Experiment set13IT028 for Escherichia coli BW25113

Compare to:

LB with Cisplatin 0.1 mg/ml

200 most detrimental genes:

  gene name fitness t score description  
b0958 sulA +3.6 14.1 SOS cell division inhibitor (NCBI) compare
b0912 ihfB +2.9 10.7 integration host factor subunit beta (NCBI) compare
b2518 ndk +2.8 10.8 nucleoside diphosphate kinase (NCBI) compare
b3493 pitA +2.6 16.5 phosphate transporter, low-affinity (NCBI) compare
b0092 ddlB +2.3 11.3 D-alanylalanine synthetase (NCBI) compare
b1235 rssB +2.0 10.8 response regulator of RpoS (NCBI) compare
b1349 recT +2.0 9.6 Rac prophage; recombination and repair protein (NCBI) compare
b3977 tyrU +1.9 2.3 tRNA-Tyr (NCBI) compare
b1712 ihfA +1.8 2.2 integration host factor subunit alpha (NCBI) compare
b2281 nuoI +1.8 5.3 NADH dehydrogenase subunit I (NCBI) compare
b1493 gadB +1.7 1.1 glutamate decarboxylase B, PLP-dependent (NCBI) compare
b3844 fre +1.7 8.4 NAD(P)H-flavin reductase (NCBI) compare
b3806 cyaA +1.6 7.4 adenylate cyclase (NCBI) compare
b2909 ygfB +1.6 5.7 orf, hypothetical protein (VIMSS) compare
b2285 nuoE +1.5 2.6 NADH dehydrogenase subunit E (NCBI) compare
b0632 dacA +1.5 9.4 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5) (NCBI) compare
b1840 yebZ +1.4 6.2 predicted inner membrane protein (NCBI) compare
b1686 ydiI +1.4 3.3 hypothetical protein (NCBI) compare
b4701 sokX +1.4 1.3 sok-related sRNA, function unknown (RefSeq) compare
b2299 yfcD +1.4 6.5 predicted NUDIX hydrolase (NCBI) compare
b2279 nuoK +1.4 2.5 NADH dehydrogenase subunit K (NCBI) compare
b1540 ydfH +1.4 2.5 predicted DNA-binding transcriptional regulator (NCBI) compare
b0432 cyoA +1.4 8.9 cytochrome o ubiquinol oxidase subunit II (NCBI) compare
b0059 hepA +1.3 9.3 ATP-dependent helicase HepA (NCBI) compare
b3398 yrfF +1.3 6.1 predicted inner membrane protein (NCBI) compare
b0428 cyoE +1.3 7.3 protoheme IX farnesyltransferase (NCBI) compare
b4294 insA-7 +1.3 3.1 KpLE2 phage-like element; IS1 repressor protein InsA (NCBI) compare
b4522 yciX_1 +1.3 3.7 hypothetical protein (NCBI) compare
b2502 ppx +1.3 7.5 exopolyphosphatase (NCBI) compare
b2516 yfgA +1.2 5.5 hypothetical protein (NCBI) compare
b2906 visC +1.2 5.7 hypothetical protein (NCBI) compare
b4533 ynfO +1.2 2.1 Qin prophage; predicted protein (NCBI) compare
b2216 rcsD +1.2 7.9 phosphotransfer intermediate protein in two-component regulatory system with RcsBC (NCBI) compare
b2218 rcsC +1.1 7.0 hybrid sensory kinase in two-component regulatory system with RcsB and YojN (RefSeq) compare
b1284 yciT +1.1 6.1 predicted DNA-binding transcriptional regulator (NCBI) compare
b1109 ndh +1.1 5.1 respiratory NADH dehydrogenase 2/cupric reductase (NCBI) compare
b3129 sohA +1.1 2.9 predicted regulator (NCBI) compare
b0142 folK +1.1 0.6 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) compare
