Experiment set15IT070 for Pseudomonas putida KT2440

Compare to:

4-Methyl-2-oxopentanoic acid carbon source

200 most important genes:

  gene name fitness t score description  
PP_3511 -6.6 -9.0 Branched-chain-amino-acid aminotransferase compare
PP_0293 -6.4 -2.9 Imidazole glycerol phosphate synthase subunit HisF compare
PP_5015 -6.2 -4.2 phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) (from data) compare
PP_4400 -6.0 -6.2 Bkd operon transcriptional regulator compare
PP_0967 -5.8 -10.9 histidinol-phosphate aminotransferase (EC 2.6.1.9) (from data) compare
PP_4066 -5.7 -4.0 methylglutaconyl-CoA hydratase compare
PP_4680 -5.6 -16.0 acetohydroxybutanoate synthase / acetolactate synthase compare
PP_0356 -5.6 -8.5 malate synthase G compare
PP_4116 -5.5 -12.5 isocitrate lyase compare
PP_4402 -5.5 -11.8 branched-chain alpha-keto acid dehydrogenase complex, beta subunit compare
PP_0083 -5.5 -3.8 tryptophan synthase beta chain compare
PP_4067 -5.2 -8.8 methylcrotonyl-CoA carboxylase biotin-containing subunit alpha compare
PP_0082 -5.2 -5.1 tryptophan synthase alpha chain compare
PP_5014 -5.2 -3.6 Phosphoribosyl-AMP cyclohydrolase compare
PP_4700 -5.1 -3.5 pantothenate synthetase compare
PP_4699 -5.1 -3.5 3-methyl-2-oxobutanoate hydroxymethyltransferase compare
PP_4678 -5.1 -13.3 Ketol-acid reductoisomerase compare
PP_1079 -5.1 -5.6 Ornithine carbamoyltransferase compare
PP_4401 -5.0 -8.0 branched-chain alpha-keto acid dehydrogenase complex, alpha subunit compare
PP_4065 -5.0 -8.4 methylcrotonyl-CoA carboxylase biotin-containing subunit beta conserved
PP_0834 -5.0 -2.3 Sec translocation complex subunit YajC compare
PP_4679 -5.0 -7.3 acetohydroxybutanoate synthase / acetolactate synthase compare
PP_5659 -5.0 -4.0 protein of unknown function compare
PP_0048 -4.9 -1.3 conserved protein of unknown function compare
PP_0290 -4.7 -8.0 Imidazole glycerol phosphate synthase subunit HisH compare
PP_4064 -4.6 -10.5 isovaleryl-CoA dehydrogenase conserved
PP_0364 -4.5 -8.2 pimeloyl-[acp] methyl ester esterase compare
PP_4909 -4.5 -8.1 phosphoserine phosphatase compare
PP_2433 -4.5 -3.5 conserved protein of unknown function compare
PP_0422 -4.3 -5.5 Indole-3-glycerol phosphate synthase compare
PP_4799 -4.1 -2.9 putative Muramoyltetrapeptide carboxypeptidase compare
PP_5128 -4.1 -6.3 Dihydroxy-acid dehydratase compare
PP_4403 -4.1 -4.9 Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex compare
PP_0362 -4.0 -10.0 Biotin synthase compare
PP_0966 -4.0 -7.7 Histidinol dehydrogenase compare
PP_0184 -4.0 -8.3 Argininosuccinate lyase compare
PP_1995 -4.0 -8.3 N-(5'-phosphoribosyl)anthranilate isomerase compare
PP_2327 -4.0 -7.0 transcriptional dual regulator / CysB-O-acetyl-L-serine compare
PP_4724 -4.0 -5.5 Carbamoyl-phosphate synthase small chain compare
PP_1664 -3.9 -5.4 phosphoribosylglycinamide formyltransferase 1 compare
PP_5095 -3.9 -2.0 pyrroline-5-carboxylate reductase compare
PP_1088 -3.8 -9.6 Argininosuccinate synthase compare
PP_5098 -3.7 -6.3 methionine biosynthesis protein MetW compare
PP_3121 -3.7 -2.7 transcriptional regulator, LysR family compare
PP_5155 -3.6 -4.3 D-3-phosphoglycerate dehydrogenase / alpha-ketoglutarate reductase compare
PP_0691 -3.6 -2.6 Glutamate 5-kinase compare
PP_4999 -3.6 -2.1 dihydroorotase-like protein compare
PP_4271 -3.6 -0.9 conserved protein of unknown function compare
