Experiment set17IT049 for Escherichia coli BW25113

Compare to:

LB with 1-Pentanol 0.5 vol%

200 most detrimental genes:

  gene name fitness t score description  
b4313 fimE +2.8 18.8 tyrosine recombinase/inversion of on/off regulator of fimA (NCBI) compare
b0462 acrB +1.8 16.1 multidrug efflux system protein (NCBI) compare
b0463 acrA +1.8 13.2 multidrug efflux system (NCBI) compare
b3163 nlpI +1.5 7.1 hypothetical protein (NCBI) compare
b2531 iscR +1.5 1.7 DNA-binding transcriptional repressor (NCBI) compare
b4552 yrhC +1.4 1.9 no description compare
b4396 rob +1.3 9.5 DNA-binding transcriptional activator (NCBI) compare
b1830 prc +1.3 6.7 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b1279 yciS +1.2 1.8 conserved inner membrane protein (NCBI) compare
b1824 yobF +1.1 4.4 hypothetical protein (NCBI) compare
b4655 ythA +1.1 2.4 expressed protein (RefSeq) compare
b1129 phoQ +1.1 2.7 sensory histidine kinase in two-compoent regulatory system with PhoP (NCBI) compare
b0018 mokC +1.1 2.4 regulatory protein for HokC, overlaps CDS of hokC (NCBI) compare
b1563 relE +1.1 3.4 Qin prophage; toxin of the RelE-RelB toxin-antitoxin system (NCBI) compare
b2625 yfjI +1.0 2.3 CP4-57 prophage; predicted protein (NCBI) compare
b1823 cspC +1.0 2.1 stress protein, member of the CspA-family (NCBI) compare
b1332 ynaJ +0.9 0.9 predicted inner membrane protein (NCBI) compare
b1151 ymfO +0.9 3.6 e14 prophage; conserved protein (RefSeq) compare
b4480 hdfR +0.9 5.5 transcriptional regulator HdfR (NCBI) compare
b2017 yefM +0.9 2.5 orf, hypothetical protein (VIMSS) compare
b1831 proQ +0.8 3.0 putative solute/DNA competence effector (NCBI) compare
b3035 tolC +0.8 5.0 outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) compare
b0303 ykgI +0.7 0.7 orf, hypothetical protein (VIMSS) compare
b1727 yniC +0.7 2.2 predicted hydrolase (NCBI) compare
b3147 yraM +0.7 5.8 hypothetical protein (NCBI) compare
b4163 glyV +0.7 1.3 tRNA-Gly (NCBI) compare
b3396 mrcA +0.7 6.3 peptidoglycan synthetase; penicillin-binding protein 1A (VIMSS) compare
b2804 fucU +0.7 2.9 L-fucose mutarotase (NCBI) compare
b1954 dsrA +0.7 2.2 regulatory antisense RNA (NCBI) compare
b3706 trmE +0.6 3.0 tRNA modification GTPase (NCBI) compare
b1754 b1754 +0.6 2.2 orf, hypothetical protein (VIMSS) compare
b3206 npr +0.6 2.8 phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) (NCBI) compare
b3644 yicC +0.6 4.3 hypothetical protein (NCBI) compare
b1643 ydhI +0.6 2.9 predicted inner membrane protein (NCBI) compare
b1959 yedA +0.6 3.3 predicted inner membrane protein (NCBI) compare
b0990 cspG +0.6 0.6 DNA-binding transcriptional regulator (NCBI) compare
b2894 xerD +0.6 0.5 site-specific tyrosine recombinase XerD (NCBI) compare
b4406 yaeP +0.6 2.0 hypothetical protein (NCBI) compare
b0377 sbmA +0.6 5.0 predicted transporter (NCBI) compare
