Experiment set13IT009 for Escherichia coli BW25113

Compare to:

LB with Ciprofloxacin Hydrochloride 0.0024 mM

200 most important genes:

  gene name fitness t score description  
b0247 ykfG -5.1 -1.4 CP4-6 prophage; predicted DNA repair protein (NCBI) compare
b2080 b2080 -4.2 -1.7 orf, hypothetical protein (VIMSS) compare
b0998 torD -4.2 -1.2 chaperone protein TorD (NCBI) compare
b1765 ydjA -3.8 -1.1 predicted oxidoreductase (NCBI) compare
b2620 smpB -3.8 -2.1 SsrA-binding protein (NCBI) compare
b3500 gor -3.7 -2.5 glutathione reductase (NCBI) compare
b4589 ylcI -3.5 -2.6 hypothetical protein (RefSeq) compare
b1575 dicB -3.5 -1.9 Qin prophage; cell division inhibition protein (NCBI) compare
b2183 rsuA -3.2 -3.2 16S rRNA pseudouridylate 516 synthase (NCBI) compare
b1192 ldcA -3.1 -4.9 L,D-carboxypeptidase A (NCBI) compare
b1573 ydfC -3.0 -1.2 Qin prophage; predicted protein (RefSeq) compare
b1480 sra -3.0 -1.4 30S ribosomal subunit protein S22 (NCBI) compare
b4481 rffT -3.0 -6.7 4-alpha-L-fucosyltransferase (NCBI) compare
b4402 yjjY -2.9 -1.2 hypothetical protein (NCBI) compare
b2642 yfjW -2.9 -1.3 CP4-57 prophage; predicted inner membrane protein (NCBI) compare
b1429 tehA -2.8 -1.3 potassium-tellurite ethidium and proflavin transporter (NCBI) compare
b4699 fnrS -2.8 -0.8 FNR-activated anaerobic sRNA antisense regulator down regulates cydDC, metE, sodA, sodB, Hfq-dependent; mediates negative FNR regulation (RefSeq) compare
b0726 sucA -2.8 -4.2 alpha-ketoglutarate decarboxylase (NCBI) compare
b0683 fur -2.8 -1.9 ferric uptake regulator (NCBI) compare
b3443 yrhA -2.8 -2.1 orf, hypothetical protein (VIMSS) compare
b2498 upp -2.7 -1.9 uracil phosphoribosyltransferase (VIMSS) compare
b0218 yafU -2.7 -1.9 predicted inner membrane protein (RefSeq) compare
b1818 manY -2.7 -2.0 mannose-specific enzyme IIC component of PTS (NCBI) compare
b1950 fliR -2.7 -1.8 flagellar biosynthesis protein R (NCBI) compare
b1506 yneL -2.7 -1.8 predicted transcriptional regulator (NCBI) compare
b1412 azoR -2.6 -1.6 acyl carrier protein phosphodiesterase (NCBI) compare
b1291 sapD -2.6 -1.8 predicted antimicrobial peptide transporter subunit (NCBI) compare
b2330 yfcB -2.6 -1.8 putative adenine-specific methylase (VIMSS) compare
b4527 b1354 -2.6 -2.3 orf, hypothetical protein (VIMSS) compare
b3794 rffM -2.5 -5.6 putative UDP-N-acetyl-D-mannosaminuronic acid transferase (NCBI) compare
b1754 b1754 -2.4 -1.4 orf, hypothetical protein (VIMSS) compare
b2597 yfiA -2.4 -1.6 cold shock protein associated with 30S ribosomal subunit (NCBI) compare
b2808 gcvA -2.3 -3.9 DNA-binding transcriptional dual regulator (NCBI) compare
b3791 rffA -2.3 -6.7 TDP-4-oxo-6-deoxy-D-glucose transaminase (NCBI) compare
b4503 yafF -2.3 -0.9 no description compare
b0471 ybaB -2.3 -3.1 hypothetical protein (NCBI) compare
b1164 ycgZ -2.3 -1.2 hypothetical protein (NCBI) compare
