| | gene | name | fitness | t score | description | |
|---|
| b0523 | purE | -6.0 | -4.1 | phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI) | compare |
| b1192 | ldcA | -5.6 | -5.4 | L,D-carboxypeptidase A (NCBI) | compare |
| b1261 | trpB | -5.5 | -5.3 | tryptophan synthase subunit beta (NCBI) | compare |
| b2020 | hisD | -5.4 | -10.3 | histidinol dehydrogenase (NCBI) | compare |
| b1263 | trpD | -5.4 | -3.7 | bifunctional indole-3-glycerol-phosphate synthase/anthranilate phosphoribosyltransferase (NCBI) | compare |
| b0522 | purK | -5.2 | -8.0 | phosphoribosylaminoimidazole carboxylase (NCBI) | compare |
| b2024 | hisA | -5.1 | -3.1 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-imidazolecarboxamide isomerase (VIMSS) | compare |
| b0907 | serC | -5.0 | -9.7 | phosphoserine aminotransferase (NCBI) | compare |
| b0073 | leuB | -5.0 | -10.6 | 3-isopropylmalate dehydrogenase (VIMSS) | compare |
| b3281 | aroE | -4.9 | -17.5 | dehydroshikimate reductase, NAD(P)-binding (NCBI) | compare |
| b0243 | proA | -4.9 | -11.3 | gamma-glutamyl phosphate reductase (NCBI) | compare |
| b2913 | serA | -4.9 | -9.3 | D-3-phosphoglycerate dehydrogenase (NCBI) | compare |
| b0072 | leuC | -4.8 | -12.9 | isopropylmalate isomerase large subunit (NCBI) | compare |
| b0074 | leuA | -4.8 | -11.7 | 2-isopropylmalate synthase (NCBI) | compare |
| b0908 | aroA | -4.8 | -10.7 | 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) | compare |
| b2499 | purM | -4.8 | -6.5 | phosphoribosylaminoimidazole synthetase (NCBI) | compare |
| b3390 | aroK | -4.7 | -3.3 | shikimate kinase I (NCBI) | compare |
| b2022 | hisB | -4.7 | -9.6 | imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS) | compare |
| b4388 | serB | -4.7 | -7.2 | 3-phosphoserine phosphatase (NCBI) | compare |
| b3771 | ilvD | -4.7 | -14.2 | dihydroxy-acid dehydratase (NCBI) | compare |
| b3774 | ilvC | -4.7 | -17.0 | ketol-acid reductoisomerase (NCBI) | compare |
| b2340 | sixA | -4.6 | -6.3 | phosphohistidine phosphatase (NCBI) | compare |
| b0004 | thrC | -4.6 | -10.3 | threonine synthase (NCBI) | compare |
| b3389 | aroB | -4.6 | -13.5 | 3-dehydroquinate synthase (NCBI) | compare |
| b4214 | cysQ | -4.6 | -14.4 | PAPS (adenosine 3'-phosphate 5'-phosphosulfate) 3'(2'),5'-bisphosphate nucleotidase (NCBI) | compare |
| b0242 | proB | -4.6 | -8.2 | gamma-glutamyl kinase (NCBI) | compare |
| b2414 | cysK | -4.5 | -13.0 | cysteine synthase A, O-acetylserine sulfhydrolase A subunit (NCBI) | compare |
| b3941 | metF | -4.5 | -10.0 | 5,10-methylenetetrahydrofolate reductase (NCBI) | compare |
| b3770 | ilvE | -4.5 | -14.6 | branched-chain amino acid aminotransferase (NCBI) | compare |
| b1129 | phoQ | -4.5 | -10.4 | sensory histidine kinase in two-compoent regulatory system with PhoP (NCBI) | compare |
| b2019 | hisG | -4.4 | -6.3 | ATP phosphoribosyltransferase (NCBI) | compare |
| b4005 | purD | -4.4 | -9.9 | phosphoribosylamine--glycine ligase (NCBI) | compare |
| b2312 | purF | -4.4 | -9.4 | amidophosphoribosyltransferase (NCBI) | compare |
| b3828 | metR | -4.4 | -12.8 | DNA-binding transcriptional activator, homocysteine-binding (NCBI) | compare |
| b4006 | purH | -4.4 | -14.3 | bifunctionalphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI) | compare |
| b1693 | aroD | -4.4 | -9.3 | 3-dehydroquinate dehydratase (NCBI) | compare |
| b2025 | hisF | -4.3 | -7.2 | imidazole glycerol phosphate synthase subunit HisF (NCBI) | compare |
