -5.6 -6.7 3-dehydroquinate dehydratase (NCBI) compare
b0072 leuC -5.6 -10.1 isopropylmalate isomerase large subunit (NCBI) compare
b1192 ldcA -5.6 -3.9 L,D-carboxypeptidase A (NCBI) compare
b3389 aroB -5.6 -7.6 3-dehydroquinate synthase (NCBI) compare
b3941 metF -5.5 -10.0 5,10-methylenetetrahydrofolate reductase (NCBI) compare
b0243 proA -5.5 -7.6 gamma-glutamyl phosphate reductase (NCBI) compare
b3172 argG -5.5 -6.5 argininosuccinate synthase (NCBI) compare
b0721 sdhC -5.4 -5.3 succinate dehydrogenase cytochrome b556 large membrane subunit (NCBI) compare
b2025 hisF -5.4 -5.3 imidazole glycerol phosphate synthase subunit HisF (NCBI) compare
b1130 phoP -5.4 -5.3 DNA-binding response regulator in two-component regulatory system with PhoQ (NCBI) compare
b2750 cysC -5.4 -6.4 adenylylsulfate kinase (NCBI) compare
b3960 argH -5.4 -9.0 argininosuccinate lyase (NCBI) compare
b1260 trpA -5.4 -5.6 tryptophan synthase subunit alpha (NCBI) compare
b1712 ihfA -5.4 -3.7 integration host factor subunit alpha (NCBI) compare
b4214 cysQ -5.3 -9.6 PAPS (adenosine 3'-phosphate 5'-phosphosulfate) 3'(2'),5'-bisphosphate nucleotidase (NCBI) compare
b2019 hisG -5.3 -5.9 ATP phosphoribosyltransferase (NCBI) compare
b3771 ilvD -5.3 -10.2 dihydroxy-acid dehydratase (NCBI) compare
b0004 thrC -5.3 -6.3 threonine synthase (NCBI) compare
b0386 proC -5.3 -3.6 pyrroline-5-carboxylate reductase (NCBI) compare
b2312 purF -5.2 -6.2 amidophosphoribosyltransferase (NCBI) compare
b3281 aroE -5.2 -13.4 dehydroshikimate reductase, NAD(P)-binding (NCBI) compare
b1235 rssB -5.2 -7.9 response regulator of RpoS (NCBI) compare
b0074 leuA -5.2 -7.9 2-isopropylmalate synthase (NCBI) compare
b4005 purD -5.1 -5.0 phosphoribosylamine--glycine ligase (NCBI) compare
b0728 sucC -5.1 -6.1 succinyl-CoA synthetase subunit beta (NCBI) compare
b0437 clpP -5.1 -7.0 ATP-dependent Clp protease proteolytic subunit (NCBI) compare
b1129 phoQ -5.0 -6.9 sensory histidine kinase in two-compoent regulatory system with PhoP (NCBI) compare
b2021 hisC -5.0 -6.0 histidinol-phosphate aminotransferase (NCBI) compare
b0003 thrB -5.0 -9.5 homoserine kinase (NCBI) compare
b4006 purH -4.9 -10.5 bifunctionalphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI) compare
b3169 nusA -4.9 -3.4 transcription elongation factor NusA (NCBI) compare
b2024 hisA -4.9 -2.5 N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-imidazolecarboxamide isomerase (VIMSS) compare
b0438 clpX -4.9 -5.8 ATP-dependent protease ATP-binding subunit (NCBI) compare
b3828 metR -4.9 -9.9 DNA-binding transcriptional activator, homocysteine-binding (NCBI) compare
b2022 hisB -4.9 -8.1 imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS) compare
b2913 serA -4.9 -6.7 D-3-phosphoglycerate dehydrogenase (NCBI) compare
b2188 yejM -4.8 -8.1 predicted hydrolase, inner membrane (NCBI) compare
b3770 ilvE -4.8 -10.8 branched-chain amino acid aminotransferase (NCBI) compare
b2320 pdxB -4.8 -8.6 erythronate-4-phosphate dehydrogenase (NCBI) compare
b0073 leuB -4.8 -9.7 3-isopropylmalate dehydrogenase (VIMSS) compare
b0522 purK -4.8 -8.0 phosphoribosylaminoimidazole carboxylase (NCBI) compare
b4388 serB -4.8 -5.6 3-phosphoserine phosphatase (NCBI) compare
b0908 aroA -4.7 -7.9 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) compare
b0723 sdhA -4.7 -7.9 succinate dehydrogenase flavoprotein subunit (NCBI) compare
b0523 purE -4.7 -4.5 phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI) compare
b2838 lysA -4.7 -9.9 diaminopimelate decarboxylase, PLP-binding (NCBI) compare
b0912 ihfB -4.6 -5.5 integration host factor subunit beta (NCBI) compare
