Experiment set10IT088 for Escherichia coli BW25113

Compare to:

LB Anaerobic with Vancomycin Hydrochloride from Streptomyces orientalis 0.00003125 mM

200 most detrimental genes:

  gene name fitness t score description  
b3194 yrbE +5.2 38.1 predicted toluene transporter subunit: membrane component of ABC superfamily (NCBI) compare
b2346 vacJ +5.1 35.6 predicted lipoprotein (NCBI) compare
b3192 yrbC +5.1 42.4 predicted ABC-type organic solvent transporter (NCBI) compare
b3193 yrbD +5.1 37.4 predicted ABC-type organic solvent transporter (NCBI) compare
b3195 yrbF +5.0 43.4 predicted toluene transporter subunit: ATP-binding component of ABC superfamily (NCBI) compare
b3026 qseC +5.0 21.0 sensory histidine kinase in two-component regulatory system with QseB (NCBI) compare
b3191 yrbB +4.7 31.3 orf, hypothetical protein (VIMSS) compare
b0632 dacA +4.3 22.2 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5) (NCBI) compare
b1830 prc +3.9 19.9 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b1049 mdoH +3.9 28.0 glucosyltransferase MdoH (NCBI) compare
b1048 mdoG +3.7 21.6 glucan biosynthesis protein, periplasmic (NCBI) compare
b4042 dgkA +3.4 11.2 diacylglycerol kinase (NCBI) compare
b3627 rfaI +3.2 20.0 UDP-D-galactose:(glucosyl)lipopolysaccharide- alpha-1,3-D-galactosyltransferase (NCBI) compare
b3794 rffM +3.2 19.0 putative UDP-N-acetyl-D-mannosaminuronic acid transferase (NCBI) compare
b3977 tyrU +3.1 4.1 tRNA-Tyr (NCBI) compare
b3786 rffE +3.1 25.4 UDP-N-acetyl glucosamine-2-epimerase (NCBI) compare
b1095 fabF +3.1 17.2 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b3790 rffC +3.0 16.3 TDP-fucosamine acetyltransferase (RefSeq) compare
b1097 yceG +3.0 18.6 predicted aminodeoxychorismate lyase (NCBI) compare
b3787 rffD +3.0 21.2 UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase (NCBI) compare
b2096 gatY +3.0 8.4 tagatose-bisphosphate aldolase 1 (VIMSS) compare
b3784 rfe +2.9 21.6 UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase (NCBI) compare
b4481 rffT +2.8 12.5 4-alpha-L-fucosyltransferase (NCBI) compare
b3628 rfaB +2.7 18.3 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase (RefSeq) compare
b3205 yhbJ +2.7 11.1 hypothetical protein (NCBI) compare
b3791 rffA +2.6 15.4 TDP-4-oxo-6-deoxy-D-glucose transaminase (NCBI) compare
b1187 fadR +2.5 13.8 fatty acid metabolism regulator (NCBI) compare
b1236 galU +2.4 11.9 glucose-1-phosphate uridylyltransferase (NCBI) compare
b0688 pgm +2.3 9.6 phosphoglucomutase (NCBI) compare
b3390 aroK +2.2 4.4 shikimate kinase I (NCBI) compare
b2093 gatB +2.2 6.0 galactitol-specific enzyme IIB component of PTS (NCBI) compare
b3979 thrT +2.2 1.1 tRNA-Thr (NCBI) compare
b0143 pcnB +2.1 10.3 poly(A) polymerase I (VIMSS) compare
b4558 yifL +2.1 6.5 predicted lipoprotein (NCBI) compare
b3785 wzzE +2.1 9.3 putative transport protein (VIMSS) compare
b1220 ychO +2.1 9.3 predicted invasin (RefSeq) compare
