Experiment set1IT017 for Pseudomonas fluorescens GW456-L13

Compare to:

L-Histidine carbon source

200 most important genes:

  gene name fitness t score description  
PfGW456L13_330 -6.5 -7.7 Formiminoglutamic iminohydrolase (EC 3.5.3.13) (from data) conserved
PfGW456L13_1010 -6.5 -4.5 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) compare
PfGW456L13_3934 -6.5 -7.7 O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) / O-succinylhomoserine sulfhydrylase (EC 2.5.1.48) compare
PfGW456L13_1007 -6.3 -7.6 Homoserine O-acetyltransferase (EC 2.3.1.31) compare
PfGW456L13_2842 -6.2 -4.3 required for sulfate utilization, putative electron transport protein for sulfite reductase (from data) compare
PfGW456L13_3940 -6.1 -4.2 Phosphoribosylanthranilate isomerase (EC 5.3.1.24) compare
PfGW456L13_1472 -6.1 -5.9 Glutamate 5-kinase (EC 2.7.2.11) / RNA-binding C-terminal domain PUA compare
PfGW456L13_1540 -6.0 -7.2 Ketol-acid reductoisomerase (EC 1.1.1.86) compare
PfGW456L13_1863 -6.0 -5.8 Quinolinate synthetase (EC 2.5.1.72) compare
PfGW456L13_1222 -5.9 -5.7 Indole-3-glycerol phosphate synthase (EC 4.1.1.48) compare
PfGW456L13_2046 -5.9 -4.1 Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) compare
PfGW456L13_845 -5.8 -4.0 Diaminopimelate decarboxylase (EC 4.1.1.20) compare
PfGW456L13_644 -5.8 -10.4 Shikimate 5-dehydrogenase I alpha (EC 1.1.1.25) compare
PfGW456L13_316 -5.7 -16.1 N-formylglutamate deformylase (EC 3.5.1.68) (from data) conserved
PfGW456L13_317 -5.7 -9.5 Imidazolonepropionase (EC 3.5.2.7) (from data) conserved
PfGW456L13_3947 -5.7 -5.5 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) compare
PfGW456L13_1363 -5.7 -3.9 Rare lipoprotein A precursor compare
PfGW456L13_1368 -5.7 -5.5 Muramoyltetrapeptide carboxypeptidase (EC 3.4.17.13) compare
PfGW456L13_913 -5.6 -6.7 N-acetylglutamate synthase (EC 2.3.1.1) compare
PfGW456L13_1739 -5.5 -7.6 Ornithine carbamoyltransferase (EC 2.1.3.3) compare
PfGW456L13_172 -5.5 -9.1 Phosphoserine phosphatase (EC 3.1.3.3) compare
PfGW456L13_1539 -5.5 -9.8 Acetolactate synthase small subunit (EC 2.2.1.6) compare
PfGW456L13_565 -5.4 -3.7 Tryptophan synthase alpha chain (EC 4.2.1.20) compare
PfGW456L13_1050 -5.3 -9.5 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) compare
PfGW456L13_3945 -5.3 -11.7 3-isopropylmalate dehydrogenase (EC 1.1.1.85) compare
PfGW456L13_3948 -5.2 -7.1 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) compare
PfGW456L13_973 -5.2 -15.5 Dihydroxy-acid dehydratase (EC 4.2.1.9) compare
PfGW456L13_1221 -5.1 -14.0 Anthranilate phosphoribosyltransferase (EC 2.4.2.18) compare
PfGW456L13_4026 -5.1 -3.5 NADPH-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.13) compare
PfGW456L13_5082 -5.1 -4.9 Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19) compare
PfGW456L13_1217 -5.0 -20.0 Anthranilate synthase, aminase component (EC 4.1.3.27) compare
PfGW456L13_1147 -5.0 -16.7 Biotin synthase (EC 2.8.1.6) compare
PfGW456L13_1524 -4.9 -7.5 Two-component sensor CbrB: intrcellular carbon:nitrogen balance compare
PfGW456L13_1233 -4.9 -4.7 N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38) compare
PfGW456L13_854 -4.8 -3.3 Argininosuccinate lyase (EC 4.3.2.1) compare
PfGW456L13_2032 -4.7 -5.6 Cysteine synthase B (EC 2.5.1.47) compare
PfGW456L13_328 -4.7 -4.5 Conserved hypothetical protein (perhaps related to histidine degradation) compare