| b1130 | phoP | -4.3 | -9.0 | DNA-binding response regulator in two-component regulatory system with PhoQ (NCBI) | compare |
| b3829 | metE | -4.3 | -18.1 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (NCBI) | compare |
| b2557 | purL | -4.2 | -11.8 | phosphoribosylformylglycinamidine synthase (NCBI) | compare |
| b0071 | leuD | -4.2 | -8.9 | isopropylmalate isomerase small subunit (NCBI) | compare |
| b2021 | hisC | -4.2 | -7.0 | histidinol-phosphate aminotransferase (NCBI) | compare |
| b0142 | folK | -4.2 | -2.1 | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) | compare |
| b3172 | argG | -4.1 | -13.5 | argininosuccinate synthase (NCBI) | compare |
| b2800 | fucA | -4.1 | -11.6 | L-fuculose phosphate aldolase (NCBI) | conserved |
| b2838 | lysA | -4.1 | -12.4 | diaminopimelate decarboxylase, PLP-binding (NCBI) | compare |
| b4232 | fbp | -4.1 | -13.5 | fructose-1,6-bisphosphatase (NCBI) | compare |
| b0720 | gltA | -3.9 | -7.9 | citrate synthase (NCBI) | compare |
| b2329 | aroC | -3.9 | -7.9 | chorismate synthase (NCBI) | compare |
| b4171 | miaA | -3.9 | -7.4 | tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) | compare |
| b1062 | pyrC | -3.8 | -11.0 | dihydroorotase (NCBI) | compare |
| b0002 | thrA | -3.8 | -16.9 | bifunctional aspartokinase I/homeserine dehydrogenase I (NCBI) | compare |
| b0439 | lon | -3.7 | -5.6 | DNA-binding ATP-dependent protease La (NCBI) | compare |
| b3772 | ilvA | -3.7 | -14.5 | threonine dehydratase (NCBI) | compare |
| b2026 | hisI | -3.7 | -10.2 | bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI) | compare |
| b2750 | cysC | -3.6 | -8.8 | adenylylsulfate kinase (NCBI) | compare |
| b2762 | cysH | -3.6 | -9.6 | phosphoadenosine phosphosulfate reductase (NCBI) | compare |
| b3960 | argH | -3.6 | -14.6 | argininosuccinate lyase (NCBI) | compare |
| b3008 | metC | -3.6 | -12.3 | cystathionine beta-lyase (NCBI) | compare |
| b2188 | yejM | -3.6 | -12.1 | predicted hydrolase, inner membrane (NCBI) | compare |
| b0003 | thrB | -3.6 | -7.2 | homoserine kinase (NCBI) | compare |
| b1291 | sapD | -3.6 | -3.4 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b0033 | carB | -3.5 | -16.8 | carbamoyl-phosphate synthase large subunit (NCBI) | compare |
| b0080 | fruR | -3.5 | -8.5 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b2830 | nudH | -3.5 | -2.4 | dinucleoside polyphosphate hydrolase (NCBI) | compare |
| b2023 | hisH | -3.5 | -7.4 | imidazole glycerol phosphate synthase subunit HisH (NCBI) | compare |
| b3956 | ppc | -3.5 | -19.1 | phosphoenolpyruvate carboxylase (NCBI) | compare |
| b3169 | nusA | -3.5 | -4.1 | transcription elongation factor NusA (NCBI) | compare |
| b3204 | ptsN | -3.5 | -7.3 | sugar-specific enzyme IIA component of PTS (NCBI) | compare |
| b0386 | proC | -3.4 | -8.7 | pyrroline-5-carboxylate reductase (NCBI) | compare |
| b1260 | trpA | -3.4 | -7.1 | tryptophan synthase subunit alpha (NCBI) | compare |
| b3082 | ygjM | -3.3 | -4.5 | predicted DNA-binding transcriptional regulator (NCBI) | compare |
| b2564 | pdxJ | -3.2 | -6.1 | pyridoxal phosphate biosynthetic protein (NCBI) | compare |
| b3939 | metB | -3.2 | -11.4 | cystathionine gamma-synthase (NCBI) | compare |
| b2763 | cysI | -3.2 | -10.6 | sulfite reductase, beta subunit, NAD(P)-binding, heme-binding (NCBI) | compare |
| b0049 | apaH | -3.2 | -7.4 | diadenosinetetraphosphatase (NCBI) | compare |
| b3959 | argB | -3.2 | -13.3 | acetylglutamate kinase (RefSeq) | compare |