b1194 ycgR -2.3 -2.3 protein involved in flagellar function (NCBI) compare
b1709 btuD -2.3 -0.8 vitamin B12-transporter ATPase (NCBI) compare
b1334 fnr -2.2 -2.3 DNA-binding transcriptional dual regulator, global regulator of anaerobic growth (NCBI) compare
b0782 moaB -2.1 -1.6 molybdopterin biosynthesis protein B (NCBI) compare
b0357 yaiN -2.1 -1.3 putative alpha helix chain (VIMSS) compare
b2518 ndk -2.1 -2.7 nucleoside diphosphate kinase (NCBI) compare
b0990 cspG -2.1 -1.0 DNA-binding transcriptional regulator (NCBI) compare
b1502 ydeQ -2.1 -1.4 predicted fimbrial-like adhesin protein (NCBI) compare
b0101 yacG -2.0 -2.2 zinc-binding protein (NCBI) compare
b3229 sspA -2.0 -3.3 stringent starvation protein A (NCBI) compare
b4146 yjeK -2.0 -1.4 predicted lysine aminomutase (NCBI) compare
b1839 yebY -2.0 -1.8 hypothetical protein (NCBI) compare
b4535 yniD -1.9 -1.2 predicted protein (RefSeq) compare
b1332 ynaJ -1.9 -0.7 predicted inner membrane protein (NCBI) compare
b4647 mokA -1.9 -1.0 no description compare
b0688 pgm -1.9 -3.8 phosphoglucomutase (NCBI) compare
b3790 rffC -1.9 -3.2 TDP-fucosamine acetyltransferase (RefSeq) compare
b1651 gloA -1.9 -2.0 glyoxalase I, Ni-dependent (NCBI) compare
b3029 ygiN -1.9 -1.9 quinol monooxygenase (NCBI) compare
b3787 rffD -1.9 -5.7 UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase (NCBI) compare
b1865 nudB -1.8 -1.2 dATP pyrophosphohydrolase (NCBI) compare
b1830 prc -1.8 -4.1 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b3228 sspB -1.8 -3.6 ClpXP protease specificity-enhancing factor (NCBI) compare
b2279 nuoK -1.8 -1.4 NADH dehydrogenase subunit K (NCBI) compare
b0232 yafN -1.7 -0.7 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b4533 ynfO -1.7 -1.5 Qin prophage; predicted protein (NCBI) compare
b3021 ygiT -1.7 -1.4 predicted DNA-binding transcriptional regulator (NCBI) compare
b4631 ykgQ -1.7 -1.2 no description compare
b4394 yjjX -1.7 -1.5 orf, hypothetical protein (VIMSS) compare
b4171 miaA -1.7 -2.5 tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) compare
b3916 pfkA -1.7 -1.1 6-phosphofructokinase (NCBI) compare
b1730 ydjO -1.7 -0.9 predicted protein (RefSeq) compare
b2433 b2433 -1.7 -1.2 orf, hypothetical protein (VIMSS) compare
b1361 ydaW -1.7 -0.4 orf, hypothetical protein (VIMSS) compare
b4451 ryhB -1.6 -0.8 Regulatory sRNA mediating positive Fur regulon response; requires Hfq for function; global iron regulator; degraded by RNase E when bound to target (RefSeq) compare
b0730 mngR -1.6 -1.1 DNA-binding transcriptional dual regulator, fatty-acyl-binding (NCBI) compare
b0850 ybjC -1.6 -1.6 predicted inner membrane protein (NCBI) compare
b3611 yibN -1.6 -2.7 predicted rhodanese-related sulfurtransferase (NCBI) compare
b4418 sraB -1.6 -1.4 unknown RNA (NCBI) compare
b0999 cbpM -1.6 -1.7 modulator of CbpA co-chaperone (NCBI) compare
b1292 sapC -1.6 -1.7 predicted antimicrobial peptide transporter subunit (NCBI) compare
