Experiment set13IT033 for Escherichia coli BW25113

Compare to:

LB with copper (II) chloride dihydrate 2 mM

200 most important genes:

  gene name fitness t score description  
b2215 ompC -2.9 -12.6 outer membrane porin protein C (NCBI) compare
b0740 tolB -2.7 -5.1 translocation protein TolB precursor (NCBI) compare
b0049 apaH -2.7 -3.9 diadenosinetetraphosphatase (NCBI) compare
b0149 mrcB -2.5 -15.3 penicillin-binding protein 1b (NCBI) compare
b0484 copA -2.4 -14.3 copper transporter (NCBI) conserved
b3404 envZ -2.4 -11.5 osmolarity sensor protein (NCBI) compare
b0688 pgm -2.3 -3.4 phosphoglucomutase (NCBI) compare
b3405 ompR -2.3 -7.3 osmolarity response regulator (NCBI) compare
b3472 b3472 -2.3 -11.0 orf, hypothetical protein (VIMSS) compare
b3792 wzxE -2.3 -8.4 O-antigen translocase (NCBI) compare
b0741 pal -2.1 -4.8 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b1111 ycfQ -2.0 -5.6 orf, hypothetical protein (VIMSS) compare
b0739 tolA -1.9 -2.8 cell envelope integrity inner membrane protein TolA (NCBI) compare
b1236 galU -1.9 -4.4 glucose-1-phosphate uridylyltransferase (NCBI) compare
b1332 ynaJ -1.9 -1.6 predicted inner membrane protein (NCBI) compare
b1860 ruvB -1.9 -1.2 Holliday junction DNA helicase B (NCBI) compare
b1192 ldcA -1.8 -6.5 L,D-carboxypeptidase A (NCBI) compare
b0726 sucA -1.8 -4.5 alpha-ketoglutarate decarboxylase (NCBI) compare
b4042 dgkA -1.8 -1.7 diacylglycerol kinase (NCBI) compare
b1856 yebA -1.8 -8.2 orf, hypothetical protein (VIMSS) compare
b2168 fruK -1.8 -1.8 1-phosphofructokinase (NCBI) compare
b2025 hisF -1.7 -5.8 imidazole glycerol phosphate synthase subunit HisF (NCBI) compare
b0737 tolQ -1.7 -2.4 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b1506 yneL -1.7 -2.4 predicted transcriptional regulator (NCBI) compare
b0738 tolR -1.6 -2.1 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b0888 trxB -1.6 -4.7 thioredoxin reductase, FAD/NAD(P)-binding (NCBI) compare
b0949 uup -1.5 -9.0 fused predicted transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b2259 pmrD -1.5 -2.0 polymyxin resistance protein B (VIMSS) compare
b2020 hisD -1.5 -5.9 histidinol dehydrogenase (NCBI) compare
b2175 spr -1.5 -4.1 predicted peptidase, outer membrane lipoprotein (NCBI) compare
b3839 tatC -1.4 -6.7 TatABCE protein translocation system subunit (NCBI) compare
b2830 nudH -1.4 -1.3 dinucleoside polyphosphate hydrolase (NCBI) compare
b2023 hisH -1.4 -6.1 imidazole glycerol phosphate synthase subunit HisH (NCBI) compare
b0990 cspG -1.4 -1.7 DNA-binding transcriptional regulator (NCBI) compare
b1291 sapD -1.4 -2.2 predicted antimicrobial peptide transporter subunit (NCBI) compare
b3500 gor -1.4 -1.9 glutathione reductase (NCBI) compare
b3842 rfaH -1.4 -5.6 transcriptional activator RfaH (NCBI) compare
b2318 truA -1.3 -2.9 tRNA pseudouridine synthase A (NCBI) compare
