Experiment set13IT009 for Escherichia coli BW25113

Compare to:

LB with Ciprofloxacin Hydrochloride 0.0024 mM

200 most detrimental genes:

  gene name fitness t score description  
b2684 mprA +4.3 7.8 DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux (NCBI) compare
b0464 acrR +2.6 17.0 DNA-binding transcriptional repressor (NCBI) compare
b0142 folK +2.2 1.4 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) compare
b1861 ruvA +2.1 2.5 Holliday junction DNA helicase motor protein (NCBI) compare
b2531 iscR +1.7 2.1 DNA-binding transcriptional repressor (NCBI) compare
b3341 rpsG +1.6 2.2 30S ribosomal protein S7 (NCBI) compare
b1103 ycfF +1.6 2.2 orf, hypothetical protein (VIMSS) compare
b0398 sbcD +1.6 9.4 exonuclease, dsDNA, ATP-dependent (NCBI) compare
b1150 ymfR +1.5 1.7 e14 prophage; predicted protein (NCBI) compare
b1362 rzpR +1.5 1.7 putative Rac prophage endopeptidase (VIMSS) compare
b1147 ymfL +1.5 2.4 e14 prophage; predicted DNA-binding transcriptional regulator (RefSeq) compare
b1882 cheY +1.5 0.9 chemotaxis regulator transmitting signal to flagellar motor component (NCBI) compare
b4426 isrA +1.5 2.8 unknown RNA (NCBI) compare
b2285 nuoE +1.5 1.9 NADH dehydrogenase subunit E (NCBI) compare
b2356 yfdM +1.5 3.5 orf, hypothetical protein (VIMSS) compare
b1613 manA +1.4 2.0 mannose-6-phosphate isomerase (VIMSS) compare
b1727 yniC +1.3 2.0 predicted hydrolase (NCBI) compare
b4592 yccB +1.3 1.7 hypothetical protein (RefSeq) compare
b2846 yqeH +1.3 0.8 orf, hypothetical protein (VIMSS) compare
b3844 fre +1.3 4.7 NAD(P)H-flavin reductase (NCBI) compare
b0880 cspD +1.3 2.9 cold shock protein homolog (NCBI) compare
b1462 b1462 +1.3 2.8 orf, hypothetical protein (VIMSS) compare
b0881 clpS +1.2 2.1 ATP-dependent Clp protease adaptor protein ClpS (NCBI) compare
b4552 yrhC +1.2 1.2 no description compare
b3002 yqhA +1.2 1.9 hypothetical protein (NCBI) compare
b4416 rybA +1.2 1.6 unknown RNA (NCBI) compare
b0542 renD +1.2 2.3 orf, hypothetical protein (VIMSS) compare
b4144 yjeI +1.2 2.8 orf, hypothetical protein (VIMSS) compare
b2945 endA +1.2 4.6 DNA-specific endonuclease I (NCBI) compare
b0082 mraW +1.2 3.4 S-adenosyl-methyltransferase (NCBI) compare
b4313 fimE +1.1 6.3 tyrosine recombinase/inversion of on/off regulator of fimA (NCBI) compare
b1138 ymfE +1.1 1.3 e14 prophage; predicted inner membrane protein (NCBI) compare
b3636 rpmG +1.1 1.2 50S ribosomal protein L33 (NCBI) compare
b1586 b1586 +1.1 2.8 orf, hypothetical protein (VIMSS) compare
b2377 yfdY +1.1 2.0 predicted inner membrane protein (NCBI) compare
b1961 dcm +1.1 0.8 DNA cytosine methylase (NCBI) compare
b4406 yaeP +1.1 1.8 hypothetical protein (NCBI) compare
b4431 rprA +1.1 1.4 Positive regulatory sRNA for RpoS translation; non-essential gene (RefSeq) compare
b1524 yneH +1.1 1.0 predicted glutaminase (NCBI) compare
