Experiment set12IT040 for Pseudomonas putida KT2440

Compare to:

4-Methyl-2-oxopentanoic acid carbon source

200 most detrimental genes:

  gene name fitness t score description  
PP_3286 +4.8 34.8 DNA-binding transcriptional repressor PaaX(phenylacetyl-CoA) compare
PP_2214 +2.0 11.7 3-hydroxyacyl-CoA dehydrogenase type-2 compare
PP_4874 +1.8 2.2 50S ribosomal protein L9 compare
PP_4776 +1.2 9.7 AsnC family transcriptional regulator compare
PP_2335 +1.2 8.3 methylcitrate synthase compare
PP_t29 +1.1 1.8 tRNA-Ala compare
PP_2430 +1.0 4.0 Transcriptional regulator, AraC family compare
PP_4642 +1.0 2.2 Cyclic diguanosine monophosphate-binding protein compare
PP_2387 +0.8 2.4 conserved protein of unknown function compare
PP_3492 +0.8 5.5 isobutyryl-CoA dehydrogenase (EC 1.3.8.5) (from data) compare
PP_2215 +0.8 4.3 acetyl-CoA acetyltransferase compare
PP_0191 +0.8 4.6 Transcriptional regulatory protein AlgQ compare
PP_4171 +0.8 6.8 conserved exported protein of unknown function compare
PP_4213 +0.7 2.0 putative dipeptidase compare
PP_5313 +0.7 2.9 DNA-binding protein HU-alpha compare
PP_5232 +0.7 2.1 conserved protein of unknown function compare
PP_5058 +0.7 4.3 Carboxy-terminal-processing protease compare
PP_4204 +0.7 2.7 antitoxin of the type II toxin-antitoxin MqsRA system and DNA-binding transcriptional repressor compare
PP_2903 +0.7 2.2 peptidyl-prolyl cis-trans isomerase B (rotamase B) compare
PP_1623 +0.7 5.2 RNA polymerase, sigma S (sigma 38) factor compare
PP_1575 +0.7 1.1 conserved protein of unknown function compare
PP_1025 +0.7 5.9 2-isopropylmalate synthase compare
PP_3946 +0.7 0.7 HTH-type transcriptional repressor NicR compare
PP_4354 +0.7 3.4 flagellar export apparatus subunit compare
PP_2773 +0.7 2.1 conserved protein of unknown function compare
PP_1142 +0.7 1.3 conserved protein of unknown function compare
PP_0803 +0.7 4.9 Protein secretion ABC efflux system, membrane fusion protein compare
PP_5331 +0.6 2.9 Long-chain acyl-CoA thioester hydrolase compare
PP_1325 +0.6 3.4 putative lipoprotein compare
PP_5076 +0.6 5.7 L-glutamate synthase(NADPH) alpha subunit compare
PP_5017 +0.6 1.4 Sec-independent protein translocase protein TatB compare
PP_0806 +0.6 6.0 putative Surface adhesion protein compare
PP_3491 +0.6 4.8 Enoly-coenzyme A hydratase/isomerase family protein compare
PP_0574 +0.6 5.4 DNA-binding response regulator, LuxR family compare
PP_2002 +0.6 1.6 putative enzyme compare
PP_1066 +0.6 3.7 C4-dicarboxylate transport transcriptional regulatory protein compare
PP_0804 +0.6 4.3 Protein secretion ABC efflux system, permease and ATP-binding protein compare
PP_4367 +0.6 2.5 Flagellar assembly protein FliH compare
PP_1999 +0.6 1.2 membrane protein required for colicin V production compare
PP_1683 +0.6 2.6 Transcriptional regulator, MarR family compare
PP_5075 +0.6 4.7 glutamate synthase (NADPH) beta subunit compare
PP_4942 +0.6 1.5 conserved protein of unknown function compare
PP_0307 +0.6 1.7 conserved exported protein of unknown function compare
PP_4406 +0.6 2.6 conserved protein of unknown function compare
PP_4172 +0.6 3.4 conserved exported protein of unknown function compare
PP_t13 +0.6 1.9 tRNA-Lys compare
PP_1237 +0.6 0.7 4-hydroxy-tetrahydrodipicolinate synthase compare
PP_1236 +0.6 3.6 putative Glycine cleavage system transcriptional repressor compare
