Experiment set15IT056 for Pseudomonas putida KT2440

Compare to:

4-Methyl-2-oxopentanoic acid carbon source

200 most important genes:

  gene name fitness t score description  
PP_2433 -7.6 -3.8 conserved protein of unknown function compare
PP_0293 -6.6 -3.4 Imidazole glycerol phosphate synthase subunit HisF compare
PP_4066 -5.9 -4.1 methylglutaconyl-CoA hydratase compare
PP_5185 -5.8 -8.9 acetylglutamate kinase-like protein (regulatory domain)/amino acid N-acetyltransferase compare
PP_4116 -5.7 -13.9 isocitrate lyase compare
PP_4678 -5.6 -15.8 Ketol-acid reductoisomerase compare
PP_4067 -5.5 -9.1 methylcrotonyl-CoA carboxylase biotin-containing subunit alpha compare
PP_0966 -5.4 -13.0 Histidinol dehydrogenase compare
PP_4402 -5.4 -14.0 branched-chain alpha-keto acid dehydrogenase complex, beta subunit compare
PP_4700 -5.3 -3.7 pantothenate synthetase compare
PP_4064 -5.3 -14.5 isovaleryl-CoA dehydrogenase conserved
PP_0184 -5.3 -6.3 Argininosuccinate lyase compare
PP_4400 -5.2 -9.1 Bkd operon transcriptional regulator compare
PP_4909 -5.2 -10.1 phosphoserine phosphatase compare
PP_4065 -5.1 -9.3 methylcrotonyl-CoA carboxylase biotin-containing subunit beta conserved
PP_4199 -5.0 -1.5 putative Lipoprotein compare
PP_4724 -5.0 -6.8 Carbamoyl-phosphate synthase small chain compare
PP_4401 -5.0 -10.6 branched-chain alpha-keto acid dehydrogenase complex, alpha subunit compare
PP_1088 -4.9 -14.0 Argininosuccinate synthase compare
PP_5289 -4.8 -6.5 Acetylglutamate kinase compare
PP_0362 -4.8 -10.2 Biotin synthase compare
PP_4403 -4.8 -7.5 Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex compare
PP_5098 -4.8 -8.8 methionine biosynthesis protein MetW compare
PP_0292 -4.8 -4.8 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase (EC 5.3.1.16) (from data) compare
PP_4680 -4.8 -13.5 acetohydroxybutanoate synthase / acetolactate synthase compare
PP_4679 -4.8 -7.3 acetohydroxybutanoate synthase / acetolactate synthase compare
PP_1079 -4.8 -5.6 Ornithine carbamoyltransferase compare
PP_0735 -4.6 -2.0 molybdopterin-synthase adenylyltransferase compare
PP_1233 -4.6 -6.5 sulfurtransferase compare
PP_0083 -4.6 -7.3 tryptophan synthase beta chain compare
PP_0356 -4.5 -8.3 malate synthase G compare
PP_0691 -4.2 -4.3 Glutamate 5-kinase compare
PP_5015 -4.2 -4.7 phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) (from data) compare
PP_0289 -4.2 -7.1 Imidazoleglycerol-phosphate dehydratase compare
PP_0366 -4.1 -5.5 dethiobiotin synthetase compare
PP_0082 -4.1 -7.4 tryptophan synthase alpha chain compare
PP_5095 -4.1 -2.4 pyrroline-5-carboxylate reductase compare
PP_5659 -4.1 -3.4 protein of unknown function compare
PP_5128 -3.9 -6.3 Dihydroxy-acid dehydratase compare
PP_4699 -3.9 -5.3 3-methyl-2-oxobutanoate hydroxymethyltransferase compare
PP_4723 -3.8 -11.4 Carbamoyl-phosphate synthase large chain compare
PP_0965 -3.7 -8.6 ATP phosphoribosyltransferase (EC 2.4.2.17) (from data) compare
PP_4999 -3.7 -2.4 dihydroorotase-like protein compare
PP_4782 -3.6 -3.7 Phosphomethylpyrimidine kinase compare
PP_4799 -3.6 -4.9 putative Muramoyltetrapeptide carboxypeptidase compare
PP_4129 -3.6 -2.4 NADH:ubiquinone oxidoreductase, membrane subunit L compare
PP_5097 -3.4 -10.8 homoserine O-acetyltransferase compare
PP_0967 -3.4 -7.5 histidinol-phosphate aminotransferase (EC 2.6.1.9) (from data) compare
PP_0365 -3.3 -7.1 Malonyl-[acyl-carrier protein] O-methyltransferase compare