b1348 lar +1.1 1.3 Rac prophage; restriction alleviation protein (NCBI) compare
b4480 hdfR +1.1 3.3 transcriptional regulator HdfR (NCBI) compare
b0957 ompA +1.1 2.8 outer membrane protein A (3a;II*;G;d) (NCBI) compare
b1293 sapB +1.0 1.5 predicted antimicrobial peptide transporter subunit (NCBI) compare
b1231 tyrT +1.0 0.7 tRNA-Tyr (NCBI) compare
b2143 cdd +1.0 1.8 cytidine deaminase (NCBI) compare
b4201 priB +1.0 2.0 primosomal replication protein N (NCBI) compare
b0927 ycbL +1.0 1.5 predicted metal-binding enzyme (NCBI) compare
b0397 sbcC +1.0 5.6 exonuclease, dsDNA, ATP-dependent (NCBI) compare
b4702 mgtL +1.0 1.9 regulatory leader peptide for mgtA (NCBI) compare
b4522 yciX_1 +1.0 1.2 hypothetical protein (NCBI) compare
b3504 yhiS +1.0 0.8 hypothetical protein (RefSeq) compare
b1728 ydjM +1.0 1.6 predicted inner membrane protein regulated by LexA (RefSeq) compare
b2083 yegZ +1.0 1.3 orf, hypothetical protein (VIMSS) compare
b4163 glyV +1.0 1.6 tRNA-Gly (NCBI) compare
b4590 ybfK +1.0 1.5 hypothetical protein (RefSeq) compare
b1547 stfQ +1.0 1.8 Qin prophage; predicted side tail fibre assembly protein (NCBI) compare
b1753 ynjA +1.0 1.3 hypothetical protein (NCBI) compare
b3204 ptsN +0.9 2.6 sugar-specific enzyme IIA component of PTS (NCBI) compare
b0222 lpcA +0.9 1.9 phosphoheptose isomerase (NCBI) compare
b0778 bioD +0.9 2.4 dethiobiotin synthetase (NCBI) compare
b3183 obgE +0.9 0.9 GTPase involved in cell partioning and DNA repair (NCBI) compare
b0560 nohB +0.9 0.9 DLP12 prophage; DNA packaging protein (NCBI) compare
b1735 chbR +0.9 2.2 DNA-binding transcriptional dual regulator (NCBI) compare
b1841 yobA +0.9 1.5 hypothetical protein (NCBI) compare
b0597 ybdB +0.9 3.2 hypothetical protein (NCBI) compare
b1423 ydcJ +0.9 1.3 hypothetical protein (NCBI) compare
b4653 yicT +0.9 1.9 no description compare
b1085 b1085 +0.9 1.1 orf, hypothetical protein (VIMSS) compare
b1038 csgF +0.9 1.3 predicted transport protein (NCBI) compare
b1917 yecC +0.9 1.3 predicted transporter subunit: ATP-binding component of ABC superfamily (NCBI) compare
b0127 yadG +0.9 2.6 predicted transporter subunit: ATP-binding component of ABC superfamily (NCBI) compare
b2528 iscA +0.9 1.1 iron-sulfur cluster assembly protein (NCBI) compare
b3280 yrdB +0.8 2.1 hypothetical protein (NCBI) compare
b4511 ybdZ +0.8 1.4 hypothetical protein (NCBI) compare
b2017 yefM +0.8 1.3 orf, hypothetical protein (VIMSS) compare
b1171 b1171 +0.8 1.2 orf, hypothetical protein (VIMSS) compare
b1520 b1520 +0.8 2.4 orf, hypothetical protein (VIMSS) compare
b3398 yrfF +0.8 2.1 predicted inner membrane protein (NCBI) compare
b2063 yegH +0.8 2.9 putative transport protein (VIMSS) compare
b1724 ydiZ +0.8 1.6 hypothetical protein (NCBI) compare
b0294 ykgK +0.8 2.4 predicted regulator (NCBI) compare