b2784 relA -4.6 -10.3 (p)ppGpp synthetase I/GTP pyrophosphokinase (NCBI) compare
b2587 kgtP -4.6 -8.2 alpha-ketoglutarate transporter (NCBI) conserved
b0889 lrp -4.6 -4.4 DNA-binding transcriptional dual regulator, leucine-binding (NCBI) compare
b0052 pdxA -4.6 -9.8 4-hydroxythreonine-4-phosphate dehydrogenase (NCBI) compare
b0724 sdhB -4.6 -4.4 succinate dehydrogenase, FeS subunit (NCBI) compare
b0080 fruR -4.6 -5.4 DNA-binding transcriptional dual regulator (NCBI) compare
b3829 metE -4.6 -15.1 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (NCBI) compare
b3236 mdh -4.6 -7.6 malate dehydrogenase (NCBI) compare
b1545 pinQ -4.5 -1.8 Qin prophage; predicted site-specific recombinase (NCBI) compare
b3772 ilvA -4.5 -12.7 threonine dehydratase (NCBI) compare
b2600 tyrA -4.5 -8.0 fused chorismate mutase T/prephenate dehydrogenase (NCBI) compare
b2424 cysU -4.5 -4.3 sulfate/thiosulfate transporter subunit (NCBI) compare
b2340 sixA -4.4 -5.3 phosphohistidine phosphatase (NCBI) compare
b0071 leuD -4.4 -8.0 isopropylmalate isomerase small subunit (NCBI) compare
b2215 ompC -4.4 -12.0 outer membrane porin protein C (NCBI) compare
b2762 cysH -4.4 -7.8 phosphoadenosine phosphosulfate reductase (NCBI) compare
b3642 pyrE -4.4 -4.2 orotate phosphoribosyltransferase (NCBI) compare
b2276 nuoN -4.4 -3.0 NADH:ubiquinone oxidoreductase, membrane subunit N (RefSeq) compare
b2557 purL -4.3 -9.3 phosphoribosylformylglycinamidine synthase (NCBI) compare
b3390 aroK -4.3 -3.0 shikimate kinase I (NCBI) compare
b0002 thrA -4.3 -15.2 bifunctional aspartokinase I/homeserine dehydrogenase I (NCBI) compare
b1293 sapB -4.3 -2.9 predicted antimicrobial peptide transporter subunit (NCBI) compare
b1290 sapF -4.3 -2.9 predicted antimicrobial peptide transporter subunit (NCBI) compare
b0033 carB -4.2 -15.6 carbamoyl-phosphate synthase large subunit (NCBI) compare
b4407 thiS -4.2 -2.7 sulfur carrier protein ThiS (NCBI) compare
b0049 apaH -4.2 -6.4 diadenosinetetraphosphatase (NCBI) compare
b3204 ptsN -4.2 -5.0 sugar-specific enzyme IIA component of PTS (NCBI) compare
b0145 dksA -4.2 -2.9 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b2023 hisH -4.2 -6.9 imidazole glycerol phosphate synthase subunit HisH (NCBI) compare
b1084 rne -4.2 -5.7 fused ribonucleaseE: endoribonuclease/RNA-binding protein/RNA degradosome binding protein (NCBI) compare
b2286 nuoC -4.1 -4.9 NADH:ubiquinone oxidoreductase, chain C,D (RefSeq) compare
b0688 pgm -4.1 -2.9 phosphoglucomutase (NCBI) compare
b0729 sucD -4.1 -4.0 succinyl-CoA synthetase subunit alpha (NCBI) compare
b2283 nuoG -4.1 -4.9 NADH:ubiquinone oxidoreductase, chain G (RefSeq) compare
b3008 metC -4.1 -12.1 cystathionine beta-lyase (NCBI) compare
b2026 hisI -4.1 -9.0 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI) compare
b2499 purM -4.1 -5.6 phosphoribosylaminoimidazole synthetase (NCBI) compare
b2284 nuoF -4.1 -4.0 NADH:ubiquinone oxidoreductase, chain F (NCBI) compare
b0222 lpcA -4.0 -2.8 phosphoheptose isomerase (NCBI) compare
b3839 tatC -4.0 -6.7 TatABCE protein translocation system subunit (NCBI) compare
b2839 lysR -4.0 -6.4 DNA-binding transcriptional dual regulator (NCBI) compare
b2329 aroC -4.0 -6.1 chorismate synthase (NCBI) compare
b2752 cysD -4.0 -7.2 sulfate adenylyltransferase subunit 2 (NCBI) compare
b0390 aroM -3.9 -10.4 hypothetical protein (NCBI) compare
b0142 folK -3.9 -1.5 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) compare
b4481 rffT -3.9 -7.8 4-alpha-L-fucosyltransferase (NCBI) compare
b0722 sdhD -3.8 -5.2 succinate dehydrogenase cytochrome b556 small membrane subunit (NCBI) compare