b3977 tyrU -1.6 -0.7 tRNA-Tyr (NCBI) compare
b1877 yecT -1.6 -2.7 orf, hypothetical protein (VIMSS) compare
b4618 tisB -1.6 -1.6 lexA-regulated toxic peptide (RefSeq) compare
b2614 grpE -1.6 -1.6 heat shock protein (NCBI) compare
b3784 rfe -1.6 -6.2 UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase (NCBI) compare
b4585 sroB -1.6 -1.0 Novel sRNA, function unknown (RefSeq) compare
b0888 trxB -1.5 -2.2 thioredoxin reductase, FAD/NAD(P)-binding (NCBI) compare
b2082 ogrK -1.5 -2.1 DNA-binding transcriptional regulator prophage P2 remnant (NCBI) compare
b1503 ydeR -1.5 -3.0 predicted fimbrial-like adhesin protein (NCBI) compare
b2136 yohD -1.5 -1.6 orf, hypothetical protein (VIMSS) compare
b3792 wzxE -1.5 -5.1 O-antigen translocase (NCBI) compare
b3613 yibP -1.5 -3.4 putative membrane protein (VIMSS) compare
b1426 ydcH -1.5 -1.1 orf, hypothetical protein (VIMSS) compare
b1777 b1777 -1.5 -1.8 orf, hypothetical protein (VIMSS) compare
b4698 mgrR -1.5 -2.2 sRNA antisense regulator down regulates YgdQ and EptB, PhoPQ-regulated, Hfq-dependent; affects sensitivity to antimicrobial peptides (RefSeq) compare
b1219 ychN -1.5 -1.3 hypothetical protein (NCBI) compare
b1066 rimJ -1.5 -3.2 ribosomal-protein-S5-alanine N-acetyltransferase (NCBI) compare
b0746 valZ -1.4 -1.7 tRNA-Val (NCBI) compare
b4546 ypeB -1.4 -0.8 hypothetical protein (NCBI) compare
b3162 deaD -1.4 -3.8 inducible ATP-independent RNA helicase (VIMSS) compare
b2831 mutH -1.4 -1.9 DNA mismatch repair protein (NCBI) compare
b0737 tolQ -1.4 -1.8 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b0550 rusA -1.4 -2.0 DLP12 prophage; endonuclease RUS (NCBI) compare
b3237 argR -1.4 -2.7 arginine repressor (NCBI) compare
b1335 ogt -1.4 -2.1 O-6-alkylguanine-DNA:cysteine-protein methyltransferase (NCBI) compare
b2567 rnc -1.4 -0.8 ribonuclease III (NCBI) compare
b1594 dgsA -1.4 -2.2 DNA-binding transcriptional repressor (NCBI) compare
b0773 ybhB -1.3 -2.6 predicted kinase inhibitor (NCBI) compare
b1614 ydgA -1.3 -2.1 hypothetical protein (NCBI) compare
b4057 yjbR -1.3 -2.2 hypothetical protein (NCBI) compare
b3026 qseC -1.3 -3.2 sensory histidine kinase in two-component regulatory system with QseB (NCBI) compare
b3238 yhcN -1.3 -1.6 orf, hypothetical protein (VIMSS) compare
b2726 hypA -1.3 -1.9 protein involved in nickel insertion into hydrogenases 3 (NCBI) compare
b4011 yjaA -1.3 -2.4 hypothetical protein (NCBI) compare
b0889 lrp -1.3 -1.5 DNA-binding transcriptional dual regulator, leucine-binding (NCBI) compare
b1600 mdtJ -1.3 -0.9 multidrug efflux system transporter (NCBI) compare
b0974 hyaC -1.3 -2.2 hydrogenase 1, b-type cytochrome subunit (NCBI) compare
b0937 ssuE -1.3 -1.8 NAD(P)H-dependent FMN reductase (NCBI) compare
b0200 gmhB -1.3 -0.8 hypothetical protein (NCBI) compare
b4042 dgkA -1.3 -1.8 diacylglycerol kinase (NCBI) compare
b2934 cmtB -1.3 -0.7 predicted mannitol-specific enzyme IIA component of PTS (NCBI) compare
