Experiment set17IT048 for Escherichia coli BW25113

Compare to:

LB with Caprolactam 7 vol%

200 most detrimental genes:

  gene name fitness t score description  
b0683 fur +1.5 1.9 ferric uptake regulator (NCBI) compare
b4529 ydbJ +1.0 1.7 hypothetical protein (NCBI) compare
b4655 ythA +1.0 2.3 expressed protein (RefSeq) compare
b1279 yciS +0.8 1.4 conserved inner membrane protein (NCBI) compare
b1563 relE +0.8 2.3 Qin prophage; toxin of the RelE-RelB toxin-antitoxin system (NCBI) compare
b1429 tehA +0.8 1.3 potassium-tellurite ethidium and proflavin transporter (NCBI) compare
b1171 b1171 +0.8 2.4 orf, hypothetical protein (VIMSS) compare
b4520 ymgF +0.7 1.5 hypothetical protein (NCBI) compare
b1514 lsrC +0.7 1.8 AI2 transporter (NCBI) compare
b4515 ybgT +0.7 2.1 hypothetical protein (NCBI) compare
b1778 yeaA +0.7 2.3 methionine sulfoxide reductase B (NCBI) compare
b1348 lar +0.7 1.5 Rac prophage; restriction alleviation protein (NCBI) compare
b2576 srmB +0.7 2.5 ATP-dependent RNA helicase (NCBI) compare
b1731 cedA +0.6 2.6 cell division modulator (RefSeq) compare
b1760 ynjH +0.6 2.4 hypothetical protein (NCBI) compare
b4406 yaeP +0.6 2.2 hypothetical protein (NCBI) compare
b4552 yrhC +0.6 0.7 no description compare
b1357 ydaS +0.6 2.1 Rac prophage; predicted DNA-binding transcriptional regulator (NCBI) compare
b1433 b1433 +0.6 2.4 putative membrane transport protein (VIMSS) compare
b4594 ymgJ +0.6 1.6 hypothetical protein (RefSeq) compare
b4215 ytfI +0.6 1.2 hypothetical protein (NCBI) compare
b1823 cspC +0.6 1.7 stress protein, member of the CspA-family (NCBI) compare
b0707 ybgA +0.6 2.6 hypothetical protein (NCBI) compare
b4394 yjjX +0.6 2.5 orf, hypothetical protein (VIMSS) compare
b1482 osmC +0.6 1.3 osmotically inducible, stress-inducible membrane protein (NCBI) compare
b1954 dsrA +0.5 1.9 regulatory antisense RNA (NCBI) compare
b2432 yfeY +0.5 1.5 hypothetical protein (NCBI) compare
b4402 yjjY +0.5 0.6 hypothetical protein (NCBI) compare
b1708 nlpC +0.5 2.6 predicted lipoprotein (NCBI) compare
b1818 manY +0.5 1.1 mannose-specific enzyme IIC component of PTS (NCBI) compare
b2444 yffM +0.5 1.4 CPZ-55 prophage; predicted protein (NCBI) compare
b0580 ybdJ +0.5 1.7 predicted inner membrane protein (NCBI) compare
b1233 ychJ +0.5 2.8 hypothetical protein (NCBI) compare
b1088 yceD +0.5 2.5 hypothetical protein (NCBI) compare
b1412 azoR +0.5 1.9 acyl carrier protein phosphodiesterase (NCBI) compare
b4480 hdfR +0.5 3.7 transcriptional regulator HdfR (NCBI) compare
b1942 fliJ +0.5 1.4 flagellar biosynthesis chaperone (NCBI) compare
b4280 yjhC +0.5 3.2 putative dehydrogenase (VIMSS) compare
b0564 appY +0.5 1.0 DLP12 prophage; DNA-binding transcriptional activator (NCBI) compare
b3858 yihD +0.5 2.2 hypothetical protein (NCBI) compare
b1434 ydcN +0.5 1.3 predicted DNA-binding transcriptional regulator (NCBI) compare
b3261 fis +0.5 1.3 DNA-binding protein Fis (NCBI) compare
b0828 iaaA +0.5 1.6 L-asparaginase (NCBI) compare
b4246 pyrL +0.5 1.2 pyrBI operon leader peptide (NCBI) compare
b4369 leuP +0.5 2.1 tRNA-Leu (NCBI) compare
b1931 yedK +0.5 2.2 hypothetical protein (NCBI) compare
b4596 yciZ +0.5 1.4 hypothetical protein (RefSeq) compare
b1111 ycfQ +0.4 2.2 orf, hypothetical protein (VIMSS) compare
b1220 ychO +0.4 2.2 predicted invasin (RefSeq) compare
b4646 yrdE +0.4 1.9 no description compare
b1527 yneK +0.4 1.3 hypothetical protein (NCBI) compare