b2948 yqgE +1.1 3.5 orf, hypothetical protein (VIMSS) compare
b1348 lar +1.1 2.2 Rac prophage; restriction alleviation protein (NCBI) compare
b0429 cyoD +1.1 4.1 cytochrome o ubiquinol oxidase subunit IV (NCBI) compare
b0226 dinJ +1.0 3.5 predicted antitoxin of YafQ-DinJ toxin-antitoxin system (NCBI) compare
b0846 ybjK +1.0 5.4 predicted DNA-binding transcriptional regulator (NCBI) compare
b2824 ygdB +1.0 3.3 orf, hypothetical protein (VIMSS) compare
b2911 ssrS +1.0 2.4 6S regulatory RNA (NCBI) compare
b1246 oppD +1.0 6.6 oligopeptide transporter ATP-binding component (NCBI) compare
b1920 fliY +1.0 2.3 cystine transporter subunit (NCBI) compare
b1358 ydaT +1.0 0.8 Rac prophage; predicted protein (NCBI) compare
b1569 dicC +1.0 2.6 Qin prophage; DNA-binding transcriptional regulator for DicB (NCBI) compare
b0081 mraZ +1.0 4.4 hypothetical protein (NCBI) compare
b1804 rnd +1.0 3.5 ribonuclease D (NCBI) compare
b4436 ryeC +1.0 1.3 Novel sRNA, function unknown; paralogous to the other QUAD sRNA genes unknown (RefSeq) compare
b0430 cyoC +1.0 4.3 cytochrome o ubiquinol oxidase subunit III (NCBI) compare
b3973 birA +1.0 3.0 biotin--protein ligase (NCBI) compare
b2284 nuoF +1.0 3.8 NADH:ubiquinone oxidoreductase, chain F (NCBI) compare
b0431 cyoB +1.0 6.7 cytochrome o ubiquinol oxidase subunit I (NCBI) compare
b4578 insP +1.0 3.1 no description compare
b2479 gcvR +1.0 4.0 transcriptional regulation of gcv operon (VIMSS) compare
b1286 rnb +0.9 2.0 exoribonuclease II (NCBI) compare
b2277 nuoM +0.9 4.2 NADH dehydrogenase subunit M (NCBI) compare
b3871 bipA +0.9 6.7 GTP-binding protein (NCBI) compare
b3229 sspA +0.9 3.2 stringent starvation protein A (NCBI) compare
b3082 ygjM +0.9 2.0 predicted DNA-binding transcriptional regulator (NCBI) compare
b1245 oppC +0.9 4.5 oligopeptide transporter subunit (NCBI) compare
b0720 gltA +0.9 4.3 citrate synthase (NCBI) compare
b0746 valZ +0.9 2.5 tRNA-Val (NCBI) compare
b1841 yobA +0.9 1.8 hypothetical protein (NCBI) compare
b2283 nuoG +0.9 4.6 NADH:ubiquinone oxidoreductase, chain G (RefSeq) compare
b0018 mokC +0.9 1.3 regulatory protein for HokC, overlaps CDS of hokC (NCBI) compare
b0088 murD +0.9 1.2 UDP-N-acetylmuramoyl-L-alanyl-D-glutamatesynthetase (NCBI) compare
b1361 ydaW +0.9 0.3 orf, hypothetical protein (VIMSS) compare
b1527 yneK +0.9 2.1 hypothetical protein (NCBI) compare
b0880 cspD +0.9 2.0 cold shock protein homolog (NCBI) compare
b4207 fklB +0.9 3.5 FKBP-type 22KD peptidyl-prolyl cis-trans isomerase (rotamase) (VIMSS) compare
b3766 ilvL +0.9 3.8 ilvG operon leader peptide (NCBI) compare
b0437 clpP +0.9 2.2 ATP-dependent Clp protease proteolytic subunit (NCBI) compare
b4538 yoeF +0.9 0.9 hypothetical protein (RefSeq) compare
b1138 ymfE +0.8 1.3 e14 prophage; predicted inner membrane protein (NCBI) compare