b0249 ykfF +0.6 2.0 CP4-6 prophage; predicted protein (NCBI) compare
b1348 lar +0.6 1.2 Rac prophage; restriction alleviation protein (NCBI) compare
b4675 yoaJ +0.6 2.6 expressed protein (RefSeq) compare
b3761 trpT +0.6 1.3 tRNA-Trp (NCBI) compare
b2741 rpoS +0.6 2.6 RNA polymerase sigma factor (NCBI) compare
b2579 yfiD +0.6 1.5 pyruvate formate lyase subunit (NCBI) compare
b1708 nlpC +0.6 3.2 predicted lipoprotein (NCBI) compare
b1572 ydfB +0.5 1.1 orf, hypothetical protein (VIMSS) compare
b3026 qseC +0.5 2.8 sensory histidine kinase in two-component regulatory system with QseB (NCBI) compare
b4151 frdD +0.5 2.0 fumarate reductase subunit D (NCBI) compare
b4535 yniD +0.5 1.0 predicted protein (RefSeq) compare
b4246 pyrL +0.5 2.0 pyrBI operon leader peptide (NCBI) compare
b3623 rfaK +0.5 1.4 lipopolysaccharide core biosynthesis (NCBI) compare
b1689 b1689 +0.5 1.9 orf, hypothetical protein (VIMSS) compare
b3764 yifE +0.5 2.0 hypothetical protein (NCBI) compare
b1088 yceD +0.5 2.2 hypothetical protein (NCBI) compare
b1307 pspD +0.5 1.3 peripheral inner membrane phage-shock protein (NCBI) compare
b1074 flgC +0.5 1.5 flagellar basal-body rod protein C (NCBI) compare
b1946 fliN +0.5 1.3 flagellar motor switch protein (NCBI) compare
b1814 sdaA +0.5 1.3 L-serine deaminase I (NCBI) compare
b1434 ydcN +0.5 0.9 predicted DNA-binding transcriptional regulator (NCBI) compare
b0580 ybdJ +0.5 0.9 predicted inner membrane protein (NCBI) compare
b4585 sroB +0.5 1.0 Novel sRNA, function unknown (RefSeq) compare
b3027 ygiZ +0.5 0.3 conserved inner membrane protein (NCBI) compare
b1366 ydaY +0.5 2.4 Rac prophage; predicted protein (RefSeq) compare
b4701 sokX +0.5 0.6 sok-related sRNA, function unknown (RefSeq) compare
b0504 ybbS +0.5 2.2 DNA-binding transcriptional activator of the allD operon (NCBI) compare
b1685 ydiH +0.5 1.0 predicted protein (RefSeq) compare
b1804 rnd +0.5 2.3 ribonuclease D (NCBI) compare
b2066 udk +0.5 2.4 uridine/cytidine kinase (VIMSS) compare
b1233 ychJ +0.5 2.3 hypothetical protein (NCBI) compare
b0127 yadG +0.5 2.6 predicted transporter subunit: ATP-binding component of ABC superfamily (NCBI) compare
b4458 oxyS +0.5 0.9 global regulatory RNA (NCBI) compare
b1282 yciH +0.5 1.8 orf, hypothetical protein (VIMSS) compare
b0379 yaiY +0.5 2.8 predicted inner membrane protein (NCBI) compare
b1429 tehA +0.5 0.6 potassium-tellurite ethidium and proflavin transporter (NCBI) compare
b4520 ymgF +0.5 0.9 hypothetical protein (NCBI) compare
b4157 yjeN +0.5 2.5 hypothetical protein (NCBI) compare
b2200 ccmB +0.5 2.5 heme exporter subunit (NCBI) compare
b1618 uidR +0.5 1.5 DNA-binding transcriptional repressor (NCBI) compare
b3120 yhaB +0.4 0.9 orf, hypothetical protein (VIMSS) compare
b4217 ytfK +0.4 2.1 orf, hypothetical protein (VIMSS) compare