b1572 ydfB +0.4 1.1 orf, hypothetical protein (VIMSS) compare
b0357 yaiN +0.4 1.5 putative alpha helix chain (VIMSS) compare
b1007 b1007 +0.4 1.2 orf, hypothetical protein (VIMSS) compare
b1164 ycgZ +0.4 0.7 hypothetical protein (NCBI) compare
b0866 ybjQ +0.4 0.9 hypothetical protein (NCBI) compare
b1856 yebA +0.4 2.8 orf, hypothetical protein (VIMSS) compare
b1850 eda +0.4 1.2 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) compare
b2579 yfiD +0.4 1.3 pyruvate formate lyase subunit (NCBI) compare
b0895 dmsB +0.4 2.8 dimethyl sulfoxide reductase, anaerobic, subunit B (NCBI) compare
b1446 ydcY +0.4 1.2 hypothetical protein (NCBI) compare
b2258 b2258 +0.4 0.8 putative transport/receptor protein (VIMSS) compare
b3029 ygiN +0.4 1.5 quinol monooxygenase (NCBI) compare
b2066 udk +0.4 2.1 uridine/cytidine kinase (VIMSS) compare
b1085 b1085 +0.4 1.2 orf, hypothetical protein (VIMSS) compare
b4163 glyV +0.4 1.1 tRNA-Gly (NCBI) compare
b4012 yjaB +0.4 2.0 predicted acetyltransferase (NCBI) compare
b1814 sdaA +0.4 1.5 L-serine deaminase I (NCBI) compare
b0556 rzpD +0.4 1.5 DLP12 prophage; predicted murein endopeptidase (NCBI) compare
b0753 ybgS +0.4 2.1 hypothetical protein (NCBI) compare
b1478 adhP +0.4 1.3 alcohol dehydrogenase (VIMSS) compare
b4533 ynfO +0.4 1.3 Qin prophage; predicted protein (NCBI) compare
b2894 xerD +0.4 0.3 site-specific tyrosine recombinase XerD (NCBI) compare
b1151 ymfO +0.4 1.8 e14 prophage; conserved protein (RefSeq) compare
b1513 lsrA +0.4 1.9 fused AI2 transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b1841 yobA +0.4 1.2 hypothetical protein (NCBI) compare
b3500 gor +0.4 0.8 glutathione reductase (NCBI) compare
b1431 ydcL +0.4 2.0 predicted lipoprotein (NCBI) compare
b4017 arpA +0.4 1.6 regulator of acetyl CoA synthetase (NCBI) compare
b0393 rdgC +0.4 3.0 recombination associated protein (NCBI) compare
b1679 sufE +0.4 1.5 cysteine desufuration protein SufE (NCBI) compare
b3163 nlpI +0.4 1.6 hypothetical protein (NCBI) compare
b2343 b2343 +0.4 1.1 orf, hypothetical protein (VIMSS) compare
b3950 frwB +0.4 1.7 predicted enzyme IIB component of PTS (NCBI) compare
b0125 hpt +0.4 2.2 hypoxanthine phosphoribosyltransferase (VIMSS) compare
b0817 mntR +0.4 1.5 DNA-binding transcriptional regulator of mntH (NCBI) compare
b2248 yfaX +0.4 0.8 predicted DNA-binding transcriptional regulator (NCBI) compare
b1726 yniB +0.4 1.0 predicted inner membrane protein (NCBI) compare
b0803 ybiI +0.4 1.5 hypothetical protein (NCBI) compare
b2741 rpoS +0.4 2.5 RNA polymerase sigma factor (NCBI) compare
b3260 dusB +0.4 1.5 tRNA-dihydrouridine synthase B (NCBI) compare
b0248 yafX +0.4 1.8 CP4-6 prophage; predicted protein (NCBI) compare
b4438 cyaR +0.4 1.2 sRNA effector of ompX mRNA instability, cAMP-induced; hfq-dependent (RefSeq) compare
b0682 ybfN +0.4 2.2 predicted lipoprotein (NCBI) compare
b3206 npr +0.4 1.4 phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) (NCBI) compare
b0462 acrB +0.4 3.4 multidrug efflux system protein (NCBI) compare
b1443 ydcV +0.4 1.4 predicted spermidine/putrescine transporter subunit (NCBI) compare
b1656 sodB +0.4 1.1 superoxide dismutase, Fe (NCBI) compare
b4653 yicT +0.4 1.1 no description compare
b1021 ycdP +0.4 2.1 predicted inner membrane protein (NCBI) compare
b0483 ybaQ +0.4 2.1 orf, hypothetical protein (VIMSS) compare
b1944 fliL +0.4 2.0 flagellar basal body-associated protein FliL (NCBI) compare