b3630 rfaP -1.3 -7.6 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b2853 ygeI -1.3 -0.8 hypothetical protein (NCBI) compare
b2021 hisC -1.3 -5.9 histidinol-phosphate aminotransferase (NCBI) compare
b0632 dacA -1.3 -7.1 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5) (NCBI) compare
b3620 rfaF -1.3 -4.6 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b3609 secB -1.3 -3.3 export protein SecB (NCBI) compare
b3035 tolC -1.2 -7.8 outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) compare
b2498 upp -1.2 -2.8 uracil phosphoribosyltransferase (VIMSS) compare
b3621 rfaC -1.2 -4.2 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b4375 prfC -1.2 -3.1 peptide chain release factor 3 (NCBI) compare
b1252 tonB -1.2 -3.1 membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) compare
b2567 rnc -1.2 -1.2 ribonuclease III (NCBI) compare
b3631 rfaG -1.2 -8.8 glucosyltransferase I (NCBI) compare
b3613 yibP -1.2 -2.4 putative membrane protein (VIMSS) compare
b0222 lpcA -1.2 -2.4 phosphoheptose isomerase (NCBI) compare
b2022 hisB -1.1 -5.9 imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS) compare
b4594 ymgJ -1.1 -2.3 hypothetical protein (RefSeq) compare
b0450 glnK -1.1 -3.1 nitrogen assimilation regulatory protein for GlnL, GlnE, and AmtB (NCBI) compare
b3052 rfaE -1.1 -4.2 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare
b3741 gidA -1.1 -3.4 glucose-inhibited division protein A (NCBI) compare
b1290 sapF -1.1 -1.7 predicted antimicrobial peptide transporter subunit (NCBI) compare
b0088 murD -1.1 -1.7 UDP-N-acetylmuramoyl-L-alanyl-D-glutamatesynthetase (NCBI) compare
b4414 tff -1.1 -2.9 unknown RNA (NCBI) compare
b0564 appY -1.1 -1.3 DLP12 prophage; DNA-binding transcriptional activator (NCBI) compare
b2019 hisG -1.1 -4.5 ATP phosphoribosyltransferase (NCBI) compare
b2024 hisA -1.1 -1.9 N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-imidazolecarboxamide isomerase (VIMSS) compare
b2912 ygfA -1.1 -3.4 putative ligase (VIMSS) compare
b3962 udhA -1.0 -5.4 putative oxidoreductase (VIMSS) compare
b3237 argR -1.0 -4.1 arginine repressor (NCBI) compare
b3811 xerC -1.0 -1.3 site-specific tyrosine recombinase XerC (NCBI) compare
b3778 rep -1.0 -5.9 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b4041 plsB -1.0 -2.1 glycerol-3-phosphate acyltransferase (VIMSS) compare
b4171 miaA -1.0 -2.5 tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) compare
b3162 deaD -1.0 -3.6 inducible ATP-independent RNA helicase (VIMSS) compare
b3169 nusA -1.0 -2.7 transcription elongation factor NusA (NCBI) compare
b2422 cysA -1.0 -5.6 sulfate/thiosulfate transporter subunit (NCBI) compare
b1518 lsrG -1.0 -2.2 autoinducer-2 (AI-2) modifying protein LsrG (NCBI) compare
b2424 cysU -1.0 -2.7 sulfate/thiosulfate transporter subunit (NCBI) compare
b4593 ymgI -1.0 -0.6 hypothetical protein (RefSeq) compare
b2282 nuoH -1.0 -2.9 NADH dehydrogenase subunit H (NCBI) compare
b4535 yniD -1.0 -1.3 predicted protein (RefSeq) compare