b2095 gatZ +2.0 8.5 D-tagatose 1,6-bisphosphate aldolase 2, subunit (NCBI) compare
b3169 nusA +2.0 5.8 transcription elongation factor NusA (NCBI) compare
b3204 ptsN +2.0 6.0 sugar-specific enzyme IIA component of PTS (NCBI) compare
b3688 yidQ +2.0 8.8 orf, hypothetical protein (VIMSS) compare
b4359 mdoB +2.0 16.2 phosphoglycerol transferase I (VIMSS) compare
b1279 yciS +2.0 2.9 conserved inner membrane protein (NCBI) compare
b0759 galE +1.9 11.3 UDP-galactose-4-epimerase (VIMSS) compare
b2092 gatC +1.9 7.4 galactitol-specific enzyme IIC component of PTS (NCBI) compare
b0125 hpt +1.9 9.8 hypoxanthine phosphoribosyltransferase (VIMSS) compare
b4041 plsB +1.9 5.2 glycerol-3-phosphate acyltransferase (VIMSS) compare
b1686 ydiI +1.7 2.4 hypothetical protein (NCBI) compare
b0051 ksgA +1.7 7.8 dimethyladenosine transferase (NCBI) compare
b0912 ihfB +1.7 4.8 integration host factor subunit beta (NCBI) compare
b4171 miaA +1.7 3.4 tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) compare
b1304 pspA +1.7 5.3 regulatory protein for phage-shock-protein operon (NCBI) compare
b1412 azoR +1.6 2.2 acyl carrier protein phosphodiesterase (NCBI) compare
b3465 yhhF +1.6 9.8 predicted methyltransferase (NCBI) compare
b2134 pbpG +1.6 9.4 penicillin-binding protein 7 (VIMSS) compare
b1349 recT +1.6 6.9 Rac prophage; recombination and repair protein (NCBI) compare
b1090 plsX +1.5 3.3 glycerolphosphate auxotrophy in plsB background (VIMSS) compare
b3632 rfaQ +1.5 13.1 lipopolysaccharide core biosynthesis protein (NCBI) compare
b1096 pabC +1.5 4.3 4-amino-4-deoxychorismate lyase (NCBI) compare
b1684 sufA +1.5 2.4 iron-sulfur cluster assembly scaffold protein (NCBI) compare
b3742 mioC +1.4 8.1 flavodoxin (NCBI) compare
b3911 cpxA +1.4 8.1 two-component sensor protein (NCBI) compare
b3806 cyaA +1.4 6.9 adenylate cyclase (NCBI) compare
b2424 cysU +1.4 2.6 sulfate/thiosulfate transporter subunit (NCBI) compare
b2350 yfdG +1.4 5.6 CPS-53 (KpLE1) prophage; bactoprenol-linked glucose translocase (flippase) (NCBI) compare
b0407 yajC +1.4 2.8 preprotein translocase subunit YajC (NCBI) compare
b4174 hflK +1.4 9.3 modulator for HflB protease specific for phage lambda cII repressor (NCBI) compare
b1805 fadD +1.4 9.4 acyl-CoA synthase (NCBI) compare
b3163 nlpI +1.4 6.5 hypothetical protein (NCBI) compare
b3009 yghB +1.3 5.6 conserved inner membrane protein (NCBI) compare
b2132 bglX +1.3 8.9 beta-D-glucoside glucohydrolase, periplasmic (NCBI) compare
b3625 rfaY +1.3 5.9 lipopolysaccharide core biosynthesis protein (NCBI) compare
b3289 rsmB +1.3 9.8 16S rRNA m5C967 methyltransferase, S-adenosyl-L-methionine-dependent (NCBI) compare
b2187 yejL +1.3 2.4 hypothetical protein (NCBI) compare
b1143 ymfI +1.3 1.6 orf, hypothetical protein (VIMSS) compare
b3207 yrbL +1.3 5.5 hypothetical protein (NCBI) compare
b2298 yfcC +1.3 7.7 putative S-transferase (VIMSS) compare