b3213 gltD -3.8 -12.2 glutamate synthase, 4Fe-4S protein, small subunit (NCBI) compare
b2564 pdxJ -3.8 -4.5 pyridoxal phosphate biosynthetic protein (NCBI) compare
b0739 tolA -3.8 -2.6 cell envelope integrity inner membrane protein TolA (NCBI) compare
b3844 fre -3.8 -6.7 NAD(P)H-flavin reductase (NCBI) compare
b3849 trkH -3.7 -11.0 potassium transporter (NCBI) compare
b3405 ompR -3.7 -2.6 osmolarity response regulator (NCBI) compare
b2278 nuoL -3.7 -7.5 NADH dehydrogenase subunit L (NCBI) compare
b3483 yhhH -3.7 -2.1 orf, hypothetical protein (VIMSS) compare
b1062 pyrC -3.6 -10.4 dihydroorotase (NCBI) compare
b2279 nuoK -3.6 -2.5 NADH dehydrogenase subunit K (NCBI) compare
b3631 rfaG -3.6 -17.1 glucosyltransferase I (NCBI) compare
b2282 nuoH -3.6 -2.5 NADH dehydrogenase subunit H (NCBI) compare
b3052 rfaE -3.6 -4.2 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare
b0032 carA -3.6 -7.2 carbamoyl-phosphate synthase small subunit (NCBI) compare
b2763 cysI -3.6 -9.4 sulfite reductase, beta subunit, NAD(P)-binding, heme-binding (NCBI) compare
b1333 uspE -3.5 -3.5 stress-induced protein (NCBI) compare
b0683 fur -3.5 -2.2 ferric uptake regulator (NCBI) compare
b0439 lon -3.5 -3.4 DNA-binding ATP-dependent protease La (NCBI) compare
b3212 gltB -3.5 -19.2 glutamate synthase, large subunit (NCBI) compare
b0737 tolQ -3.5 -3.4 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b2764 cysJ -3.5 -10.9 sulfite reductase, alpha subunit, flavoprotein (NCBI) compare
b0585 fes -3.5 -7.7 enterobactin/ferric enterobactin esterase (NCBI) compare
b0588 fepC -3.5 -8.5 iron-enterobactin transporter subunit (NCBI) compare
b1292 sapC -3.5 -3.3 predicted antimicrobial peptide transporter subunit (NCBI) compare
b1859 znuB -3.4 -8.4 high-affinity zinc transporter membrane component (NCBI) compare
b2280 nuoJ -3.4 -6.1 NADH dehydrogenase subunit J (NCBI) compare
b2897 ygfY -3.4 -4.0 hypothetical protein (NCBI) compare
b3368 cysG -3.4 -17.0 fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase (NCBI) compare
b0430 cyoC -3.4 -5.6 cytochrome o ubiquinol oxidase subunit III (NCBI) compare
b0740 tolB -3.4 -5.6 translocation protein TolB precursor (NCBI) compare
b3792 wzxE -3.4 -10.2 O-antigen translocase (NCBI) compare
b2281 nuoI -3.4 -4.0 NADH dehydrogenase subunit I (NCBI) compare
b1281 pyrF -3.4 -5.0 orotidine 5'-phosphate decarboxylase (NCBI) compare
b3957 argE -3.3 -13.6 acetylornithine deacetylase (NCBI) compare
b3838 tatB -3.3 -9.9 sec-independent translocase (NCBI) compare
b3035 tolC -3.3 -10.6 outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) compare
b3387 dam -3.3 -15.2 DNA adenine methylase (NCBI) compare
b3630 rfaP -3.3 -12.2 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b1858 znuC -3.3 -7.5 high-affinity zinc transporter ATPase (NCBI) compare
b2479 gcvR -3.2 -4.4 transcriptional regulation of gcv operon (VIMSS) compare
b3726 pstA -3.2 -7.5 phosphate transporter subunit (NCBI) compare
b3398 yrfF -3.2 -4.4 predicted inner membrane protein (NCBI) compare
b3006 exbB -3.2 -10.2 membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) compare
b0592 fepB -3.2 -10.7 iron-enterobactin transporter subunit (NCBI) compare
b1291 sapD -3.2 -3.1 predicted antimicrobial peptide transporter subunit (NCBI) compare
b3939 metB -3.2 -11.8 cystathionine gamma-synthase (NCBI) compare
b3958 argC -3.2 -13.0 N-acetyl-gamma-glutamyl-phosphate reductase (NCBI) compare
b3791 rffA -3.2 -9.9 TDP-4-oxo-6-deoxy-D-glucose transaminase (NCBI) compare
b3959 argB -3.2 -11.8 acetylglutamate kinase (RefSeq) compare
b2285 nuoE -3.2 -3.0 NADH dehydrogenase subunit E (NCBI) compare