| b4013 | metA | -3.1 | -7.7 | homoserine O-succinyltransferase (NCBI) | compare |
| b3764 | yifE | -3.1 | -7.6 | hypothetical protein (NCBI) | compare |
| b1281 | pyrF | -3.1 | -4.8 | orotidine 5'-phosphate decarboxylase (NCBI) | compare |
| b0912 | ihfB | -3.1 | -3.9 | integration host factor subunit beta (NCBI) | compare |
| b0945 | pyrD | -3.0 | -13.1 | dihydroorotate dehydrogenase (NCBI) | compare |
| b3957 | argE | -3.0 | -15.4 | acetylornithine deacetylase (NCBI) | compare |
| b4242 | mgtA | -3.0 | -19.5 | magnesium transporter (NCBI) | compare |
| b0145 | dksA | -3.0 | -5.6 | DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) | compare |
| b4245 | pyrB | -3.0 | -11.6 | aspartate carbamoyltransferase catalytic subunit (NCBI) | compare |
| b2476 | purC | -2.9 | -4.8 | phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI) | compare |
| b0077 | ilvI | -2.9 | -13.0 | acetolactate synthase III large subunit (NCBI) | compare |
| b3806 | cyaA | -2.9 | -6.4 | adenylate cyclase (NCBI) | compare |
| b0118 | acnB | -2.9 | -2.8 | aconitate hydratase (NCBI) | compare |
| b3958 | argC | -2.9 | -12.8 | N-acetyl-gamma-glutamyl-phosphate reductase (NCBI) | compare |
| b0113 | pdhR | -2.9 | -6.8 | transcriptional regulator of pyruvate dehydrogenase complex (NCBI) | compare |
| b2501 | ppk | -2.9 | -11.7 | polyphosphate kinase (NCBI) | compare |
| b3962 | udhA | -2.8 | -10.9 | putative oxidoreductase (VIMSS) | compare |
| b0052 | pdxA | -2.8 | -9.8 | 4-hydroxythreonine-4-phosphate dehydrogenase (NCBI) | compare |
| b2764 | cysJ | -2.8 | -11.4 | sulfite reductase, alpha subunit, flavoprotein (NCBI) | compare |
| b3844 | fre | -2.8 | -8.0 | NAD(P)H-flavin reductase (NCBI) | compare |
| b2424 | cysU | -2.8 | -3.4 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b2567 | rnc | -2.8 | -1.9 | ribonuclease III (NCBI) | compare |
| b3725 | pstB | -2.8 | -1.9 | phosphate transporter subunit (NCBI) | compare |
| b3870 | glnA | -2.7 | -2.6 | glutamine synthetase (NCBI) | compare |
| b0032 | carA | -2.7 | -6.2 | carbamoyl-phosphate synthase small subunit (NCBI) | compare |
| b0078 | ilvH | -2.7 | -9.5 | acetolactate synthase small subunit (NCBI) | compare |
| b1712 | ihfA | -2.7 | -3.7 | integration host factor subunit alpha (NCBI) | compare |
| b0114 | aceE | -2.7 | -3.2 | pyruvate dehydrogenase subunit E1 (NCBI) | compare |
| b3368 | cysG | -2.7 | -16.3 | fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase (NCBI) | compare |
| b3642 | pyrE | -2.7 | -6.3 | orotate phosphoribosyltransferase (NCBI) | compare |
| b0222 | lpcA | -2.7 | -4.7 | phosphoheptose isomerase (NCBI) | compare |
| b2600 | tyrA | -2.6 | -6.7 | fused chorismate mutase T/prephenate dehydrogenase (NCBI) | compare |
| b2752 | cysD | -2.6 | -6.6 | sulfate adenylyltransferase subunit 2 (NCBI) | compare |
| b3405 | ompR | -2.6 | -6.4 | osmolarity response regulator (NCBI) | compare |
| b3728 | pstS | -2.5 | -6.3 | phosphate transporter subunit (NCBI) | compare |
| b4702 | mgtL | -2.5 | -4.2 | regulatory leader peptide for mgtA (NCBI) | compare |
| b0726 | sucA | -2.5 | -4.4 | alpha-ketoglutarate decarboxylase (NCBI) | compare |
| b4177 | purA | -2.5 | -2.4 | adenylosuccinate synthetase (NCBI) | compare |
| b3236 | mdh | -2.5 | -9.7 | malate dehydrogenase (NCBI) | compare |
| b0200 | gmhB | -2.5 | -2.3 | hypothetical protein (NCBI) | compare |
| b2320 | pdxB | -2.5 | -7.8 | erythronate-4-phosphate dehydrogenase (NCBI) | compare |