b4172 hfq -1.2 -0.8 RNA-binding protein Hfq (NCBI) compare
b0740 tolB -1.2 -3.0 translocation protein TolB precursor (NCBI) compare
b1370 insH-5 -1.2 -1.1 Rac prophage; IS5 transposase and trans-activator (NCBI) compare
b1565 ydfV -1.2 -2.4 Qin prophage; predicted protein (NCBI) compare
b1675 ydhZ -1.2 -4.1 hypothetical protein (NCBI) compare
b1516 lsrB -1.2 -1.6 AI2 transporter (NCBI) compare
b1183 umuD -1.2 -1.2 DNA polymerase V, subunit D (NCBI) compare
b2912 ygfA -1.2 -2.0 putative ligase (VIMSS) compare
b1931 yedK -1.2 -2.4 hypothetical protein (NCBI) compare
b3786 rffE -1.2 -5.5 UDP-N-acetyl glucosamine-2-epimerase (NCBI) compare
b4675 yoaJ -1.2 -2.6 expressed protein (RefSeq) compare
b4458 oxyS -1.2 -0.9 global regulatory RNA (NCBI) compare
b4594 ymgJ -1.2 -1.5 hypothetical protein (RefSeq) compare
b2545 yphC -1.2 -3.0 putative oxidoreductase (VIMSS) compare
b1299 puuR -1.2 -2.7 DNA-binding transcriptional repressor (NCBI) compare
b1496 yddA -1.2 -4.3 fused predicted multidrug transporter subunits of ABC superfamily: membrane component/ATP-binding component (NCBI) compare
b3198 kdsC -1.2 -1.5 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (NCBI) compare
b1671 ydhX -1.2 -1.2 predicted 4Fe-4S ferridoxin-type protein (RefSeq) compare
b1025 ycdT -1.2 -0.8 predicted diguanylate cyclase (NCBI) compare
b1628 rsxB -1.2 -1.9 electron transport complex protein RnfB (NCBI) compare
b4048 yjbM -1.2 -0.8 hypothetical protein (NCBI) compare
b1803 yeaX -1.1 -1.9 predicted oxidoreductase (NCBI) compare
b0467 priC -1.1 -2.6 primosomal replication protein N'' (NCBI) compare
b0125 hpt -1.1 -1.9 hypoxanthine phosphoribosyltransferase (VIMSS) compare
b1855 lpxM -1.1 -1.8 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase (NCBI) compare
b4414 tff -1.1 -1.5 unknown RNA (NCBI) compare
b1160 elbA -1.1 -0.6 hypothetical protein (NCBI) compare
b2141 yohJ -1.1 -1.2 hypothetical protein (NCBI) compare
b3361 fic -1.1 -2.2 stationary-phase protein, cell division (NCBI) compare
b4184 yjfL -1.1 -3.3 conserved inner membrane protein (NCBI) compare
b4608 ryfC -1.1 -1.5 Novel sRNA, function unknown (RefSeq) compare
b4477 dgoA -1.1 -2.5 2-dehydro-3-deoxy-6-phosphogalactonate aldolase (NCBI) compare
b1253 yciA -1.1 -1.8 predicted hydrolase (NCBI) compare
b2237 inaA -1.1 -1.4 hypothetical protein (NCBI) compare
b3630 rfaP -1.1 -5.7 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b2685 emrA -1.1 -3.8 multidrug efflux system (NCBI) compare
b0187 yaeR -1.1 -1.4 orf, hypothetical protein (VIMSS) compare
b3728 pstS -1.1 -2.2 phosphate transporter subunit (NCBI) compare
b1782 mipA -1.1 -2.5 scaffolding protein for murein synthesizing machinery (NCBI) compare
b4676 yoaK -1.1 -0.4 expressed protein (RefSeq) compare
b1004 wrbA -1.1 -2.1 TrpR binding protein WrbA (NCBI) compare
b2490 b2490 -1.0 -0.9 putative protein processing element (VIMSS) compare