b0741 pal -3.1 -5.2 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b3621 rfaC -3.0 -4.2 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b0589 fepG -3.0 -9.4 iron-enterobactin transporter subunit (NCBI) compare
b3842 rfaH -3.0 -5.7 transcriptional activator RfaH (NCBI) compare
b2818 argA -2.9 -10.0 N-acetylglutamate synthase (NCBI) compare
b4042 dgkA -2.9 -3.5 diacylglycerol kinase (NCBI) compare
b2287 nuoB -2.9 -3.5 NADH dehydrogenase subunit B (NCBI) compare
b3794 rffM -2.9 -9.5 putative UDP-N-acetyl-D-mannosaminuronic acid transferase (NCBI) compare
b0726 sucA -2.9 -2.0 alpha-ketoglutarate decarboxylase (NCBI) compare
b2422 cysA -2.8 -8.4 sulfate/thiosulfate transporter subunit (NCBI) compare
b3619 rfaD -2.8 -3.3 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b3728 pstS -2.8 -5.3 phosphate transporter subunit (NCBI) compare
b3404 envZ -2.8 -9.9 osmolarity sensor protein (NCBI) compare
b0590 fepD -2.8 -8.0 iron-enterobactin transporter subunit (NCBI) compare
b1857 yebL -2.8 -4.9 putative adhesin (VIMSS) compare
b1185 dsbB -2.7 -4.4 reoxidizes DsbA protein following formation of disulfide bond in P-ring of flagella. (VIMSS) compare
b3727 pstC -2.7 -7.9 phosphate transporter subunit (NCBI) compare
b1863 ruvC -2.7 -5.1 Holliday junction resolvase (NCBI) compare
b2103 thiD -2.7 -7.1 phosphomethylpyrimidine kinase (NCBI) compare
b0630 lipB -2.7 -1.8 protein of lipoate biosynthesis (VIMSS) compare
b3620 rfaF -2.7 -4.4 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b2277 nuoM -2.7 -5.4 NADH dehydrogenase subunit M (NCBI) compare
b2423 cysW -2.7 -6.4 sulfate/thiosulfate transporter subunit (NCBI) compare
b3993 thiE -2.6 -7.9 thiamine-phosphate pyrophosphorylase (NCBI) compare
b1252 tonB -2.6 -4.6 membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) compare
b0088 murD -2.6 -3.3 UDP-N-acetylmuramoyl-L-alanyl-D-glutamatesynthetase (NCBI) compare
b0114 aceE -2.6 -1.8 pyruvate dehydrogenase subunit E1 (NCBI) compare
b2830 nudH -2.6 -2.5 dinucleoside polyphosphate hydrolase (NCBI) compare
b0676 nagC -2.6 -8.3 DNA-binding transcriptional dual regulator, repressor of N-acetylglucosamine (NCBI) compare
b1262 trpC -2.6 -3.6 N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase (VIMSS) compare
b4171 miaA -2.6 -6.6 tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) compare
b0584 fepA -2.6 -11.6 iron-enterobactin outer membrane transporter (NCBI) compare
b2144 sanA -2.5 -15.8 hypothetical protein (NCBI) compare
b2189 proL -2.5 -2.4 tRNA-Pro (NCBI) compare
b2288 nuoA -2.5 -3.5 NADH dehydrogenase I chain A (VIMSS) compare
b0118 acnB -2.5 -2.4 aconitate hydratase (NCBI) compare
b0200 gmhB -2.4 -1.7 hypothetical protein (NCBI) compare
b3870 glnA -2.4 -1.7 glutamine synthetase (NCBI) compare
b3290 trkA -2.4 -1.7 potassium transporter peripheral membrane component (NCBI) compare
b0101 yacG -2.4 -4.5 zinc-binding protein (NCBI) compare
b4395 ytjC -2.4 -5.8 phosphoglycerate mutase (NCBI) compare
b0926 ycbK -2.4 -7.8 hypothetical protein (NCBI) compare
b3962 udhA -2.4 -9.6 putative oxidoreductase (VIMSS) compare
b0945 pyrD -2.3 -11.3 dihydroorotate dehydrogenase (NCBI) compare
b2567 rnc -2.3 -1.6 ribonuclease III (NCBI) compare
b3609 secB -2.3 -4.6 export protein SecB (NCBI) compare
b3725 pstB -2.3 -1.6 phosphate transporter subunit (NCBI) compare
b3232 yhcM -2.3 -10.6 conserved protein with nucleoside triphosphate hydrolase domain (NCBI) compare


Specific Phenotypes

For 28 genes in this experiment

For carbon source a-Ketoglutaric acid disodium salt hydrate in Escherichia coli BW25113

For carbon source a-Ketoglutaric acid disodium salt hydrate across organisms