PfGW456L13_327 -4.6 -8.8 hypothetical protein compare
PfGW456L13_5067 -4.6 -13.2 Ornithine decarboxylase (EC 4.1.1.17) / Arginine decarboxylase (EC 4.1.1.19) compare
PfGW456L13_2176 -4.5 -6.6 Chorismate mutase I (EC 5.4.99.5) / Prephenate dehydratase (EC 4.2.1.51) compare
PfGW456L13_4165 -4.5 -5.3 Chorismate synthase (EC 4.2.3.5) compare
PfGW456L13_793 -4.5 -4.3 Acetylglutamate kinase (EC 2.7.2.8) compare
PfGW456L13_320 -4.5 -5.7 Histidine ammonia-lyase (EC 4.3.1.3) (from data) conserved
PfGW456L13_2656 -4.5 -9.9 Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) / Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) compare
PfGW456L13_1538 -4.4 -15.5 Acetolactate synthase large subunit (EC 2.2.1.6) compare
PfGW456L13_326 -4.4 -17.0 Urocanate hydratase (EC 4.2.1.49) (from data) conserved
PfGW456L13_2230 -4.3 -11.4 Cys regulon transcriptional activator CysB compare
PfGW456L13_1151 -4.3 -11.1 Dethiobiotin synthetase (EC 6.3.3.3) compare
PfGW456L13_2843 -4.3 -11.5 Sulfite reductase [NADPH] hemoprotein beta-component (EC 1.8.1.2) compare
PfGW456L13_943 -4.1 -7.1 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) compare
PfGW456L13_1006 -4.1 -5.8 Homoserine O-acetyltransferase (EC 2.3.1.31) compare
PfGW456L13_3960 -4.1 -7.1 Biosynthetic Aromatic amino acid aminotransferase alpha (EC 2.6.1.57) @ Aromatic-amino-acid aminotransferase (EC 2.6.1.57) compare
PfGW456L13_1220 -4.0 -6.9 Anthranilate synthase, amidotransferase component (EC 4.1.3.27) @ Para-aminobenzoate synthase, amidotransferase component (EC 2.6.1.85) compare
PfGW456L13_1148 -4.0 -18.1 8-amino-7-oxononanoate synthase (EC 2.3.1.47) compare
PfGW456L13_656 -3.9 -5.4 Lipid A biosynthesis lauroyl acyltransferase (EC 2.3.1.-) compare
PfGW456L13_275 -3.9 -2.7 3-dehydroquinate synthase (EC 4.2.3.4) compare
PfGW456L13_1044 -3.9 -12.9 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62) compare
PfGW456L13_2103 -3.8 -5.4 Phosphate:acyl-ACP acyltransferase PlsX compare
PfGW456L13_276 -3.8 -1.9 Shikimate kinase I (EC 2.7.1.71) compare
PfGW456L13_4517 -3.8 -18.2 L-aspartate oxidase (EC 1.4.3.16) compare
PfGW456L13_566 -3.8 -8.4 Tryptophan synthase beta chain (EC 4.2.1.20) compare
PfGW456L13_4854 -3.8 -10.3 2-isopropylmalate synthase (EC 2.3.3.13) compare
PfGW456L13_5086 -3.7 -6.1 tRNA pseudouridine synthase B (EC 4.2.1.70) compare
PfGW456L13_420 -3.7 -3.4 Phosphoenolpyruvate carboxykinase [ATP] (EC 4.1.1.49) compare
PfGW456L13_2551 -3.6 -5.4 Cell division trigger factor (EC 5.2.1.8) compare
PfGW456L13_779 -3.6 -12.9 Bona fide RidA/YjgF/TdcF/RutC subgroup compare
PfGW456L13_318 -3.5 -14.4 Histidine transport protein (permease) conserved
PfGW456L13_4038 -3.4 -2.4 DNA topoisomerase I (EC 5.99.1.2) compare
PfGW456L13_1749 -3.4 -6.5 Argininosuccinate synthase (EC 6.3.4.5) compare
PfGW456L13_1603 -3.3 -3.6 Malate:quinone oxidoreductase (EC 1.1.5.4) compare
PfGW456L13_4859 -3.3 -5.7 Outer membrane protein YfgL, lipoprotein component of the protein assembly complex (forms a complex with YaeT, YfiO, and NlpB) compare
PfGW456L13_1139 -3.3 -12.5 Malate synthase G (EC 2.3.3.9) compare
PfGW456L13_5008 -3.2 -3.0 Uncharacterized ABC transporter, ATP-binding protein YrbF compare
PfGW456L13_2035 -3.2 -11.8 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I / Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2) compare
PfGW456L13_4009 -3.2 -10.8 Transaldolase (EC 2.2.1.2) compare