b2236 yfaE +0.4 1.7 predicted 2Fe-2S cluster-containing protein (NCBI) compare
b3236 mdh +0.4 2.8 malate dehydrogenase (NCBI) compare
b2742 nlpD +0.4 3.0 predicted outer membrane lipoprotein (NCBI) compare
b1161 ycgX +0.4 0.5 hypothetical protein (NCBI) compare
b4698 mgrR +0.4 1.9 sRNA antisense regulator down regulates YgdQ and EptB, PhoPQ-regulated, Hfq-dependent; affects sensitivity to antimicrobial peptides (RefSeq) compare
b1251 yciI +0.4 1.4 orf, hypothetical protein (VIMSS) compare
b2620 smpB +0.4 0.7 SsrA-binding protein (NCBI) compare
b0972 hyaA +0.4 2.6 hydrogenase 1, small subunit (NCBI) compare
b0564 appY +0.4 0.7 DLP12 prophage; DNA-binding transcriptional activator (NCBI) compare
b1278 pgpB +0.4 1.1 phosphatidylglycerophosphatase B (NCBI) compare
b1862 yebB +0.4 1.6 orf, hypothetical protein (VIMSS) compare
b1953 b1953 +0.4 2.0 orf, hypothetical protein (VIMSS) compare
b2539 hcaF +0.4 1.7 3-phenylpropionate dioxygenase, small (beta) subunit (NCBI) compare
b1553 ydfP +0.4 1.6 Qin prophage; conserved protein (NCBI) compare
b4451 ryhB +0.4 0.8 Regulatory sRNA mediating positive Fur regulon response; requires Hfq for function; global iron regulator; degraded by RNase E when bound to target (RefSeq) compare
b4369 leuP +0.4 1.1 tRNA-Leu (NCBI) compare
b2156 lysP +0.4 2.8 lysine transporter (NCBI) compare
b4294 insA-7 +0.4 1.4 KpLE2 phage-like element; IS1 repressor protein InsA (NCBI) compare
b3032 cpdA +0.4 3.1 cyclic 3',5'-adenosine monophosphate phosphodiesterase (NCBI) compare
b1920 fliY +0.4 1.0 cystine transporter subunit (NCBI) compare
b1382 ynbE +0.4 0.7 predicted lipoprotein (NCBI) compare
b1446 ydcY +0.4 1.1 hypothetical protein (NCBI) compare
b1261 trpB +0.4 1.4 tryptophan synthase subunit beta (NCBI) compare
b1590 ynfH +0.4 1.5 oxidoreductase, membrane subunit (NCBI) compare
b1594 dgsA +0.4 1.7 DNA-binding transcriptional repressor (NCBI) compare
b4454 rdlD +0.4 2.3 sRNA antisense regulator affects LdrD translation; proposed addiction module in LDR-D repeat, with toxic peptide LdrD (RefSeq) compare
b1891 flhC +0.4 2.0 DNA-binding transcriptional dual regulator with FlhD (NCBI) compare
b1904 yecR +0.4 1.2 hypothetical protein (NCBI) compare
b1190 dadX +0.4 1.9 alanine racemase (NCBI) compare
b2258 b2258 +0.4 0.7 putative transport/receptor protein (VIMSS) compare
b1940 fliH +0.4 2.3 flagellar biosynthesis; export of flagellar proteins? (VIMSS) compare
b0685 ybfE +0.4 1.1 orf, hypothetical protein (VIMSS) compare
b1171 b1171 +0.4 1.0 orf, hypothetical protein (VIMSS) compare
b0753 ybgS +0.4 1.5 hypothetical protein (NCBI) compare
b3101 yqjF +0.4 1.4 orf, hypothetical protein (VIMSS) compare
b1635 gst +0.4 2.0 glutathionine S-transferase (NCBI) compare
b3228 sspB +0.4 1.6 ClpXP protease specificity-enhancing factor (NCBI) compare
b4546 ypeB +0.4 0.7 hypothetical protein (NCBI) compare