PP_0364 -3.3 -6.7 pimeloyl-[acp] methyl ester esterase compare
PP_0290 -3.3 -5.7 Imidazole glycerol phosphate synthase subunit HisH compare
PP_4984 -3.2 -9.2 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase compare
PP_3511 -3.2 -6.0 Branched-chain-amino-acid aminotransferase compare
PP_0422 -3.1 -5.9 Indole-3-glycerol phosphate synthase compare
PP_5104 -3.1 -7.1 thiazole synthase compare
PP_1654 -3.1 -4.7 cysteine synthase B compare
PP_4890 -3.1 -4.4 ATP phosphoribosyltransferase regulatory subunit compare
PP_2720 -3.0 -2.0 conserved protein of unknown function compare
PP_5014 -3.0 -4.1 Phosphoribosyl-AMP cyclohydrolase compare
PP_2000 -3.0 -2.9 amidophosphoribosyl transferase compare
PP_2371 -2.9 -5.6 Sulphite reductase hemoprotein, beta subunit compare
PP_4121 -2.9 -2.0 NADH-quinone oxidoreductase subunit C/D compare
PP_1428 -2.9 -2.0 Sigma factor AlgU negative regulatory protein compare
PP_1994 -2.9 -3.3 tRNA pseudouridine (38-40)synthase compare
PP_1214 -2.9 -2.6 putative transcriptional regulatory protein compare
PP_4696 -2.8 -4.6 Nitrogen regulation protein NR(I) compare
PP_0393 -2.8 -1.9 putative 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase compare
PP_0421 -2.7 -6.5 Anthranilate phosphoribosyltransferase compare
PP_1348 -2.7 -4.0 putative MutT/nudix family protein/thiamine-phosphate pyrophosphorylase compare
PP_0363 -2.6 -9.6 8-amino-7-oxononanoate synthase compare
PP_2378 -2.6 -3.0 Fe/S biogenesis protein NfuA compare
PP_1995 -2.5 -5.5 N-(5'-phosphoribosyl)anthranilate isomerase compare
PP_0417 -2.5 -11.5 Anthranilate synthase component 1 compare
PP_4120 -2.5 -2.9 NADH-quinone oxidoreductase subunit B compare
PP_2001 -2.4 -6.8 O-succinylhomoserine sulfhydrylase compare
PP_2370 -2.4 -2.0 conserved protein of unknown function compare
PP_4098 -2.4 -2.6 UvrABC system protein C compare
PP_1826 -2.3 -3.6 Hydrolase, isochorismatase family compare
PP_5225 -2.3 -1.9 frataxin compare
PP_5155 -2.3 -4.7 D-3-phosphoglycerate dehydrogenase / alpha-ketoglutarate reductase compare
PP_4131 -2.3 -6.4 NADH-quinone oxidoreductase subunit N compare
PP_4124 -2.3 -2.7 NADH-quinone oxidoreductase subunit G compare
PP_3649 -2.2 -4.5 Transcriptional regulator, GntR family compare
PP_2302 -2.2 -4.8 DNA-binding, ATP-dependent protease compare
PP_4922 -2.2 -7.0 Phosphomethylpyrimidine synthase compare
PP_4910 -2.1 -3.7 conserved protein of unknown function compare
PP_1733 -2.1 -2.5 membrane ATPase of the MinC-MinD-MinE system compare
PP_1186 -2.1 -2.3 two component system DNA-binding transcriptional dual regulator compare
PP_4964 -2.1 -3.7 D-erythrose 4-phosphate dehydrogenase compare
PP_0856 -2.1 -1.4 conserved lipoprotein of unknown function compare
PP_2337 -2.1 -2.9 aconitate isomerase compare
PP_1215 -2.1 -1.0 Crossover junction endodeoxyribonuclease RuvC compare
PP_3999 -2.1 -7.1 Uroporphyrinogen-III C-methyltransferase/Precorrin-2 dehydrogenase/Sirohydrochlorin ferrochelatase compare
PP_4482 -2.0 -3.3 Transcriptional regulator, AraC family compare
PP_1664 -2.0 -3.5 phosphoribosylglycinamide formyltransferase 1 compare
PP_2217 -2.0 -4.3 enoyl-CoA hydratase compare
PP_0164 -1.9 -5.4 conserved protein of unknown function compare
PP_3122 -1.9 -5.4 acetoacetyl CoA-transferase (subunit A) compare
PP_4247 -1.9 -2.6 Exonuclease compare
PP_2327 -1.9 -4.5 transcriptional dual regulator / CysB-O-acetyl-L-serine compare
PP_4695 -1.9 -6.2 Sensory box histidine kinase compare