b1251 yciI -1.0 -2.4 orf, hypothetical protein (VIMSS) compare
b0405 queA -1.0 -2.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase (NCBI) compare
b1985 yeeO -1.0 -3.4 predicted multidrug efflux system (RefSeq) compare
b1890 motA -1.0 -1.7 flagellar motor protein MotA (NCBI) compare
b1382 ynbE -1.0 -0.7 predicted lipoprotein (NCBI) compare
b3979 thrT -1.0 -0.3 tRNA-Thr (NCBI) compare
b3778 rep -1.0 -3.8 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b2814 metZ -1.0 -0.9 tRNA-Met (NCBI) compare
b1945 fliM -1.0 -3.5 flagellar motor switch protein M (NCBI) compare
b1344 ydaO -1.0 -1.7 predicted C32 tRNA thiolase (NCBI) compare
b2564 pdxJ -1.0 -2.0 pyridoxal phosphate biosynthetic protein (NCBI) compare
b1853 yebK -1.0 -1.4 predicted DNA-binding transcriptional regulator (NCBI) compare
b1527 yneK -1.0 -1.3 hypothetical protein (NCBI) compare
b0844 b0844 -1.0 -2.7 orf, hypothetical protein (VIMSS) compare
b1322 ycjF -1.0 -2.5 hypothetical protein (NCBI) compare
b0226 dinJ -1.0 -1.8 predicted antitoxin of YafQ-DinJ toxin-antitoxin system (NCBI) compare
b0630 lipB -1.0 -1.1 protein of lipoate biosynthesis (VIMSS) compare
b0810 glnP -1.0 -2.6 glutamine ABC transporter permease protein (NCBI) compare
b1090 plsX -1.0 -2.2 glycerolphosphate auxotrophy in plsB background (VIMSS) compare
b1013 ycdC -1.0 -1.2 predicted DNA-binding transcriptional regulator (NCBI) compare
b2499 purM -0.9 -1.7 phosphoribosylaminoimidazole synthetase (NCBI) compare
b2354 yfdK -0.9 -2.9 CPS-53 (KpLE1) prophage; conserved protein (NCBI) compare
b3163 nlpI -0.9 -1.9 hypothetical protein (NCBI) compare
b1223 narK -0.9 -1.6 nitrate/nitrite transporter (NCBI) compare
b4543 ypaA -0.9 -1.5 predicted protein (NCBI) compare
b3563 yiaB -0.9 -3.0 orf, hypothetical protein (VIMSS) compare
b3706 trmE -0.9 -2.9 tRNA modification GTPase (NCBI) compare
b4685 yrbN -0.9 -1.5 expressed protein (RefSeq) compare
b1518 lsrG -0.9 -0.8 autoinducer-2 (AI-2) modifying protein LsrG (NCBI) compare
b1357 ydaS -0.9 -0.7 Rac prophage; predicted DNA-binding transcriptional regulator (NCBI) compare
b2699 recA -0.9 -0.6 recombinase A (NCBI) compare
b0217 yafT -0.9 -2.2 predicted aminopeptidase (NCBI) compare
b4559 yjdO -0.9 -2.7 hypothetical protein (NCBI) compare
b3024 ygiW -0.9 -1.4 hypothetical protein (NCBI) compare
b2683 ygaH -0.9 -2.5 predicted inner membrane protein (NCBI) compare
b1286 rnb -0.9 -1.5 exoribonuclease II (NCBI) compare
b2537 hcaR -0.9 -2.3 DNA-binding transcriptional activator of 3-phenylpropionic acid catabolism (NCBI) compare
b1175 minD -0.9 -2.2 membrane ATPase of the MinC-MinD-MinE system (NCBI) compare
b0976 hyaE -0.9 -0.9 protein involved in processing of HyaA and HyaB proteins (NCBI) compare


Specific Phenotypes

For 2 genes in this experiment

For stress Ciprofloxacin Hydrochloride in Escherichia coli BW25113

For stress Ciprofloxacin Hydrochloride across organisms