b3292 zntR +0.4 1.2 zinc-responsive transcriptional regulator (NCBI) compare
b4329 yjiG +0.4 1.7 conserved inner membrane protein (NCBI) compare
b3625 rfaY +0.4 1.8 lipopolysaccharide core biosynthesis protein (NCBI) compare
b4279 yjhB +0.4 0.2 putative transport protein (VIMSS) compare
b2676 nrdF +0.4 2.1 ribonucleotide-diphosphate reductase beta subunit (NCBI) compare
b0825 mipB +0.4 1.6 putative transaldolase (VIMSS) compare
b4085 alsE +0.4 1.7 allulose-6-phosphate 3-epimerase (NCBI) compare
b1949 fliQ +0.4 0.8 flagellar biosynthesis protein Q (NCBI) compare
b3029 ygiN +0.4 1.0 quinol monooxygenase (NCBI) compare
b3150 yraP +0.4 2.3 hypothetical protein (NCBI) compare
b1063 yceB +0.4 1.3 predicted lipoprotein (NCBI) compare
b2814 metZ +0.4 0.7 tRNA-Met (NCBI) compare
b1835 yebU +0.4 2.1 putative nucleolar proteins (VIMSS) compare
b1433 b1433 +0.4 1.6 putative membrane transport protein (VIMSS) compare
b1287 yciW +0.4 2.1 putative oxidoreductase (VIMSS) compare
b4327 yjiE +0.4 2.2 predicted DNA-binding transcriptional regulator (NCBI) compare
b1441 ydcT +0.4 1.6 predicted spermidine/putrescine transporter subunit (NCBI) compare
b1963 b1963 +0.4 1.4 orf, hypothetical protein (VIMSS) compare
b3858 yihD +0.4 0.8 hypothetical protein (NCBI) compare
b1213 ychQ +0.4 1.4 predicted transcriptional regulator (NCBI) compare
b4438 cyaR +0.4 1.5 sRNA effector of ompX mRNA instability, cAMP-induced; hfq-dependent (RefSeq) compare
b0340 cynS +0.4 0.8 cyanate hydratase (NCBI) compare
b0798 ybiA +0.4 1.4 hypothetical protein (NCBI) compare
b2187 yejL +0.4 1.5 hypothetical protein (NCBI) compare
b2356 yfdM +0.4 1.0 orf, hypothetical protein (VIMSS) compare
b3753 rbsR +0.3 2.6 DNA-binding transcriptional repressor of ribose metabolism (NCBI) compare
b1134 ymfB +0.3 1.1 bifunctional thiamin pyrimidine pyrophosphate hydrolase/ thiamin pyrophosphate hydrolase (NCBI) compare
b1220 ychO +0.3 1.7 predicted invasin (RefSeq) compare
b2754 ygbF +0.3 1.2 orf, hypothetical protein (VIMSS) compare
b2428 yfeU +0.3 1.9 N-acetylmuramic acid-6-phosphate etherase (NCBI) compare
b0456 ybaA +0.3 1.6 hypothetical protein (NCBI) compare
b1697 ydiQ +0.3 2.2 hypothetical protein (NCBI) compare
b0230 mbhA +0.3 2.2 putative motility protein (VIMSS) compare
b3260 dusB +0.3 1.6 tRNA-dihydrouridine synthase B (NCBI) compare
b1426 ydcH +0.3 0.8 orf, hypothetical protein (VIMSS) compare
b2260 menE +0.3 2.8 O-succinylbenzoic acid--CoA ligase (NCBI) compare
b1189 dadA +0.3 2.3 D-amino acid dehydrogenase (quinone) DadA (EC 1.4.5.1) (from data) compare
b1004 wrbA +0.3 2.1 TrpR binding protein WrbA (NCBI) compare
b3194 yrbE +0.3 2.6 predicted toluene transporter subunit: membrane component of ABC superfamily (NCBI) compare
b1698 ydiR +0.3 1.4 predicted electron transfer flavoprotein, FAD-binding (NCBI) compare