PP_2345 -1.9 -3.5 conserved exported protein of unknown function compare
PP_0003 -1.8 -3.5 16S RNA methyltransferase compare
PP_4130 -1.8 -3.8 NADH:ubiquinone oxidoreductase, membrane subunit M compare
PP_5309 -1.8 -1.3 oxidative and nitrosative stress transcriptional dual regulator compare
PP_2868 -1.8 -5.6 Transcriptional regulator, Cro/CI family compare
PP_3123 -1.8 -7.3 acetoacetyl CoA-transferase (subunit B) compare
PP_1054 -1.8 -1.5 Type II secretion pathway protein XcpZ compare
PP_4902 -1.8 -2.9 Oligoribonuclease compare
PP_4693 -1.7 -4.9 RNA polymerase-binding transcription factor DksA compare
PP_4122 -1.7 -2.1 proton-pumping NADH:ubiquinone oxidoreductase, respiratory complex I, subunit E compare
PP_2499 -1.7 -1.3 conserved protein of unknown function compare
PP_2087 -1.7 -3.1 CmpX protein compare
PP_2031 -1.7 -1.3 conserved protein of unknown function compare
PP_5198 -1.6 -2.0 conserved protein of unknown function compare
PP_2336 -1.5 -2.9 aconitate hydratase 1 compare
PP_4058 -1.5 -6.7 1,4-alpha-glucan branching enzyme compare
PP_1112 -1.5 -6.5 conserved membrane protein of unknown function compare
PP_3248 -1.5 -2.3 Dyp-type peroxidase family protein compare
PP_5274 -1.4 -2.8 conserved protein of unknown function compare
PP_0787 -1.4 -3.2 quinolinate phosphoribosyltransferase (decarboxylating) monomer compare
PP_0852 -1.4 -1.8 Transcriptional regulator, Cro/CI family compare
PP_0022 -1.3 -0.9 hypothetical protein compare
PP_4937 -1.3 -2.6 toluene tolerance protein compare
PP_0065 -1.3 -2.2 NAD-binding component of TrK potassium transporter compare
PP_5227 -1.3 -4.8 diaminopimelate decarboxylase compare
PP_0063 -1.3 -2.7 putative Lipid A biosynthesis lauroyl acyltransferase compare
PP_4532 -1.3 -1.4 ATP-dependent DEAD-box RNA helicase require for 50S ribosomal subunit biogenesis compare
PP_5090 -1.3 -1.7 putative cell division protein compare
PP_1353 -1.3 -2.0 conserved membrane protein of unknown function compare
PP_5045 -1.3 -2.6 tRNA sulfurtransferase compare
PP_4073 -1.3 -2.4 conserved exported protein of unknown function compare
PP_5352 -1.3 -5.9 DNA-dependent ATPase I and helicase II, nucleotide Excision Repair Complex compare
PP_4126 -1.2 -1.2 NADH-quinone oxidoreductase subunit I compare
PP_1774 -1.2 -2.5 conserved exported protein of unknown function compare
PP_1734 -1.2 -2.5 Probable septum site-determining protein MinC compare
PP_1138 -1.2 -2.6 branched chain amino acid transporter - ATP binding subunit compare
PP_1137 -1.2 -4.4 high-affinity branched-chain amino acid transporter, ATP binding compare
PP_1217 -1.2 -2.4 Holliday junction ATP-dependent DNA helicase RuvB compare
PP_3904 -1.2 -2.0 conserved protein of unknown function compare
PP_5350 -1.2 -1.9 Transcriptional regulator, RpiR family compare
PP_1237 -1.2 -1.0 4-hydroxy-tetrahydrodipicolinate synthase compare
PP_0001 -1.2 -1.1 probable chromosome-partitioning protein compare
PP_0319 -1.2 -1.6 conserved protein of unknown function compare
PP_2820 -1.1 -2.9 HTH-type transcriptional regulator nfxB compare
PP_1231 -1.1 -3.2 quinolinate synthase [4Fe-4S] cluster subunit compare
PP_0848 -1.1 -1.7 donor of Fe2+ and regulator of cysteine desulfurase activity compare
PP_3541 -1.1 -2.7 Transporter, MgtC family compare
PP_5028 -1.1 -2.2 proline iminopeptidase compare
PP_4342 -1.1 -1.7 flagellar synthesis regulator, putative ATPase compare