b3870 glnA -0.9 -2.7 glutamine synthetase (NCBI) compare
b0386 proC -0.9 -4.2 pyrroline-5-carboxylate reductase (NCBI) compare
b2330 yfcB -0.9 -1.0 putative adenine-specific methylase (VIMSS) compare
b3261 fis -0.9 -1.7 DNA-binding protein Fis (NCBI) compare
b3545 proK -0.9 -2.2 tRNA-Pro (NCBI) compare
b3871 bipA -0.9 -6.7 GTP-binding protein (NCBI) compare
b3426 glpD -0.9 -2.6 sn-glycerol-3-phosphate dehydrogenase, aerobic, FAD/NAD(P)-binding (NCBI) compare
b3838 tatB -0.9 -3.9 sec-independent translocase (NCBI) compare
b4172 hfq -0.9 -0.6 RNA-binding protein Hfq (NCBI) compare
b3398 yrfF -0.9 -2.8 predicted inner membrane protein (NCBI) compare
b2189 proL -0.9 -1.6 tRNA-Pro (NCBI) compare
b3619 rfaD -0.9 -2.7 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b1882 cheY -0.8 -0.6 chemotaxis regulator transmitting signal to flagellar motor component (NCBI) compare
b2576 srmB -0.8 -2.3 ATP-dependent RNA helicase (NCBI) compare
b4191 ulaR -0.8 -3.1 DNA-binding transcriptional dual regulator (NCBI) compare
b2287 nuoB -0.8 -2.7 NADH dehydrogenase subunit B (NCBI) compare
b3026 qseC -0.8 -2.6 sensory histidine kinase in two-component regulatory system with QseB (NCBI) compare
b2026 hisI -0.8 -4.1 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI) compare
b3611 yibN -0.8 -3.7 predicted rhodanese-related sulfurtransferase (NCBI) compare
b0436 tig -0.8 -4.7 trigger factor (NCBI) compare
b3005 exbD -0.8 -4.2 membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) compare
b3150 yraP -0.8 -4.0 hypothetical protein (NCBI) compare
b0767 ybhE -0.8 -3.1 6-phosphogluconolactonase (NCBI) compare
b0439 lon -0.8 -3.1 DNA-binding ATP-dependent protease La (NCBI) compare
b1176 minC -0.8 -2.4 septum formation inhibitor (NCBI) compare
b2423 cysW -0.7 -3.9 sulfate/thiosulfate transporter subunit (NCBI) compare
b2894 xerD -0.7 -0.5 site-specific tyrosine recombinase XerD (NCBI) compare
b1658 purR -0.7 -3.6 DNA-binding transcriptional repressor, hypoxanthine-binding (NCBI) compare
b1048 mdoG -0.7 -3.4 glucan biosynthesis protein, periplasmic (NCBI) compare
b3912 cpxR -0.7 -4.7 DNA-binding response regulator in two-component regulatory system with CpxA (NCBI) compare
b1796 yoaG -0.7 -2.7 hypothetical protein (NCBI) compare
b0890 ftsK -0.7 -2.3 DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) compare
b0388 aroL -0.7 -3.0 shikimate kinase II (NCBI) compare
b0014 dnaK -0.7 -1.3 molecular chaperone DnaK (NCBI) compare
b0585 fes -0.7 -3.6 enterobactin/ferric enterobactin esterase (NCBI) compare
b1505 ydeT -0.7 -0.7 hypothetical protein (RefSeq) compare
b2433 b2433 -0.7 -2.0 orf, hypothetical protein (VIMSS) compare
b3790 rffC -0.7 -3.3 TDP-fucosamine acetyltransferase (RefSeq) compare
b1293 sapB -0.7 -1.2 predicted antimicrobial peptide transporter subunit (NCBI) compare
b2518 ndk -0.7 -2.0 nucleoside diphosphate kinase (NCBI) compare