PP_5667 +0.5 2.3 putative microcin B17-like-processing protein, McbC family compare
PP_4625 +0.5 2.6 anti-holin regulator of holin CidA compare
PP_3392 +0.5 1.4 conserved protein of unknown function compare
PP_1554 +0.5 2.7 conserved protein of unknown function compare
PP_1048 +0.5 1.7 putative protein secretion protein for export compare
PP_3105 +0.5 1.9 conserved membrane protein of unknown function compare
PP_4910 +0.5 1.2 conserved protein of unknown function compare
PP_2152 +0.5 2.2 glycerophosphoryl diester phosphodiesterase compare
PP_2889 +0.5 2.7 putative Transmembrane regulator PrtR compare
PP_2213 +0.5 3.3 putative acyl-CoA synthetase compare
PP_1386 +0.5 3.6 Probable efflux pump periplasmic linker TtgA compare
PP_4383 +0.5 3.1 Flagellar P-ring protein compare
PP_0065 +0.5 1.0 NAD-binding component of TrK potassium transporter compare
PP_0401 +0.5 1.3 Ribosomal RNA small subunit methyltransferase A compare
PP_1055 +0.5 0.7 Type II secretion pathway protein GspN compare
PP_1553 +0.5 1.6 conserved protein of unknown function compare
PP_1455 +0.5 1.8 conserved protein of unknown function compare
PP_2313 +0.5 1.0 conserved membrane protein of unknown function compare
PP_3660 +0.5 2.5 Transcriptional regulator, LysR family compare
PP_1761 +0.5 3.7 diguanylate cyclase with phosphodiesterase domain compare
PP_4546 +0.5 1.7 ATP-dependent helicase HrpA compare
PP_4268 +0.5 0.8 nucleoid-associated broad specificity regulator compare
PP_4944 +0.5 2.1 Carbamoyltransferase compare
PP_4006 +0.5 4.0 Putative arginyl-tRNA--protein transferase compare
PP_1788 +0.5 1.8 conserved protein of unknown function compare
PP_5283 +0.5 2.7 periplasmic dipeptide transport protein compare
PP_2291 +0.5 2.3 conserved protein of unknown function compare
PP_0250 +0.5 1.3 heat shock protein Hsp15 involved in ribosome recycling compare
PP_3401 +0.5 1.8 conserved protein of unknown function compare
PP_2334 +0.5 2.7 2-methylisocitrate lyase compare
PP_1384 +0.5 2.5 Probable efflux pump outer membrane protein TtgC compare
PP_3643 +0.5 2.1 putative Oxidoreductase compare
PP_1650 +0.5 4.1 Sensor protein GacS compare
PP_5528 +0.5 1.5 conserved protein of unknown function compare
PP_3241 +0.5 0.9 conserved exported protein of unknown function compare
PP_5671 +0.4 1.8 conserved protein of unknown function compare
PP_4870 +0.4 1.7 Azurin compare
PP_1583 +0.4 1.9 putative Structural protein P5 compare
PP_1385 +0.4 3.7 Probable efflux pump membrane transporter TtgB compare
PP_1632 +0.4 1.3 conserved protein of unknown function compare
PP_5589 +0.4 2.0 protein of unknown function containing Rhs repeat-associated core domain compare
PP_3233 +0.4 1.3 transcriptional regulator with 4Fe-4S cluster, Crp/Fnr family compare
PP_3454 +0.4 1.9 putative transcriptional regulatory protein compare
PP_0674 +0.4 3.5 ADP/ATP ratio sensor and inhibitor of translation compare
PP_5139 +0.4 2.2 cadmium translocating P-type ATPase compare
PP_4738 +0.4 2.0 conserved exported protein of unknown function compare
PP_1658 +0.4 1.3 conserved protein of unknown function compare
PP_4820 +0.4 2.3 tRNA-dihydrouridine synthase B compare
PP_4394 +0.4 2.7 flagella basal body P-ring formation protein compare
PP_4366 +0.4 3.5 flagellum-specific ATP synthase compare