b2488 hyfH +0.4 2.1 hydrogenase 4, Fe-S subunit (NCBI) compare
b1926 fliT +0.4 1.9 predicted chaperone (NCBI) compare
b1789 yeaL +0.4 1.7 conserved inner membrane protein (NCBI) compare
b3644 yicC +0.4 2.1 hypothetical protein (NCBI) compare
b4598 yncL +0.4 1.2 hypothetical protein (RefSeq) compare
b3916 pfkA +0.3 1.1 6-phosphofructokinase (NCBI) compare
b2200 ccmB +0.3 1.9 heme exporter subunit (NCBI) compare
b4651 yibW +0.3 0.2 no description compare
b0167 glnD +0.3 1.6 PII uridylyl-transferase (NCBI) compare
b3028 mdaB +0.3 2.1 NADPH quinone reductase (NCBI) compare
b2399 yfeD +0.3 1.9 predicted DNA-binding transcriptional regulator (RefSeq) compare
b2250 b2250 +0.3 1.6 orf, hypothetical protein (VIMSS) compare
b3024 ygiW +0.3 1.4 hypothetical protein (NCBI) compare
b1628 rsxB +0.3 1.5 electron transport complex protein RnfB (NCBI) compare
b1329 b1329 +0.3 2.3 putative transport periplasmic protein (VIMSS) compare
b1802 yeaW +0.3 1.3 predicted 2Fe-2S cluster-containing protein (NCBI) compare
b0632 dacA +0.3 2.4 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5) (NCBI) compare
b0463 acrA +0.3 2.6 multidrug efflux system (NCBI) compare
b1424 mdoD +0.3 1.7 glucan biosynthesis protein, periplasmic (RefSeq) compare
b2136 yohD +0.3 0.6 orf, hypothetical protein (VIMSS) compare
b4104 phnE +0.3 1.6 phosphonate/organophosphate ester transporter subunit (NCBI) compare
b3406 greB +0.3 2.5 transcription elongation factor GreB (NCBI) compare
b3195 yrbF +0.3 2.6 predicted toluene transporter subunit: ATP-binding component of ABC superfamily (NCBI) compare
b2571 rseB +0.3 1.9 periplasmic negative regulator of sigmaE (NCBI) compare
b0226 dinJ +0.3 1.4 predicted antitoxin of YafQ-DinJ toxin-antitoxin system (NCBI) compare
b2092 gatC +0.3 2.2 galactitol-specific enzyme IIC component of PTS (NCBI) compare
b2428 yfeU +0.3 1.7 N-acetylmuramic acid-6-phosphate etherase (NCBI) compare
b1179 ycgL +0.3 1.0 conserved protein (NCBI) compare
b1837 yebW +0.3 1.1 orf, hypothetical protein (VIMSS) compare
b2095 gatZ +0.3 1.9 D-tagatose 1,6-bisphosphate aldolase 2, subunit (NCBI) compare
b2420 yfeS +0.3 1.8 hypothetical protein (NCBI) compare
b2637 yfjT +0.3 1.0 CP4-57 prophage; predicted protein (NCBI) compare
b1647 ydhF +0.3 1.9 predicted oxidoreductase (NCBI) compare
b2377 yfdY +0.3 1.0 predicted inner membrane protein (NCBI) compare
b0946 ycbW +0.3 1.5 orf, hypothetical protein (VIMSS) compare
b3817 yigF +0.3 1.8 conserved inner membrane protein (NCBI) compare
b2457 cchA +0.3 1.6 detox protein (VIMSS) compare
b1798 yeaS +0.3 1.8 neutral amino-acid efflux system (NCBI) compare
b0836 yliH +0.3 1.3 hypothetical protein (NCBI) compare
b4675 yoaJ +0.3 0.9 expressed protein (RefSeq) compare
b3761 trpT +0.3 0.7 tRNA-Trp (NCBI) compare
b2792 yqcC +0.3 1.0 hypothetical protein (NCBI) compare
b4325 yjiC +0.3 1.2 orf, hypothetical protein (VIMSS) compare
b1669 ydhT +0.3 1.3 hypothetical protein (NCBI) compare
b1285 gmr +0.3 1.8 modulator of Rnase II stability (NCBI) compare
b3587 yiaW +0.3 1.8 conserved inner membrane protein (NCBI) compare
b2930 yggF +0.3 1.7 predicted hexoseP phosphatase (NCBI) compare
b1377 ompN +0.3 1.5 outer membrane pore protein N, non-specific (NCBI) compare
b3423 glpR +0.3 2.2 DNA-binding transcriptional repressor (NCBI) compare
b2198 ccmD +0.3 1.3 cytochrome c biogenesis protein (NCBI) compare
b1959 yedA +0.3 1.5 predicted inner membrane protein (NCBI) compare