PfGW456L13_2034 -3.1 -4.1 hypothetical protein compare
PfGW456L13_1735 -3.0 -4.6 Glycerol uptake facilitator protein compare
PfGW456L13_1580 -3.0 -11.5 FIG140336: TPR domain protein compare
PfGW456L13_283 -3.0 -11.5 NADP-dependent malic enzyme (EC 1.1.1.40) compare
PfGW456L13_1972 -2.9 -2.8 Arginine N-succinyltransferase, alpha subunit (EC 2.3.1.109) compare
PfGW456L13_1845 -2.9 -5.0 Cold shock protein CspC compare
PfGW456L13_1153 -2.9 -12.9 Acyl-CoA dehydrogenase (EC 1.3.8.7) compare
PfGW456L13_4254 -2.8 -6.2 FIG00955360: hypothetical protein compare
PfGW456L13_4836 -2.8 -9.0 Transglycosylase, Slt family compare
PfGW456L13_1150 -2.7 -13.0 Biotin synthesis protein BioC compare
PfGW456L13_4041 -2.7 -3.1 Enoyl-CoA hydratase (EC 4.2.1.17) / Delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase (EC 5.3.3.8) / 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35) / 3-hydroxybutyryl-CoA epimerase (EC 5.1.2.3) compare
PfGW456L13_355 -2.6 -6.9 Carboxyl-terminal protease (EC 3.4.21.102) compare
PfGW456L13_5005 -2.6 -5.6 Uncharacterized ABC transporter, auxiliary component YrbC compare
PfGW456L13_430 -2.5 -10.6 Glutamate--cysteine ligase (EC 6.3.2.2) compare
PfGW456L13_742 -2.5 -9.1 Aspartate ammonia-lyase (EC 4.3.1.1) compare
PfGW456L13_757 -2.5 -3.9 Phosphate transport system regulatory protein PhoU compare
PfGW456L13_1219 -2.5 -3.5 hypothetical protein compare
PfGW456L13_3894 -2.4 -2.2 Integration host factor alpha subunit compare
PfGW456L13_3936 -2.3 -6.2 Colicin V production protein compare
PfGW456L13_3305 -2.2 -5.7 BatD compare
PfGW456L13_5089 -2.2 -2.1 Transcription termination protein NusA compare
PfGW456L13_1851 -2.2 -4.0 Crossover junction endodeoxyribonuclease RuvC (EC 3.1.22.4) compare
PfGW456L13_427 -2.2 -2.9 Two-component system response regulator OmpR compare
PfGW456L13_4668 -2.1 -6.2 RecA protein compare
PfGW456L13_4125 -2.1 -3.2 Phosphoadenylyl-sulfate reductase [thioredoxin] (EC 1.8.4.8) / Adenylyl-sulfate reductase [thioredoxin] (EC 1.8.4.10) compare
PfGW456L13_5017 -2.1 -5.6 Hypothetical ATP-binding protein UPF0042, contains P-loop compare
PfGW456L13_274 -2.0 -10.1 DamX, an inner membrane protein involved in bile resistance compare
PfGW456L13_157 -2.0 -3.6 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) compare
PfGW456L13_2651 -2.0 -4.5 Cell division protein FtsK compare
PfGW456L13_874 -2.0 -14.3 Polyphosphate kinase (EC 2.7.4.1) compare
PfGW456L13_1584 -2.0 -6.3 Molybdopterin biosynthesis protein MoeB compare
PfGW456L13_4040 -1.9 -2.8 3-ketoacyl-CoA thiolase (EC 2.3.1.16) @ Acetyl-CoA acetyltransferase (EC 2.3.1.9) compare
PfGW456L13_3398 -1.9 -4.2 Transcriptional regulator, TetR family compare
PfGW456L13_2768 -1.9 -3.8 FIG00959468: hypothetical protein compare
PfGW456L13_2237 -1.8 -3.2 Organic hydroperoxide resistance transcriptional regulator compare
PfGW456L13_1520 -1.8 -3.5 Pantoate--beta-alanine ligase (EC 6.3.2.1) compare
PfGW456L13_4015 -1.8 -3.7 NADPH dependent preQ0 reductase (EC 1.7.1.13) compare
PfGW456L13_2552 -1.8 -5.1 ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) compare
PfGW456L13_3179 -1.8 -2.9 Organic hydroperoxide resistance transcriptional regulator compare
PfGW456L13_5006 -1.8 -2.7 Uncharacterized ABC transporter, periplasmic component YrbD compare
PfGW456L13_4229 -1.8 -9.9 Long-chain fatty acid transport protein compare