b1231 tyrT +0.8 0.8 tRNA-Tyr (NCBI) compare
b3119 tdcR +0.8 1.6 threonine dehydratase operon activator protein (VIMSS) compare
b1259 yciG +0.8 1.6 orf, hypothetical protein (VIMSS) compare
b1279 yciS +0.8 0.9 conserved inner membrane protein (NCBI) compare
b2022 hisB +0.8 4.4 imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS) compare
b4042 dgkA +0.8 1.9 diacylglycerol kinase (NCBI) compare
b1656 sodB +0.8 1.9 superoxide dismutase, Fe (NCBI) compare
b0764 modB +0.8 2.7 molybdate ABC transporter permease protein (NCBI) compare
b1438 ydcQ +0.8 2.2 predicted DNA-binding transcriptional regulator (RefSeq) compare
b2419 yfeK +0.8 0.8 hypothetical protein (NCBI) compare
b4536 yobH +0.8 2.7 hypothetical protein (NCBI) compare
b0102 yacF +0.8 3.4 hypothetical protein (NCBI) compare
b0853 ybjN +0.8 3.0 predicted oxidoreductase (NCBI) compare
b4180 rlmB +0.7 4.5 23S rRNA (Gm2251)-methyltransferase (NCBI) compare
b0225 yafQ +0.7 2.4 predicted toxin of the YafQ-DinJ toxin-antitoxin system (NCBI) compare
b0232 yafN +0.7 0.5 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b1104 ycfL +0.7 1.1 hypothetical protein (NCBI) compare
b1850 eda +0.7 1.3 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) compare
b0783 moaC +0.7 2.8 molybdenum cofactor biosynthesis protein C (NCBI) compare
b2287 nuoB +0.7 2.3 NADH dehydrogenase subunit B (NCBI) compare
b1079 flgH +0.7 2.3 flagellar L-ring protein precursor H (NCBI) compare
b2446 yffO +0.7 2.1 CPZ-55 prophage; predicted protein (NCBI) compare
b1213 ychQ +0.7 2.2 predicted transcriptional regulator (NCBI) compare
b1103 ycfF +0.7 0.9 orf, hypothetical protein (VIMSS) compare
b0619 citA +0.7 3.8 sensory histidine kinase in two-component regulatory system with citB (NCBI) compare
b1733 chbG +0.7 2.3 hypothetical protein (NCBI) compare
b3071 yqjI +0.7 3.2 predicted transcriptional regulator (NCBI) compare
b1243 oppA +0.7 2.4 oligopeptide transporter subunit (NCBI) compare
b2111 yehD +0.7 1.9 predicted fimbrial-like adhesin protein (NCBI) compare
b2005 yeeV +0.7 3.3 CP4-44 prophage; toxin of the YeeV-YeeU toxin-antitoxin system (NCBI) compare
b2113 mrp +0.7 3.4 putative ATPase (VIMSS) compare
b3636 rpmG +0.7 0.9 50S ribosomal protein L33 (NCBI) compare
b2540 hcaC +0.7 1.5 3-phenylpropionate dioxygenase, predicted ferredoxin subunit (NCBI) compare
b3742 mioC +0.7 2.9 flavodoxin (NCBI) compare
b1150 ymfR +0.7 0.7 e14 prophage; predicted protein (NCBI) compare
b3354 yheU +0.7 3.0 hypothetical protein (NCBI) compare
b4407 thiS +0.7 1.1 sulfur carrier protein ThiS (NCBI) compare
b4568 ytjA +0.7 1.6 predicted protein (RefSeq) compare
b0806 ybiM +0.7 1.8 orf, hypothetical protein (VIMSS) compare
b1152 ymfP +0.7 1.7 orf, hypothetical protein (VIMSS) compare
b2278 nuoL +0.7 4.0 NADH dehydrogenase subunit L (NCBI) compare
b1572 ydfB +0.7 1.2 orf, hypothetical protein (VIMSS) compare