| b1290 | sapF | -2.4 | -3.6 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b3290 | trkA | -2.4 | -2.9 | potassium transporter peripheral membrane component (NCBI) | compare |
| b3386 | rpe | -2.4 | -1.6 | ribulose-phosphate 3-epimerase (NCBI) | compare |
| b2599 | pheA | -2.4 | -6.9 | fused chorismate mutase P/prephenate dehydratase (NCBI) | compare |
| b0928 | aspC | -2.3 | -6.7 | aspartate aminotransferase, PLP-dependent (NCBI) | compare |
| b2189 | proL | -2.3 | -3.2 | tRNA-Pro (NCBI) | compare |
| b1262 | trpC | -2.3 | -4.4 | N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase (VIMSS) | compare |
| b3849 | trkH | -2.3 | -12.8 | potassium transporter (NCBI) | compare |
| b2297 | pta | -2.3 | -3.0 | phosphate acetyltransferase (NCBI) | compare |
| b1415 | aldA | -2.3 | -6.3 | Lactaldehyde / glycolaldehyde dehydrogenase aldA (EC 1.2.1.22; EC 1.2.1.21) (from data) | compare |
| b3706 | trmE | -2.3 | -7.0 | tRNA modification GTPase (NCBI) | compare |
| b2751 | cysN | -2.2 | -8.7 | sulfate adenylyltransferase subunit 1 (NCBI) | compare |
| b1236 | galU | -2.2 | -7.2 | glucose-1-phosphate uridylyltransferase (NCBI) | compare |
| b2818 | argA | -2.2 | -9.6 | N-acetylglutamate synthase (NCBI) | compare |
| b2803 | fucK | -2.2 | -8.6 | L-fuculokinase (NCBI) | conserved |
| b2479 | gcvR | -2.2 | -5.7 | transcriptional regulation of gcv operon (VIMSS) | compare |
| b0585 | fes | -2.2 | -7.7 | enterobactin/ferric enterobactin esterase (NCBI) | compare |
| b1084 | rne | -2.2 | -6.1 | fused ribonucleaseE: endoribonuclease/RNA-binding protein/RNA degradosome binding protein (NCBI) | compare |
| b3726 | pstA | -2.1 | -7.3 | phosphate transporter subunit (NCBI) | compare |
| b3741 | gidA | -2.1 | -9.4 | glucose-inhibited division protein A (NCBI) | compare |
| b3671 | ilvB | -2.1 | -11.0 | acetolactate synthase large subunit (NCBI) | compare |
| b2500 | purN | -2.1 | -4.9 | phosphoribosylglycinamide formyltransferase (NCBI) | compare |
| b0588 | fepC | -2.1 | -9.1 | iron-enterobactin transporter subunit (NCBI) | compare |
| b4480 | hdfR | -2.1 | -5.8 | transcriptional regulator HdfR (NCBI) | compare |
| b3483 | yhhH | -2.1 | -2.6 | orf, hypothetical protein (VIMSS) | compare |
| b0889 | lrp | -2.0 | -4.4 | DNA-binding transcriptional dual regulator, leucine-binding (NCBI) | compare |
| b0630 | lipB | -2.0 | -2.6 | protein of lipoate biosynthesis (VIMSS) | compare |
| b2839 | lysR | -2.0 | -6.5 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b3650 | spoT | -2.0 | -7.9 | bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase (NCBI) | compare |
| b1292 | sapC | -1.9 | -3.6 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b3863 | polA | -1.9 | -1.8 | DNA polymerase I (NCBI) | compare |
| b1264 | trpE | -1.9 | -3.7 | anthranilate synthase component I (NCBI) | compare |
| b4018 | iclR | -1.9 | -9.0 | repressor of aceBA operon (VIMSS) | compare |
| b3619 | rfaD | -1.9 | -5.0 | ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) | compare |
| b2799 | fucO | -1.9 | -6.7 | L-1,2-propanediol oxidoreductase (NCBI) | compare |
| b1858 | znuC | -1.9 | -7.0 | high-affinity zinc transporter ATPase (NCBI) | compare |
| b2422 | cysA | -1.9 | -7.5 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b0589 | fepG | -1.8 | -7.8 | iron-enterobactin transporter subunit (NCBI) | compare |
| b0592 | fepB | -1.8 | -9.1 | iron-enterobactin transporter subunit (NCBI) | compare |
| b2805 | fucR | -1.8 | -8.0 | DNA-binding transcriptional activator (NCBI) | conserved |