PfGW456L13_1525 -1.7 -7.4 Two-component sensor CbrA: intrcellular carbon:nitrogen balance compare
PfGW456L13_772 -1.7 -5.9 ATP-dependent DNA helicase RecG (EC 3.6.1.-) compare
PfGW456L13_1997 -1.7 -6.7 Negative regulator of flagellin synthesis FlgM compare
PfGW456L13_990 -1.7 -2.4 Ribosomal RNA small subunit methyltransferase D (EC 2.1.1.-) compare
PfGW456L13_2773 -1.7 -2.6 Phage protein compare
PfGW456L13_72 -1.7 -4.1 hypothetical protein compare
PfGW456L13_4012 -1.7 -2.2 VacJ-like lipoprotein precursor compare
PfGW456L13_1973 -1.7 -3.8 Arginine N-succinyltransferase (EC 2.3.1.109) compare
PfGW456L13_1574 -1.7 -3.9 GTP-binding and nucleic acid-binding protein YchF compare
PfGW456L13_1860 -1.6 -6.5 TPR repeat containing exported protein; Putative periplasmic protein contains a protein prenylyltransferase domain compare
PfGW456L13_1625 -1.6 -2.4 FIG00958649: hypothetical protein compare
PfGW456L13_4207 -1.6 -4.9 Periplasmic protease compare
PfGW456L13_672 -1.6 -4.1 rRNA small subunit 7-methylguanosine (m7G) methyltransferase GidB compare
PfGW456L13_1852 -1.6 -5.0 Holliday junction DNA helicase RuvA compare
PfGW456L13_2221 -1.6 -8.8 ErfK/YbiS/YcfS/YnhG family protein compare
PfGW456L13_4088 -1.6 -3.7 Transcriptional regulator, GntR family compare
PfGW456L13_4842 -1.6 -2.6 Translation elongation factor LepA compare
PfGW456L13_3304 -1.6 -6.0 TPR domain protein in aerotolerance operon compare
PfGW456L13_1356 -1.5 -3.9 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) compare
PfGW456L13_1842 -1.5 -7.1 Outer membrane porin, OprD family compare
PfGW456L13_4582 -1.5 -4.7 RND efflux system, outer membrane lipoprotein CmeC compare
PfGW456L13_2496 -1.5 -1.8 3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100) compare
PfGW456L13_1009 -1.5 -1.8 Integral membrane protein YggT, involved in response to extracytoplasmic stress (osmotic shock) compare
PfGW456L13_1789 -1.5 -2.3 FIG00954094: hypothetical protein compare
PfGW456L13_3300 -1.5 -7.6 MoxR-like ATPase in aerotolerance operon compare
PfGW456L13_5011 -1.4 -2.1 Uncharacterized protein YrbK clustered with lipopolysaccharide transporters compare
PfGW456L13_2271 -1.4 -2.1 Phosphonate ABC transporter phosphate-binding periplasmic component (TC 3.A.1.9.1) compare
PfGW456L13_140 -1.4 -3.9 FIG003573: hypothetical protein compare
PfGW456L13_4512 -1.4 -6.0 Exported zinc metalloprotease YfgC precursor compare
PfGW456L13_2854 -1.4 -3.2 CobW GTPase involved in cobalt insertion for B12 biosynthesis compare
PfGW456L13_2170 -1.4 -3.8 Similar to phosphoglycolate phosphatase, clustered with ubiquinone biosynthesis SAM-dependent O-methyltransferase compare
PfGW456L13_769 -1.4 -1.4 DNA-binding protein HU-alpha compare
PfGW456L13_5074 -1.4 -1.6 1-phosphofructokinase (EC 2.7.1.56) compare
PfGW456L13_3535 -1.4 -2.1 membrane protein, putative compare
PfGW456L13_1671 -1.3 -3.9 FIG074102: hypothetical protein compare
PfGW456L13_1985 -1.3 -2.2 Alginate biosynthesis transcriptional activator compare
PfGW456L13_50 -1.3 -4.9 3-dehydroquinate dehydratase II (EC 4.2.1.10) compare
PfGW456L13_567 -1.3 -6.9 Glycine cleavage system transcriptional activator conserved
PfGW456L13_5003 -1.3 -1.7 YrbA protein compare
PfGW456L13_2897 -1.3 -2.1 hypothetical protein compare
PfGW456L13_4451 -1.3 -4.0 ATP-dependent RNA helicase SrmB compare
PfGW456L13_4507 -1.3 -2.2 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) compare