PP_5185 -3.5 -4.9 acetylglutamate kinase-like protein (regulatory domain)/amino acid N-acetyltransferase compare
PP_4723 -3.4 -9.2 Carbamoyl-phosphate synthase large chain compare
PP_5289 -3.4 -3.3 Acetylglutamate kinase compare
PP_0965 -3.4 -7.4 ATP phosphoribosyltransferase (EC 2.4.2.17) (from data) compare
PP_4922 -3.4 -9.8 Phosphomethylpyrimidine synthase compare
PP_0366 -3.4 -3.9 dethiobiotin synthetase compare
PP_0289 -3.3 -5.7 Imidazoleglycerol-phosphate dehydratase compare
PP_0365 -3.3 -7.6 Malonyl-[acyl-carrier protein] O-methyltransferase compare
PP_0959 -3.3 -2.4 phospholipid ABC transporter compare
PP_1233 -3.2 -3.9 sulfurtransferase compare
PP_4696 -3.2 -2.2 Nitrogen regulation protein NR(I) compare
PP_3999 -3.2 -8.3 Uroporphyrinogen-III C-methyltransferase/Precorrin-2 dehydrogenase/Sirohydrochlorin ferrochelatase compare
PP_1994 -3.2 -2.2 tRNA pseudouridine (38-40)synthase compare
PP_2378 -3.1 -2.1 Fe/S biogenesis protein NfuA compare
PP_4890 -3.1 -4.8 ATP phosphoribosyltransferase regulatory subunit compare
PP_2302 -2.9 -5.1 DNA-binding, ATP-dependent protease compare
PP_2633 -2.9 -1.9 conserved protein of unknown function compare
PP_4482 -2.9 -3.4 Transcriptional regulator, AraC family compare
PP_1186 -2.8 -2.3 two component system DNA-binding transcriptional dual regulator compare
PP_5104 -2.8 -4.0 thiazole synthase compare
PP_0363 -2.8 -7.4 8-amino-7-oxononanoate synthase compare
PP_4129 -2.8 -3.3 NADH:ubiquinone oxidoreductase, membrane subunit L compare
PP_4984 -2.8 -6.2 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase compare
PP_5528 -2.8 -1.7 conserved protein of unknown function compare
PP_2001 -2.8 -6.5 O-succinylhomoserine sulfhydrylase compare
PP_1269 -2.8 -1.6 Universal stress protein family compare
PP_4121 -2.7 -1.9 NADH-quinone oxidoreductase subunit C/D compare
PP_2371 -2.7 -4.2 Sulphite reductase hemoprotein, beta subunit compare
PP_1428 -2.7 -1.7 Sigma factor AlgU negative regulatory protein compare
PP_5097 -2.7 -8.9 homoserine O-acetyltransferase compare
PP_2337 -2.6 -3.1 aconitate isomerase compare
PP_0393 -2.6 -1.8 putative 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase compare
PP_2000 -2.6 -3.0 amidophosphoribosyl transferase compare
PP_4364 -2.6 -2.9 putative Anti-sigma F factor antagonist compare
PP_0421 -2.6 -5.3 Anthranilate phosphoribosyltransferase compare
PP_3649 -2.5 -3.1 Transcriptional regulator, GntR family compare
PP_0063 -2.5 -1.7 putative Lipid A biosynthesis lauroyl acyltransferase compare
PP_4782 -2.4 -2.7 Phosphomethylpyrimidine kinase compare
PP_1632 -2.3 -2.4 conserved protein of unknown function compare
PP_0846 -2.3 -1.3 DnaK-like molecular chaperone specific for IscU compare
PP_2402 -2.3 -1.7 putative Sensor histidine kinase compare
PP_0232 -2.3 -1.0 ATP-binding taurine transporter subunit compare
PP_2087 -2.3 -3.9 CmpX protein compare
PP_4124 -2.2 -1.5 NADH-quinone oxidoreductase subunit G compare
PP_0962 -2.2 -1.7 toluene-tolerance protein compare
PP_0292 -2.1 -2.3 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase (EC 5.3.1.16) (from data) compare
PP_1348 -2.1 -3.8 putative MutT/nudix family protein/thiamine-phosphate pyrophosphorylase compare
PP_5028 -2.1 -3.4 proline iminopeptidase compare
PP_4695 -2.1 -7.5 Sensory box histidine kinase compare
PP_1217 -2.1 -1.4 Holliday junction ATP-dependent DNA helicase RuvB compare