b4588 ylcH +0.8 1.9 hypothetical protein, DLP12 prophage (RefSeq) compare
b1233 ychJ +0.8 2.3 hypothetical protein (NCBI) compare
b0367 tauC +0.8 1.5 taurine transporter subunit (NCBI) compare
b3658 selC +0.8 1.5 tRNA-Sec (NCBI) compare
b4548 ypjJ +0.8 1.5 hypothetical protein (NCBI) compare
b3107 yhaL +0.8 1.1 orf, hypothetical protein (VIMSS) compare
b1920 fliY +0.8 2.0 cystine transporter subunit (NCBI) compare
b4536 yobH +0.8 1.6 hypothetical protein (NCBI) compare
b0225 yafQ +0.8 2.0 predicted toxin of the YafQ-DinJ toxin-antitoxin system (NCBI) compare
b1272 sohB +0.8 2.9 predicted inner membrane peptidase (NCBI) compare
b1837 yebW +0.8 1.4 orf, hypothetical protein (VIMSS) compare
b1581 rspA +0.8 1.8 predicted dehydratase (NCBI) compare
b2352 yfdI +0.8 1.0 CPS-53 (KpLE1) prophage; predicted inner membrane protein (NCBI) compare
b0977 hyaF +0.8 2.4 protein involved in nickel incorporation into hydrogenase-1 proteins (NCBI) compare
b3649 rpoZ +0.8 2.6 DNA-directed RNA polymerase subunit omega (NCBI) compare
b0440 hupB +0.8 3.0 HU, DNA-binding transcriptional regulator, beta subunit (NCBI) compare
b0249 ykfF +0.8 1.3 CP4-6 prophage; predicted protein (NCBI) compare
b1427 rimL +0.8 1.0 ribosomal-protein-L7/L12-serine acetyltransferase (NCBI) compare
b2423 cysW +0.8 2.3 sulfate/thiosulfate transporter subunit (NCBI) compare
b2659 b2659 +0.8 1.6 orf, hypothetical protein (VIMSS) compare
b3813 uvrD +0.8 5.5 DNA-dependent ATPase I and helicase II (NCBI) compare
b1692 ydiB +0.8 1.6 quinate/shikimate 5-dehydrogenase, NAD(P)-binding (NCBI) compare
b1821 b1821 +0.8 2.2 orf, hypothetical protein (VIMSS) compare
b4598 yncL +0.8 1.3 hypothetical protein (RefSeq) compare
b1259 yciG +0.8 1.0 orf, hypothetical protein (VIMSS) compare
b2509 xseA +0.8 3.5 exodeoxyribonuclease VII large subunit (NCBI) compare
b3390 aroK +0.8 1.1 shikimate kinase I (NCBI) compare
b1621 malX +0.8 2.0 fused maltose and glucose-specific PTS enzymes: IIB component -! IIC component (NCBI) compare
b1465 narV +0.8 1.5 nitrate reductase 2 (NRZ), gamma subunit (NCBI) compare
b1726 yniB +0.8 1.3 predicted inner membrane protein (NCBI) compare
b2859 ygeO +0.8 1.1 hypothetical protein (RefSeq) compare
b1918 yecS +0.7 1.8 predicted transporter subunit: membrane component of ABC superfamily (NCBI) compare
b1954 dsrA +0.7 1.3 regulatory antisense RNA (NCBI) compare
b0839 dacC +0.7 3.2 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 6a) (NCBI) compare
b2258 b2258 +0.7 0.7 putative transport/receptor protein (VIMSS) compare
b2263 yfbB +0.7 2.0 predicted peptidase (NCBI) compare
b4000 hupA +0.7 1.6 HU, DNA-binding transcriptional regulator, alpha subunit (NCBI) compare
b4436 ryeC +0.7 1.0 Novel sRNA, function unknown; paralogous to the other QUAD sRNA genes unknown (RefSeq) compare
b2319 usg +0.7 1.8 hypothetical protein (NCBI) compare