b0617 citD +0.7 1.1 citrate lyase, acyl carrier (gamma) subunit (NCBI) compare
b0790 ybhP +0.7 2.4 predicted DNase (NCBI) compare
b4011 yjaA +0.7 1.8 hypothetical protein (NCBI) compare
b0966 hspQ +0.7 3.2 DNA-binding protein, hemimethylated (RefSeq) compare
b1357 ydaS +0.7 1.5 Rac prophage; predicted DNA-binding transcriptional regulator (NCBI) compare
b0852 rimK +0.7 1.9 ribosomal protein S6 modification protein (NCBI) compare
b1426 ydcH +0.6 1.1 orf, hypothetical protein (VIMSS) compare
b1247 oppF +0.6 2.9 oligopeptide transporter subunit (NCBI) compare
b2175 spr +0.6 1.5 predicted peptidase, outer membrane lipoprotein (NCBI) compare
b1944 fliL +0.6 2.0 flagellar basal body-associated protein FliL (NCBI) compare
b2490 b2490 +0.6 1.6 putative protein processing element (VIMSS) compare
b2876 b2876 +0.6 2.5 orf, hypothetical protein (VIMSS) compare
b1261 trpB +0.6 1.0 tryptophan synthase subunit beta (NCBI) compare
b1431 ydcL +0.6 2.2 predicted lipoprotein (NCBI) compare
b4570 lomR +0.6 1.1 no description compare
b1939 fliG +0.6 2.2 flagellar motor switch protein G (NCBI) compare
b1591 b1591 +0.6 1.4 putative oxidoreductase component (VIMSS) compare
b3414 gntY +0.6 2.8 predicted gluconate transport associated protein (NCBI) compare
b2276 nuoN +0.6 2.3 NADH:ubiquinone oxidoreductase, membrane subunit N (RefSeq) compare
b2286 nuoC +0.6 2.8 NADH:ubiquinone oxidoreductase, chain C,D (RefSeq) compare
b2061 wzb +0.6 1.4 protein-tyrosine phosphatase (NCBI) compare
b2409 yfeR +0.6 1.6 predicted DNA-binding transcriptional regulator (NCBI) compare
b3740 gidB +0.6 4.5 glucose-inhibited division protein B (NCBI) compare
b4062 soxS +0.6 1.5 DNA-binding transcriptional dual regulator (NCBI) compare
b1992 cobS +0.6 0.5 cobalamin synthase (NCBI) compare
b4571 wbbL +0.6 1.5 no description compare
b1854 pykA +0.6 3.4 pyruvate kinase (NCBI) compare
b1128 ycfD +0.6 3.6 orf, hypothetical protein (VIMSS) compare
b4655 ythA +0.6 1.0 expressed protein (RefSeq) compare
b3184 yhbE +0.6 3.5 conserved inner membrane protein (NCBI) compare
b2078 baeS +0.6 2.6 sensory histidine kinase in two-component regulatory system with BaeR (NCBI) compare
b1410 ynbC +0.6 2.6 predicted hydrolase (NCBI) compare
b0340 cynS +0.6 1.7 cyanate hydratase (NCBI) compare
b0781 moaA +0.6 2.9 molybdenum cofactor biosynthesis protein A (NCBI) compare
b1070 flgN +0.6 0.9 export chaperone for FlgK and FlgL (NCBI) compare
b4210 ytfF +0.6 3.4 predicted inner membrane protein (RefSeq) compare
b1648 b1648 +0.6 0.8 orf, hypothetical protein (VIMSS) compare
b2730 hypE +0.6 2.5 carbamoyl phosphate phosphatase, hydrogenase 3 maturation protein (RefSeq) compare
b0998 torD +0.6 0.8 chaperone protein TorD (NCBI) compare
b3210 arcB +0.6 2.8 hybrid sensory histidine kinase in two-component regulatory system with ArcA (NCBI) compare