PP_1237 -2.0 -1.2 4-hydroxy-tetrahydrodipicolinate synthase compare
PP_5495 -2.0 -1.7 protein of unknown function compare
PP_4126 -2.0 -1.2 NADH-quinone oxidoreductase subunit I compare
PP_1231 -2.0 -3.6 quinolinate synthase [4Fe-4S] cluster subunit compare
PP_1322 -1.9 -1.9 putative Lipoprotein compare
PP_4058 -1.9 -7.0 1,4-alpha-glucan branching enzyme compare
PP_4094 -1.9 -2.7 conserved protein of unknown function compare
PP_2217 -1.9 -2.3 enoyl-CoA hydratase compare
PP_4693 -1.8 -5.3 RNA polymerase-binding transcription factor DksA compare
PP_0417 -1.8 -8.7 Anthranilate synthase component 1 compare
PP_4045 -1.8 -2.8 conserved protein of unknown function compare
PP_0001 -1.8 -1.2 probable chromosome-partitioning protein compare
PP_4120 -1.8 -3.3 NADH-quinone oxidoreductase subunit B compare
PP_2568 -1.8 -1.1 Ring-cleaving dioxygenase compare
PP_4943 -1.8 -1.8 putative Glycosyl transferase compare
PP_3123 -1.8 -4.4 acetoacetyl CoA-transferase (subunit B) compare
PP_1733 -1.8 -2.3 membrane ATPase of the MinC-MinD-MinE system compare
PP_2142 -1.7 -2.6 Cell division inhibitor SulA compare
PP_0874 -1.7 -2.2 conserved protein of unknown function compare
PP_0246 -1.7 -1.3 two-component system DNA-binding response transcriptional dual regulator compare
PP_5007 -1.7 -1.7 Polyhydroxyalkanoate granule-associated protein GA2 compare
PP_5309 -1.7 -1.2 oxidative and nitrosative stress transcriptional dual regulator compare
PP_5279 -1.7 -3.0 conserved protein of unknown function compare
PP_5274 -1.6 -1.0 conserved protein of unknown function compare
PP_0787 -1.6 -1.8 quinolinate phosphoribosyltransferase (decarboxylating) monomer compare
PP_5085 -1.6 -3.8 malic enzyme B compare
PP_2581 -1.6 -1.2 conserved protein of unknown function compare
PP_3505 -1.6 -1.3 conserved protein of unknown function compare
PP_2499 -1.6 -1.0 conserved protein of unknown function compare
PP_5352 -1.5 -7.0 DNA-dependent ATPase I and helicase II, nucleotide Excision Repair Complex compare
PP_2475 -1.5 -3.3 Transcriptional regulator, TetR family compare
PP_4875 -1.5 -3.2 conserved membrane protein of unknown function compare
PP_0848 -1.5 -1.6 donor of Fe2+ and regulator of cysteine desulfurase activity compare
PP_1020 -1.5 -1.6 putative glucose-6-phosphate 1-epimerase compare
PP_2510 -1.5 -1.5 conserved protein of unknown function compare
PP_0164 -1.5 -4.0 conserved protein of unknown function compare
PP_2540 -1.5 -1.8 Oxidoreductase, short-chain dehydrogenase/reductase family compare
PP_2868 -1.5 -4.5 Transcriptional regulator, Cro/CI family compare
PP_4684 -1.5 -4.4 conserved protein of unknown function with kinase-like domain compare
PP_4213 -1.4 -2.6 putative dipeptidase compare
PP_1022 -1.4 -2.8 glucose 6-phosphate-1-dehydrogenase compare
PP_5453 -1.4 -1.8 conserved protein of unknown function compare
PP_0195 -1.4 -2.0 conserved protein of unknown function compare
PP_4130 -1.4 -2.9 NADH:ubiquinone oxidoreductase, membrane subunit M compare
PP_3806 -1.4 -2.4 Hydrolase, isochorismatase family compare
PP_1112 -1.3 -5.1 conserved membrane protein of unknown function compare
PP_1535 -1.3 -2.6 putative Methyltransferase compare
PP_0122 -1.3 -2.3 conserved exported protein of unknown function compare
PP_2503 -1.3 -3.0 putative 3-oxoacyl-(Acyl-carrier-protein) reductase compare
PP_3122 -1.3 -3.4 acetoacetyl CoA-transferase (subunit A) compare