b1495 yddB +0.7 3.3 predicted porin protein (NCBI) compare
b2027 wzzB +0.7 2.1 regulator of length of O-antigen component of lipopolysaccharide chains (VIMSS) compare
b1258 yciF +0.7 0.8 hypothetical protein (NCBI) compare
b3119 tdcR +0.7 1.2 threonine dehydratase operon activator protein (VIMSS) compare
b0776 bioF +0.7 2.6 8-amino-7-oxononanoate synthase (NCBI) compare
b2012 yeeD +0.7 1.5 hypothetical protein (NCBI) compare
b0131 panD +0.7 1.5 aspartate 1-decarboxylase precursor (NCBI) compare
b0965 b0965 +0.7 1.5 orf, hypothetical protein (VIMSS) compare
b2758 ygcJ +0.7 2.8 hypothetical protein (NCBI) compare
b0462 acrB +0.7 5.0 multidrug efflux system protein (NCBI) compare
b0852 rimK +0.7 1.6 ribosomal protein S6 modification protein (NCBI) compare
b0530 sfmA +0.7 1.9 putative fimbrial-like protein (VIMSS) compare
b2135 yohC +0.7 1.4 orf, hypothetical protein (VIMSS) compare
b3349 slyD +0.7 2.8 FKBP-type peptidyl prolyl cis-trans isomerase (rotamase) (NCBI) compare
b0388 aroL +0.7 2.1 shikimate kinase II (NCBI) compare
b2398 yfeC +0.7 1.4 orf, hypothetical protein (VIMSS) compare
b1849 purT +0.7 2.5 phosphoribosylglycinamide formyltransferase 2 (NCBI) compare
b3259 prmA +0.7 2.9 ribosomal protein L11 methyltransferase (NCBI) compare
b2301 yfcF +0.7 2.0 predicted enzyme (NCBI) compare
b4045 yjbJ +0.7 1.1 predicted stress response protein (NCBI) compare
b0015 dnaJ +0.7 3.0 chaperone Hsp40, co-chaperone with DnaK (NCBI) compare
b2189 proL +0.7 0.8 tRNA-Pro (NCBI) compare
b0326 yahL +0.7 2.0 hypothetical protein (NCBI) compare
b0463 acrA +0.7 3.7 multidrug efflux system (NCBI) compare
b1936 intG +0.7 0.5 predicted defective phage integrase (pseudogene) (RefSeq) compare
b1648 b1648 +0.7 0.8 orf, hypothetical protein (VIMSS) compare
b4094 phnN +0.7 1.9 ribose 1,5-bisphosphokinase (NCBI) compare
b1664 ydhQ +0.7 2.2 hypothetical protein (NCBI) compare
b2583 yfiP +0.7 2.9 orf, hypothetical protein (VIMSS) compare
b3101 yqjF +0.7 2.2 orf, hypothetical protein (VIMSS) compare
b2570 rseC +0.7 2.1 RseC protein involved in reduction of the SoxR iron-sulfur cluster (NCBI) compare
b3889 yiiE +0.7 1.8 predicted transcriptional regulator (RefSeq) compare
b1800 yeaU +0.7 2.3 predicted dehydrogenase (NCBI) compare
b1359 ydaU +0.7 1.3 Rac prophage; conserved protein (NCBI) compare
b1523 yneG +0.7 0.9 hypothetical protein (NCBI) compare
b3781 trxA +0.7 1.9 thioredoxin 1 (VIMSS) compare
b1182 hlyE +0.7 0.7 hemolysin E (VIMSS) compare
b0295 ykgL +0.7 2.2 hypothetical protein (NCBI) compare
b0789 ybhO +0.7 2.1 cardiolipin synthase 2 (NCBI) compare
b2918 argK +0.7 1.9 arginine/ornithine transport system ATPase (NCBI) compare
b1124 potC +0.7 2.0 spermidine/putrescine ABC transporter membrane protein (NCBI) compare
b1843 yobB +0.6 2.0 hypothetical protein (NCBI) compare