PfGW456L13_3303 -1.3 -5.2 BatA (Bacteroides aerotolerance operon) compare
PfGW456L13_1160 -1.2 -3.8 Putative DNA-binding protein in cluster with Type I restriction-modification system compare
PfGW456L13_3052 -1.2 -2.1 Response regulator compare
PfGW456L13_3302 -1.2 -1.3 FIG00954674: hypothetical protein compare
PfGW456L13_1691 -1.2 -2.2 Molybdenum cofactor biosynthesis protein MoaE compare
PfGW456L13_2602 -1.2 -5.8 putative exported protein compare
PfGW456L13_4361 -1.2 -3.0 Flagellin protein FlaG compare
PfGW456L13_59 -1.2 -5.2 Sensor histidine kinase/response regulator compare
PfGW456L13_350 -1.2 -2.6 Protein export cytoplasm chaperone protein (SecB, maintains protein to be exported in unfolded state) compare
PfGW456L13_2038 -1.2 -2.3 hypothetical protein compare
PfGW456L13_2763 -1.2 -3.0 putative tellurium resistance protein compare
PfGW456L13_2601 -1.2 -7.6 Uncharacterized protein YtfM precursor compare
PfGW456L13_3224 -1.1 -2.9 Paraquat-inducible protein A compare
PfGW456L13_1553 -1.1 -5.5 Carbonic anhydrase (EC 4.2.1.1) compare
PfGW456L13_1192 -1.1 -2.4 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) compare
PfGW456L13_4506 -1.1 -3.9 Outer membrane protein NlpB, lipoprotein component of the protein assembly complex (forms a complex with YaeT, YfiO, and YfgL); Lipoprotein-34 precursor compare
PfGW456L13_3393 -1.1 -2.3 FIG00481831: hypothetical protein compare
PfGW456L13_4424 -1.1 -3.6 FIG00953416: hypothetical protein compare
PfGW456L13_3810 -1.1 -1.8 hypothetical protein compare
PfGW456L13_728 -1.1 -6.5 Pyruvate carboxyl transferase subunit A (EC 6.4.1.1) compare
PfGW456L13_213 -1.1 -7.6 Glutamate-ammonia-ligase adenylyltransferase (EC 2.7.7.42) compare
PfGW456L13_2150 -1.1 -1.7 Carbon storage regulator compare
PfGW456L13_815 -1.1 -6.9 Putrescine utilization regulator compare
PfGW456L13_1528 -1.1 -1.2 C4-type zinc finger protein, DksA/TraR family compare
PfGW456L13_5112 -1.1 -1.1 tmRNA-binding protein SmpB compare
PfGW456L13_1453 -1.1 -6.8 Glutathione-regulated potassium-efflux system ATP-binding protein compare
PfGW456L13_674 -1.1 -3.5 Chromosome (plasmid) partitioning protein ParB compare
PfGW456L13_3941 -1.1 -6.3 tRNA pseudouridine synthase A (EC 4.2.1.70) compare
PfGW456L13_325 -1.1 -4.4 Purine-cytosine permease conserved
PfGW456L13_1838 -1.1 -4.2 Sensory box histidine kinase compare
PfGW456L13_3520 -1.1 -2.1 FIG00956261: hypothetical protein compare
PfGW456L13_1021 -1.0 -2.8 Glutathione synthetase (EC 6.3.2.3) compare
PfGW456L13_1011 -1.0 -1.7 Hypothetical protein YggS, proline synthase co-transcribed bacterial homolog PROSC compare
PfGW456L13_930 -1.0 -6.0 Putrescine transport ATP-binding protein PotG (TC 3.A.1.11.2) compare
PfGW456L13_3000 -1.0 -1.3 FIG00961385: hypothetical protein compare
PfGW456L13_4944 -1.0 -0.9 FIG00963370: hypothetical protein compare
PfGW456L13_2553 -1.0 -4.6 ATP-dependent Clp protease ATP-binding subunit ClpX compare
PfGW456L13_705 -1.0 -0.9 FIG00953800: hypothetical protein compare
PfGW456L13_482 -1.0 -2.6 FIG028593: membrane protein compare
PfGW456L13_4955 -1.0 -1.3 FIG00954638: hypothetical protein compare
PfGW456L13_3445 -1.0 -1.2 hypothetical protein compare
PfGW456L13_1824 -1.0 -1.0 transcriptional regulator MvaT, P16 subunit compare


Specific Phenotypes

For 8 genes in this experiment

For carbon source L-Histidine in Pseudomonas fluorescens GW456-L13

For carbon source L-Histidine across organisms