PP_4836 -1.3 -1.6 conserved exported protein of unknown function compare
PP_0206 -1.3 -1.9 Ferredoxin, 4Fe-4S compare
PP_2999 -1.3 -1.1 Glyoxalase family protein compare
PP_5580 -1.3 -1.6 protein of unknown function compare
PP_0593 -1.3 -0.6 putative ribosome-binding factor compare
PP_5054 -1.3 -1.3 glutaredoxin 3 compare
PP_4122 -1.3 -1.5 proton-pumping NADH:ubiquinone oxidoreductase, respiratory complex I, subunit E compare
PP_4362 -1.3 -2.2 conserved protein of unknown function compare
PP_1139 -1.2 -5.7 branched chain amino acid transporter - permease subunit compare
PP_1829 -1.2 -1.8 Hydrolase, alpha/beta fold family compare
PP_3938 -1.2 -1.4 conserved protein of unknown function compare
PP_1137 -1.2 -3.7 high-affinity branched-chain amino acid transporter, ATP binding compare
PP_1654 -1.2 -2.5 cysteine synthase B compare
PP_2029 -1.2 -1.4 von Willebrand factor type A domain protein compare
PP_0401 -1.2 -1.9 Ribosomal RNA small subunit methyltransferase A compare
PP_2336 -1.2 -2.6 aconitate hydratase 1 compare
PP_3248 -1.2 -1.7 Dyp-type peroxidase family protein compare
PP_3312 -1.2 -1.4 putative Heat shock protein compare
PP_0248 -1.2 -5.2 Probable alpha-L-glutamate ligase compare
PP_4769 -1.2 -2.3 conserved protein of unknown function compare
PP_5381 -1.2 -3.3 hypothetical protein compare
PP_4640 -1.2 -3.9 conserved protein of unknown function compare
PP_1629 -1.2 -3.1 Protein RecA compare
PP_1734 -1.2 -2.4 Probable septum site-determining protein MinC compare
PP_5253 -1.2 -1.6 Arylesterase compare
PP_2416 -1.1 -1.3 putative Iron ABC transporter, ATP-binding protein compare
PP_0781 -1.1 -1.9 conserved protein of unknown function compare
PP_t11 -1.1 -1.8 tRNA-Lys compare
PP_4531 -1.1 -1.8 conserved exported protein of unknown function compare
PP_2655 -1.1 -1.0 conserved protein of unknown function compare
PP_3164 -1.1 -1.7 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase compare
PP_0585 -1.1 -1.4 putative metal-sensitive transcriptional regulator, MerR family compare
PP_0888 -1.1 -1.2 Photosynthetic apparatus regulatory protein RegA compare
PP_2253 -1.1 -1.7 Transcriptional regulator, GntR family compare
PP_5533 -1.1 -0.8 conserved protein of unknown function compare
PP_2345 -1.1 -1.4 conserved exported protein of unknown function compare
PP_1111 -1.1 -3.2 putative Synthetase compare
PP_3102 -1.1 -1.8 conserved protein of unknown function compare
PP_4902 -1.1 -1.6 Oligoribonuclease compare
PP_1833 -1.1 -2.6 conserved protein of unknown function compare
PP_4937 -1.0 -1.7 toluene tolerance protein compare
PP_2878 -1.0 -1.3 conserved protein of unknown function compare
PP_5487 -1.0 -1.7 conserved protein of unknown function compare
PP_2976 -1.0 -1.5 putative transposase compare
PP_4726 -1.0 -1.3 Chaperone protein DnaJ compare
PP_3766 -1.0 -2.5 Lactoylglutathione lyase compare
PP_5346 -1.0 -4.3 pyruvate carboxylase subunit B compare
PP_4874 -1.0 -0.5 50S ribosomal protein L9 compare
PP_5348 -1.0 -4.2 Transcriptional regulator, LysR family compare
PP_4131 -1.0 -2.8 NADH-quinone oxidoreductase subunit N compare
PP_5248 -1.0 -0.9 putative hydrolase compare
PP_0792 -1.0 -3.3 catabolite repressor-activator, DNA-binding transcriptional dual regulator compare


Specific Phenotypes

For 7 genes in this experiment

For carbon source 4-Methyl-2-oxovaleric acid in Pseudomonas putida KT2440

For carbon source 4-Methyl-2-oxovaleric acid across organisms