PP_1876 -1.1 -1.7 putative ATP/GTP-binding protein of the AAA+ family compare
PP_1493 -1.1 -3.1 chemotaxis response regulator protein-glutamate methylesterase of group 3 operon compare
PP_2402 -1.1 -1.7 putative Sensor histidine kinase compare
PP_2299 -1.1 -2.3 Trigger factor compare
PP_4419 -1.1 -1.9 transposase compare
PP_5507 -1.1 -2.0 protein of unknown function compare
PP_0248 -1.1 -6.2 Probable alpha-L-glutamate ligase compare
PP_3505 -1.1 -2.0 conserved protein of unknown function compare
PP_5548 -1.1 -1.4 protein of unknown function compare
PP_5230 -1.0 -2.0 Tyrosine recombinase XerC compare
PP_1404 -1.0 -2.1 conserved protein of unknown function compare
PP_3748 -1.0 -1.7 conserved hypothetical protein compare
PP_4179 -1.0 -4.5 Chaperone protein HtpG compare
PP_5453 -1.0 -1.6 conserved protein of unknown function compare
PP_4797 -1.0 -2.2 conserved protein of unknown function compare
PP_5267 -1.0 -2.3 putative cytochrome c5 compare
PP_0855 -1.0 -1.3 conserved protein of unknown function compare
PP_4320 -1.0 -5.4 cytochrome c-type biogenesis protein compare
PP_2857 -1.0 -1.5 conserved exported protein of unknown function compare
PP_5310 -1.0 -3.4 junction-specific ATP-dependent DNA helicase compare
PP_4213 -1.0 -1.7 putative dipeptidase compare
PP_0846 -1.0 -1.3 DnaK-like molecular chaperone specific for IscU compare
PP_1139 -1.0 -5.5 branched chain amino acid transporter - permease subunit compare
PP_2999 -1.0 -1.1 Glyoxalase family protein compare
PP_1328 -1.0 -0.7 Protein MraZ compare
PP_4254 -1.0 -1.1 conserved protein of unknown function compare
PP_5191 -1.0 -2.0 conserved exported protein of unknown function compare
PP_1959 -1.0 -4.0 conserved protein of unknown function compare
PP_5085 -1.0 -3.6 malic enzyme B compare
PP_0949 -0.9 -3.1 putative ATP-binding protein UPF0042 compare
PP_5571 -0.9 -1.1 conserved protein of unknown function compare
PP_4988 -0.9 -3.9 signal transduction histidine kinase CheA/CheY-like receiver compare
PP_2328 -0.9 -3.3 Phosphoadenosine phosphosulfate reductase compare
PP_1111 -0.9 -3.7 putative Synthetase compare
PP_0002 -0.9 -3.3 probable chromosome partition protein compare
PP_4214 -0.9 -2.6 pyoverdine biosynthesis related protein compare
PP_1140 -0.9 -5.8 branched chain amino acid transporter - permease subunit compare
PP_0420 -0.9 -3.3 aminodeoxychorismate synthase / para-aminobenzoate synthase multi-enzyme complex compare
PP_1387 -0.9 -3.1 Probable HTH-type transcriptional regulator TtgR compare
PP_1141 -0.9 -3.7 branched-chain amino acids ABC transporter - periplasmic leucine binding subunit compare
PP_1759 -0.9 -2.5 conserved exported protein of unknown function compare
PP_2013 -0.9 -3.3 conserved protein of unknown function compare
PP_4471 -0.9 -2.3 Magnesium transporter compare
PP_1185 -0.9 -2.3 Outer membrane protein H1 compare
PP_3903 -0.9 -1.3 conserved protein of unknown function compare
PP_3924 -0.9 -1.6 conserved protein of unknown function compare
PP_4340 -0.8 -2.8 response regulator for chemotactic signal transduction compare
PP_4787 -0.8 -1.5 putative protein with nucleoside triphosphate hydrolase domain compare
PP_1268 -0.8 -2.4 putative HtrA suppressor protein sohA compare
PP_5347 -0.8 -4.4 pyruvate carboxylase subunit A compare


Specific Phenotypes

For 9 genes in this experiment

For carbon source 4-Methyl-2-oxovaleric acid in Pseudomonas putida KT2440

For carbon source 4-Methyl-2-oxovaleric acid across organisms