b3203 yhbH +1.3 1.7 predicted ribosome-associated, sigma 54 modulation protein (NCBI) compare
b0191 yaeJ +1.3 3.1 hypothetical protein (NCBI) compare
b2835 ygeD +1.2 7.3 predicted inner membrane protein (NCBI) compare
b0819 ybiS +1.2 6.0 hypothetical protein (NCBI) compare
b4577 sgrS +1.2 1.9 small antisense RNA (NCBI) compare
b2836 aas +1.2 8.7 2-acyl-glycerophospho-ethanolamine acyltransferase (NCBI) compare
b1685 ydiH +1.2 2.0 predicted protein (RefSeq) compare
b4175 hflC +1.2 7.8 modulator for HflB protease specific for phage lambda cII repressor (NCBI) compare
b3630 rfaP +1.2 9.2 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b2340 sixA +1.2 4.6 phosphohistidine phosphatase (NCBI) compare
b1423 ydcJ +1.2 4.0 hypothetical protein (NCBI) compare
b4392 slt +1.2 9.2 soluble lytic murein transglycosylase (VIMSS) compare
b0678 nagB +1.1 3.2 glucosamine-6-phosphate deaminase (NCBI) compare
b1584 speG +1.1 5.8 spermidine N1-acetyltransferase (NCBI) compare
b1424 mdoD +1.1 5.2 glucan biosynthesis protein, periplasmic (RefSeq) compare
b1656 sodB +1.1 2.1 superoxide dismutase, Fe (NCBI) compare
b2261 menC +1.1 5.1 O-succinylbenzoate synthase (NCBI) compare
b4552 yrhC +1.1 1.2 no description compare
b1833 yebS +1.1 5.4 conserved inner membrane protein (NCBI) compare
b2263 yfbB +1.1 2.9 predicted peptidase (NCBI) compare
b2094 gatA +1.1 4.0 galactitol-specific enzyme IIA component of PTS (NCBI) compare
b3788 rffG +1.1 5.1 dTDP-glucose 4,6-dehydratase (NCBI) compare
b0418 pgpA +1.1 5.7 phosphatidylglycerophosphatase A (NCBI) compare
b1047 mdoC +1.1 6.9 glucans biosynthesis protein (NCBI) compare
b2262 menB +1.1 4.2 naphthoate synthase (NCBI) compare
b1266 yciV +1.1 2.5 hypothetical protein (NCBI) compare
b0122 yacC +1.0 3.6 orf, hypothetical protein (VIMSS) compare
b3423 glpR +1.0 5.9 DNA-binding transcriptional repressor (NCBI) compare
b3164 pnp +1.0 2.2 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b2260 menE +1.0 6.7 O-succinylbenzoic acid--CoA ligase (NCBI) compare
b4438 cyaR +1.0 1.8 sRNA effector of ompX mRNA instability, cAMP-induced; hfq-dependent (RefSeq) compare
b0209 yafD +1.0 4.4 hypothetical protein (NCBI) compare
b2927 epd +1.0 5.1 D-erythrose 4-phosphate dehydrogenase (NCBI) compare
b3493 pitA +1.0 5.8 phosphate transporter, low-affinity (NCBI) compare
b1129 phoQ +1.0 1.8 sensory histidine kinase in two-compoent regulatory system with PhoP (NCBI) compare
b1429 tehA +1.0 1.0 potassium-tellurite ethidium and proflavin transporter (NCBI) compare
b2432 yfeY +1.0 2.7 hypothetical protein (NCBI) compare
b2701 mltB +1.0 4.4 membrane-bound lytic murein transglycosylase B (NCBI) compare
b3474 yhhT +0.9 6.1 orf, hypothetical protein (VIMSS) compare
b0722 sdhD +0.9 3.1 succinate dehydrogenase cytochrome b556 small membrane subunit (NCBI) compare
b1915 yecF +0.9 4.6 hypothetical protein (NCBI) compare