b1703 ydiA +0.6 2.2 hypothetical protein (NCBI) compare
b1073 flgB +0.6 2.5 flagellar basal-body rod protein B (NCBI) compare
b1242 ychE +0.6 2.2 predicted inner membrane protein (NCBI) compare
b1586 b1586 +0.6 2.8 orf, hypothetical protein (VIMSS) compare
b1765 ydjA +0.6 0.5 predicted oxidoreductase (NCBI) compare
b0146 sfsA +0.6 2.4 sugar fermentation stimulation protein A (NCBI) compare
b4513 kdpF +0.5 1.5 potassium ion accessory transporter subunit (NCBI) compare
b1476 fdnI +0.5 0.6 formate dehydrogenase-N, cytochrome B556 (gamma) subunit, nitrate-inducible (NCBI) compare
b2708 gutQ +0.5 2.0 orf, hypothetical protein (VIMSS) compare
b2443 yffL +0.5 2.6 CPZ-55 prophage; predicted protein (NCBI) compare
b1512 lsrR +0.5 2.1 lsr operon transcriptional repressor (NCBI) compare
b0539 ybcC +0.5 2.5 DLP12 prophage; predicted exonuclease (RefSeq) compare
b3537 yhjT +0.5 1.9 orf, hypothetical protein (VIMSS) compare
b2586 yfiM +0.5 1.3 predicted protein (RefSeq) compare
b1730 ydjO +0.5 0.6 predicted protein (RefSeq) compare
b4373 rimI +0.5 1.2 ribosomal-protein-alanine N-acetyltransferase (NCBI) compare
b4595 yciY +0.5 1.0 hypothetical protein (RefSeq) compare
b1548 nohA +0.5 0.7 Qin prophage; predicted packaging protein (RefSeq) compare
b1085 b1085 +0.5 1.2 orf, hypothetical protein (VIMSS) compare
b1171 b1171 +0.5 1.1 orf, hypothetical protein (VIMSS) compare
b3271 yhdZ +0.5 1.9 predicted amino-acid transporter subunit (NCBI) compare
b2282 nuoH +0.5 1.6 NADH dehydrogenase subunit H (NCBI) compare
b1675 ydhZ +0.5 2.0 hypothetical protein (NCBI) compare
b0427 yajR +0.5 3.3 putative transport protein (VIMSS) compare
b3784 rfe +0.5 3.7 UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase (NCBI) compare
b1811 yoaH +0.5 1.7 hypothetical protein (NCBI) compare
b3920 yiiQ +0.5 2.1 hypothetical protein (NCBI) compare
b0247 ykfG +0.5 0.8 CP4-6 prophage; predicted DNA repair protein (NCBI) compare
b4394 yjjX +0.5 1.2 orf, hypothetical protein (VIMSS) compare
b4234 yjgA +0.5 2.8 hypothetical protein (NCBI) compare
b1597 asr +0.5 1.7 acid shock protein (VIMSS) compare
b0705 ybfL +0.5 0.6 putative receptor protein (VIMSS) compare
b2356 yfdM +0.5 1.1 orf, hypothetical protein (VIMSS) compare
b0592 fepB +0.5 3.3 iron-enterobactin transporter subunit (NCBI) compare
b0580 ybdJ +0.5 0.8 predicted inner membrane protein (NCBI) compare
b2955 yggW +0.5 2.2 coproporphyrinogen III oxidase (NCBI) compare
b1491 yddW +0.5 2.7 predicted liprotein (NCBI) compare
b4461 yfjD +0.5 2.8 predicted inner membrane protein (RefSeq) compare
b1669 ydhT +0.5 0.9 hypothetical protein (NCBI) compare
b2013 yeeE +0.5 2.5 predicted inner membrane protein (NCBI) compare


Specific Phenotypes

For 20 genes in this experiment

For stress Cisplatin in Escherichia coli BW25113

For stress Cisplatin across organisms