b1411 ynbD +0.3 1.9 predicted phosphatase, inner membrane protein (NCBI) compare
b1255 yciC +0.3 1.2 hypothetical protein (NCBI) compare
b2644 yfjY +0.3 1.5 CP4-57 prophage; predicted DNA repair protein (NCBI) compare
b1752 ydjZ +0.3 1.6 conserved inner membrane protein (NCBI) compare
b3238 yhcN +0.3 1.0 orf, hypothetical protein (VIMSS) compare
b1221 narL +0.3 1.7 DNA-binding response regulator in two-component regulatory system with NarX (or NarQ) (NCBI) compare
b4504 ykfH +0.3 1.0 hypothetical protein (NCBI) compare
b0825 mipB +0.3 1.4 putative transaldolase (VIMSS) compare
b0711 ybgJ +0.3 1.7 predicted enzyme subunit (NCBI) compare
b3181 greA +0.3 1.4 transcription elongation factor: cleaves 3' nucleotide of paused mRNA (VIMSS) compare
b4380 yjjI +0.3 2.2 hypothetical protein (NCBI) compare
b3153 yhbO +0.3 1.8 orf, hypothetical protein (VIMSS) compare
b1569 dicC +0.3 1.5 Qin prophage; DNA-binding transcriptional regulator for DicB (NCBI) compare
b4314 fimA +0.3 2.0 major type 1 subunit fimbrin (pilin) (NCBI) compare
b4511 ybdZ +0.3 1.1 hypothetical protein (NCBI) compare
b4704 arrS +0.3 0.1 Antisense sRNA ArrS, function unknown (NCBI) compare
b0368 tauD +0.3 1.3 taurine dioxygenase (NCBI) compare
b4702 mgtL +0.3 0.8 regulatory leader peptide for mgtA (NCBI) compare
b1728 ydjM +0.3 1.0 predicted inner membrane protein regulated by LexA (RefSeq) compare
b4152 frdC +0.3 1.1 fumarate reductase subunit C (NCBI) compare
b4212 ytfH +0.3 1.9 orf, hypothetical protein (VIMSS) compare
b3764 yifE +0.3 1.3 hypothetical protein (NCBI) compare
b0858 ybjO +0.3 1.0 predicted inner membrane protein (NCBI) compare
b0821 ybiU +0.3 2.0 hypothetical protein (NCBI) compare
b3643 rph +0.3 2.1 ribonuclease PH (NCBI) compare
b2363 yfdT +0.3 0.7 CPS-53 (KpLE1) prophage; predicted protein (NCBI) compare
b3243 aaeR +0.3 1.6 predicted DNA-binding transcriptional regulator, efflux system (NCBI) compare
b2971 yghG +0.3 2.0 hypothetical protein (NCBI) compare
b3083 ygjN +0.3 2.0 hypothetical protein (NCBI) compare
b1035 ycdY +0.3 1.7 hypothetical protein (NCBI) compare
b2221 atoD +0.3 1.4 acetyl-CoA:acetoacetyl-CoA transferase, alpha subunit (NCBI) compare
b1946 fliN +0.3 1.6 flagellar motor switch protein (NCBI) compare
b2141 yohJ +0.3 1.2 hypothetical protein (NCBI) compare
b1020 phoH +0.3 1.3 conserved protein with nucleoside triphosphate hydrolase domain (NCBI) compare
b2033 wbbJ +0.3 1.9 predicted acyl transferase (NCBI) compare
b2744 surE +0.3 1.8 acid phosphatase (NCBI) compare
b4299 yjhI +0.3 1.6 KpLE2 phage-like element; predicted DNA-binding transcriptional regulator (NCBI) compare
b1441 ydcT +0.3 1.3 predicted spermidine/putrescine transporter subunit (NCBI) compare
b1202 ycgV +0.3 2.2 predicted adhesin (NCBI) compare
b2123 yehR +0.3 1.3 orf, hypothetical protein (VIMSS) compare
b0350 mhpD +0.3 1.8 2-keto-4-pentenoate hydratase (VIMSS) compare
b4566 yjhX +0.3 1.1 hypothetical protein (NCBI) compare
b1486 ddpB +0.3 0.7 D-ala-D-ala transporter subunit (NCBI) compare
b1675 ydhZ +0.3 1.4 hypothetical protein (NCBI) compare
b4157 yjeN +0.3 1.6 hypothetical protein (NCBI) compare
b4363 yjjB +0.3 1.1 conserved inner membrane protein (RefSeq) compare
b0840 deoR +0.3 1.1 DNA-binding transcriptional repressor (NCBI) compare


Specific Phenotypes

None in this experiment

For Escherichia coli BW25113 in stress experiments

For stress Caprolactam across organisms