b2195 ccmG +0.9 2.8 periplasmic thioredoxin of cytochrome c-type biogenesis (NCBI) compare
b0877 ybjX +0.9 2.3 hypothetical protein (NCBI) compare
b2953 yggU +0.9 2.2 orf, hypothetical protein (VIMSS) compare
b3180 yhbY +0.9 3.1 predicted RNA-binding protein (NCBI) compare
b3258 panF +0.9 5.7 sodium/pantothenate symporter (VIMSS) compare
b1704 aroH +0.9 4.5 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tryptophan repressible (NCBI) compare
b0685 ybfE +0.9 3.0 orf, hypothetical protein (VIMSS) compare
b1064 grxB +0.9 2.6 glutaredoxin 2 (Grx2) (NCBI) compare
b1179 ycgL +0.9 2.5 conserved protein (NCBI) compare
b3389 aroB +0.9 4.1 3-dehydroquinate synthase (NCBI) compare
b3154 yhbP +0.9 5.0 hypothetical protein (NCBI) compare
b2682 ygaZ +0.9 3.8 predicted transporter (NCBI) compare
b2814 metZ +0.9 1.3 tRNA-Met (NCBI) compare
b3842 rfaH +0.9 3.5 transcriptional activator RfaH (NCBI) compare
b1752 ydjZ +0.9 1.8 conserved inner membrane protein (NCBI) compare
b1618 uidR +0.9 1.9 DNA-binding transcriptional repressor (NCBI) compare
b1842 holE +0.9 1.5 DNA polymerase III, theta subunit (NCBI) compare
b3418 malT +0.9 6.5 transcriptional regulator MalT (NCBI) compare
b0908 aroA +0.9 4.7 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) compare
b0493 ybbO +0.9 4.2 short chain dehydrogenase (NCBI) compare
b2684 mprA +0.9 2.6 DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux (NCBI) compare
b0114 aceE +0.9 1.4 pyruvate dehydrogenase subunit E1 (NCBI) compare
b0991 ymcE +0.9 3.4 cold shock gene (NCBI) compare
b1811 yoaH +0.9 2.6 hypothetical protein (NCBI) compare
b0250 ykfB +0.8 2.7 CP4-6 prophage; predicted protein (NCBI) compare
b0713 ybgL +0.8 4.0 hypothetical protein (NCBI) compare
b3918 cdh +0.8 4.5 CDP-diacylglycerol pyrophosphatase (NCBI) compare
b1693 aroD +0.8 2.7 3-dehydroquinate dehydratase (NCBI) compare
b1722 ydiY +0.8 4.7 hypothetical protein (NCBI) compare
b3631 rfaG +0.8 6.9 glucosyltransferase I (NCBI) compare
b2229 b2229 +0.8 3.2 orf, hypothetical protein (VIMSS) compare
b1712 ihfA +0.8 1.0 integration host factor subunit alpha (NCBI) compare
b2906 visC +0.8 3.7 hypothetical protein (NCBI) compare
b0796 ybiH +0.8 3.0 putative transcriptional regulator (VIMSS) compare
b1563 relE +0.8 1.1 Qin prophage; toxin of the RelE-RelB toxin-antitoxin system (NCBI) compare
b2264 menD +0.8 4.5 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase (NCBI) compare
b3926 glpK +0.8 6.3 glycerol kinase (NCBI) compare
b1362 rzpR +0.8 1.8 putative Rac prophage endopeptidase (VIMSS) compare
b1939 fliG +0.8 2.7 flagellar motor switch protein G (NCBI) compare
b3248 yhdE +0.8 3.5 Maf-like protein (NCBI) compare
b1834 yebT +0.8 4.5 orf, hypothetical protein (VIMSS) compare
b0982 yccY +0.8 3.2 putative phosphatase (VIMSS) compare
b4409 blr +0.8 4.2 beta-lactam resistance membrane protein (NCBI) compare
b4414 tff +0.8 1.8 unknown RNA (NCBI) compare