b3390 aroK -0.7 -1.6 shikimate kinase I (NCBI) compare
b1205 ychH -0.7 -1.6 predicted inner membrane protein (NCBI) compare
b2620 smpB -0.7 -0.8 SsrA-binding protein (NCBI) compare
b1286 rnb -0.6 -1.6 exoribonuclease II (NCBI) compare
b1536 ydeI -0.6 -0.6 hypothetical protein (NCBI) compare
b1164 ycgZ -0.6 -1.0 hypothetical protein (NCBI) compare
b0605 ahpC -0.6 -2.7 alkyl hydroperoxide reductase, C22 subunit (NCBI) compare
b3006 exbB -0.6 -3.4 membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) compare
b2450 yffS -0.6 -1.5 CPZ-55 prophage; predicted protein (RefSeq) compare
b0339 cynT -0.6 -2.1 carbonic anhydrase (NCBI) compare
b2080 b2080 -0.6 -1.5 orf, hypothetical protein (VIMSS) compare
b2689 yqaA -0.6 -2.4 conserved inner membrane protein (NCBI) compare
b4603 rseX -0.6 -0.7 sRNA regulating ompA and ompC translation, with Hfq (RefSeq) compare
b3616 tdh -0.6 -3.1 L-threonine 3-dehydrogenase (NCBI) compare
b1182 hlyE -0.6 -0.4 hemolysin E (VIMSS) compare
b1346 ydaQ -0.6 -0.7 orf, hypothetical protein (VIMSS) compare
b2951 yggS -0.6 -2.9 predicted enzyme (NCBI) compare
b1926 fliT -0.6 -2.2 predicted chaperone (NCBI) compare
b3726 pstA -0.6 -2.6 phosphate transporter subunit (NCBI) compare
b4410 ecnA -0.6 -1.2 entericidin A membrane lipoprotein, antidote entericidin B (NCBI) compare
b3794 rffM -0.6 -3.7 putative UDP-N-acetyl-D-mannosaminuronic acid transferase (NCBI) compare
b4494 arpB -0.6 -1.1 no description compare
b2058 wcaB -0.6 -0.8 predicted acyl transferase (NCBI) compare
b1062 pyrC -0.6 -3.4 dihydroorotase (NCBI) compare
b3940 metL -0.6 -4.2 bifunctional aspartate kinase II/homoserine dehydrogenase II (NCBI) compare
b1409 ynbB -0.6 -0.7 predicted CDP-diglyceride synthase (NCBI) compare
b1690 ydiM -0.6 -1.1 predicted transporter (NCBI) compare
b1095 fabF -0.6 -3.2 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b0082 mraW -0.6 -1.9 S-adenosyl-methyltransferase (NCBI) compare
b1446 ydcY -0.6 -1.2 hypothetical protein (NCBI) compare
b0051 ksgA -0.6 -2.3 dimethyladenosine transferase (NCBI) compare
b2688 gshA -0.6 -3.3 glutamate--cysteine ligase (NCBI) compare
b1968 yedV -0.6 -1.4 predicted sensory kinase in two-component regulatory system with YedW (NCBI) compare
b1863 ruvC -0.6 -0.9 Holliday junction resolvase (NCBI) compare
b1084 rne -0.6 -1.9 fused ribonucleaseE: endoribonuclease/RNA-binding protein/RNA degradosome binding protein (NCBI) compare
b1400 paaY -0.6 -1.6 predicted hexapeptide repeat acetyltransferase (NCBI) compare
b3205 yhbJ -0.6 -2.0 hypothetical protein (NCBI) compare
b1380 ldhA -0.5 -1.6 D-lactate dehydrogenase (NCBI) compare
b1855 lpxM -0.5 -2.3 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase (NCBI) compare
b2340 sixA -0.5 -2.2 phosphohistidine phosphatase (NCBI) compare
b0630 lipB -0.5 -0.8 protein of lipoate biosynthesis (VIMSS) compare
b3204 ptsN -0.5 -2.4 sugar-specific enzyme IIA component of PTS (NCBI) compare