b1108 ycfP +0.3 1.1 orf, hypothetical protein (VIMSS) compare
b4411 ecnB +0.3 1.5 entericidin B membrane lipoprotein (NCBI) compare
b4378 yjjV +0.3 1.5 predicted DNase (NCBI) compare
b2324 b2324 +0.3 1.9 putative peptidase (VIMSS) compare
b2899 yqfA +0.3 1.7 predicted oxidoreductase, inner membrane subunit (NCBI) compare
b2953 yggU +0.3 0.7 orf, hypothetical protein (VIMSS) compare
b4215 ytfI +0.3 0.7 hypothetical protein (NCBI) compare
b1763 topB +0.3 1.1 DNA topoisomerase III (NCBI) compare
b4376 osmY +0.3 1.7 periplasmic protein (NCBI) compare
b3361 fic +0.3 1.8 stationary-phase protein, cell division (NCBI) compare
b4651 yibW +0.3 0.2 no description compare
b1919 yedO +0.3 0.8 putative 1-aminocyclopropane-1-carboxylate deaminase (VIMSS) compare
b1248 b1248 +0.3 1.0 orf, hypothetical protein (VIMSS) compare
b4172 hfq +0.3 0.3 RNA-binding protein Hfq (NCBI) compare
b2477 nlpB +0.3 1.4 lipoprotein-34 (VIMSS) compare
b1818 manY +0.3 0.7 mannose-specific enzyme IIC component of PTS (NCBI) compare
b3641 ttk +0.3 2.5 putative transcriptional regulator (VIMSS) compare
b0767 ybhE +0.3 0.9 6-phosphogluconolactonase (NCBI) compare
b3229 sspA +0.3 1.0 stringent starvation protein A (NCBI) compare
b4532 yncN +0.3 1.3 orf, hypothetical protein (VIMSS) compare
b2567 rnc +0.3 0.4 ribonuclease III (NCBI) compare
b4692 oweE +0.3 1.2 no description compare
b1836 yebV +0.3 1.4 orf, hypothetical protein (VIMSS) compare
b1424 mdoD +0.3 1.4 glucan biosynthesis protein, periplasmic (RefSeq) compare
b1143 ymfI +0.3 0.9 orf, hypothetical protein (VIMSS) compare
b1725 yniA +0.3 2.0 predicted phosphotransferase/kinase (NCBI) compare
b0388 aroL +0.3 1.2 shikimate kinase II (NCBI) compare
b1141 ymfG +0.3 1.2 e14 prophage; predicted excisionase (NCBI) compare
b0895 dmsB +0.3 1.6 dimethyl sulfoxide reductase, anaerobic, subunit B (NCBI) compare
b2792 yqcC +0.3 1.3 hypothetical protein (NCBI) compare
b1006 ycdG +0.3 1.5 putative transport protein (VIMSS) compare
b3102 yqjG +0.3 1.8 predicted S-transferase (NCBI) compare
b2945 endA +0.3 1.4 DNA-specific endonuclease I (NCBI) compare
b4345 mcrC +0.3 0.3 5-methylcytosine-specific restriction enzyme McrBC, subunit McrC (NCBI) compare
b1566 flxA +0.3 1.5 Qin prophage; predicted protein (NCBI) compare
b2868 xdhC +0.3 1.5 xanthine dehydrogenase, Fe-S binding subunit (NCBI) compare
b2485 hyfE +0.3 1.4 hydrogenase 4, membrane subunit (NCBI) compare
b1595 ynfL +0.3 0.7 predicted DNA-binding transcriptional regulator (NCBI) compare
b2940 yqgC +0.3 1.1 hypothetical protein (NCBI) compare
b1488 ddpX +0.3 1.2 D-ala-D-ala dipeptidase, Zn-dependent (NCBI) compare
b2646 ypjF +0.3 1.2 CP4-57 prophage; toxin of the YpjF-YfjZ toxin-antitoxin system (NCBI) compare


Specific Phenotypes

For 1 genes in this experiment

For stress 1-Pentanol in Escherichia coli BW25113

For stress 1-Pentanol across organisms