PP_1268 +0.4 1.3 putative HtrA suppressor protein sohA compare
PP_4173 +0.4 3.1 Sensor histidine kinase/response regulator compare
PP_3094 +0.4 1.5 conserved exported protein of unknown function compare
PP_5422 +0.4 1.4 hypothetical protein compare
PP_1300 +0.4 2.0 putative amino acid ABC transporter - ATP-binding subunit compare
PP_5365 +0.4 3.4 putative fatty acid methyltransferase compare
PP_5706 +0.4 0.8 Sec translocation complex - SecG subunit compare
PP_2748 +0.4 1.2 putative Branched-chain amino acid ABC transporter, ATP-binding protein compare
PP_5201 +0.4 0.9 conserved protein of unknown function, UPF0149 family compare
PP_0510 +0.4 2.4 Thioredoxin compare
PP_4895 +0.4 1.0 tRNA dimethylallyltransferase compare
PP_0805 +0.4 2.8 Outer membrane efflux protein compare
PP_4504 +0.4 1.4 conserved exported protein of unknown function compare
PP_4835 +0.4 1.7 conserved exported protein of unknown function compare
PP_3089 +0.4 1.8 conserved protein of unknown function compare
PP_4808 +0.4 1.4 23S rRNA m3psi1915 methyltransferase compare
PP_5566 +0.4 2.6 protein of unknown function compare
PP_t11 +0.4 1.7 tRNA-Lys compare
PP_2907 +0.4 1.8 DNA-binding response regulator compare
PP_2126 +0.4 2.4 DNA-binding response regulator, LuxR family compare
PP_4943 +0.4 0.8 putative Glycosyl transferase compare
PP_4073 +0.4 1.4 conserved exported protein of unknown function compare
PP_3884 +0.4 1.9 Phage holin, lambda family compare
PP_4629 +0.4 1.8 Sensory box protein compare
PP_1352 +0.4 1.7 UPF0234 protein PP_1352 compare
PP_1176 +0.4 0.9 conserved protein of unknown function compare
PP_3874 +0.4 2.0 conserved protein of unknown function compare
PP_3318 +0.4 1.0 conserved protein of unknown function compare
PP_2765 +0.4 1.2 putative Sulfonate monooxygenase MsuD compare
PP_5586 +0.4 2.1 exported protein of unknown function compare
PP_2899 +0.4 1.2 conserved exported protein of unknown function compare
PP_3757 +0.4 1.0 Chemotaxis protein CheY compare
PP_2592 +0.4 2.1 Ferric siderophore ABC transporter, ATP-binding protein compare
PP_2759 +0.4 1.3 ribose ABC transporter - ATP-binding subunit compare
PP_0893 +0.4 1.8 ThiJ/PfpI family protein compare
PP_5441 +0.4 1.4 protein of unknown function compare
PP_2653 +0.4 1.8 Transcriptional regulator, Cro/CI family compare
PP_4197 +0.4 2.9 Transcriptional regulator, GntR family compare
PP_2810 +0.4 2.5 conserved exported protein of unknown function compare
PP_2454 +0.4 2.4 ribose ABC transporter, periplasmic ribose-binding subunit compare
PP_3081 +0.4 1.4 conserved protein of unknown function compare
PP_0512 +0.4 1.3 hypothetical protein compare
PP_4396 +0.4 2.0 conserved protein of unknown function compare
PP_1131 +0.4 1.4 outer membrane lipoprotein compare
PP_2640 +0.4 1.6 Acetyltransferase, GNAT family compare
PP_2457 +0.4 2.4 DNA-binding transcriptional repressor compare
PP_0329 +0.4 2.8 conserved protein of unknown function compare
PP_2031 +0.4 0.9 conserved protein of unknown function compare
PP_5212 +0.4 1.8 Oxidoreductase, iron-sulfur-binding compare
PP_0583 +0.4 1.8 Transcriptional regulator, AraC family compare
PP_4099 +0.4 3.4 two-componenent system BarA/UvrY - regulatory subunit compare
PP_3274 +0.4 2.0 ring 1,2-phenylacetyl-CoA epoxidase, reductase subunit compare
PP_4036 +0.3 2.3 D-hydantoinase/dihydropyrimidinase compare