b1533 ydeD -0.5 -1.8 orf, hypothetical protein (VIMSS) compare
b0001 thrL -0.5 -1.0 thr operon leader peptide (NCBI) compare
b1842 holE -0.5 -1.3 DNA polymerase III, theta subunit (NCBI) compare
b1712 ihfA -0.5 -0.7 integration host factor subunit alpha (NCBI) compare
b2288 nuoA -0.5 -1.8 NADH dehydrogenase I chain A (VIMSS) compare
b3935 priA -0.5 -1.7 primosome assembly protein PriA (NCBI) compare
b0606 ahpF -0.5 -2.9 alkyl hydroperoxide reductase, F52a subunit; detoxification of hydroperoxides (VIMSS) compare
b1075 flgD -0.5 -1.5 flagellar basal body rod modification protein D (NCBI) compare
b3238 yhcN -0.5 -1.3 orf, hypothetical protein (VIMSS) compare
b3068 ygjF -0.5 -1.6 G/U mismatch-specific DNA glycosylase (NCBI) compare
b1709 btuD -0.5 -0.6 vitamin B12-transporter ATPase (NCBI) compare
b1298 ycjL -0.5 -2.3 probable amidotransferase subunit (VIMSS) compare
b1001 yccE -0.5 -0.3 hypothetical protein (NCBI) compare
b3414 gntY -0.5 -2.6 predicted gluconate transport associated protein (NCBI) compare
b0237 pepD -0.5 -3.4 aminoacyl-histidine dipeptidase (peptidase D) (NCBI) compare
b0113 pdhR -0.5 -2.5 transcriptional regulator of pyruvate dehydrogenase complex (NCBI) compare
b1651 gloA -0.5 -1.7 glyoxalase I, Ni-dependent (NCBI) compare
b1351 racC -0.5 -0.4 Rac prophage; predicted protein (NCBI) compare
b2947 gshB -0.5 -2.2 glutathione synthetase (NCBI) compare
b1530 marR -0.5 -1.6 multiple antibiotic resistance protein; repressor of mar operon (VIMSS) compare
b1138 ymfE -0.5 -0.8 e14 prophage; predicted inner membrane protein (NCBI) compare
b2278 nuoL -0.5 -3.3 NADH dehydrogenase subunit L (NCBI) compare
b1143 ymfI -0.5 -0.9 orf, hypothetical protein (VIMSS) compare
b3786 rffE -0.5 -4.1 UDP-N-acetyl glucosamine-2-epimerase (NCBI) compare
b3229 sspA -0.5 -1.4 stringent starvation protein A (NCBI) compare
b4679 yohP -0.5 -1.2 expressed protein (RefSeq) compare
b0763 modA -0.5 -2.6 molybdate transporter subunit (NCBI) compare
b3199 yrbK -0.5 -1.2 hypothetical protein (NCBI) compare
b1573 ydfC -0.5 -0.5 Qin prophage; predicted protein (RefSeq) compare
b2569 lepA -0.5 -1.8 GTP-binding protein LepA (NCBI) compare
b1049 mdoH -0.5 -3.2 glucosyltransferase MdoH (NCBI) compare
b2263 yfbB -0.5 -1.5 predicted peptidase (NCBI) compare
b1462 b1462 -0.5 -1.5 orf, hypothetical protein (VIMSS) compare
b0705 ybfL -0.5 -0.3 putative receptor protein (VIMSS) compare
b2937 speB -0.5 -2.4 agmatinase (NCBI) compare
b1497 b1497 -0.5 -0.2 putative enzyme (VIMSS) compare
b1499 ydeO -0.5 -0.2 predicted DNA-binding transcriptional acfivator (NCBI) compare
b1551 b1551 -0.5 -0.2 orf, hypothetical protein (VIMSS) compare
b1545 pinQ -0.5 -0.2 Qin prophage; predicted site-specific recombinase (NCBI) compare


Specific Phenotypes

For 3 genes in this experiment

For stress copper (II) chloride dihydrate in Escherichia coli BW25113

For stress copper (II) chloride dihydrate across organisms