b2025 hisF +0.6 1.6 imidazole glycerol phosphate synthase subunit HisF (NCBI) compare
b1263 trpD +0.6 0.8 bifunctional indole-3-glycerol-phosphate synthase/anthranilate phosphoribosyltransferase (NCBI) compare
b2066 udk +0.6 1.2 uridine/cytidine kinase (VIMSS) compare
b1000 cbpA +0.6 2.4 curved DNA-binding protein, DnaJ homologue that functions as a co-chaperone of DnaK (NCBI) compare
b1463 nhoA +0.6 1.7 N-hydroxyarylamine O-acetyltransferase (NCBI) compare
b1526 yneJ +0.6 1.2 predicted DNA-binding transcriptional regulator (NCBI) compare
b0279 yagM +0.6 0.7 CP4-6 prophage; predicted protein (NCBI) compare
b0081 mraZ +0.6 1.8 hypothetical protein (NCBI) compare
b1588 ynfF +0.6 1.1 oxidoreductase subunit (RefSeq) compare
b1835 yebU +0.6 0.9 putative nucleolar proteins (VIMSS) compare
b0323 yahI +0.6 1.8 predicted carbamate kinase-like protein (NCBI) compare
b2577 yfiE +0.6 2.8 putative transcriptional regulator LYSR-type (VIMSS) compare
b1488 ddpX +0.6 1.1 D-ala-D-ala dipeptidase, Zn-dependent (NCBI) compare
b4692 oweE +0.6 1.1 no description compare
b1486 ddpB +0.6 0.7 D-ala-D-ala transporter subunit (NCBI) compare
b1983 yeeN +0.6 1.9 hypothetical protein (NCBI) compare
b3205 yhbJ +0.6 1.2 hypothetical protein (NCBI) compare
b1156 tfaE +0.6 2.2 e14 prophage; predicted tail fiber assembly protein (NCBI) compare
b0981 yccC +0.6 2.0 cryptic autophosphorylating protein tyrosine kinase Etk (NCBI) compare
b1519 tam +0.6 1.1 trans-aconitate 2-methyltransferase (NCBI) compare
b2741 rpoS +0.6 1.3 RNA polymerase sigma factor (NCBI) compare
b1418 cybB +0.6 1.6 cytochrome b(561) (VIMSS) compare
b1791 yeaN +0.6 1.3 predicted transporter (NCBI) compare
b3032 cpdA +0.6 2.3 cyclic 3',5'-adenosine monophosphate phosphodiesterase (NCBI) compare
b0488 ybbJ +0.6 1.9 conserved inner membrane protein (RefSeq) compare
b2906 visC +0.6 2.0 hypothetical protein (NCBI) compare
b1900 araG +0.6 1.1 fused L-arabinose transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b1940 fliH +0.6 1.2 flagellar biosynthesis; export of flagellar proteins? (VIMSS) compare
b1832 yebR +0.6 1.6 free methionine-(R)-sulfoxide reductase (RefSeq) compare
b1358 ydaT +0.6 0.5 Rac prophage; predicted protein (NCBI) compare
b1809 b1809 +0.6 2.3 orf, hypothetical protein (VIMSS) compare
b3617 kbl +0.6 2.4 2-amino-3-ketobutyrate coenzyme A ligase (NCBI) compare
b2071 yegJ +0.6 1.0 hypothetical protein (NCBI) compare
b3663 yicN +0.6 2.5 orf, hypothetical protein (VIMSS) compare
b4644 ypjI +0.6 1.7 no description compare
b1266 yciV +0.6 1.0 hypothetical protein (NCBI) compare
b2904 gcvH +0.6 0.8 glycine cleavage system protein H (NCBI) compare
b0404 yajB +0.6 1.0 hypothetical protein (NCBI) compare


Specific Phenotypes

For 2 genes in this experiment

For stress Ciprofloxacin Hydrochloride in Escherichia coli BW25113

For stress Ciprofloxacin Hydrochloride across organisms