PP_3522 +0.3 1.0 conserved protein of unknown function compare
PP_2455 +0.3 1.7 ribose ABC transporter - ATP-binding subunit compare
PP_4050 +0.3 3.0 glycogen synthase compare
PP_0919 +0.3 1.2 conserved protein of unknown function compare
PP_2826 +0.3 1.5 Transcriptional regulator MexT compare
PP_5007 +0.3 0.8 Polyhydroxyalkanoate granule-associated protein GA2 compare
PP_4262 +0.3 1.1 Cytochrome oxidase maturation protein, cbb3-type compare
PP_3931 +0.3 2.5 putative transporter compare
PP_0258 +0.3 1.6 regulator of murein cross-linking compare
PP_4893 +0.3 2.4 GTPase HflX compare
PP_2729 +0.3 1.5 conserved protein of unknown function compare
PP_4762 +0.3 1.9 Acyl-CoA thioesterase II compare
PP_1892 +0.3 1.1 conserved protein of unknown function compare
PP_2092 +0.3 1.9 Nitrate transporter compare
PP_4917 +0.3 1.3 3',5'-cyclic-nucleotide phosphodiesterase compare
PP_5223 +0.3 2.1 regulator of nucleotide diphosphokinase compare
PP_4070 +0.3 1.9 conserved protein of unknown function compare
PP_0593 +0.3 0.6 putative ribosome-binding factor compare
PP_0195 +0.3 1.0 conserved protein of unknown function compare
PP_2194 +0.3 1.7 Transcriptional regulator, LysR family compare
PP_5445 +0.3 0.9 conserved protein of unknown function compare
PP_2894 +0.3 1.4 conserved protein of unknown function compare
PP_0711 +0.3 1.3 putative hydrolase compare
PP_5565 +0.3 1.7 conserved protein of unknown function compare
PP_1034 +0.3 2.4 multicopper oxidase compare
PP_3908 +0.3 1.8 conserved protein of unknown function compare
PP_0504 +0.3 1.9 Outer membrane protein OprG compare
PP_1058 +0.3 2.9 conserved protein of unknown function compare
PP_1007 +0.3 2.4 putative Transmembrane sensor compare
PP_2281 +0.3 1.7 putative Capsid assembly protein compare
PP_4478 +0.3 2.1 N-succinylglutamate 5-semialdehyde dehydrogenase compare
PP_1113 +0.3 2.5 Pyridoxal-phosphate dependent enzyme family protein compare
PP_2379 +0.3 1.6 putative cytochrome oxidase biogenesis protein compare
PP_4947 +0.3 2.7 proline dehydrogenase/1-pyrroline-5-carboxylate dehydrogenase compare
PP_5256 +0.3 1.4 Cyclic nucleotide-binding protein compare
PP_1362 +0.3 1.0 pyruvate kinase II compare
PP_0725 +0.3 1.4 conserved hypothetical TPR repeat protein compare
PP_3593 +0.3 2.1 L-lysine and D-lysine ABC transporter, substrate-binding component (from data) compare
PP_4227 +0.3 0.7 conserved protein of unknown function compare
PP_0151 +0.3 1.4 conserved exported protein of unknown function compare
PP_3846 +0.3 1.9 (R)-stereoselective amidase compare
PP_2101 +0.3 1.8 DNA-binding response regulator in two-component regulatory system with EvgS compare
PP_1022 +0.3 1.2 glucose 6-phosphate-1-dehydrogenase compare
PP_4424 +0.3 1.1 Uncharacterized HTH-type transcriptional regulator y4tD compare
PP_2211 +0.3 1.7 Transcriptional regulator, AraC family compare
PP_0385 +0.3 1.2 putative serine acetyltransferase compare
PP_3861 +0.3 1.9 Phage FluMu protein gp46 compare
PP_3978 +0.3 1.4 conserved protein of unknown function compare
PP_5504 +0.3 1.4 conserved protein of unknown function compare


Specific Phenotypes

For 15 genes in this experiment

For carbon source 4-Methyl-2-oxovaleric acid in Pseudomonas putida KT2440

For carbon source 4-Methyl-2-oxovaleric acid across organisms