b0001 thrL +0.8 1.9 thr operon leader peptide (NCBI) compare
b0463 acrA +0.8 4.4 multidrug efflux system (NCBI) compare
b4546 ypeB +0.8 1.0 hypothetical protein (NCBI) compare
b1475 fdnH +0.7 3.7 formate dehydrogenase-N, Fe-S (beta) subunit, nitrate-inducible (NCBI) compare
b3746 yieN +0.7 5.8 putative 2-component regulator (VIMSS) compare
b3789 rffH +0.7 2.5 glucose-1-phosphate thymidylyltransferase (NCBI) compare
b0505 allA +0.7 1.6 ureidoglycolate hydrolase (NCBI) compare
b3728 pstS +0.7 2.1 phosphate transporter subunit (NCBI) compare
b0965 b0965 +0.7 1.2 orf, hypothetical protein (VIMSS) compare
b2951 yggS +0.7 2.2 predicted enzyme (NCBI) compare
b4390 nadR +0.7 5.0 probable nadAB transcriptional regulator (VIMSS) compare
b1113 ycfS +0.7 3.1 hypothetical protein (NCBI) compare
b3611 yibN +0.7 2.7 predicted rhodanese-related sulfurtransferase (NCBI) compare
b0841 ybjG +0.7 2.8 undecaprenyl pyrophosphate phosphatase (NCBI) compare
b3242 yhcR +0.7 2.2 orf, hypothetical protein (VIMSS) compare
b1104 ycfL +0.7 0.9 hypothetical protein (NCBI) compare
b3281 aroE +0.7 4.6 dehydroshikimate reductase, NAD(P)-binding (NCBI) compare
b3644 yicC +0.7 3.2 hypothetical protein (NCBI) compare
b3029 ygiN +0.7 1.5 quinol monooxygenase (NCBI) compare
b4533 ynfO +0.7 1.4 Qin prophage; predicted protein (NCBI) compare
b3035 tolC +0.7 4.5 outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) compare
b1533 ydeD +0.7 1.2 orf, hypothetical protein (VIMSS) compare
b1075 flgD +0.7 1.4 flagellar basal body rod modification protein D (NCBI) compare
b0619 citA +0.7 2.9 sensory histidine kinase in two-component regulatory system with citB (NCBI) compare
b3745 yieM +0.7 5.5 predicted von Willibrand factor containing protein (NCBI) compare
b1531 marA +0.7 1.9 multiple antibiotic resistance; transcriptional activator of defense systems (VIMSS) compare
b0869 ybjT +0.7 3.0 putative dTDP-glucose enzyme (VIMSS) compare
b1296 ycjJ +0.7 2.2 putative amino acid/amine transport protein (VIMSS) compare
b4567 yjjZ +0.7 2.3 hypothetical protein (NCBI) compare
b1856 yebA +0.7 3.3 orf, hypothetical protein (VIMSS) compare
b0920 ycbC +0.7 2.3 conserved inner membrane protein (NCBI) compare
b1699 ydiS +0.7 1.5 predicted oxidoreductase with FAD/NAD(P)-binding domain (NCBI) compare
b1523 yneG +0.7 1.1 hypothetical protein (NCBI) compare
b2516 yfgA +0.6 3.0 hypothetical protein (NCBI) compare
b2754 ygbF +0.6 2.3 orf, hypothetical protein (VIMSS) compare
b2356 yfdM +0.6 1.6 orf, hypothetical protein (VIMSS) compare
b1796 yoaG +0.6 1.9 hypothetical protein (NCBI) compare
b0520 ylbF +0.6 3.0 hypothetical protein (NCBI) compare
b0772 ybhC +0.6 4.5 predicted pectinesterase (NCBI) compare


Specific Phenotypes

For 54 genes in this experiment

For stress Vancomycin Hydrochloride from Streptomyces orientalis in Escherichia coli BW25113

For stress Vancomycin Hydrochloride from Streptomyces orientalis across organisms