| b2168 | fruK | -1.8 | -2.6 | 1-phosphofructokinase (NCBI) | compare |
| b0739 | tolA | -1.8 | -5.2 | cell envelope integrity inner membrane protein TolA (NCBI) | compare |
| b2802 | fucI | -1.8 | -10.5 | L-fucose isomerase (NCBI) | conserved |
| b1857 | yebL | -1.8 | -5.6 | putative adhesin (VIMSS) | compare |
| b2318 | truA | -1.8 | -5.0 | tRNA pseudouridine synthase A (NCBI) | compare |
| b0590 | fepD | -1.7 | -6.9 | iron-enterobactin transporter subunit (NCBI) | compare |
| b3916 | pfkA | -1.7 | -4.6 | 6-phosphofructokinase (NCBI) | compare |
| b0963 | mgsA | -1.7 | -7.9 | methylglyoxal synthase (VIMSS) | compare |
| b2330 | yfcB | -1.6 | -2.2 | putative adenine-specific methylase (VIMSS) | compare |
| b3052 | rfaE | -1.6 | -5.6 | fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) | compare |
| b1333 | uspE | -1.6 | -3.8 | stress-induced protein (NCBI) | compare |
| b1859 | znuB | -1.6 | -6.6 | high-affinity zinc transporter membrane component (NCBI) | compare |
| b3839 | tatC | -1.6 | -8.5 | TatABCE protein translocation system subunit (NCBI) | compare |
| b3469 | zntA | -1.6 | -10.6 | zinc, cobalt and lead efflux system (NCBI) | compare |
| b0683 | fur | -1.6 | -2.3 | ferric uptake regulator (NCBI) | compare |
| b3212 | gltB | -1.5 | -11.6 | glutamate synthase, large subunit (NCBI) | compare |
| b3572 | avtA | -1.5 | -8.8 | valine--pyruvate transaminase (NCBI) | compare |
| b2215 | ompC | -1.5 | -9.2 | outer membrane porin protein C (NCBI) | compare |
| b3493 | pitA | -1.5 | -8.4 | phosphate transporter, low-affinity (NCBI) | compare |
| b0075 | leuL | -1.5 | -3.3 | leu operon leader peptide (NCBI) | compare |
| b1861 | ruvA | -1.5 | -3.0 | Holliday junction DNA helicase motor protein (NCBI) | compare |
| b1837 | yebW | -1.5 | -3.1 | orf, hypothetical protein (VIMSS) | compare |
| b3213 | gltD | -1.4 | -8.6 | glutamate synthase, 4Fe-4S protein, small subunit (NCBI) | compare |
| b3398 | yrfF | -1.4 | -3.9 | predicted inner membrane protein (NCBI) | compare |
| b4577 | sgrS | -1.4 | -2.2 | small antisense RNA (NCBI) | compare |
| b0740 | tolB | -1.4 | -5.3 | translocation protein TolB precursor (NCBI) | compare |
| b3205 | yhbJ | -1.4 | -3.8 | hypothetical protein (NCBI) | compare |
| b0750 | nadA | -1.4 | -5.9 | quinolinate synthetase (NCBI) | compare |
| b2392 | mntH | -1.3 | -7.1 | manganese transport protein MntH (NCBI) | compare |
| b2801 | fucP | -1.3 | -7.9 | L-fucose transporter (NCBI) | conserved |
| b2103 | thiD | -1.3 | -6.2 | phosphomethylpyrimidine kinase (NCBI) | compare |
| b2683 | ygaH | -1.3 | -5.0 | predicted inner membrane protein (NCBI) | compare |
| b3237 | argR | -1.3 | -4.6 | arginine repressor (NCBI) | compare |
| b2528 | iscA | -1.3 | -2.0 | iron-sulfur cluster assembly protein (NCBI) | compare |
| b3121 | yhaC | -1.3 | -2.0 | hypothetical protein (NCBI) | compare |
| b1269 | rluB | -1.3 | -4.1 | 23S rRNA pseudouridylate synthase (NCBI) | compare |
| b1293 | sapB | -1.3 | -1.4 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b1656 | sodB | -1.3 | -3.2 | superoxide dismutase, Fe (NCBI) | compare |
| b0767 | ybhE | -1.3 | -4.0 | 6-phosphogluconolactonase (NCBI) | compare |
| b3621 | rfaC | -1.3 | -5.2 | ADP-heptose:LPS heptosyl transferase I (NCBI) | compare |
| b1185 | dsbB | -1.2 | -3.1 | reoxidizes DsbA protein following formation of disulfide bond in P-ring of flagella. (VIMSS) | compare |
| b0053 | surA | -1.2 | -5.2 | peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) | compare |